Researchers found that Wikipedia's cancer information is accurate but poorly readable compared to peer-reviewed sites like the National Cancer Institute's PDQ. Readability was highly statistically significant, with Wikipedia written at a college level while PDQ was suitable for a 9th grader.
A nearly 2,300-person study by the University of Minnesota definitively links indoor tanning to increased risk of melanoma, with frequent users facing a 74% higher likelihood. The study found that risk is associated more with how much a person tans and not the age or device type.
The need for longitudinal cohorts in sub-Saharan Africa is highlighted due to the growing burden of non-communicable diseases. These studies can investigate multiple complex diseases and risk factors over an individual's lifetime.
A genetic link has been discovered between sporadic and familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. The study found that protein FUS forms characteristic inclusions in spinal motor neurons in most ALS cases, suggesting a common pathogenic pathway for motor neuron degeneration.
Research found an association between leisure time physical exercise and a future risk of developing fibromyalgia. Women who exercised regularly had a lower risk of developing the condition compared to inactive women. High BMI is also identified as an independent risk factor for future development of FM.
A new reliable method for diagnosing fibromyalgia has been developed by analyzing patients' walk parameters. The study found that patients with fibromyalgia exhibit altered motion parameters associated with psychosocial and fitness aspects, providing a potential complementary diagnostic tool.
Researchers use the GeoViz Toolkit to analyze disease statistics and identify trends in geographic patterns. This allows for better understanding of complex events like the spread of Swine flu.
A global study of over 65,000 individuals has identified more than a dozen genes associated with chronic kidney disease. The researchers found that common genetic variations in these genes were more frequent in people with poor kidney function or chronic kidney disease.
A meta-analysis found that the ATG16L1 variant is associated with a higher risk of Crohn's disease and ulcerative colitis. The study also suggests a role for autophagy in IBD development, highlighting the need for further research on the gene's etiology.
Louis J. Soslowsky, a renowned orthopaedic surgeon and bioengineer, has been awarded the AAOS Kappa Delta Ann Doner Vaughan Award for his groundbreaking research on rotator cuff injuries. His studies using rat models have provided valuable insights into the etiology, pathogenesis, and repair response of these injuries.
Researchers have found a new oncogenic signaling pathway by which arsenic may lead to adverse health effects, including bladder cancer. High levels of arsenic exposure are associated with high levels of Hedgehog activity, supporting the link between arsenic and increased cancer risk.
Research found that hospitalization for Crohn's disease was more common among women and younger people, while ulcerative colitis was more common among older people. The study suggests that social deprivation and distance traveled to hospital are associated with Crohn's disease, but not ulcerative colitis.
Two recent studies identified regions with higher than expected numbers of autism cases in California, strongly associated with higher parental education and proximity to specialty research centers. Ongoing studies exploring environmental exposures and social factors will help uncover the causes of these clustering.
Researchers report a rare diagnosis of superior mesenteric artery syndrome in a diabetic patient, causing similar symptoms to gastroparesis. Computed tomography and upper GI series are reliable diagnostic tools, while adequate nutrition supply and bodyweight gain aim to relieve symptoms.
A study of mucosal biopsies from patients with ileal pouch-anal anastomosis reveals protein expression changes in pouchitis and antibiotic-induced remission. Proteomic analysis identifies novel biomarkers for disease activity, diagnosis, and prognosis.
A study of over 15,659 adolescents found that those with earlier parental set bedtimes were less likely to suffer from depression and suicidal ideation. The association was most pronounced among adolescents who slept for five hours or fewer per night.
A prospective case-control survey found that male factor infertility is associated with a higher rate of medical comorbidities, as objectively scored with the Charlson Comorbidity Index. The study suggests that men with male factor infertility may be less healthy than age-comparable fertile men, regardless of their underlying causes.
A new study from Michigan Medicine links nasopharyngeal cancer to human papillomavirus (HPV), a rare type of head and neck cancer affecting less than 1 in 100,000 Americans. The researchers found that HPV-positive tumors are more responsive to chemotherapy or radiation, leading to improved survival rates.
Researchers found that physical activity in adolescence was associated with a 36% lower risk of glioma, the most common type of brain cancer. Participants who were obese during adolescence had an increased risk of glioma, while height was linked to twice the risk.
The article examines asthma risk factors across different age groups, including prenatal, infancy, childhood, and adulthood. Genetic, environmental, and host characteristics are identified as significant contributors to the development of persistent asthma.
A randomized controlled study found that laparoscopic uterosacral nerve ablation (LUNA) did not improve chronic pelvic pain, painful menstruation or quality of life compared to laparoscopic surgery without pelvic denervation. The study involved 487 women with chronic pelvic pain and followed them for up to five years.
