A new robotic design uses vine-like structures to lift and grasp a variety of objects, including humans, with a gentler approach. The robot can snake around obstacles, squeeze through tight spaces, and even secure itself in a closed loop to create a sling.
Researchers will examine protein stability mechanisms in Thermus thermophilus to advance treatments for diseases such as Alzheimer's, ALS, and cancer. The team will explore the structure of Rieske proteins and their role in energy production to understand how to restore stability.
A memristor-based accelerator accelerates compressed sensing by 11 times through hardware-software co-optimization, achieving near-software accuracy and overcoming hardware non-idealities. The approach uses a 128Kb memristor chip with computing-in-memory architecture to eliminate data movement bottleneck.
A new AI-driven framework reimagines chemical risk assessment by merging high-throughput screening, AI-enabled toxicity mapping, and quantitative in vitro–to–in vivo risk modeling. This unified approach enables rapid identification of hazardous chemicals and prediction of risk thresholds.
Researchers have identified a novel role of DDAH1 in regulating hepatic lipid metabolism during fasting. Studies revealed that DDAH1 promotes lipid accumulation by increasing fatty acid uptake and inhibiting lipid droplet degradation, highlighting the complex context-dependent nature of metabolic regulators.
Researchers at UCLA have developed a new method for creating thorium-based nuclear clocks using an electroplating technique. This breakthrough could lead to smaller, more efficient nuclear clocks that can be used in navigation systems, including satellite-free navigation and submarine navigation.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A team of scientists simulated high-pressure conditions and found that onion-like layering in iron alloys can explain seismic anomalies in the Earth's inner core. This discovery suggests a compositional gradient with increasing core depth, linking anisotropy to chemical stratification.
Researchers discovered a fingerprint in the tar used to build the Hjortspring boat, believed to be from an ancient seafarer. The find provides a direct link to the attackers who used the boat over 2,000 years ago.
A recent study found that home-delivered groceries can significantly improve blood sugar control among adults with type 2 diabetes who experience food insecurity. The program provided culturally relevant, medically tailored groceries and education materials, leading to a clinically meaningful reduction in hemoglobin A1c levels.
A new study published in Nature found that contraception and castration increase life expectancy in both males and females. In males, castration extends lifespan, while in females, various forms of sterilization are associated with increased life expectancy due to reduced energetic costs of pregnancy and lactation.
A University of Kansas scholar argues that decades of reform efforts have not improved education, instead trying to fix past problems. The new book proposes a focus on personalized learning and AI to customize education for each individual.
Researchers used AI to identify a new viral surface protein that triggers the production of neutralizing antibodies, offering a breakthrough for developing effective vaccines and antibody therapies. The discovery could also provide insights into treating smallpox, a related virus posing a bioterrorism risk.
A SETI Institute team monitored pulsar PSR J0332+5434 for 10 months to study its radio signal twinkling as it passes through gas between the star and Earth. The team observed slow, significant changes in the twinkling pattern over time, which can help distinguish human-made radio signals from signals from other star systems.
A new study describes a three-hit metabolic signaling model that reframes autism as a treatable disorder of cellular communication and energy metabolism. The model suggests that up to half of all autism cases might be prevented or reduced with prenatal and early-life interventions.
Insilico Medicine's Chemistry42 platform enables the efficient discovery of a potent, oral CBLB inhibitor with low toxicity risks and favorable ADME/PK profiles. The compound demonstrates strong in vitro activity and improved metabolic stability in mouse, rat, and dog models.
Scientists from Mass General Brigham and the Broad Institute have identified a genetic modifier for Friedreich’s ataxia, suggesting a potential treatment strategy. By understanding how cells can bypass the need for frataxin, researchers have discovered that reducing FDX2 levels can restore iron sulfur cluster synthesis and cell health.
Researchers developed a manure-integrated nitrogen management strategy that rebalances soil microbes to reduce N₂O emissions while maintaining high crop yields. The approach improved soil quality and enriched key N₂O-reducing microbes, leading to lower greenhouse gas emissions.
Research by Politecnico di Milano finds that even a small percentage of individuals who don't follow health measures can significantly increase the infection peak and strain healthcare facilities. The study emphasizes the need to monitor and adapt public health strategies to individual urban contexts, making interventions more effective.
New research using earthquake and satellite data reveals the Iberian Peninsula is rotating clockwise due to collision between Eurasia and Africa plates. The study provides insights into geodynamic processes and deformation fields in the region.
