Researchers used DNA barcoding to track cancer cells in solid and liquid biopsies, finding that tumour heterogeneity varies widely depending on necrosis and tumour burden. This study suggests that combining both strategies may provide a more accurate representation of the disease.
Researchers have uncovered a dense network of magnetic nodal lines in cobalt, which are intrinsically spin-polarised and give rise to fast, topologically robust charge carriers. These unique properties open new perspectives for exploiting magnetic topological states in future information technologies.
A new study finds that the quality of macronutrients matters more than their quantity for heart health, with diets rich in whole grains, fruits, and vegetables associated with a lower risk of coronary heart disease. The study also found improved cardiovascular biomarkers in healthy versions of low-carb and low-fat diets.
A case report investigates a woman's development of acute lymphoblastic leukemia and lymphoblastic lymphoma after receiving her second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine, highlighting potential genetic and molecular mechanisms involved in disease pathogenesis.
Researchers at the University at Buffalo have developed a new inhalable form of tuberculosis (TB) treatment that delivers rifampin directly to the lungs, reducing liver damage and improving immune activity. The study found that inhaled nanoparticle treatment kept higher levels of the drug in the lungs for up to a week after a single dose.
Astronomers at UCLA and UCSD have discovered hydrogen sulfide in the atmospheres of four distant gas giant planets orbiting HR 8799, confirming their planetary status. The detection uses a new data analysis technique that will improve the search for life on other planets.
Researchers suggest that seabirds were used to fertilize Peru's Chincha Valley as early as 1250 CE, potentially supporting the growth of a pre-Inca society. This ancient practice could have played a significant role in the region's agricultural development.
A phase 3 trial will assess the efficacy of baricitinib in reducing persistent neurological and cardiopulmonary symptoms of long COVID. The study, REVERSE-LC, aims to address the massive public health problem of long COVID, which affects millions worldwide.
The center aims to strengthen food and environmental resilience, train the next generation of AI-enabled agricultural scientists, and help producers respond to emerging biological and climate threats. Students are immersed in federal agricultural research projects through a USDA-supported summer research program.
A new analysis found that rural cancer patients treated locally have similar surgical outcomes to those who traveled to urban facilities. The study used Surveillance, Epidemiology, and End Results data from Medicare-eligible patients with lung or colon cancer, aged 65 or older, residing in rural areas.
A new IIASA-led study examines critiques of global climate mitigation scenarios' equity and justice, proposing practical ways to advance fairness in climate pathways. The research synthesizes growing evidence that current scenarios fall short, identifying a roadmap for integrating fairness into future climate futures.
Ken Herrmann will lead the journal for five years, focusing on global engagement and impact. He succeeds Johannes Czernin, who guided JNM through significant growth and expansion.
Scientists have uncovered practical strategies that can significantly reduce harmful air pollution from composting while improving the quality of organic fertilizers. Biochar emerged as the most effective single solution, consistently reducing ammonia and nitrous oxide emissions while enhancing nitrogen retention.
Researchers have created a new computational method to simulate Tip-Enhanced Raman spectroscopy (TERS) signals with high accuracy. This enables the study of atomic motion down to individual molecules or defects in metallic surfaces. The method provides a detailed understanding of the signatures of local atomic motion and its sensitivit...
A new study identifies 36 genetic regions associated with bicuspid aortic valve disease, suggesting a polygenic contribution. The findings support the notion that BAV is an inherited disease caused by a combination of common genetic variants.
Researchers discover that magnetism can expand into unexpectedly large topological textures spanning hundreds of nanometres in twisted double-bilayer chromium triiodide. This finding challenges the assumption that magnetic order follows the moiré unit cell and opens up new possibilities for designing topological magnetic states.
A new study finds that US South Asians have higher rates of prediabetes, diabetes, and hypertension than other population groups, despite healthier diets and exercise habits. The study identifies a critical window in the 40s when risk is already high, but disease is still preventable with early intervention.
A new study assesses indoor heat vulnerability for each single-family home in Austin, finding that 85% of homes would pose significant risk to an elderly person during a power outage. The city can now take a methodical approach to mitigating risk through cooling centers and home weatherization programs.
Scientists in China have developed a novel silicon-based nanothrombolytic therapy that achieves efficient thrombus clearance and in situ regulation of the coagulation microenvironment while minimizing systemic bleeding risk. The strategy combines enzymatic clot dissolution with intelligent microenvironment reprogramming.
Researchers at UC San Diego developed a new training method for AI systems to improve their performance in solving complex problems that require both text and image interpretation. The approach evaluates the quality of training data and grades models based on their logical reasoning, reducing the risk of incorrect interpretations.
