Researchers from McGill University and Ontario Tech University examine the drivers of specialty drug diffusion. They propose a framework that suggests clinical studies affect the diffusion through a multi-stage scientific evidence production process. The study finds that marketing activities have no significant effect on prescriptions.
A study found that harm reduction treatment reduced substance use, including cannabis and polysubstance use, among people experiencing homelessness. Participants in the treatment group used cannabis 41% fewer days than the control group. The approach led to improved quality of life and basic needs, making it a sustainable option.
The TCT 2023 Program Guide features four days of innovation and cutting-edge science in interventional cardiovascular medicine. The event marks 35 years of leading the field and will gather top researchers and clinicians to present evidence-based research.
A study of 142 nations found a strong link between access to formal financial services and lower COVID-19 mortality rates. Access to bank accounts, credit cards, or loans from a financial institution is a key predictor of lower mortality risk, even stronger than comorbidities.
Scientists at UCSF and NIBSC have developed two new oral polio vaccines with genetically engineered weakened poliovirus to reduce reversion to dangerous forms. These vaccines aim to boost the World Health Organization's efforts to eradicate polio, which has persisted despite successful international vaccination campaigns.
A plant-based, oral delivery of proinsulin regulated blood sugar within 15 minutes similar to naturally secreted insulin in diabetic mice. This method eliminates the need for expensive laboratory equipment and results in a shelf-stable product, making it more affordable and accessible.
University of Queensland researchers used a video game algorithm to study the behavior of molecules within live brain cells. The algorithm, originally designed for tracking bullets in combat games, was adapted to analyze the movement and clustering of tiny molecules within brain cells.
Researchers found rock-forming elements in the atmosphere of WASP-76 b, which suggests it might have accreted a smaller Mercury-like planet. The discovery provides unprecedented insight into the presence and abundance of rock-forming elements in giant planets.
Many physicians and scientists reported being harassed on social media due to their advocacy, often based on gender, race, or disability. The study highlights the need for greater protection and support for individuals facing online abuse.
A cutting-edge experiment has revealed the quantum dynamics of photosynthesis, starting with a single photon. The discovery solidifies current understanding and will help answer questions about how life works at the smallest scales. By studying individual photons, scientists can build artificial systems that generate renewable fuels.
Researchers at Leibniz Institute for Food Systems Biology identify two key odorants: sotolon from Maggi seasoning and (2 E ,4 E ,6 Z )-nona-2,4,6-trienal from oatmeal. Maintaining a one-to-one ratio is crucial to reproduce the characteristic walnut aroma.
Researchers have discovered a new phase of matter called the chiral bose-liquid state, which has surprising characteristics, such as robust spin and long-range entanglement. This discovery opens up new possibilities for understanding the physical world and potentially leading to breakthroughs in quantum computing.
A team at the University of Vienna has developed a method to controllably create single atomic vacancies in hexagonal boron nitride (hBN) using ultra-high vacuum and aberration-corrected scanning transmission electron microscopy. This breakthrough enables the creation of defects that can emit single photons, opening up new opportunitie...
A study published in Cell Press reveals that ants have a dedicated brain region that processes alarm pheromones, triggering panic responses and colony-wide behavior changes. Researchers used GCaMP to scan the brain activity of clonal raider ants exposed to danger signals, finding a specific section lit up in response.
A recent Finnish register-based study found no association between inhaled beta-2 agonist use and reduced risk of Parkinson's disease. Accumulation of alpha-synuclein protein is a key factor in the disease. The study controlled for age, sex, and comorbidities to rule out confounding factors.
Researchers have found high levels of phosphates in the water on Saturn's moon Enceladus, a key component of DNA and cell membranes. The discovery increases the chances of finding habitable worlds across the galaxy, as Enceladus can support life over a wider range of distances from its star.
An international expert panel has revised concussion management guidelines to optimize athlete care at all levels of participation. The updated recommendations include new age-appropriate assessment tools and strategies for prevention, early intervention, rehabilitation, and return to sport and education.
A new study by University of Arkansas researchers determines that hundreds of human skulls and mandibles at the Crenshaw site are local ancestors of the Caddo Nation. The findings use a novel dating technique to test lead and strontium isotopes in human teeth, revealing a multiregional pattern indicative of local ancestry.
