A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
The new guidelines, based on 137 systematic reviews, emphasize the importance of consistency and effort in resistance training. The primary goal for most adults should be to build a consistent routine, which can be achieved with elastic bands, bodyweight training, or home-based routines.
A large study found that Asian mothers experience a 1.5-fold higher rate of obstetric trauma, while Black immigrant and refugee mothers have a 20-30% higher risk. The study also found that immigrants with shorter duration of residence had higher initial risk of obstetric trauma, which declined with increasing time in Canada.
A study extending pregnancy monitoring from conception to 6 weeks postpartum found nearly 10,000 cases of severe maternal complications in Canada each year. This reveals significant cases were previously missed, emphasizing the importance of postpartum care and timely interventions.
A new framework, DUPGT-CDR, uses gating networks to effectively incorporate both positive and negative feedback in cross-domain recommendation systems, achieving lower prediction errors and improved convergence speed. The framework offers more precise product recommendations and personalized learning resources across various domains.
A team of international researchers successfully demonstrates time-bin QKD over 120 km with an on-demand telecom semiconductor QD device. The system achieves exceptional stability and maintains high security key rates, making it suitable for real-world text message encryption applications.
The study reveals that bonding heterogeneity, rather than geometric similarity, governs relaxation dynamics in glasses. By incorporating electronic structure and chemical interactions, researchers establish a new physical framework for understanding structure-relaxation coupling in glasses.
Prof. Yanquan Geng's team has devised a way to carve variable-depth, three-dimensional trenches into gallium antimonide using a microscopic tip vibrating thousands of times per second. This process improves the crystal's structural integrity and enables the creation of pristine 3D nanogrooves with controlled depths and widths.
Researchers used microwave-based 3D printing to create ceramic components with near-zero porosity and improved strength. The hybrid technique eliminates microscopic holes and traps gas bubbles, allowing for more bending force before breaking.
A recent study found that women have a 21% lower risk of death compared to men, but a 12% higher risk of severe side effects from cancer treatment. The research, conducted in partnership with international collaborators, analyzed data from over 20,000 cancer patients and identified sex-based differences in survival and treatment toxicity.
Researchers reveal that coronaviruses hijack specific cellular protein to build large compartments for viral assembly, leading to reduced viral production in cells lacking the HGS protein. The discovery opens new avenues for antiviral therapy by targeting the interaction between HGS and viral proteins.
Researchers developed a new eDNA sampling membrane that captures DNA fragments with high efficiency, detecting multiple tropical coral reef fish species. The membrane, coated with molybdenum disulfide nanosheets, enables preferential interactions with DNA bases, improving the capture of trace eDNA from large volumes of seawater.
Researchers have developed bioengineered extracellular vesicles with enhanced therapeutic functionality, which can precisely target injured cardiac tissue and deliver therapeutic cargos. These bioengineered EVs have shown promising results in preclinical models of myocardial infarction, heart failure, and pulmonary arterial hypertension.
Researchers have developed an 'ECI patch' that reads brain signals and controls cars with 93.5% accuracy. The patch, powered by ultra-thin sheets called MXene, detects fatigue and mental states without causing skin irritation.
A research team has pioneered a novel optical neural network that physically 'learns' through associative light exposure, eliminating the need for traditional computing algorithms. The system successfully recognized letters and demonstrated capability in handwritten digit recognition.
A new study found that A&E patients with visible blood in their urine who receive a scan within 48 hours are 2.5% less likely to die within three months. The study also showed that patients with cancer are diagnosed significantly faster when they receive prompt investigation.
Researchers compare prostate cancer screening to breast cancer screening, finding similarities in identifying significant cancers and reducing mortality. The study suggests that prostate cancer screening should be reconsidered, offering benefits over harms, and highlights the need for further analysis on costs.
ToxIndex integrates three tiers of New Approach Methodologies, leveraging AI agents to access and orchestrate toxicological resources, and providing comprehensive, source-traceable risk assessments in a fraction of the time required by traditional methods.
The RESIL-Card tool helps hospital cardiovascular professionals and stakeholders assess and strengthen care pathways, ensuring continuity of care during crises. The tool offers a structured self-assessment framework, identifying concrete actions to maintain care continuity and patient safety.
A team from Tokyo Metropolitan University successfully detects laser-assisted electron scattering using circularly polarized light, shedding light on atomic scale helicity and its impact on electron-matter interaction. The signal agrees with theory, but further work is needed to improve detection efficiency and accuracy.