Researchers developed a blood mRNA expression signature that accurately identified influenza infection and distinguished between viral and bacterial infections. This breakthrough may lead to the creation of a blood test for diagnosing respiratory infections and predicting treatment outcomes.
Scripps Research scientists discover a new drug tafamidis that significantly halts disease progression for patients with Transthyretin amyloid polyneuropathy. The drug targets protein misfolding, providing a potential therapeutic strategy for this rare inherited disease.
A surgical procedure, palliative cardia resection with gastroesophageal reconstruction, was performed on a 82-year-old man with iatrogenic perforation of adenocarcinoma of the GE junction. The patient recovered quickly and showed no complaints after treatment.
The study found that molecular adsorbent recirculating system (MARS) treatment is effective in patients with acute liver failure. The etiology of liver failure and the grade of encephalopathy before MARS treatment were significant prognostic factors, while coagulation factor 5 levels were also predictive for unknown etiologies.
A study published in JNCI found that carrying one allele of SNP 2q35-rs13387042 increases the risk of breast cancer, particularly in ER-positive and -negative cases. The association was observed in over 31,000 women with invasive breast cancer and those without the disease.
A meta-analysis of published studies on Bell's palsy found no improved recovery with corticosteroids and antiviral combination therapy. Facial motor function recovery was not significantly different between the two groups.
A study published in the World Journal of Gastroenterology found that females are at a higher risk of developing gastric cancer than males when their mothers have a history of non-gastric cancer. The research analyzed family histories of 2260 patients with gastric cancer and identified key genetic and environmental factors contributing...
A new study reveals that only heavy alcohol consumption above 5 drinks per day significantly raises the risk of chronic pancreatitis. Dose-dependent smoking also contributes to the risk, with smokers having more severe pancreatitis and longer smoking history.
Researchers found that donor steatosis does not affect liver disease progression, but transplants from donors with higher Donor Risk Index scores negatively impact HCV-positive recipients' outcomes. The studies suggest using high-risk grafts carefully in HCV-positive patients.
Research suggests different invasive breast cancer subtypes have distinct etiologic pathways and prognoses. Patients with specific subtypes exhibit varying demographics, lifestyle traits, and risk factors, highlighting the need for refined tumor subtyping to elucidate development patterns.
A study investigated the link between high ferritin levels and steatosis in a non-obese cohort of non-alcoholic patients, finding hyperferritinemia as a surrogate marker of advanced liver disease. The research suggests that high ferritin levels are associated with low platelet count, steatosis and clinical relevance.
The Opioid Growth Factor (OGF) and its receptor (OGFr) play a crucial role in regulating cell proliferation by modulating cyclin-dependent kinase inhibitors. The study found that transport of OGFr into the nucleus required two out of three nuclear localization signals, highlighting the importance of this pathway in cancer treatment.
Research suggests that young children who struggle with self-regulation are more likely to gain weight and develop obesity by their pre-teen years. Studies found that children with limited ability to delay gratification were 29% more likely to be overweight at age 11.
Dr. Jonathan Berg received the inaugural Richard King Trainee Award for his publication on microduplications in the 22q11.2 region. The award recognizes the utility of array CGH technology in identifying genomic imbalances and its impact on defining molecular etiology and clinical phenotypes.
Dr. Robert Burne, a renowned oral microbiologist, has received the prestigious IADR Research in Dental Caries Award for his groundbreaking studies on Streptococcus mutans and the formation of oral biofilms. The award recognizes his extensive contributions to understanding caries etiology and prevention.
A 23-year-old man developed severe autoimmune hepatitis after contracting varicella zoster virus, responding dramatically to steroid treatment. The case highlights the importance of considering AIH in patients with persistent altered liver enzymes following a viral infection.
Researchers have identified two causes of critical illness hypeglycemia in children: peripheral insulin resistance and primary beta-cell dysfunction. The study found that those with respiratory failure only had CIH caused by elevated insulin resistance, while those with both respiratory and cardiovascular failure had CIH caused by prim...
The Pneumonia Etiology Research for Child Health (PERCH) initiative aims to study the causes of pediatric pneumonia in five to ten countries, using modern diagnostics and methods to guide vaccine and treatment development. This effort could help prevent many pneumonia deaths and develop tools to tackle even more cases.
A study analyzed histologic features of liver biopsies from 86 infants with intrahepatic neonatal cholestasis (IHNC) and found no significant differences among different etiologies. However, a significant difference was observed in IHNC of infectious etiology, presenting with more severe erythropoiesis.
