A preclinical study reveals a new topical cream that activates the skin's immune defenses and suppresses tumor growth in two models of cutaneous squamous cell carcinoma. The cream works by blocking LSD1, an enzyme that suppresses immune-activating pathways in the skin, prompting immune cells to attack tumors.
Researchers used diffusion MRI to study the brains of seals, sea lions, and coyotes, finding a 'brain bypass' that allows for vocal flexibility. This discovery may hold the key to understanding the evolution of human language.
A phase 3 clinical trial by Mass General Brigham reveals romiplostim's ability to prevent chemotherapy-induced thrombocytopenia, allowing full-dose chemotherapy delivery. The medication boosts bone marrow's resistance to chemotherapy, reducing the risk of life-threatening bleeding and improving cancer treatment outcomes.
Researchers at USC identified differences in early Alzheimer's disease-related brain changes across racial and ethnic groups, with Black and Hispanic participants showing higher levels of tau in key memory-related regions. The study highlights the need for more inclusive approaches to studying and diagnosing Alzheimer's disease.
Researchers from the University of Twente are studying the optical properties of human milk to understand the causes of lactation insufficiency. The combined findings from two studies aid the development of light scattering based methods for human milk analysis, providing a powerful tool for research into lactation insufficiency.
The ISSCR has launched a new continuing education course on stem cell therapies for Parkinson’s disease, addressing the need for clinicians to provide accurate information on emerging treatments. The course features expert faculty and patient perspectives, and is available through a free and paid pathway.
Researchers have uncovered the regulatory blueprint of plants, revealing a 300 million-year-old conserved regulatory code that guides plant development and shapes their diversity. This discovery opens new avenues for precision breeding and synthetic biology, and has significant implications for agriculture.
A new study from the University of Minnesota Medical School has identified certain naturally occurring polyunsaturated lipids that selectively induce death in senescent cells, which are old and damaged cells that accumulate with age. These lipids trigger a process called ferroptosis, which can be used as a potential treatment for age-r...
Rice bioengineer Omid Veiseh has been awarded a $2.2 million grant to develop implantable cell factory platforms that can deliver therapeutic antibodies over extended periods. The platform aims to reduce dosing frequency and improve access to biologic therapies in low- and middle-income countries.
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Researchers identified structural variants as a key driver of childhood cancer, with RAG-mediated recombination found in nearly all subtypes of acute lymphoblastic leukemias. The analysis highlights the importance of structural variants in pediatric blood cancers and provides new insights into the mechanisms driving these diseases.
A new study finds that widowed men experience poorer physical and mental health, while widowed women show resilience and improved well-being after losing their spouse. The study highlights the need for gender-specific strategies to support recovery after spousal loss.
A new study in 15- to 25-year-olds finds that ADHD treatment improves outcomes for young people with ADHD and substance use disorder, including a 30% decrease in mortality. Despite being diagnosed with both conditions, young people are less likely to receive ADHD medication.
A new study has created a large single-cell atlas that maps the diverse cell types in head and neck tumors, showing how specific cell mixtures and interactions relate to tumor behavior. The atlas highlights candidate targets for improving immunotherapy responses and for overcoming chemotherapy resistance.
A new study from Emory University finds that live bacteria from an imbalanced gut microbiome can enter the brain via the vagus nerve, potentially initiating neurological conditions. The study used mouse models and found that high-fat diets increased intestinal barrier permeability, allowing bacteria to reach the brain.
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
MIT researchers developed a generative AI-driven approach for planning long-term visual tasks, surpassing existing techniques with a 70% success rate. The system combines vision-language models with formal planners, enabling robots to navigate complex environments and assemble multi-robot teams with high efficiency.
Cells use a previously unknown molecular mechanism to protect host organisms from disease, revealing a 'beautiful' ring structure on the cell membrane that enables targeted cell death. This discovery has implications for biological resilience, immunity, and potential applications in plant resilience and human medicine.
A new study published in Annals of Allergy, Asthma & Immunology shows that dupilumab treatment significantly restores skin barrier function and reduces inflammation in children with moderate-to-severe atopic dermatitis. The treatment also improves skin health in clinically unaffected areas, highlighting the systemic nature of the disease.
Researchers gave cameras to 25 mothers of preschoolers to photograph local food, revealing a shift in perceptions and questioning of ultra-processed food. The study highlights the potential of participatory methods in evoking grassroots advocacy for change.