A new smartphone app has been shown to significantly improve sex life and delay ejaculation in men with premature ejaculation. The app, developed by urologists and psychologists, teaches men therapeutic techniques and exercises to manage arousal and control ejaculation.
A young female fisher traveled 118 kilometers from Durham to the White Mountains in New Hampshire, the longest recorded dispersal for the species. This journey, documented over winter with deep snow, underscores the fisher's adaptability and highlights the need for further research into movement patterns.
The photonics technology can detect molecular signals long before symptoms emerge, enabling earlier diagnosis and treatment. The technology uses nanomaterials and photonics to interact with microRNAs and detect cancer signals.
A new RNA therapy has been developed to enhance the heart's own ability to protect and repair itself after a heart attack. The therapy, which involves injecting particles into the arm, significantly reduced scarring and improved heart function in lab experiments, offering a potential breakthrough for heart patients.
The new law, House Bill 1266, guides curriculum and teacher training to prepare students for a data-rich world. By integrating data science across K–12 subjects, Indiana aims to develop critical thinking and problem-solving skills for future success.
Researchers at Rice University developed a safe bioelectronic sensor using naturally occurring polymer chitosan to effectively communicate with bacteria. The system uses a hydrogel to trap bacteria near an electrode, generating a stable electronic current when exposed to target substances.
A new University of Arizona study found that exposure to certain pesticides before pregnancy is associated with lower Apgar scores, a measure of newborn health. The study suggests that pesticides can affect the next generation, highlighting the importance of regulating pesticide use to improve maternal and child health.
Researchers transformed waste into high-performance porous carbon materials for soil and water conservation. The study identified top-performing materials from agricultural wastes, which exhibited high surface areas and favorable pore structures, enhancing adsorption capacity and water retention.
Insilico Medicine's inclusion in the Hang Seng Index and Stock Connect program is expected to enhance stock liquidity and market attention, strengthening the company's capital market influence. The company has achieved multiple drug development milestones, including 12 IND-enabling programs and preclinical candidates ISM0676 and ISM5059.
Insilico Medicine's Alex Zhavoronkov chairs precision aging discussion and presents Luminary Award to OpenAI president Greg Brockman. The company's AI-driven approaches accelerate drug discovery and advance precision medicine for aging and age-related diseases.
Researchers at Duke University have developed a technique using microbubbles and ultrasound to deliver large cancer drugs into cells, causing them to self-destruct. The technology, called SonoPIN, shows promise in precisely delivering therapeutics to cancer cells with minimal off-target effects.
Researchers found that seniors are willing to travel more than an hour for routine or specialized medical care, but this willingness varies by socioeconomic status, mobility, and location. The study's findings have implications for telehealth expansion and transportation policy, suggesting that programs offering ride services, improved...
Engineers from the University of Colorado Boulder have discovered the mathematical rules that fireflies follow to sync up their flashes in a South Carolina swamp. The team's findings could lead to new designs for robots that move in swarms and help scientists understand other examples of synchrony in biology.
A study in ferrets demonstrates that immunity to two proteins on the surface of the influenza virus can reduce transmission and viral evolution. Targeting both hemagglutinin and neuraminidase proteins can effectively curb the spread of the virus, with transmission rates dropping by half in animals with immunity to both.
Researchers at Albert Einstein College of Medicine have developed a new strategy to engineer immune cells that prolong their effectiveness, addressing a major limitation of current treatments. The new method generates longer-lasting immune cells that provide more sustained control of human blood cancers and suppression of HIV-infection.
A systematic review found a significant association between excessive smartphone use and eating disorder symptom severity in young people, including disordered eating and food addiction. The study highlights the need for early intervention strategies to address excessive phone use in young people displaying eating disorder symptoms.
The updated guideline consolidates evidence-based recommendations for managing dyslipidemias, offering a comprehensive approach to lower risk of atherosclerotic cardiovascular disease. The guideline recommends earlier intervention through healthy lifestyle changes and considers the use of a new cardiovascular disease risk calculator, P...
Researchers have confirmed the existence of a long-theorized molecule in oxidation, which has implications for atmospheric chemistry, biochemistry, and medicine. The discovery was made using a unique mass-spectrometric technique and has significant implications for understanding reaction steps and products in oxidation processes.
Researchers used afterimages to measure brain predictions of visual consequences of eye movements, finding that predictions are accurate but subject to systematic errors. The brain's efference copy helps predict visual shifts, but this prediction falls short of the actual eye movement's consequences.
A new framework, 'just-shoring,' aims to shift focus from competition and security to the rights and interests of local communities whose lands are most at risk. The approach prioritizes accountability and transparency, giving communities a legal right to co-govern throughout the mineral lifecycle.
