Researchers seek to harness protein cage encapsulation to combine and regulate multiple enzymes, creating a 'nano-reactor' that breaks down toxic substances more efficiently. The goal is to expedite the biodegradation process and reduce harmful intermediates.
Researchers induced senescence in worms by manipulating transcription factor TFEB, mimicking mammalian aging. Key growth factors insulin and TGFbeta were identified as crucial signaling molecules in circumventing senescence.
A new study by University of Massachusetts Amherst researchers found that low-income patients are less likely to contest denied health insurance claims and experience lower success rates when they do. The study recommends simplifying billing rules and creating user-friendly ways for patients to appeal denials.
Researchers have developed an innovative ASPIRE cooler that leverages a dual-alignment structure within a hygroscopic hydrogel to achieve high-power passive daytime cooling. The study reveals the potential for this technology to enable sustainable cooling solutions for various applications.
Scientists developed a method to use ultrasound to chemically activate drugs, selectively targeting tumors and stimulating immune cells. This approach achieved a 99% tumor suppression rate in colon cancer models without harming healthy tissues.
Researchers review interfacial modulation strategies to enhance air stability, ion-transfer kinetics, and phase evolution in sodium layered oxide cathodes. These approaches improve electrochemical performance and mitigate phase transitions.
Researchers at OIST introduce a mouse motion capture method using marker-based approach to track high-quality data on complex movements. The method avoids pitfalls associated with smaller animals, enabling detailed studies of neuroscientific and physiological foundations of mouse movement.
A Rutgers analysis of medical records reveals that Medicaid and Medicare patients with opioid addiction tend to receive behavioral health care services less often than those with other types of funding. Patients with public insurance alone were less likely to utilize treatment services compared to those with multiple funding sources.
A novel catalyst achieves unprecedented efficiency in light alkane aromatization, yielding high propane conversion and aromatics selectivity rates. The technology holds promise for reducing reliance on petroleum resources and advancing carbon neutrality goals.
A new study developed a powerful method for detecting simultaneous nitrogen and water deficiencies in field-grown sesame using deep learning and multiple data sources. The integration of hyperspectral, thermal, and RGB imaging enabled identification of combined nutrient and water-related deficiencies.
Researchers found skewed sex ratios at birth among mothers from China, India, and Vietnam, with some mothers preferring boys over girls. The imbalance increased with multiple children, but remained stable for Australian-born mothers.
A new study reveals that women with polycystic ovary syndrome (PCOS) have a sharp reduction in the beneficial gut bacterium Parabacteroides merdae, alongside elevated levels of branched-chain amino acids. These changes may impair endometrial health and reproductive complications in women with PCOS.
Researchers at Xidian University explore the integration of large language models and evolutionary algorithms to enhance learning and exploration capabilities. The study reveals potential synergies between the two, offering fresh perspectives for cross-disciplinary technical integration.
Researchers develop multiresonant fiber acoustic sensor with stabilized triple-phase demodulation, achieving flat low noise floor and high sensitivity across a wide acoustic spectrum. The sensor detects weak sounds and exhibits outstanding performance in ecosystem monitoring, speech recognition, and high-intensity shock detection.
A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation. Researchers mapped how human immune cells interact with pig kidney tissue, revealing critical early markers of rejection and potential intervention strategies.
A study reveals that ribonuclease 4, derived from pancreatic islet β cells, promotes β cell proliferation and blood glucose homeostasis regulation. Rnase4 supplementation reverses β cell disorders triggered by genetic defects or chemical damage.
A new study shows that a simple blood test taken in the first trimester of pregnancy can accurately identify women at risk of developing preeclampsia five months before clinical diagnosis. The test uses cell-free RNA, or cfRNA, to capture subtle molecular signals from multiple maternal tissues.
A new international study reveals that male partners over 45 carry significantly increased miscarriage risks and lower live birth rates even when young donor eggs are used. The study found that older paternal age is linked to genetic mutations, sperm DNA fragmentation, and epigenetic changes, impairing embryo development.
Researchers achieved a 2-fold enhancement in NV center coherence time by graphene-diamond hybridization, clarifying the physical mechanism and providing a novel approach to improve nanoscale quantum sensors. This technique leverages mature graphene transfer processes to reduce noise from diamond surfaces.
