A KAIST research team has developed a platform that generates specific signaling molecules in situ from a single precursor under an applied electrical signal, enabling switch-like, precise spatiotemporal control of cellular responses. The platform can produce either nitric oxide or ammonia on demand using only an electrical signal.
Researchers at Penn Medicine and Wharton have developed AI tools, CellSpectra and SISKA, to analyze kidney disease at the cellular level, matching effective treatments. The tools offer clues to better treatments for kidney disease and beyond.
Researchers at Case Western Reserve University have made a breakthrough discovery that could lead to new treatments for patients with spinal cord injuries who struggle to breathe on their own. The study identified a subset of interneurons in the brain and spinal cord that can boost breathing when faced with physiological challenges.
In US cities once marked as 'hazardous,' ambulances often take longer to arrive than in previously favored areas. The study analyzed 236 urban areas and found that 7.06% of residents in Grade D tracts lacked rapid access to emergency medical services, compared to 4.36% in Grade A tracts.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
Researchers at North Carolina State University have developed a controlled evolution technique that dramatically increases plasmid DNA (pDNA) production in E. coli bacteria. This breakthrough could significantly reduce the cost of gene therapies and expedite research, making pDNA resources more accessible.
A study by Annenberg Public Policy Center found that firearm use in popular US movies increased by 200% from 2000 to 2021, mirroring the rise in firearm homicide rates among young people aged 15-24. The research suggests that portrayal of guns in entertainment may play a role in promoting their use for violent purposes.
Researchers found that the sediment surge after the Wenchuan Earthquake led to a significant increase in bedload flux, accounting for 65% of the overall sediment flowing through the river. The elevated flux persisted for at least ten years, with no evidence of declining back to background levels.
A new few-shot learning model, PlantCaFo, achieves 93.53% accuracy in controlled tests and surpasses existing approaches in real-world settings. The model's ability to learn from limited samples makes it suitable for agricultural applications where data collection is expensive and time-consuming.
Scientists used operando neutron tomography to visualize the dynamic wetting of lithium-sulphur pouch cells, gaining insights into cell failure mechanisms. The study found that discharge/charge processes improve electrolyte homogeneity, promoting electrochemical activation and enhanced capacity.
Researchers created a detailed list of molecular parts necessary for Mycoplasma pneumoniae survival, accelerating the development of 'living medicines'. The study's highest-resolution essentiality map can predict how tweaks to the microbe's genome slow growth or stress the cell.
A new study published in Environmental Research has found a link between traffic noise and mental health disorders, including depression and anxiety, in young adults. The study suggests that exposure to traffic noise above 53 decibels increases the risk of developing these conditions.
Researchers found that cyantraniliprole and spinosad seed treatments in snap bean performed as well or better than standard neonicotinoid, while five alternative seed treatments proved effective for sweet corn. However, some alternatives had inconsistent results for dry beans.
Researchers predict significant declines in Arctic reindeer populations, with potential losses of up to 80% by 2100, due to climate change. This could have far-reaching ecological implications and exacerbate climatic warming.
NewYork-Presbyterian/Weill Cornell Medical Center has been recognized as a mitral valve repair reference center by the Mitral Foundation for three consecutive years. The award highlights the institution's commitment to delivering high-quality care and advancing best practices in surgical treatment of mitral valve disease.
Researchers at University of California San Diego School of Medicine have identified a specific genetic region called HAR123 that promotes human-specific cognitive flexibility, unlearning and replacing knowledge. The study offers a molecular explanation for radical changes in the human brain over evolution.
An international team of researchers has tracked changes in over 114,000 rivers in High-mountain Asia, finding nearly 10% of them saw an increase in flow from glacial ice melt. This shift poses a challenge for the region's energy future, particularly hydroelectricity generation, due to increased sediment and reduced reservoir capacity.
A new study published in JDR Clinical & Translational Research found that arginine dentifrices can significantly reduce childhood caries. The 8.0% arginine-containing dentifrice demonstrated a 26.0% reduction in DMFS scores compared to the control group.
A team of researchers at Mizzou identified which immune cells in pigs have receptors most reactive to influenza. This knowledge may help develop improved therapies or vaccines for both species. The study's findings could also aid in the creation of more effective flu vaccines that provide immunity for longer periods.
The University of Texas at San Antonio (UTSA) has exceeded its $500 million fundraising goal through the Be Bold: A Campaign for Our Future initiative. The campaign, which aimed to accelerate student success, advance research excellence, and expand community impact, garnered support from over 60,000 donors contributing over 200,000 gif...