Researchers found systematic plant imagery in ancient Halafian pottery with precise symmetry and numerical sequences, suggesting early farming villages had sophisticated mathematical thinking about dividing space and quantities. The study contributes to ethnomathematics, identifying mathematical knowledge embedded in cultural expression.
A new Danish study reveals that social inequities in survival after atrial fibrillation have remained unchanged over the past 20 years. Individuals with low income, education, and social relationships live significantly shorter lives than those with high-income backgrounds.
A new study found that carrying rare archaic versions of human-specific DNA changes, such as the SSH2 variant, does not necessarily lead to noticeable consequences. However, some variants like TKTL1 showed no extreme differences in brain structure or cognitive function despite previous dramatic effects in lab-based experiments.
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
A study published in Science Advances found that unusually large particles of wildfire smoke had a significant cooling effect on the region they were observed in, increasing outgoing radiation by 30-36% compared to smaller smoke particles. This effect has not been included in current climate models.
Researchers at University of California San Diego School of Medicine discovered that immune cells can slow fat breakdown when exposed to physiological stressors, helping early humans preserve energy stores. This finding provides new insight into the underlying metabolism of obesity and other metabolic disorders.
A new concept, tethered resilience, challenges the traditional 'move' or 'stay' dichotomy in climate migration. Individuals and families are drawn to alternative strategies that balance economic, social, and cultural factors. This approach recognizes the importance of social infrastructure and networks in enabling adaptation and future...
A study found that duckweed effectively suppresses HONO and NOₓ emissions but intensifies N₂O and NH₃ losses, posing environmental trade-offs. Duckweed improves nitrogen retention and may enhance nitrogen-use efficiency, but its use raises concerns about greenhouse gas emissions.
A new AI model has been developed to improve the accuracy of recurrence risk stratification in hormone receptor-positive, HER2-negative breast cancer. The model, called ICM+, uses a combination of clinical, molecular, and histopathological data to provide better prognostic information about cancer recurrence risk out to 15 years.
Researchers use nano-phases to create strong and tough materials by controlling the interface between nano-phases and Ti matrix. The optimal configurations include network and laminated structures, which effectively increase toughness and prevent catastrophic failure.
Researchers at MIT have identified three clusters of pragmatic skills that are based on the same kinds of inferences and may have similar underlying neural processes. These skills include interpreting social conventions, understanding physical world knowledge, and distinguishing between tones to convey emphasis or emotion.
Professor Sarah Bailey received an award for her career-long work promoting openness and transparency around animal research. She has championed openness, openly discussing her research with animals since the 2000s, and led the University's Openness Strategy to implement the Concordat's commitments.
Researchers at Florida Atlantic University have developed a deep learning model that detects and evaluates Alzheimer's disease (AD) and frontotemporal dementia (FTD) using EEG brainwave analysis. The model achieved over 90% accuracy in distinguishing individuals with dementia from cognitively normal participants.
This study introduces a carrier-free PDR nanoassembly with a tumor-suppressing peptide, pH-sensitive daunorubicin prodrug, and siRNA targeting the LILRB4 gene, achieving targeted therapy of acute myeloid leukemia. The combination treatment significantly enhances cytotoxicity and anti-leukemia effects.
Scientists at Northwestern University have developed the fastest test yet for diagnosing hepatitis C virus, delivering results in just 15 minutes – up to 75% faster than current rapid tests. The highly accurate diagnostic could revolutionize HCV care by improving diagnosis and accelerating treatment uptake.
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
A recent study mapped the evolutionary history of Asia-Pacific Balanophora species, revealing its retained plastids despite losing photosynthetic genes. This allows it to survive entirely as a parasite on specific tree roots, with some species producing seeds without fertilization.
A study suggests that one in two individuals arrested and detained in London may have undiagnosed attention-deficit/hyperactivity disorder (ADHD), while one in 20 may have undiagnosed autism. Screening for neurodivergence could enable better support for vulnerable individuals.
The phase III lidERA trial found that giredestrant improved invasive disease-free survival compared to standard-of-care endocrine therapy. Patients who received giredestrant were 30% less likely to develop invasive disease progression and had a clinically meaningful superiority to currently established endocrine agents.
A new platform integrates magnetic actuation with electrophysiological sensing for high-fidelity, multisite monitoring on dynamic ex vivo tissue surfaces. The soft electrode platform successfully recorded stable signals from cardiac tissue and demonstrated excellent motion control and stretchability.
This study reveals two key aspects of intracontinental orogeny: independence from active plate boundaries and control by continental weak zones. Intracontinental orgens are formed through reactivation of tectonic weak zones, involving dual dynamic mechanisms.