The American Meteorological Society and partners urge reinstatement of climate science chapter in judicial reference manual, citing concerns over public access to scientific knowledge. The statement emphasizes the overwhelming agreement among experts on climate change, its impacts, and human activities as primary drivers.
A new study reveals that selfish chromosomes exploit the Overdrive gene to destroy rival sperm, boosting their chances of passing into the next generation. The gene acts as a quality control checkpoint during sperm development, normally eliminating abnormal sperm cells, but selfish chromosomes hijack the system to kill competitors.
The study found that using heavy water in the electrolyte solution significantly increased energy output from the yarns, with up to 2.5 times higher peak electrical power and 1.8 times more energy per stretching cycle. The energy conversion efficiency reached 9.5%, higher than any other previously reported twistron harvester operating ...
The 2025 update provides 5 overarching principles and 9 individual recommendations for managing rheumatoid arthritis, emphasizing patient-centered care and simplifying clinical approaches. The update prioritizes treatment targets, monitoring frequency, and the role of methotrexate, glucocorticoids, biologics, and JAK inhibitors.
Kalinin's work is reshaping how new materials are designed, tested, and studied, enabling researchers to predict promising new materials computationally. He has developed machine learning-driven systems that can synthesize and characterize new materials at unprecedented speed.
A tropical insect has been found to change color from hot pink to green within a fortnight, resembling the young leaves of rainforest plants. This remarkable adaptation allows the insect to blend in with its surroundings, suggesting a finely tuned survival strategy.
Researchers at the University of Arkansas have developed a sulfide coating that significantly increases the life, power, and safety of lithium batteries. The coating, applied to nickel-rich cathodes, protects the battery electrolyte from decomposition and stabilizes the interface, leading to improved performance and longer lifespan.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) and the Global Lung Function Initiative (GLI) have agreed on diagnostic criteria for COPD, aiming to improve diagnosis and treatment. The new guidelines will help reduce the number of undiagnosed cases and promote the use of spirometry tests.
A new study finds that the North Atlantic's exceptional warmth played a key role in the Valencia DANA storm's intensity, with precipitation 40% lower without it. The research highlights the importance of oceanic context in extreme weather events, reinforcing the need for global climate simulations.
Scientists discovered a 4-meter-long Polycotylus fossil with a huge tooth embedded in its neck vertebrae, suggesting a violent attack by an enormous bony fish called Xiphactinus. The fossil's internal structure was analyzed using CT scanning, revealing a three-dimensional model of the tooth and its attacker.
A new study found that bilingual consent forms significantly improve cancer treatment understanding among people with limited English, with understanding rising from 35% to 60%. The study, published in Supportive Care in Cancer, examined the impact of different translation approaches on cancer treatment understanding among Bengali- and...
Researchers investigated the Mississippi River's hydrological trends, ocean carbon storage, and gender dynamics in flood mortality. A study found that precipitation increases, but soil moisture decreases, while high-resolution models reveal stronger Southern Ocean carbon absorption. Additionally, data showed men are overrepresented in ...
Researchers found that cortisol significantly worsens orientation in individuals, particularly in environments without landmarks. The brain's internal GPS system, grid cells, lose function under stress, leading to impaired navigation.
Researchers tested AlphaZero-style self-play on the children's matchstick game Nim and found that agents can miss optimal moves, even with heavy training. The study suggests that impartial games require analytic representations, not pattern learning, to achieve optimal performance.
A cohort study found that 180-minute drives from a donor care unit are common, highlighting the need to improve system efficiency and donation outcomes by opening additional DCUs in acute care hospitals and expanding donor transport across existing boundaries
A mixed-methods cohort study found daily living impairment is linked to slower recovery in older adults post-surgery. Targeted interventions, such as preoperative education and caregiver support, can optimize recovery experiences for both patients and caregivers.
A genetic mutation found in high-altitude animals may help regenerate myelin sheath and repair nerve damage in conditions like MS and cerebral paralysis. The mutation increases production of a metabolite that promotes myelin production and maturation.
Researchers have discovered that vitamin B2 protects cancer cells from ferroptosis, a type of programmed cell death. By targeting vitamin B2 metabolism, cancer cells may become more susceptible to ferroptosis, paving the way for new cancer therapies.
Researchers found that treating severe fetal megacystis with a vesicoamniotic shunt in the first trimester can improve survival rates and kidney function. In the study, 75% of children were born alive and 68% survived their first year of life, with most showing normal or only slightly impaired kidney function.