A study of 1,081 elderly patients with AFMR found that TEER minimally invasive valve repair significantly lowered mortality and hospitalization rates compared to standard medical therapy alone. The procedure's success was also linked to the degree of residual mitral regurgitation after surgery.
Researchers at Stanford Medicine developed a way to replace more than half of the most severely affected brain cells with non-genetically matched precursor cells in mice. The approach helped animals live longer and reduced behavioral symptoms of the disease, offering hope for families of children with these rare diseases.
A recent study in Nature Geoscience offers important new insights into the hidden role of ancient groundwater beneath the ocean floor. Researchers found that fossil groundwater changed its composition after the retreat of the Fennoscandian ice sheet, becoming vulnerable to mixing with seawater.
This review synthesizes evidence highlighting immune aging as a critical accelerator of type 2 diabetes pathogenesis. Chronic low-grade inflammation, organelle stress pathways, and the ominous octet framework contribute to metabolic-inflammatory vortex, disrupting β-cell function and insulin signaling.
Researchers from the National Institute of Physiological Sciences evaluated the impact of denoising algorithms on dMRI data for detecting tissue abnormalities in glaucoma. They found that denoising increased signal-to-noise ratio and altered image appearance, but had limited effect on disease-related changes.
Scientists have developed a breakthrough method to grow human kidney organoids from tissue stem cells, mirroring fetal kidney development over months. The organoids can be used for research and testing of new treatments for kidney diseases.
A new study suggests that MNEs can control crises and reduce supplier-induced ESG controversies by building small-world supply networks. This approach enables MNEs to moderate the behaviors of their suppliers, improving sustainability and reducing reputational risks.
Researchers developed molecular capsules that can impart strong chiral properties to inherently non-chiral metal-containing dyes. The capsules create flexible, adaptable chiral cavities that induce chirality without requiring chemical modifications.
A new principle for AI regulation, multiplicity, aims to design systems that expose users to a broader range of narratives, support diverse alternatives, and encourage critical engagement. This can help enrich the human experience and prevent the suppression of diverse perspectives, cultural diversity, and social tolerance.
Researchers discovered a strong association between pregnancy complications and an increased risk of early stroke. Preeclampsia, preterm birth, gestational diabetes, and stillbirth were among the most significant risks found in the study.
A new analysis of data on scientists with exceptional early-career success identified common characteristics, including affiliation with institutions in less developed countries and work in specific fields. These findings could aid efforts to distinguish stellar talent from problematic behaviors.
A study from the University of Georgia finds that lake sturgeon are reproducing on their own in the Coosa River, with some fish estimated to be over 2 years old. This marks a significant step forward in the reintroduction project, which aims to establish a self-sustaining population of these ancient fish.
Researchers at Heinrich Heine University Düsseldorf found that static friction can cause the cooling of active particles. By studying a swarm of mini-robots, they discovered that collisions between the robots lead to the formation of clusters that are no longer moving, effectively cooling them down.
A study published in Contemporary Economic Policy found that delaying the disbursement of food assistance payments can reduce robbery incidents by 0.03 per 100,000 population. The researchers estimate a potential crime reduction benefit of $2.7 million annually in the United States.
The European Union has launched a new toolkit to help eliminate viral hepatitis B and C in prisons across Europe. The toolkit provides practical tools and guidance for implementing interventions in prisons, with the goal of reducing transmission rates and promoting public health.
Researchers have discovered a rare white dwarf remnant with a carbon signature, suggesting it formed from the merger of two stars. The high-mass white dwarf, WD 0525+526, has a thin atmosphere that allows carbon to reach its surface, providing insights into the early stages of stellar evolution.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
A study of over 452,000 adults found that metformin users had significantly lower risks of dementia and all-cause death compared to non-users. The benefits were seen across all categories of overweight and obesity, with reduced risks of up to 26% for death.
Scientists have achieved a high level of quantum purity in nano glass spheres, eliminating gravitational force and detecting zero-point fluctuations. This breakthrough enables the development of quantum sensors and technological applications at room temperature.
Researchers have made significant breakthroughs in understanding the regeneration of a freshwater snail's eyes, which share anatomical and genetic features with human eyes. The study shows that snails can regrow their eyes after amputation, with all eye structures present within a month.
A new study published in the Journal of the American Heart Association has found that excessive screen time among children and young adults may pose heart health risks. The analysis of over 1,000 participants showed a significant association between increased recreational screen time and higher cardiovascular and cardiometabolic risks.