A new study from the University of Missouri-Columbia highlights the importance of consistent primary care coordination in cancer survivorship care. The research found that only a third of patients consistently saw the same primary care clinician during and after cancer treatment, leading to fragmented care and gaps in patient services.
A new MSU study found that natural microbial exposure impacts brain structure immediately after birth and may influence development while still in the womb. The research team discovered that germ-free mice had fewer neurons in a key brain region, regardless of whether they received microbes after birth.
A study found that expectant mothers are often left to navigate decisions on prenatal screening for Down syndrome without sufficient information or emotional support. The research highlights the need for a national pathway to support families and provide clear information about screenings.
The NRG-BN007 clinical trial found that combining ipilimumab and nivolumab with radiation therapy did not improve progression-free survival for patients with newly diagnosed MGMT-unmethylated glioblastoma. The treatment combination showed no significant difference in overall survival either.
The study found that health officials in Chicago used social media to engage in one-way communication, which could enhance public trust but also spread misinformation. Communications with images or videos received higher engagement levels, while maternal and child health topics outperformed COVID-19 and mpox topics.
A new study from Denmark shows that men with biochemically recurrent prostate cancer who undergo PSMA PET/CT before salvage radiotherapy have improved survival rates compared to those who do not. This research confirms that PSMA PET/CT is a valuable tool for identifying patients likely to benefit from salvage radiotherapy, potentially ...
St. Jude researchers developed a computational method to design tandem CARs that target two cancer-related proteins, overcoming previous challenges and function better in treating animal models of cancer. The approach demonstrated improved surface expression and anti-tumor function, clearing tumors in four out of five mice.
A new project at FAU aims to advance water quality monitoring in Lake Okeechobee by understanding how common contaminants break down after being released into freshwater environments. The team will deploy passive sampling devices and use cutting-edge chemical analysis to predict which contaminants are forming dangerous byproducts.
A recent study published in The Journal of Maternal-Fetal & Neonatal Medicine showcases Ultrasound AI's proprietary technology, which accurately predicts time to delivery using standard ultrasound images. This non-invasive tool has the potential to improve pregnancy outcomes and combat preterm birth.
Researchers from Flinders University found a consistent increase in Obstructive Sleep Apnea (OSA) severity on weekends, driven by lifestyle choices and irregular sleep patterns. Maintaining a regular sleep routine is crucial to combat social apnea, which can lead to serious health conditions like heart disease, depression, and dementia.
Researchers at Stellenbosch University discovered flavoalkaloids in Cannabis leaves, a rare class of phenolics with promising biomedical applications. The study highlights the potential medicinal value of Cannabis plant material, which is often regarded as waste.
Parents and men in particular may be susceptible to infidelity-related risk factors during high-stress life events. A new study reveals that parents reported a higher desire for and engagement in infidelity during the COVID-19 pandemic, with similar patterns observed across genders.
A study led by Lancaster University found that social and environmental factors impact a patient's physical readiness for surgery. Patients from socioeconomically deprived areas tend to have lower cardiorespiratory fitness, which can lead to poorer surgical outcomes.
The study introduces a new method for mapping tree crown interactions, which is coupled with advanced regression models to predict hard-to-measure traits like HMCW. The approach achieves higher realism by incorporating crown width, distance, and shading effects, leading to more accurate predictions and improved forest management.
A new study from the University of Vaasa demonstrates that fuels refined from waste and industrial by-products can significantly reduce emissions in existing engine applications. Renewable naphtha and marine gas oil, derived from crude tall oil and recycled lubricants respectively, offer efficient and cleaner combustion options.
This new method combines top-down and bottom-up approaches to address the challenge of increasing grain production while reducing pollution. The 'Technology Backyard' serves as a problem collection station and testing ground for technologies developed in collaboration with frontline producers.
A National Institutes of Health (NIH)-supported clinical trial found that two intravenous doses of the antibiotic dalbavancin seven days apart are as good as daily IV doses of conventional antibiotics over four to six weeks for treating complicated Staphylococcus aureus bloodstream infections. The study results provide clear evidence f...
Researchers at Caltech have created a hybrid approach for storing quantum states by translating electrical information into sound waves. This method allows quantum states from superconducting qubits to survive in storage for an extended period.
A University of Houston study found that positive childhood experiences, such as supportive relationships and regular household routines, can protect against disordered eating behaviors in college students. Adverse childhood experiences, including abuse and neglect, were also linked to increased risk factors for disordered eating.