Research from King's College London found that theobromine in dark chocolate is linked to lower biological age. The study tested blood-based markers of biological ageing and found a correlation between theobromine levels and reduced biological age.
For patients with HR-positive, HER2-negative advanced breast cancers who have received endocrine therapy, sacituzumab govitecan-hziy offers comparable progression-free survival rates as standard chemotherapy. The study also found higher response rates and longer response durations for patients treated with sacituzumab govitecan-hziy.
The study refines the 3-PG model by adding a carbon storage pool, allowing it to account for the 'carry-over effect' in tree growth. The updated model achieves stronger agreement with observations and improves predictions of annual variations in tree-ring widths.
Cholera-causing bacteria show substantial genetic diversity and widespread multi-drug resistance to commonly used antibiotics in Africa. A new study analyzed genomic data from 104 isolates across Cote d'Ivoire, Ghana, Zambia, and South Africa, highlighting the urgent need for antimicrobial stewardship.
The addition of tucatinib to first-line maintenance therapy with trastuzumab and pertuzumab delayed disease progression in HER2-positive metastatic breast cancer patients, particularly those with brain metastasis. This delay allowed for prolonged time off chemotherapy and maintained disease control.
Researchers have successfully detected the interaction of neutrinos with carbon atoms in a vast underground detector, marking a breakthrough in understanding stellar processes, nuclear fusion, and the universe. The observation uses a unique 'delayed coincidence' method to separate real neutrino interactions from background noise.
The SWIFTT project presents a hybrid seminar to showcase its platform that helps foresters detect and prevent insect outbreaks, analyse windthrow and fire damage. The event features live demos and presentations from the project team, highlighting the platform's benefits for sustainable forest management.
Researchers have developed the Joint Open Genome and Omics Platform 1.0 (JoGo 1.0), which organizes human gene types into four levels based on global frequency. The database catalogs 19,194 human genes with a novel naming system, enabling secure integration of sensitive datasets and linking each gene type to public resources.
Researchers at TUM have developed a method to boost oxidase biosensor accuracy from 50% to 99%, paving the way for new uses in personalized medicine, AI-driven healthcare, and agriculture. This breakthrough could enable on-site adjustments to fertilization, reducing environmental impact.
Researchers developed a simple mechanochemical strategy to modify hexagonal boron nitride flakes using liquid metal, achieving high-efficiency EMW absorption and thermal conductivity in a single composite. The optimized composites exhibit excellent performance in electromagnetic wave attenuation and heat dissipation.
A review of scientific literature reveals that artificial beaver dams can make waterways more resilient to climate change, increasing water storage and enhancing flood-plain connectivity. The practice has shown promise in improving fish habitat and contributing to fish-population growth.
Researchers found that thinning adjusts competition, maintaining forest productivity over time. Thinning levels the playing field, weakening large trees' dominance and giving smaller ones a chance to catch up.
Research reveals beech trees adjust roots to short-term changes in soil moisture, improving drought readiness and survival in fluctuating environments. Fine root traits vary more in upper 10 cm of soil due to nutrient availability.
A team of scientists has developed a novel Tb3+-doped glass scintillator that exhibits zero-thermal-quenching luminescence and excellent scintillating performance. The material shows improved thermal stability and high X-ray absorption capacity, making it suitable for use in extreme scenarios.
Researchers have identified two proteins that allow cancer cells to evade destruction by brain immune cells, known as microglia. By removing these proteins, microglia play a key role in eliminating cancer cells during the early stage of their arrival in the brain.
A new study by the University of Zurich suggests that Uranus and Neptune may be more rocky than icy, challenging their classification as ice giants. The researchers developed a unique simulation process to model the planets' interiors, which found that the two planets could have either water-rich or rock-rich compositions.
A new oral endocrine therapy, giredestrant, has been shown to significantly lower the risk of breast cancer recurrence in early-stage HR-positive/HER2-negative patients. In a large clinical trial, patients treated with giredestrant were 30% less likely to have invasive disease recur or progress.
Researchers developed a hybrid estimator that uses probability-based sampling to work directly with available data, generating reliable estimates for forest attributes. The method achieved a sampling precision of over 90% and was comparable in efficiency to conventional model-based methods using superior Sentinel-2 data.
The Global Virus Network has appointed eight distinguished leaders to its Board of Directors, including experts in virology, public health, and communications. The new board members aim to strengthen the network's mission to advance collaboration, foster innovation, and ensure global preparedness for viral threats.