A new microchip technology test kit has been developed and validated for efficient point-of-care testing in remote locations. The kit provides similar accuracy to traditional RT-qPCR tests while using 10-fold less reagents and taking results in as little as 30 minutes.
Researchers Farrokh Alemi and Amira Roess received funding to evaluate the effectiveness of symptom screening with predictive algorithm combined with at-home testing, finding it more accurate than alone.
A recent study by Lero researchers found that COVID-19 growth largely explained changes in stock prices globally, but had little impact on China or the MSCI World index. The study suggests that investor sentiment and economic factors such as crude oil and bond yields played a greater role in shaping market prices.
A new study by the ISARIC Coronavirus Clinical Characterisation Consortium found that in-hospital mortality declined from 32% to 16% as treatments like steroids and dexamethasone improved patient outcomes. Improvements in respiratory support and critical care also contributed to the better survival rates.
A large study of over 160,000 Medicare patients found no statistically significant difference in mortality between those treated with drug-coated and non-drug-coated peripheral devices. The research aimed to address concerns raised by a previous analysis and provides new insights into the safety of these devices.
Researchers have successfully treated a patient with vaccine-induced thrombotic thrombocytopenia (VITT) using intravenous immunoglobulin concentrates, cortisone, and specific anticoagulants. Prompt diagnosis and treatment can prevent life-threatening thrombosis.
Researchers have found that Tesla's patented valve can control flows and generate turbulence at low speeds, making it a potential alternative to conventional check valves. The device can harness vibrations in engines to pump fuel, coolant, lubricant, or other gases and liquids.
Researchers uncover how histone demethylase KDM5A promotes myeloma cell proliferation by regulating histone methylation. A novel KDM5 inhibitor inhibits cancer cell growth and is expected to develop into a new therapeutic strategy for multiple myeloma and other cancers.
The experimental drug omecamtiv mecarbil significantly reduces hospitalizations for patients with severe heart failure and low ejection fractions. It offers improved benefits over current medications, especially in those with more severely impaired hearts.
Research at ATS 2021 International Conference found a link between severe obstructive sleep apnea (OSA) and increased COVID-19 risk. Patients who adhered to positive airway pressure (PAP) therapy for longer periods had lower infection rates, suggesting PAP has a direct physiological benefit.
The central-western Greenland Ice Sheet is losing mass at an accelerating rate, with early warning signals suggesting a critical transition. The melt-elevation feedback mechanism drives this destabilization, indicating significantly enhanced melting in the near future.
A new study published in Cognitive Science found that parents' use of iconic words improves children's ability to learn new words, especially when introducing novel names. This is because iconicity aids attention to word meaning by exploiting similarities between sound and meaning.
Developed by Inserm teams and French company NEOVACS, the conjugate vaccine induces sustained production of antibodies against IL-4 and IL-13, significantly reducing asthma symptoms.
Researchers at the University of Tsukuba found that both endurance and high-intensity intermittent training improved exercise capacity and brain function in rats. HIIT resulted in increased cellular aerobic capacity and better memory for spatial learning trials.
Researchers at Mount Sinai found that SARS-CoV-2 can infect surface cells of the eye, revealing presence of infection-associated proteins and suppressed IFNβ. Ocular surface cells are susceptible to infection, while central cornea is less vulnerable.
A new study by Columbia University Mailman School of Public Health found that Photovoice, an educational intervention, significantly improves STEM-capacity scores and environmental awareness in low-income, urban youth. The results suggest a potential solution to environmental justice issues.
Researchers at the University of Adelaide found Cypriot grape varieties Maratheftiko and Xynisteri are well-suited for hot climates and deliver desirable flavor compounds. The study revealed comparable concentration of flavor compounds in Cypriot wines to popular Australian wines.
Researchers at Stanford University are urging the development of AI medical devices that account for diverse demographics to prevent inequities. The study highlights issues with data collection and evaluation methods, particularly regarding sex and race biases in pulse oximeters.
Researchers found that premature boys age more quickly than their normal weight counterparts, with a biological age gap of 4.6 years by age 30-35. This accelerated aging may be influenced by prenatal stress and hospital care after birth, emphasizing the need for monitoring and healthy aging strategies.
A study examining global occurrences and population estimates for approximately 92% of all extant bird species found that there are approximately 50 billion individual birds in the world. Most bird species are rare, with only a few having estimated global populations of over 1 billion individuals.
A multidisciplinary study has found that cells at the centre of kidney tumours have a higher potential to spread to secondary sites around the body. By contrast, cells at the tumour edge had lower rates of metastasis and growth.
