A multinational clinical trial found that balanced crystalloid fluid and 0.9% saline are equally safe and effective for treating septic shock in children. The study enrolled over 9,000 children and showed no difference in outcomes between the two IV fluids.
A University of Manchester astronomer led a major international effort to update the long-standing 'post-detection protocols' used in Search for Extraterrestrial Intelligence (SETI). The revised Declaration of Principles marks the first major update in over 15 years, reflecting a media landscape transformed by social media and artifici...
A new study presented at EULAR 2026 highlights the importance of structured cardiac evaluation in systemic sclerosis, particularly for patients with multi-system disease. The research also identified PDE4B as a promising therapeutic target across various tissues and cell subsets, offering potential benefits for patients with early dise...
A new study reveals that the Atacama Desert's hyperarid core became arid 45 million years ago, contradicting previous assumptions. The research team used cosmogenic nuclide dating to analyze quartz clasts and found exceptionally high concentrations of rare isotopes, indicating that surface clasts remained undisturbed for tens of millio...
A study published in JAMA Network Open found that maternal RSV vaccination reduces hospitalization risk in young infants by nearly 70%. The vaccine also showed effectiveness against severe lung infections caused by the virus.
The DIVINE cohort database contains clinical information from 5,813 COVID-19 patients, including characteristics, risk factors, treatments, and outcomes. The data can be used to study disease progression, identify associated factors, and validate predictive models.
A new AI tool, AIDD, combines brain scans with machine learning to accurately diagnose two common forms of dementia. The tool showed near-perfect accuracy in identifying Alzheimer's disease and dementia with Lewy bodies, offering a promising future for clinicians.
A study found that passive AI use can lead to a decline in outcome satisfaction of 21% compared to manual writing, while collaborative AI use showed similar scores. Passive AI use also reduced feelings of ownership and perceived meaningfulness by nearly 20%.
Researchers discover repetitive regions of the human genome, previously considered 'junk DNA', could contribute to cancer development through epigenetic and transcriptional alterations. The study uses advanced sequencing technologies to characterize these regions and their molecular interactions.
Researchers developed a mineralized DNA hydrogel that coordinates immune regulation and sustained bone regeneration. The material promotes healing-friendly macrophage activity while supporting bone-forming stem cells, accelerating bone repair and improving tissue mineralization.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Patients described GLP-1 RA therapy as a facilitator of lifestyle change, highlighting the need for standardized guidelines on patient education and clinical support. The quality of care was highly variable, leading to potential expectation management issues around adverse effects and long-term management.
Researchers successfully engineered a novel platinum cluster catalyst that maximizes hydrogen production performance while minimizing platinum usage. The catalyst enables precise control over the number of atoms in each cluster, achieving world-leading hydrogen production per unit of platinum.
A study finds that maternal RSV prefusion F vaccination protects against RSV-associated acute respiratory illness and lowers hospitalization rates among infants under 1 year. The findings support the effectiveness of this vaccine in preventing severe respiratory illnesses.
A new study has overturned longstanding ideas about how germinal centers function, revealing that they are far more selective than once thought. The findings suggest that the immune system ultimately produces stronger antibodies by repeating a noisy, almost random process over and over across many germinal centers.
Researchers at University of Alicante uncover significant evidence of large-scale arms trading and commercial exchange in the western Mediterranean during the late medieval period. The 43 helmets, originally attributed to Roman origin, have been redated to between the late 14th and early 15th centuries.
A multidisciplinary patient organisation provides accessible, person-centred support through professional counselling, offering a non-clinical setting to discuss everyday challenges and work-related issues. The service also offers unique insights into unmet needs, such as medication shortages and administrative barriers.
Researchers developed an interferometric second-harmonic generation imaging approach to identify antiparallel domains and detect hidden structural defects in hBN thin films. The study finds that SHG intensity is closely associated with differences in crystal orientation and destructive interference between domains.
A POSTECH research team developed a haptic device that can operate inside MRI scanners, enabling the measurement of brain activity during VR experiences. The study found that adding tactile feedback increased brain activation in areas responsible for motor control, attention, and cognitive processing.
Scientists have developed a genome engineering platform that enables simultaneous gene knockout, base substitution, insertion, deletion, duplication, and inversion in a single framework. The TRIM platform integrates multiple desirable traits by combining gene knockout with prime editing-based sequence modification.
New research from Griffith University reveals how Florida Governor Ron DeSantis' anti-ESG politics are reshaping financial markets. The study found that fossil fuel companies played a significant role in limiting banks and pension funds' investments in ESG-aligned companies.