A new American Heart Association journal issue highlights unique risk factors among women and gender disparities in stroke care. Researchers found that women were less likely to receive perfect care, had a lower discharge rate, and received less aggressive treatment than men.
Researchers discovered that idiopathic QT interval prolongation significantly increases the risk of sudden death among coronary artery disease patients. The study found a five-fold increase in odds for abnormally prolonged QT intervals of unknown etiology, highlighting its potential as a predictor for sudden cardiac death.
A recent whole-genome study identified genetic variants associated with Kawasaki disease, an inflammatory condition in children that affects the cardiovascular system. The research team found that genes involved in cardiovascular function and inflammation are key players, suggesting potential new diagnostics and treatments.
A new screening test using barium meal follow through with pneumocolon has been proposed for chronic abdominal pain of luminal origin. The test can detect both small and large bowel lesions, reducing the need for separate colonoscopy procedures.
A study published in the World Journal of Gastroenterology found that almost 30% of patients with CSX no longer exhibited typical chest pain after gastroenterological workup. Treatment with proton pump inhibitors significantly improved symptoms, suggesting a strong link between acid-related disorders and CSX.
A new study found that women with diabetes have a seven times higher risk of severe pelvic girdle syndrome. Hormonal factors, such as relaxin, may play an important role in the development of the condition.
Researchers used ultrasound imaging to view carotid intima media thickness, revealing those in the higher end of low-risk group had intermediate risk for coronary heart disease. The study found that about 4% of individuals with estimated 0-5% risk had a heart attack, while over 13% of those with 5-10% risk suffered from coronary events.
A recent study investigated the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) in alcoholic patients. The research found an inverse correlation between pancreatic and liver function tests, suggesting that these diseases evolve differently and have distinct etiopathogeny.
Frank L. Meyskens Jr., a renowned cancer prevention researcher, has received the AACR-Prevent Cancer Foundation Award for his significant contributions to the field. His work on chemoprevention, including the development of topical all-trans-retinoic acid for cervical intraepithelial neoplasia, has moved the field forward.
Researchers investigated etiology, diagnosis, and treatment of spontaneous colon perforation, a rare condition with high mortality rate. The study found that chronic constipation was common among patients and that surgical intervention was often necessary.
A study found that hypertriglyceridemia is independently associated with the severity of acute pancreatitis and leads to systemic complications. High triglyceride levels were linked to increased incidence of admission hypocalcemia, renal failure, shock, infection, and mortality in patients with severe acute pancreatitis.
This epidemiologic study investigates the prevalence and demography of microscopic colitis in Turkey. Lymphocytic colitis was found to be 4 times more frequent than collagenous colitis in patients with chronic non-bloody diarrhea of unexplained etiology.
Researchers identified rhinovirus as the biggest contributor to future asthma development in children. Wheezing with RV during early childhood increased asthma odds by nearly 10-fold, with children who wheezed at three years of age facing a 30-fold risk.
A new study at the AAO-HNSF Annual Meeting & OTO EXPO found that patients with sudden sensorineural hearing loss (SSHL) receive inconsistent care due to lack of established clinical practice guidelines. SSHL is a rare but serious otological event affecting between 5 and 20 people per 100,000 per year.
A new study presented at the American Academy of Otolaryngology meeting found that 33% of children with recurrent croup had narrowing in their upper airways, which could indicate laryngopharyngeal reflux. Researchers believe that treating reflux may help prevent future episodes of croup.
Researchers found 61.1% of steroid-naive UC patients entered remission after leukocytapheresis sessions, suggesting its efficacy as a second-line treatment. Endoscopic findings can predict the treatment's success, making LCAP a suitable option for moderately active UC patients.
A new study combines endoscopic treatment with ursodeoxycholic acid to effectively treat non-transplant patients with biliary cast syndrome. The approach led to normalization of liver function tests and improved symptoms in a 76-year-old diabetic patient.
A study analyzed patient cohorts and imaging studies to determine the differentiating feature between benign and malignant bile duct strictures, finding involvement of blood vessels was significant but not conclusive due to low incidence rate.
Dr. Adrian Lussi is recognized as a pioneer in dental erosion and caries research, with over 160 publications and executive positions. He received the Research in Dental Caries Award for innovative achievements in caries diagnosis.
Research by Skai W. Schwartz of the University of South Florida found that African-Americans were significantly less likely to use CPAP at all time points compared to Caucasians and Asians. The study, which focused on 1,486 patients prescribed and tried CPAP between 2003-2007, highlights a disparity in adherence rates among different r...