Research reveals that equine-assisted interventions can transform a child's emotional world, promoting trust, emotional safety, and healing through horse interactions and natural settings
Researchers from Shanghai Jiao Tong University have developed high-energy, stable all-solid-state lithium batteries using aluminum-based anodes and high-nickel cathodes. The study aims to address the challenges of electrode-electrolyte interface instability and achieve long-term cycling stability in these batteries.
New research reveals that chlorothalonil, a widely used fungicide, severely impacts insect reproduction and survival in fruit flies, even at low concentrations. The study found a 37% drop in egg production with minimal exposure.
The article discusses how AI systems are transforming historical records without transparency around methodology selection, weighting, and interpretation. Historian Marnie Hughes-Warrington argues that AI can be an opportunity to engage with its development to ensure complex histories are reflected.
A study on hybrid fish found that allelic genes and testis-specific genes play a crucial role in maintaining fertility, while orphan genes facilitate adaptation to new genetic environments. The research used long-read sequencing and Hi-C technology to construct high-quality genomes for reciprocal hybrids.
A new e-textile platform developed by KAIST's research team combines 3D printing technology with advanced materials engineering to create customized training models for individual combatants. The platform uses flexible and highly durable sensors and electrodes printed directly onto textile substrates, enabling precise movement and huma...
A global study by Michigan State University found that livestock manure contains high levels of antibiotic resistance genes, posing a significant threat to human health. The research team developed a map highlighting regions with the most common dangerous genes and ranked them based on their risk to human health.
Researchers developed a classification system to accurately distinguish granulomas from peripheral lung cancers based on thin-section computed tomography (TSCT) features. Satellite lesions, halo sign, and calcification are indicative of granulomas, while well-defined solid nodules with lobulation raise suspicion for PLCs.
This study identifies pre-neadjuvant carcinoembryonic antigen (CEA) and neutrophil-to-lymphocyte ratio (NLR) as significant predictors of postoperative recurrence-free survival in non-small cell lung cancer (NSCLC) patients after neoadjuvant therapy. Smoking history is also a predictor of recurrence in LUSC patients.
Researchers identified a novel non-defensin peptide attractant in Arabidopsis, named NPA1, which expands the known diversity of fertilization cues in flowering plants. The study revealed that NPA1 functions independently of typical defensin-like peptides and plays a role in species-preferential fertilization.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
The Families First Coronavirus Response Act led to a significant decrease in Medicaid health insurance loss. The study found that the Act reduced the risk of losing health insurance for individuals enrolled in the Medicaid program.
Breast cancer metastasis relies heavily on mitochondrial oxidative metabolism, with adaptations including lipid metabolism and oxidative phosphorylation. Targeting mitochondrial fission, fusion, and mitophagy shows promise in preclinical models, while challenges remain due to heterogeneity and drug resistance.
The AI tool, StateViewer, helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single scan. It enables clinicians to interpret brain scans nearly twice as fast and with up to three times greater accuracy than standard workflows.
A team led by Ruth Signorell at ETH Zurich has found a previously unknown reaction pathway for urea formation on water surfaces under ambient conditions. This spontaneous reaction could have occurred on prebiotic Earth and provides insights into the origin of life.
A new study found that almost all Medicaid managed care plans (MCPs) cover at least one form of naloxone, with 94% covering generic injectables or 4-mg nasal sprays. However, certain restrictions and quantity limits may prevent people from accessing this life-saving drug.
The study found that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment outcomes for pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL). Researchers identified a 'multipotency score' to predict clinical outcomes, providing valuable insights into drug resistance and str...
Researchers used computational simulations to investigate changes in synaptic connections during sleep-wake states. They found that synaptic connections are strengthened when specific levels of neural activity accompanied typical synaptic learning rules, enabling theoretical predictions of sleep learning conditions.
A new urine-based tumor DNA test can help personalize bladder cancer treatment by predicting which patients are at higher risk for recurrence after immunotherapy. The test, UroAmp, analyzes urine samples to identify bladder cancer-related mutations and generate a genomic profile for each patient.
A collaborative study from the University of Cologne has discovered the key role of mitochondrial protein AIFM1 in regulating cellular energy metabolism. The research found that AIFM1 interacts with AK2A to maintain energy homeostasis, and visualized its complex structure using cryo-electron microscopy.
Professor Roberto Morandotti has won the 2025 IEEE Photonics Society Quantum Electronics Award for his groundbreaking research on entanglement generation and processing of complex quantum states in photonic devices and systems. His work at INRS's Ultrahigh Speed Light Manipulation Laboratory has led to numerous patents and collaboratio...