A new study reveals that IS110 elements use two RNA-guided pathways to insert donor DNA into target sites, challenging the classical 'cut-out-paste-in' model. The researchers identified a figure-eight DNA intermediate in one pathway and a direct-transfer pathway without forming a conventional intermediate.
Researchers present findings on a novel therapeutic strategy for PsA, using synovial biopsy-driven treatment with biologics targeting IL-17/23 axis. A separate study evaluates the effectiveness of personalized dietary interventions in improving clinical outcomes.
Researchers developed a transistor technology that enables a single device to perform multiple circuit functions simultaneously, simplifying circuit design and increasing data processing speed. The new approach reduces required transistors by 75% and increases data processing speed fourfold.
A new study by Agbonma Onyeka and colleagues demonstrates that Lentinus squarrosulus can be cultivated using locally available agricultural waste, reducing waste management issues and creating a safer alternative protein source. The researchers successfully grew the mushroom on different sawdust species types, producing edible biomass ...
Researchers discovered a previously unknown enzyme system in anaerobic bacteria that converts toxic chloromethane into non-toxic substances. The system, found in species Acetobacterium dehalogenans, has implications for environmental remediation and climate research.
A population-based cohort study found that IIM subtypes differ in incidence, particularly by sex and ethnicity. Automated quantitative nailfold videocapillaroscopy (NVC) model shows superior discriminative capacity for predicting disease activity compared to traditional serum biomarkers.
A landmark review proposes cytoskeletal prestress homeostasis as fundamental biological principle regulating cellular behaviors, including cell stiffness and gene transcription. Dysregulated prestress homeostasis is linked to cellular senescence and cancer metastasis.
A modified culture medium can quickly and affordably detect fidaxomicin resistance in C. difficile infections, saving 201 hours of work and $9,075 per 1,000 patients screened. The new method correctly identifies resistant isolates with 100% sensitivity.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
New AI algorithms demonstrate improved accuracy in evaluating radiographic data and assessing joint inflammation. These innovations include the RADAR algorithm, ADMIRA, and thermography-based systems, offering promising alternatives to traditional imaging methods.
A new study found that sewage overflows in homes can introduce antibiotic-resistant and multidrug-resistant bacteria, making infections difficult to treat. The research collected samples from 86 Maryland homes and found nearly half had E. enterococci present, with over a third harboring antibiotic-resistant strains.
A systematic review of 73 studies found that early diet may shape cognitive performance and academic outcomes in adolescents. Unhealthy dietary patterns in infancy have lasting consequences for intelligence in adolescence, according to the study.
A new method for sequencing hantaviruses improves on existing strategies by generating whole-genome data from low-viral concentration samples. The approach, developed by Janet Manson and colleagues, has already proven useful in the field and shows promise for expanding to other viruses.
Research in flies shows that tumor cells with chromosomal instability can become senescent and release signals altering neighboring tissue behavior. This process promotes tumor growth by inducing the death of nearby healthy cells.
Researchers have discovered a new subtype of foam cells that form in early atherosclerosis, driven by mechanical stacking stress. These coralthelial cells promote inflammation and accelerate lesion development. The study offers promising therapeutic targets and novel prevention strategies for cardiovascular disease prevention.
A recent study published in Development reveals that the UTY gene on the human Y chromosome still contributes to transcriptional regulation during early development. Despite its low expression and reduced enzymatic activity, UTY co-occupies active regulatory elements with its X chromosome homolog UTX.
Researchers developed a multifunctional protective layer to overcome limitations of high-capacity, lithium-rich Mn-based oxide (LRMO) materials. The new cathode achieves exceptional fast-charging capability, long-term cycling stability, and high energy density with minimal Sc consumption.
The updated ASAS-SPARTAN revised classification criteria for axSpA prioritize MRI of the sacroiliac joints and incorporate a focused set of clinical variables. The new recommendations also emphasize the role of imaging in diagnosing and managing both axial and peripheral SpA.
A new study has discovered a crucial protein interaction that controls the photosynthetic machinery in plants. The discovery sheds light on how plants adapt to changes in light conditions and balance the light-harvesting capacities of both photosystems, enabling efficient energy transformation.
Researchers developed a new method to observe nanoscale spin waves, directly detecting short-wavelength magnons using resonant soft X-rays. The technique, called magnon momentum microscopy (MMM), reveals strong nonlinear interactions and four-magnon scattering processes in magnetic materials.