Researchers found that compounds inhibiting bitter taste receptors, such as (R)-(-)-carvone, can reduce the bitter aftertaste of artificial sweeteners like saccharin and acesulfame K. This discovery has potential applications in food products to enhance palatability.
A new technology enables early detection of esophageal cancer by combining optical coherence tomography and optoacoustic imaging to visualize tissue structure and function. This could reduce treatment costs from €140,000 to €10,000 per patient.
Researchers consider natural rubber's potential as a sustainable material for flexible sensors, self-powered systems, and energy harvesting devices. The study aims to enhance natural rubber's electrical and mechanical properties while minimizing its environmental impact.
Researchers found that users who continued to use the app were more active than before, with average increases in brisk and non-brisk walking over time. After 30 months, users still used the app were doing more physical activity than beforehand.
Researchers found that low-oxygen environments can protect the brain and restore movement in mice with Parkinson's-like disease by reducing excess oxygen molecules. The study suggests that hypoxia could be a new approach to treating Parkinson's, potentially targeting cellular dysfunction rather than protein clumps.
Researchers found that increasing tree cover on cocoa farms across Ghana and Côte d'Ivoire to a minimum of 30% could sequester significant amounts of carbon dioxide equivalent, benefiting the environment and ecosystems. Agroforestry has the potential to deliver meaningful mitigation for the chocolate industry.
Researchers at Osaka Metropolitan University found that elevated phosphate levels are associated with poor outcomes in canine respiratory disorders. The study used medical records from 133 dogs and identified heart rate, body temperature, and other factors as significant prognostic indicators.
Researchers studied pollinator-bee interactions in the Amazonvine, finding that temporal overlap affects plant fitness and flower size. Within-season mismatches between plants and pollinators can drive change in plant traits and influence evolutionary outcomes.
Researchers found a 9% increased risk of death from all causes for those living in flood-affected zip codes, with higher risks in Connecticut and New York City. The study highlights the importance of considering long-term health impacts of hurricane-related flooding on older adults.
Researchers at the University of Vermont have developed a more precise way to assess stroke risk in people with atrial fibrillation. The improved CHA 2 DS 2 -VASc-Biomarkers risk calculator accounts for additional risk factors and can help physicians better determine who needs anticoagulant medications.
Researchers created a large-scale mouse behavior dataset to study complex behaviors like problem-solving and goal-directed actions. The dataset, featuring over 100 hours of footage and detailed human annotations, provides a benchmark for developing algorithms that analyze animal cognition.
Lactic acid regulates tumor-immune crosstalk through pH control, G-protein-coupled receptor signaling, and post-translational modification. Therapeutic counter-strategies cluster into three themes: glycolytic restriction, immune-potentiating combinations, and metabolic repurposing to enhance antitumor cytotoxicity.
Researchers have discovered a method to temporarily halt ultrafast melting of silicon by using precisely timed laser pulses. This breakthrough could improve the accuracy of experiments studying energy transfer between electrons and atoms in solids.
Immune-related adverse events (irAEs) are a significant concern in cancer immunotherapy, arising from the overactivation of the immune system. Clinical characteristics include multi-organ involvement, heterogeneous onset times, and distinct toxicity profiles among different ICIs.
A new study sampled different lung regions in cystic fibrosis patients before and after treatment with modulators, revealing that infections persisted throughout the lungs and drove inflammation. The findings suggest damage may not be the main cause of infection persistence, raising concerns about ongoing lung function deterioration.
A landmark study found that adopting five healthy lifestyle habits—healthy weight, no smoking, regular physical activity, high-quality diet, and moderate alcohol intake—can reduce cardiovascular disease risk by up to 86% in women with a history of gestational diabetes. Women who followed all these habits had no cardiovascular events ov...
Researchers at Nagoya University developed a catalyst system that converts alcohols to valuable chemical products at lower temperatures using safer iodine compounds. The new system eliminates toxic heavy metal waste, cuts reaction temperatures by over half, and reduces energy costs.
The interleukin family is involved in the development of acute kidney injury through inflammatory and fibrotic mechanisms. Protective ILs like IL-2, IL-10, and IL-37 mitigate injury, while pro-inflammatory ILs such as IL-1α and IL-18 exacerbate damage.
Advanced sensor technologies enhance lithium-ion batteries with real-time monitoring, predictive maintenance, and intelligent protection against thermal runaway and gas venting. This innovation enables the development of smarter, safer, and more efficient electric vehicles, renewable energy storage systems, and portable electronics.