Researchers believe Earth's formation was facilitated by the accumulation of small pebbles, resulting in the presence of water as a byproduct. This new theory increases the likelihood of finding habitable planets outside our Solar System.
Researchers at Iowa State University found that limiting social media usage to 30 minutes a day significantly improved mental health outcomes, including lower anxiety, depression, and loneliness scores. Participants who exceeded the time limit still showed improvement, highlighting the importance of self-limiting behavior.
Researchers used a nonequilibrium-statistical model to predict the stopping process of heavy ions at high LHC energies, gaining insights into original states of matter and quark-gluon plasma. Future experiments may confirm predicted stopping behavior and reveal properties of gluons.
A new research project at University of Leicester will develop a digital 'twin' of the UK using artificial intelligence and big data to inform environmentally-friendly land use. The project aims to reduce emissions from cattle and sheep farming, which contribute around 10% of the UK's emissions.
A new study analyzing death records data found that men had a 2–3 times greater rate of overdose mortality from opioids and psychostimulants. The researchers noted that biological, behavioral, and social factors likely combined to increase the mortality risk for men.
Researchers developed transgenic ants with fluorescent neurons that flashed green in response to odorants, allowing them to study the ant olfactory system. Contrary to previous findings, they discovered that only a few specific areas of the olfactory system responded to alarm pheromones, suggesting a more localized processing mechanism.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
Only one in four US adolescent residential addiction treatment facilities offer buprenorphine and one in eight offer it for ongoing treatment. Nearly two-thirds of adult residential facilities provide this medication, highlighting a significant gap in care for adolescents.
Researchers have discovered that microplastics can accumulate in the nasal cavity and oropharynx, increasing the risk of respiratory diseases. The study's findings highlight the importance of awareness about microplastic exposure and its potential health impacts.
The American College of Medical Genetics and Genomics has released an updated minimum variant set of 100 CFTR gene variants for carrier screening, replacing the previous 23-variant list. The new recommendations apply to genetic testing to determine carrier status, not diagnosis or newborn screening.
Research finds that positive parenting strengthens brain resilience against childhood stress, reducing deleterious effects on hippocampal volume and behavioral problems. The study supports evidence for interventions promoting positive parenting, associated with improved youth outcomes.
Flying squirrels in China's southern rainforests use a unique storage method, chewing grooves into nuts and wedging them between branches, to keep them safe from decomposition. This behavior demonstrates their cognitive and engineering skills, potentially contributing to the dispersal of nut-producing trees throughout the forest.
Artificial night-time light confuses a colour-changing coastal woodlouse, according to new research. The sea slater's ability to change colour and blend in is disrupted by diffuse light, making it more visible to predators.
Research suggests that the Bhopal gas disaster had long-term intergenerational effects on health and education. Men exposed in utero to toxic gas had a higher risk of disabilities and cancers, while those born later had reduced educational attainment. The sex ratio of births also changed among children born near the incident site.
A new approach enables prediction of structure-color relationships in biomimetic materials using computational reverse-engineering methods. This allows for the design and fabrication of materials with custom, robust colorations, which could be used in various applications such as energy, optics, photonics, and biomedicine.
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
A biologist at Binghamton University has developed a new method to uncover the parent species of hybrid plants and animals. By examining genomic patterns within these hybrids, researchers can identify distinct ancestries and determine the order in which chromosomes were inherited from their progenitor species.
A new study from Keck Medicine of USC reveals significant racial disparities in the diagnosis and treatment of peripheral artery disease (PAD) among Black and white patients. Black patients are nearly 50% less likely to receive vascular interventions, leading to a higher risk of stroke, heart attack, or amputation.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
A clinical trial found that repeat intraocular corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema, reducing retinal swelling by 35% compared to ranibizumab and methotrexate.
A team of researchers has discovered a nearly complete side-necked turtle fossil in the UK, dating back to the Lower Cretaceous period around 127 million years ago. The fossil was radiometrically dated using a new technique and provided valuable insights into its structure and composition.
A handheld bioprinter has been developed to address limitations of previous designs, paving the way for applications in regenerative medicine, drug development, and custom orthotics. The device's modular design allows for control over printing mixture and properties, enabling repair and regeneration of defective tissues and organs.