Ancient DNA analysis reveals a single lineage survived Ice Age, while modern fallow deer display unusually low genetic variation. This study highlights the impact of climate and human activities on species conservation.
Researchers created a detailed atlas of human brain-vessel morphology, revealing subtle changes linked to stroke prognosis and suggesting that small-vessel features may help explain worse recovery outcomes. The atlas, MARVAL, provides a standardized tool for measuring the vascular network in large populations.
The American Heart Association introduces a new certification to recognize advanced expertise in managing stroke programs, improving outcomes and driving quality improvements. Certified coordinators play a central role in reducing length of stay, lowering mortality rates, and decreasing readmissions.
A new study reveals that adolescents who use their smartphones more before bed have more late-night smartphone usage. The research found that teenagers with greater pre-bedtime smartphone use had greater late-night use, with an average of 46 minutes of late-night use per night.
Researchers will investigate the link between SYNGAP1 protein deficiency, cilia dysfunction, and clinical symptoms of SYNGAP1-Related Disorders. The study aims to inform rational drug design and provide new insights for targeted therapies.
Recent studies show finerenone preserves kidney function, reduces cardiovascular risk and improves survival across a broader range of CKD patients. Finerenone also reduces kidney failure, heart failure or cardiovascular death risk by 23-24% in non-diabetic patients.
TIGIT is a second-generation immune checkpoint that exerts immunosuppressive effects through multiple pathways, promoting a hypoxic tumor microenvironment. Combination with PD-1 inhibitors has shown remarkable promise, improving objective remission rates and progression-free survival.
Researchers clarify microscopic origin of charge noise in silicon spin qubits, attributing it to electronic transitions between conduction band and trap states. Higher temperatures improve gate fidelity by reducing switching rates and transition times.
In an exploratory analysis, finerenone was found to slow kidney function decline, reduce albuminuria, and lower the risk of kidney failure or substantial loss of kidney function in patients with glomerular diseases. These findings suggest a crucial role for finerenone in preserving kidney function in this population.
Researchers summarize recent developments in terahertz biophotonics, highlighting its potential for overcoming technical limitations in fields like skin cancer diagnosis, wound assessment, and drug discovery. The study provides a roadmap for future research to improve the field's practical applications.
A new study reveals that global warming will increase natural methane emissions, overwhelming those consumed by microbes, leading to a positive feedback loop in climate change. The research, led by Queen Mary University of London, used unique natural experiments to test the effect of warming on methane balance.
Small reservoirs worldwide are losing storage capacity at a rate of 7.3% per decade, affecting billions of people. The study identifies 16 global sedimentation hotspots and estimates that over half of global reservoirs may experience functional degradation by 2060.
A novel asymmetric alloying method enables the creation of carbon-centered gold(I)-silver(I) chiral bicapped square antiprism polyhedral clusters, exhibiting phosphorescence and distinct chirality-dependent properties. The approach offers a new paradigm for precise alloying and stereocontrol of metal clusters.
Researchers have found that horizontal gene transfer contributed to the repeated evolution of fungi-like, absorption-feeding life across eukaryotes. The study identified 166 cases where genes were transferred between four groups of eukaryotes, including Fungi and Pseudofungi.
Research from the University of Gothenburg has found that spring storms in Europe are becoming more common, with a shift towards more intense and frequent winter storms. The study, which analyzed historical weather data from 1940 to 2024, suggests that Arctic sea ice reduction is a key factor contributing to these changes.
A new reference essay examines Japanese migration to Canada from 1877 to 1988, highlighting the development of vibrant communities and women's roles in shaping immigrant life. The article also explores the forced removal and incarceration of Japanese Canadians during WWII and their ongoing struggle for justice.
Researchers from Frontiers, a multidisciplinary team, spent years searching for the tallest tree in Taiwan after discovering an estimated 5,000 different species thrive on the island. They used LiDAR technology and citizen scientists to identify the 'Heaven Sword,' a 84.1-meter-tall Taiwania fir, as East Asia's tallest tree.
A study by researchers at the University of Minnesota found that improving land use and management can increase both economic output and environmental performance, without sacrificing one for the other. The analysis showed potential gains in biodiversity, climate change mitigation, and economic development, with possible increases of o...
Researchers found that atmospheric rivers have intensified in recent decades, leading to more frequent extreme rainfall events in Japan. This trend aligns with global warming and increased atmospheric water vapor content.