Researchers found that more traditional perceptions of gender roles are associated with lower employment rates and lower personal income for women. The study suggests that changing cultural norms through education and publicity is necessary to address employment inequality in China.
Researchers found glycoRNAs, sugar-coated RNAs, decorating the surface of mammalian cells, interacting with other molecules. This discovery upends the current understanding of how cells handle RNAs and glycans, opening a possible role for glycoRNAs in immune disease.
Researchers at the Francis Crick Institute have discovered how lipid droplets in kidney cells help prevent damage from excess dietary fats. The study found that lipid droplets act as a safe haven for storing excess fats, and boosting the ATGL enzyme can repair damage caused by a high-fat diet.
A new European collaboration outlines initial steps towards a united global plan to protect the ocean's health. The researchers emphasize holistic collaboration to address threats like climate change and pollution, while highlighting the benefits of access to healthy coasts on human wellbeing.
Researchers used meta-analytic methods to evaluate data from 22 studies involving 5,349 individuals in 1,356 groups, finding strong support for a general factor of collective intelligence. Group collaboration processes were twice as important for predicting CI than individual skill, and group composition, including female proportion an...
Researchers detected new early-warning signals indicating the Greenland Ice Sheet's destabilization and potential melting at limited warming levels. The study suggests that a tipping point is approaching in the central-western part of the ice sheet, which could lead to substantial long-term sea level rise.
Using new methods in astronomy, researchers have identified the most precise ages of red giant stars in the galaxy, shedding light on the timing of the early Milky Way's formation. The study suggests that the merger with the satellite galaxy Gaia-Enceladus occurred around 10 billion years ago.
A new study evaluates ecological legacies, archaeo-ecosystem restoration and Indigenous co-management practices in the Bears Ears region. The research found that dense concentrations of archaeological features had a higher diversity of culturally significant plant species, indicating people left behind plants as a living legacy.
Researchers from Federal Research Centre of Biotechnology RAS deciphered activation mechanism of Orange Carotenoid Protein (OCP) upon exposure to light. The study used structural biology, biochemistry, spectroscopy, and quantum chemistry methods to determine OCP's crystal structure with high spatial resolution.
Researchers have dated the oldest stars in our galaxy with unprecedented precision by combining data from their oscillations with information about their chemical composition. The team found that these ancient stars were originally part of a satellite galaxy called Gaia-Enceladus, which collided with the Milky Way early in its history.
University of Maryland faculty members Shelby Bensi, Gregg Duncan, Katrina Groth, and Katharina Maisel have received CAREER grants for their innovative research in hazard assessment, gene therapy, risk assessment, and immunotherapy. Their work aims to advance the fields of civil engineering, bioengineering, and mechanical engineering.
A new paper suggests that current carbon budgets fail to account for permafrost thawing and Arctic feedback loops, exacerbating warming and potentially triggering an exponential increase in emissions. Global leaders are urged to incorporate the latest science into climate models and update risk assessments to meet climate goals.
A team of scientists at Cincinnati Children's Hospital Medical Center has discovered a promising new approach to preventing obesity-driven liver damage. By controlling a subgroup of immune system cells that trigger non-alcoholic fatty liver disease (NAFLD), researchers have identified a potential treatment target.
Researchers investigated seismic anisotropy in the Tianshan Tectonic Belt's upper crust, finding zoning patterns that correlate with tectonic stress fields. Time delays of slow waves also exhibit spatial differences, indicating stronger anisotropy in certain zones.
A new study describes four previously undiscovered species of sponges collected from popular dive spots in Southern California, highlighting their unique characteristics and genetic differences. The discovery sheds light on the vast diversity of marine life that remains to be explored and studied.
A team of scientists identified a critical checkpoint mechanism that fine-tunes gene transcription and is implicated in cancer. By targeting this mechanism, researchers found promising results in preclinical models of solid and hematopoietic malignancies.
A study of over 350,000 people found that genetic variants in mitochondrial DNA can increase the risk of type 2 diabetes, multiple sclerosis, and other diseases. Additionally, mitochondrial DNA influences characteristics such as height and lifespan. The study suggests complex interaction between mitochondrial and nuclear DNA.
A weather pattern known as atmospheric blocking causes reduced snowfall in Greenland, exposing older, darker snow that absorbs more heat. This results in faster melting of the ice sheet, with a potential impact of up to 25 gigatons of lost ice over three years.