Insilico Medicine and CMS announce multiple collaborations on AI-empowered drug discovery in central nervous system and autoimmune diseases. The partnerships aim to accelerate research, development, and translation of high-potential innovative therapies, leveraging complementary strengths across the entire value chain.
A study published in Progress in Neurobiology found that synthetic oxytocin carbetocin can prevent anxiety-related behaviors in laboratory rats exposed to social stress. The researchers observed that carbetocin had a preventive effect on anxiety without having direct anxiolytic effects.
Researchers at Oregon State University have developed a deep learning-based model for rapid bacterial contamination detection, eliminating misclassifications of food debris. The enhanced model can reliably detect bacteria in three hours and has the potential to prevent outbreaks and protect consumer health.
Researchers discovered an mRNA-based therapy that instructs skin cells to produce telomerase reverse transcriptase (TERT), reducing DNA damage and protecting against genomic DNA injury. This breakthrough could lead to new therapies preventing radiation burns and long-term scarring, improving quality of life for millions of cancer patie...
Research led by Dr. Simon Grelet at the University of South Alabama has been recognized as one of Science magazine's Top 10 Scientific Breakthroughs of 2025. The study identified a novel mechanism by which neurons transfer mitochondria to cancer cells, fueling cancer metastasis and opening new possibilities for therapeutic intervention.
An international working group has been appointed to advance the Global Workforce Development in Stem Cell Research and Regenerative Medicine Initiative, a collaboration between ISSCR and Canada's Stem Cell Network. The initiative aims to strengthen workforce development and ensure the field of regenerative medicine delivers meaningful...
Researchers used advanced imaging to uncover early molecular changes in bone associated with osteoarthritis. The study found that subchondral bone beneath damaged cartilage showed strong upregulation of specific collagen fragments, suggesting that disease-related bone changes begin earlier than previously recognized.
A new study found that patients with Long COVID have a larger choroid plexus, which tracks with Alzheimer's disease markers and greater dementia risk. The research also suggests that CP alterations may predict long-term cognitive issues in some individuals.
Syracuse University professor Gabriel Merrin has developed a software tool called CATAcode to help researchers handle demographic data more thoughtfully. The tool addresses the issue of respondents selecting multiple options for characteristics such as race, gender identity, or other traits. By providing systematic approaches for explo...
A team of researchers at the Institute of Industrial Science, The University of Tokyo, developed an ensemble technique to improve climate modeling by tracing water molecules' movement. They found a general increase in atmospheric water vapor associated with warming temperatures, linking it to large-scale climate phenomena.
Researchers at George Mason University are developing an AI-driven proof-of-concept for cyber-physical manufacturing to address national security concerns. The project aims to integrate data-driven learning with knowledge-driven modeling for proactive detection and adaptive mitigation of cyber threats.
Researchers found that an experimental compound SB-216 reduced the growth of pancreatic ductal adenocarcinoma cells by inhibiting oncogenic microtubules and mitochondrial function. This approach may reduce cancer cell adaptation and survival.
Research from the University of Texas at Austin reveals that increased bank competition can result in higher interest rates for borrowers. With more banks competing for loans, each additional bank is associated with a 7 basis point increase in interest rates. This is due to the 'winner's curse' effect, where lenders become risk-averse ...
Researchers have developed a more reliable method for measuring natural nitrogen isotope signatures of atmospheric ammonia, allowing for stronger tools to trace pollution sources and improve air quality management. The new approach uses sulfuric acid absorption, achieving higher ammonia recovery rates and stable isotope measurements.
A new study found avian malaria at 63 of 64 sites tested statewide, including areas with diverse bird communities. This suggests that many different bird species in Hawaiʻi—both native and non-native—are capable of infecting southern house mosquitoes, the primary vector of avian malaria.
Hajo Eicken takes over as scientific director of the Alfred Wegener Institute, building bridges between social sciences and natural sciences. The institute aims to exploit partnerships and globally unique research platforms to tackle Earth system research questions.
A new study by the University of Konstanz and University of Lucerne reveals that locals view foreign employees who live in Switzerland as members of society, leading to increased acceptance. In contrast, cross-border commuters are perceived less positively due to concerns about job competition and fairness.
A new University of Michigan study found that Asian American Olympians Chloe Kim and Eileen Gu were subjected to
Researchers uncover novel mechanism of sound production in boxfishes, highlighting evolutionary transition from mute to vocal species. A comparative anatomical analysis reveals absence of sound mechanism in related Aracanidae family, supporting importance of acoustic communication in fish evolution.
Researchers found that patients with substance use disorder received life-saving treatments only when addiction consult services were involved. Fentanyl use was associated with dramatically worse visual outcomes, highlighting the importance of addressing underlying conditions alongside acute medical problems.