A group of scientists from the JIHT, HSE and MIPT have developed a novel solution: OpenDust, a fast, open-source code that performs calculations ten times faster than existing analogues. The algorithm uses multiple GPUs simultaneously to accelerate computations.
Research identifies beneficial changes in immune system during pregnancy, which can lead to new treatment strategies for MS. Women with MS experience a 70% decrease in relapses during the last third of pregnancy, possibly due to epigenetic changes and hormone regulation.
Lero is recruiting 16 world-class researchers to work on privacy, trust and inclusion in software development through the €2.9 million SyMeCo programme. The programme will attract outstanding international candidates from computer science and related fields.
A new study quantified the economic costs of biological invasions in the European Union, revealing substantial knowledge gaps and alarming underestimations. The research projected unreported costs to be potentially 501% higher than currently recorded, reaching a staggering €26.64 billion.
A multidisciplinary study found evidence of increased neuronal connectivity in the brains of serial entrepreneurs, suggesting they possess greater cognitive flexibility. This increased flexibility enables them to alternate between exploration and exploitation, crucial for entrepreneurial success.
Researchers created a detailed snapshot of the structure of human cilia using advanced microscopy and artificial intelligence techniques. The study found that key elements of the axoneme structure are missing in people with primary ciliary dyskinesia, leading to defective cilia and breathing difficulties.
A new family-based treatment approach for childhood obesity has been successfully implemented in pediatric primary care settings, leading to improved weight outcomes over 24 months. The treatment's effectiveness was found to extend beyond the treated child, with siblings also experiencing improvements in weight.
Researchers elucidated Siglec-15's crystal structure and binding epitope, revealing its interaction with T cells and CD11b. The study shows that Siglec-15 binds to α(2,3)- and α(2,6)-linked sialic acids, providing new insights into glycosylation-dependent immune responses.
Researchers aim to characterize theory structure using symmetry, but find it doesn't capture enough information for a thorough comparison of complexity. They explore alternative approaches to measuring structural complexity, but ultimately conclude that symmetry-based methods may be limited.
Researchers have developed a meta-holographic display that generates holograms in both the visible and ultraviolet spectral regions. The breakthrough overcomes previous limitations and enables applications in security technologies such as anti-counterfeiting measures.
The InVADER Mission successfully deployed a high-tech laser laboratory on the ocean floor, marking a paradigm shift in ocean research and exploration. The Laser Divebot collects compositional data without disturbing the environment, removing the need for physical samples.
A new online protocol is being developed to record people's thoughts while answering trick questions, revealing insights into cognitive quirks and decision-making. The tool aims to decrease the time required for think-out-loud experiments, allowing researchers to reach a broader population and gain greater confidence in their results.
Researchers developed a method to analyze element distribution and transport pathways in plant roots, allowing for the identification of cell type-specific elemental concentrations. The study revealed a steep concentration gradient between outer and inner cell layers in roots and identified a cell type-specific enrichment of manganese ...
A new study analyzed over six million births in England and found that being born 'out of hours' did not carry a significantly higher risk of death from anoxia or trauma. The study suggests focusing on reducing risks for emergency caesarean births without labour, rather than all out-of-hours births.
A new study models optimal investment in China's grid-connected offshore wind, suggesting at least 1000 GW of capacity could be deployed at a lower cost than nuclear units. The research aims to improve provincial deployment plans and boost national renewable penetration from 31.5% to 40%.
A new study highlights disparities in access to digital technology, leading to fewer health care options for rural communities. The study found that socially vulnerable communities face barriers to adequate health care and have less access to high-speed internet.
Researchers developed a primer scheme for the human monkeypox virus that can be easily integrated into existing sequencing and bioinformatics infrastructure. This approach enables public health laboratories to rapidly adapt their genomic workflows in response to new outbreaks.
Researchers found tiny salt crystals in an asteroid sample, indicating the presence of liquid water. The discovery challenges previous assumptions that ordinary chondrite asteroids lack hydrated minerals.
The study highlights the potential benefits of using emoji in medical charts, including improved communication and patient outcomes. It also emphasizes the need for further research on utilizing advanced data analytics tools to interpret emoji and create more characters in the emoji language.