Higher levels of interleukin 1β in an aggression-related brain region lead to fewer aggressive behaviors in mice, likely via its effects on serotonin neurons. The study suggests that interleukin 1β and serotonin neurons might be potential drug targets for reducing aggression.
A randomized survey experiment found heightened awareness of immigration detention fosters beliefs that the US immigration system lacks procedural and outcome fairness. Individuals' intentions to migrate were not influenced by heightened awareness of immigration detention or nonjudicial removals.
A new study by the University of New South Wales estimates that there are approximately 50 billion individual birds in the world, with many iconic Australian species falling within this number. However, other rare species like the Black-breasted Buttonquail have only around 100 members left, highlighting the need for conservation efforts.
Researchers assess Ethiopian bird species through six years' worth of bird banding efforts, finding high species richness near lower elevations and six new species at higher elevations. The study establishes baseline observations for tropical birds in East Africa.
A large study of plasma proteins and dementia found abnormal blood levels of dozens of proteins up to five years earlier may predict dementia, including Alzheimer's disease. High levels of one protein, SVEP1, are linked to the disease process.
Breast cancer researchers followed the progression of cancer in an animal model and found a path that transforms slow-growing ER+/HER2+ cancer into fast-growing ER-/HER2+ cancer. The study suggests different treatments may be needed for each subtype, depending on the path the cells follow.
Researchers at Skoltech have developed an enriched approach to boost the capacity of next-generation metal-ion battery cathode materials, applicable to lithium-ion and alternative batteries. The scalable method uses reducing agents, which can be recycled after use, making it suitable for large-scale applications.
A UCI study shows that human-sourced greenhouse gas and aerosol pollution is lengthening and intensifying droughts globally. Drought hotspots in the Americas, Africa, and Asia have seen significant shifts due to anthropogenic forcing.
GlycoRNA is a small ribbon of ribonucleic acid (RNA) with sugar molecules, appearing ubiquitously in and on cells. Its discovery suggests the existence of unknown biomolecular pathways and associations with autoimmune diseases.
Linda Mason at George Mason University received funding to support inclusive practice in early childhood education. The project aims to promote inclusion through Teachstone CLASS training for Virginia Early Childhood Special Education professionals.
A new study explores how banks' expectations about climate-related risks affect the low-carbon transition. The researchers developed a model to assess the transmission channels of two main policies: a carbon tax and a green supporting factor.
The DESI instrument will capture light from tens of millions of galaxies and other distant objects to construct a detailed three-dimensional map of the universe. The data will help scientists better understand dark energy's repulsive force and its impact on the expansion of the universe.
Brigham cardiologists presented findings on IL-6 inhibitors, SGLT1/2 inhibitors and statin drugs in COVID-19 patients, highlighting potential benefits and limitations. The studies suggest new therapeutic options for preventing future cardiovascular events and improving outcomes for patients with heart failure and kidney disease.
A study reveals that fly ash accounts for 37-72% of fossilized particulate organic carbon flux in the Yangtze River basin. The results suggest anthropogenic carbon cycling can match the pace of geological cycles through various mechanisms.
A Phase 1 study of Z-endoxifen in patients with solid tumors reported partial responses in three patients and prolonged stable disease in eight. The study suggests that Z-endoxifen can benefit patients who have progressed on tamoxifen treatment, particularly those with desmoid tumors.
Researchers at Monell Chemical Senses Center found that insulin is essential for maturing and regenerating olfactory sensory neurons after injury. Insulin promotes regeneration of OSNs, even in nondiabetic mice, indicating a new therapy option for treating smell loss.
During the COVID-19 pandemic, online search data revealed increased interest in home births in both the US and UK. This trend is attributed to the desire for safer alternatives to hospital births amidst rising infection rates and hospital capacity issues.
A recent study found that only 6% of people with alcohol use disorder receive treatment, despite most having access to healthcare. The researchers suggest that primary care doctors may not feel comfortable addressing drinking issues due to lack of training, leading to a gap in treatment.
The LTER Network's 40 years of careful science reveals the connections between ecosystems, allowing researchers to anticipate and adapt to changes. The network's team-oriented approach and collaborative research facilitate solving complex environmental problems.
Researchers found that sotagliflozin reduced the risk of death or worsening heart failure by 22-43% in patients with both diabetes and heart failure. The medication showed significant benefits across various patient subgroups, including those with preserved ejection fraction.
A randomized double-blind controlled trial of convalescent plasma for adults hospitalized with severe COVID-19 found mortality at 28 days in the treatment arm was half the rate seen in the control arm. However, treatment was not associated with other improvements in clinical status among patients.