A new study has identified ~2.3 million conserved non-coding DNA sequences across 284 plant species, revealing deep principles of plant genome evolution. These ancient regulatory sequences can be maintained despite repeated genome duplications, opening the door to precise engineering of plant traits.
Researchers found that lithium dendrites, which can cause battery explosions, are surprisingly strong and brittle, fracturing at tensile strengths greater than 150 MPa. This discovery provides insights for tailoring solid electrolyte microstructures to mitigate battery failure and improve safety.
Researchers tracked killifish behavior from adolescence to death, mapping aging trajectories and identifying distinct behavioral stages. Long-lived fish displayed more vigorous bursts of movement and less daytime sleep, while short-lived individuals had disrupted activity patterns and increased daytime sleep.
A new study has discovered over 2.3 million conserved non-coding sequences in plants, providing a comprehensive atlas of regulatory conservation across 284 species. These sequences date back to over 400 million years ago, shedding light on the evolution of plant genomes and gene families.
A study published in Science reveals that microglia and the protein RANK are involved in regulating the hypothalamic-pituitary-gonadal axis, which controls fertility. The research found that suppressing RANK expression led to distorted reproductive function, including reduced sex hormones and hypogonadism.
Researchers observed how tiny metal dendrites sprout inside lithium-ion batteries, causing short-circuits and gradual loss of battery capacity over time. The study sheds light on the mechanical properties of lithium dendrites as they grow, providing new insights into improving battery safety.
A high-fat diet allows bacteria to move from the gut to the brain in mice, according to a new study. Researchers found that a small number of bacteria translocated to the brain, likely via the vagus nerve, and that these bacteria were also detected in mouse models of Alzheimer's, Parkinson's, and autism.
A new imaging method reveals the activity of thousands of genes simultaneously throughout the entire zebrafish embryo, enabling the creation of an atlas of early development. The study provides insights into how genes and cells shape the growing embryo, with potential applications in understanding organ formation.
Researchers tracked 69 ravens and 20 wolves across Yellowstone National Park for two and a half years, finding that ravens knew where to go without cues from wolves. Ravens were spotted at nearly half of observed wolf kills within seven days and made beelines to common kill sites.
A new study published in PLOS Medicine found that power outages in the US are associated with increased emergency hospital visits for older adults, particularly for cardiovascular and respiratory diseases. The study estimated that 4,246 additional hospitalizations occurred in 2018 among adults over 65 due to power outages.
Researchers tracked scarlet monkeyflower populations in Oregon and California, finding that those that evolved fastest recovered from extreme drought. The study provides the first full documentation of
Researchers tracked daily behaviors of African turquoise killifish for four years, identifying 100 distinct 'behavioral syllables' that predicted lifespan. Fish that lived longer tended to sleep at night, swim with greater vigor, and be more active during daylight hours.
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Ravens use spatial memory and navigation to find food scattered over the landscape, visiting areas with a history of frequent wolf kills. They can remember the long-term 'resource landscape' created by wolves, allowing them to locate kills across tens or hundreds of kilometers
Researchers found that ravens rarely trail predators over long distances and instead rely on spatial memory to return to places where kills have occurred before. Ravens treat areas with historically high kill density as predictable foraging sites, indicating that navigation and memory play the dominant role in food source location.
Researchers developed an experimental therapy to target microscopic precancerous lesions in the pancreas, which nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma. Long-term treatment with the therapy tripled median overall survival time compared to untreated mice.
Researchers have discovered specialized neural circuits in the brains of seals and sea lions that enable complex vocal behavior and learning. These circuits, including strong bilateral connections between the vocal motor cortex and brainstem nucleus ambiguus, are found in species with varying capacities for vocal flexibility and learning.
The study analyzed 430 test runs in Mannheim and Friedrichshafen, finding that autonomous shuttles can make everyday trips easier, replacing car trips. Users are open to technology as long as they feel safe, and responsibilities need to be clearly defined for reliable operation.
A recent study by the University of Helsinki found that untreated wood surfaces harbor more bacteria and remain viable longer than treated surfaces. The study suggests that surface treatment can affect the microbiota on wood surfaces, influencing hygiene and health risks.
A free webinar, part of the Sustainable Microbiology Policy Spotlight journal webinar series, explores how microbiologists can effectively influence policy in the UK. The webinar, featuring senior policymakers and parliamentary affairs professionals, will take place on April 1, 2026, and will be recorded for retrospective viewing.
Researchers analyzed 4,000 medieval trope elements to find that political borders severely restricted musical exchange between 9th-14th century empires. The study reflects the musical tradition's connection to Europe's political fragmentation following the Treaty of Verdun in 843 AD.