Researchers have developed a method to exploit local microstrain as a precise tuning knob for single-atom catalysts, unlocking record-setting oxygen reduction performance and long-term stability. This breakthrough uses nanoscopic curvature to control bond strain, transforming static motifs into dynamically self-optimizing centers.
The gut microbiome and its metabolite short-chain fatty acids play a crucial role in regulating skeletal fate. Research suggests that altering the gut microbiota can prevent bone loss in postmenopausal osteoporosis, with fecal microbiota transplantation and probiotic supplementation showing promise as potential therapies.
A study by UniSA found that social media enhances news diversity in Australia, with more diverse sources available compared to traditional media. The research used Facebook engagement metrics and concentration analysis to show the growing importance of online news.
Researchers identify key apoptotic signaling pathways involved in glucocorticoid-induced osteonecrosis, including CD95/CD95L and PI3K/Akt survival pathways. They also highlight genetic biomarkers and novel therapeutic strategies, such as targeting specific molecular pathways with natural compounds.
A landmark study reveals how the Emeishan mantle plume shattered a Permian carbonate ramp into a complex platform system, creating a 400-kilometer-long dolostone hydrocarbon reservoir belt. The research identifies novel exploration targets and suggests potential submarine volcanic eruptions in southwestern Sichuan.
A recent study has found that rheumatoid arthritis (RA) is a causal factor for idiopathic pulmonary fibrosis (IPF), while IPF is not causally related to RA. The research also identified shared biomarkers, including CCL2 and CXCL2, which were significantly elevated in RA patients.
Research highlights HOXB13's dualistic nature as both oncogene and tumour suppressor, with varying effects across multiple malignancies. Post-transcriptional and protein-level mechanisms modulate its expression, interacting with various partners to drive tumour initiation and progression.
Researchers explore converting bioprecursors into fossil-free graphite, providing sustainable alternatives to traditional materials. This transition has significant implications for industrial decarbonization and the development of eco-friendly technologies.
A three-year follow-up study of a personalized program of cognitive functional therapy (CFT) found clinically significant improvements in pain-related activity and pain intensity compared to usual care. The treatment produced large benefits that were sustained over time, offering potential for major human and economic impact.
A review of research on solastalgia and mental health found positive associations between the two, including depression, anxiety, PTSD, and somatisation. Solastalgia is linked to feelings of helplessness and resignation due to a perceived loss of control over environmental changes.
The deliberate destruction of health services and systems is now termed 'healthocide,' with medical practitioners called to action. The authors highlight the need for critical reflection and decisive action to address this growing concern, emphasizing the importance of medical neutrality and international humanitarian law.
Research finds CPAP lowers cardiovascular risk by 17% in patients with high-risk OSA, but may increase risk by 22% in those without high-risk OSA. The study suggests a more personalized approach to treating OSA, focusing on patients with high-risk features.
A comprehensive analysis reveals how cancer cells hijack immune checkpoints on NK cells to disable the body's frontline defense system. Anti-TIGIT antibodies and CAR-NK innovation offer promising breakthroughs in liver cancer trials and acute myeloid leukemia treatment.
Researchers analyzed 20,000 tree-ring records to find that tropical trees grow 2.5% less during droughts, but recover almost completely the following year. Drier regions show greater reductions in growth and increased tree mortality.
Research on gorillas reveals that females prioritize relationships with females they've lived with in the past when joining a new group, indicating importance of familiar connections. This network strategy helps facilitate the formation and maintenance of social relationships, even after years apart.
A proposed earthquake early warning system for Alaska could provide critical seconds of warning time before strong shaking, according to research by Alex Fozkos. The system would use a network of seismic sensors to detect an earthquake's fast-moving primary waves and send alerts before slower secondary waves arrive.
Researchers captured unique footage of Indian Ocean seabirds catching flying fish in mid-air using lightweight cameras. The study showed that these birds exploit windy conditions to conserve energy while hunting, suggesting a possible adaptation to patchy food sources.
A randomized controlled trial found that cognitive functional therapy (CFT) can effectively reduce disability due to chronic low back pain for more than a year. The current trial is the first to show that these effects are sustained up to three years. CFT was shown to improve physical activity participation in patients with low back pain.
Researchers discovered how glycosylation modulates IgG antibody architecture, enabling precision immunotherapies for cancer and autoimmune diseases. The study's findings highlight the power of integrating experimental and computational approaches to decode glycoprotein dynamics and optimize clinical performance.
A new study from the University of Sheffield found that urban landscapes support 43% fewer pollinator species, with a decline in tree canopy and semi-natural habitats driving the loss. Pollinating insects are vital for up to 90% of wild flowering plant species and crop diversity.