Researchers found that rough grinding creates fine scratches on the surface of stainless steel, which damage embedded manganese sulfide particles. This damage weakens the material's corrosion resistance. The study suggests that improving surface finishing methods can enhance the durability and reliability of stainless-steel components.
A University of Stirling professor has warned that tree-planting may not be as effective at reducing climate change as previously assumed due to potential soil carbon losses. The study found that deep soils in forests may lose more carbon over time than expected, which could reduce the net climate benefits of tree planting.
A new strain of yellow rust pathogen has broken down a key resistance gene, leaving over 50% of the UK's wheat acreage vulnerable. Researchers are racing against time to find new resistance genes and breed them into modern wheat varieties.
A research team led by Boyce Thompson Institute has created the most comprehensive genetic map of cucumber ever made, revealing nearly 172,000 large-scale DNA rearrangements that shape its evolution and agronomic traits. The study found that structural variants were purged during domestication, but continued to be present in global var...
A health economic analysis found that school restrictive smartphone policies may reduce staff costs by £94 per pupil, but have minimal impact on pupils' mental wellbeing and quality of life. The study also revealed that school staff spend a significant amount of time administering smartphone policies.
A new study highlights the importance of farmer-led collaboration in addressing biodiversity loss in agricultural landscapes. Farmer clusters, groups of farmers working together to support biodiversity-sensitive farming, show varying levels of maturity and collaboration, influenced by factors such as leadership quality and institutiona...
Researchers at UNC-Chapel Hill discovered that chronic inflammation fundamentally alters macrophages, immune cells that drive both inflammation and tissue repair. Chronic inflammation triggers a breakdown in the ability of macrophages to adapt, trapping them in dysfunctional hybrid states.
Researchers say tech companies need to adopt user-centered approaches to create authentication systems that are secure by design. They call for more inclusive and consistent methods, avoiding one-size-fits-all models that burden users with complex security rules.
Researchers developed a novel unsupervised lightweight 3D convolutional network (UL3DCN) for enhanced infrared imaging in wearable devices, addressing poor image quality issues. The UL3DCN achieves excellent image enhancement effect and good real-time performance, successfully integrating into a wearable infrared firefighting mask.
Researchers at Weill Cornell Medicine discovered that food shortages trigger a coordinated system to uphold immune function while conserving energy. Calorie-restricted mice fought off infection using very little glucose, thanks to glucocorticoids, which reorganized immune cells and their energy usage.
Three UK researchers will receive the top prize of £100,000 each, while six finalists will receive £30,000. The winners have developed groundbreaking techniques to study protein aggregates, detect fleeting electrons, and develop safer treatments for snakebites.
A prospective study of 49 treatment-naive CHB patients found that HBV genotype significantly influences liver histological response. Patients with genotype B showed higher histological improvement rates and greater inflammation resolution compared to those with genotype C.
A team from UNIGE has shown that certain antibodies to seasonal flu can also target avian flu. Stimulating these antibodies could strengthen protection in the event of a pandemic. Vaccinated individuals show increased levels of cross-reactive antibodies capable of neutralizing the H5N1 virus, which may result in milder symptoms.
A study published in Molecular Cancer found that the KLF5 gene plays a crucial role in fueling the growth of spreading pancreatic cancer by altering epigenetic changes. The researchers used CRISPR technology to silence genes and identified KLF5 as the most impactful gene associated with cell growth.
Researchers have identified novel DNA-binding proteins in Icelandic volcanic lakes and deep-sea vents, which can improve rapid medical tests for infectious diseases. The newly discovered proteins are stable under harsh conditions, making them suitable for biotechnology and medicine applications.
The study found excess adiposity remained highly prevalent among US youths in 2024, with certain racial and ethnic subgroups affected more. The prevalence of severe obesity was also higher for these subgroups.
A study of 116 individuals with hypermobile Ehlers–Danlos syndrome (hEDS) identified three key biological systems affected by genetic variations. The analysis found a higher burden of variants in the collagen biosynthesis pathway, HLA/adaptive immune axis, and mitochondrial respiratory chain compared to unaffected family members.
Research found that entrepreneurs using AI demonstrate sharper judgement and greater flexibility in volatile business environments. The study suggests that AI broadens how people approach problems, enabling deliberate, forward-looking strategies.
A new study shows that mindfulness helps patients relax during endoscopy, allowing for detailed examinations without sedation or general anaesthesia. This approach can detect cancers earlier, reducing complications and costs to the NHS.
The EMG-driven EVF robot enhances both voluntary motor control and sensory feedback to the wrist and hand muscles, improving sensorimotor integration and restoring balanced motor control. Significant improvements were observed in Fugl-Meyer Assessment scores and Action Research Arm Test scores.