A new study reveals that abandoned termite mounds serve as microhabitats for a wide range of insects and other invertebrates in Bornean tropical rainforest. The team found five to nine times higher abundance of insects in unoccupied mounds compared to surrounding soil, with ants being the most commonly found insect group.
Researchers have discovered atacamite, a mineral with unusual magnetic properties, which exhibits magnetocaloric behavior at low temperatures. The material's strong cooling effect has sparked interest in its potential use for energy-efficient cooling and liquefaction of gases.
Some precursor plasma cells in patients with MGUS and SMM enter cellular senescence, a dormant state that prevents cancer progression. In contrast, patients who develop bone marrow cancer lack this protective mechanism. The discovery offers hope for early intervention and potential treatments that promote or inhibit senescence.
A study found that male patients, those of older age, individuals with lower and higher socioeconomic status levels, and those speaking languages other than English were at higher risk for ED presentations after skin cancer diagnosis. The prevalence of ED presentation was 29% in Australian patients.
Researchers found that hepatitis B virus worsens liver inflammation, making patients more susceptible to early cancer development caused by environmental carcinogens. Limiting carcinogen exposure or reducing inflammation may mitigate this risk.
A 4-year-old intervention program has been shown to effectively treat depression in young children, with a majority of participants achieving remission. The treatment, called PCIT-ED, helps parents interact with their children differently in the emotional domain, leading to improved mental health outcomes.
A new study found that extending Medicaid coverage for 12 months after birth improved access to medical and behavioral health services. This expansion may help mitigate adverse outcomes, including chronic condition management.
The proposed scheme utilizes periodic structured light and engineered electron beams to achieve coherent inverse Compton scattering, resulting in significantly higher-intensity scattered photon beams. This technology has the potential to dramatically enhance beam intensity in the EUV and soft X-ray range.
A new study reveals that early modern humans at Blombos Cave in South Africa used ochre as a multi-use tool for stone toolmaking, showcasing advanced technical skills. The discovery challenges traditional interpretations of ochre and highlights its integral role within technological systems.
A study by Carnegie Mellon University researchers found that the closures resulted in a 4% reduction in physicians per capita and declines in infant, non-infant, and total mortality rates. The Flexner Report era reforms led to significant changes in the US medical education landscape.
The study identifies the brain circuit controlling associations between stimuli and allows for indirect associations. The amygdala plays a crucial role in linking olfactory and taste stimuli.
A global effort to preserve healthy microbes is now entering an active growth phase, with a team of scientists laying out an ethical framework to ensure equitable collaboration and depositor sovereignty. The Microbiota Vault Initiative aims to safeguard microbial diversity for future generations.
A study on a 240-day closed experiment found that conflicts emerged among crew members, followed by stabilization through expert intervention. The blurring of boundaries between task-related and personal activities did not negatively impact team cohesion or performance levels.
A team of researchers at Princeton University and Harvard found that fish schools do not form diamond shapes as previously believed. Instead, they adopt a dynamic ladder pattern, allowing them to stagger in multiple planes and reduce energy expenditure.
Eliminating the fee increased overall usage by 7.8 percentage points, particularly benefiting underserved populations, including non-English speakers and those from socioeconomically disadvantaged areas. Despite gains, some disparities persisted, highlighting the need for additional strategies to ensure equitable access.
Researchers at Tulane University developed a handheld TB test inspired by the bombardier beetle's natural defense mechanism. The ASTRA device requires only a drop of blood and delivers same-day diagnoses without need for laboratory or trained staff, outperforming traditional tests in detection of TB with HIV co-infection.
The IPK research team has discovered a new protein, SCEP3, which plays a crucial role in the synaptonemal complex during meiosis. The study found that SCEP3 is essential for genetic recombination and influences both the distribution and number of crossovers.
Dan M. Frangopol, a pioneer in life-cycle civil engineering, has been recognized by the International Association of Structural Safety and Reliability (IASSAR) for his sustained service to the organization. He is the inaugural recipient of the Distinguished Service Award, established in 2013.
Researchers at HonorHealth Institute used non-surgical techniques to treat damaged heart valves, increasing survival rates for patients suffering from structural shock. The study found that 86% of patients survived at least 3 months and 73% survived at least 6 months.
Researchers have developed a new genetic risk score to identify type 1 and type 2 diabetes in Chinese populations. The test was tested on over 5,000 patients and showed improved accuracy in diagnosis, particularly for those with high family risk of developing type 1 diabetes.