The DKMS John Hansen Research Grant is supporting innovative research projects in blood cancer therapy, aiming to improve treatment outcomes. The grant, worth almost €1 million, will support young scientists with a focus on transplant immunology and novel diagnostic and therapeutic strategies.
Scientists have discovered new fossils of Australopithecus and Homo coexisting between 2.6 to 2.8 million years ago, shedding light on human evolution. The new species of Australopithecus has been identified as a distinct lineage, challenging traditional views of human origins.
A study investigated approach/avoidance tendencies in male AUD patients through a gait initiation task, using posturography. The findings suggest that analyzing micromovements and reaction times may help predict if individuals will relapse following treatment.
Women in counties with low cervical cancer screening rates experience nearly double the rate of cervical cancer diagnoses, particularly late-stage disease, and death. Timely screening can identify precancerous lesions for removal before they develop into cancer.
Researchers at Columbia University have discovered a potential universal antiviral therapy inspired by a rare immune condition that grants individuals resistance to all viruses. The therapy mimics the immune superpowers of people with ISG15 deficiency, which causes mild but persistent systemic inflammation.
Researchers at WSU have identified the biological mechanism behind coho salmon die-offs linked to tire preservative 6PPD-quinone. The toxin disrupts the blood-brain and blood-gill barriers, causing oxygen deprivation, which is fatal to the fish.
Researchers at WashU are developing a genetic switch to make microbes work efficiently over extended periods during bioproduction. The goal is to overcome challenges in continuous fermentation and create more efficient, cost-effective methods for producing chemicals and materials.
Adults who quit smoking were more likely to achieve sustained remission of substance use disorder symptoms. The analysis found a 42% greater odds of recovery when quitting smoking was combined with addiction recovery efforts.
A study found that athletes from high-disadvantage neighborhoods had a thinner outer layer in certain areas of the brain and smaller brain volumes, which can be early signs of neurodegeneration. Researchers suggest that recognizing stressors can help inform more equitable approaches to protecting long-term brain health.
Researchers found that soybean plants can pass on adaptive responses to stress across generations without changing their DNA. This phenomenon, known as transgenerational plasticity, can lead to improved defense against pests but also reduces yield and fitness.
A NIH-funded study by Georgetown University researchers found that strokes can rob a person's ability to use word meanings to recognize words while reading. The study, published in the journal Brain, identified a key brain region and connections affected by this deficit.
A study found that many low carbon taxes were initially implemented for non-climate reasons, such as generating revenue or meeting international expectations. Despite being ratcheted up over time, only a few countries showed strong evidence of sequencing to increase emissions reduction.
A study using stalagmite analysis found eight wet season droughts lasting over three years between 871-1021 CE, contributing to the Maya civilization's decline. This climate data aligns with historical and archaeological evidence, providing a new framework for analyzing human-climate interactions.
The researchers developed a novel approach to virtual contrast enhancement in MRI imaging, using pixelwise gradient methods with Generative Adversarial Networks. The model excelled in capturing intricate details and textures, outperforming its predecessor in texture representation.
Researchers developed a borate-water-based electrolyte that enables safe, fast-charging lithium-ion batteries under ambient conditions. The new technology also offers direct recycling of active materials through water dispersal, ensuring a sustainable approach to battery production.
A new study found that tolcapone increases activity in the prefrontal cortex during self-control tasks, associated with better behavioral control and reduced alcohol consumption. The findings suggest that medications increasing prefrontal dopamine could be a promising lead for treating alcohol use disorder.
Monarch butterflies utilize magnetic fields for migratory directionality, with orientation recalibrated by cold temperatures. Experimental study suggests this ability may be disrupted under climate change, threatening their migration patterns.
The study reveals that China's green technology innovations have improved crop yields and reduced fertilizer use by 40% and 0.83 million tons, respectively. The researchers propose four strategies to address challenges and predict significant increases in food output by 2050.
MIT researchers developed microparticles containing iron or iodine to fortify foods and beverages, addressing global iron deficiency. The particles can be easily added to staple foods and drinks, reducing the risk of nutrient deficiencies.
A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients with high-risk non-muscle-invasive bladder cancer. The treatment was well-tolerated and showed improved outcomes compared to standard treatments.
A significant proportion of patients with high-grade serous ovarian cancer missed genetic testing and surgical prevention opportunities due to limited effective screening options and treatment limitations. The study emphasizes the importance of addressing these gaps to eradicate this aggressive form of ovarian cancer.