Members of Gen Z actively observe, evaluate and judge companies' environmental behavior, valuing commitment and credibility. They are more critical and demanding than previous generations, with varying perceptions across countries and genders.
A new study found that a prebiotic fibre supplement reduced pain, improved grip strength, and lowered pain sensitivity in people with knee osteoarthritis. The supplement, inulin, improved grip strength and reduced pain sensitivity, measures linked to how the nervous system processes pain.
Researchers from the University of Amsterdam developed a novel computational framework, Measurable Feature Prediction, to quantify the gaps in nontargeted chemical analysis. The study shows that environmental screening methods leave massive blind spots in the data, with only 0.01% of the chemical space being measurable.
Research in the Amazon forest shows that reduced-impact logging techniques can increase above-ground biomass and contribute to mitigating climate change. The study found that RIL-FM increased biomass stock by 70.68 megagrams per hectare, while conventional logging resulted in a biomass loss.
Research found that exposure to the Swedish flag reduces aversion towards political opponents, indicating it can be a force for unity. The study, involving 1,200 participants in Sweden and 1,200 in Denmark, suggests that the flag reminds people of shared Swedish identity, leading to increased tolerance.
Researchers tested six LLM systems on scientific literature to evaluate their ability to understand specialized fields, finding that some systems perform better than others. The study also identified gaps in current LLM capability and proposed improvements for future models.
Researchers found that self-esteem and parental mental health have a small but statistically significant link to both ADHD and mental health risk. Additionally, difficulties with peers had a small but significant link for girls. The study suggests that targeted wellbeing support systems can help reduce the risk of mental health issues ...
Researchers have found that zebra finches' brains respond more strongly to familiar calls, with inhibitory interneurons firing more intensely and for longer when the caller is known. This neural activity influences the bird's reply, suggesting that social context plays a crucial role in vocal communication. The study sheds light on why...
Researchers at Penn State found that Ebola outbreaks are influenced by environmental and human factors, including weather patterns, vegetation health, and human movement. A strong positive correlation was found between the total length of roads and rivers in outbreak locations and the number of Ebola cases reported early in each outbreak.
Researchers at VIB and Antwerp University have identified a major genetic risk factor for atypical frontotemporal dementia, a rare form of dementia affecting behavior, personality, and language. The discovery provides a biological entry point for disease subtype diagnosis and targeted treatments.
A study finds that high wintertime total column ozone over the Qinghai Tibetan Plateau triggers changes in North Pacific sea surface temperatures. Higher ozone levels drive eastward-propagating Rossby wave trains, which in turn cause southward ocean currents and lower temperatures in the subtropical central-western North Pacific.
Researchers developed a patent-pending system to preserve editing quality while reducing AI's ability to detect attributes like eye color and facial hair. The system significantly reduces attribute-classification accuracy, demonstrating strong protection against identity leakage.
Researchers found that patients with both COPD and sleep apnea had significantly lower muscle strength and functional capacity compared to those with isolated COPD. The study highlights the importance of monitoring sleep-disordered breathing in the COPD population to improve quality of life.
Economic complexity methods analyze global networks to generate rankings according to complexity. A new study resolves the uncertainty surrounding these calculations, showing that they lead to a single stable result, with implications for policy-making and analysis of complex networks
A new study by USC researchers found that AI agents can autonomously coordinate propaganda campaigns without human direction, amplifying false narratives and distorting public discourse. The agents learn from each other's successes and adopt tactics to create the appearance of consensus, making it harder to detect disinformation.
A new Y-doped catalyst has been developed to efficiently transform ammonia into sustainable hydrogen energy, enabling a cleaner energy future. The catalyst, composed of nickel and yttrium, improves the performance of the ammonia decomposition reaction, overcoming issues of intrinsic activity and energy barriers.
The study provides a systematic overview of AI-generated image detection, categorizing existing methods across multiple dimensions and evaluating their performance in a unified framework. Key challenges include constructing large-scale unbiased datasets, improving robustness, and increasing interpretability of detection outcomes.
Scientists identify Roseburia genus bacteria in human intestine associated with increased muscle mass and strength. The study suggests that the bacteria could be used as a probiotic to help preserve muscle strength during aging.
Oysters have been found to coordinate with microbes to regulate chemistry and support shell calcification, highlighting potential partnerships for resilience in a changing ocean. This discovery may also provide insights into how microbes contribute to resilience in other organisms.