Researchers have identified and cloned ovarian cancer stem cells, which may be the source of recurrence and resistance to chemotherapy. These stem cells can replicate indefinitely and are highly resistant to conventional treatment.
A new study suggests that pregnant breast cancer patients can benefit from the same treatment as non-pregnant women with minimal health risks to the baby. The research collected data from 122 patients and found that most received surgery and chemotherapy without significant harm to the newborn.
Researchers at the University of Western Ontario discovered that abdominal fat tissue produces a hormone called Neuropeptide Y (NPY), which stimulates fat cell production. This novel finding may lead to new therapeutic targets for combating obesity, including the development of a simple blood test to detect increased levels of NPY.
A study published in New England Journal of Medicine found that female sex, antenatal corticosteroid treatment, singleton birth, and higher birth weight are equally important as gestational age in determining the care needs of these infants. The research involved nearly 4,500 infants born between 22-25 weeks gestation.
Researchers found that continuous oral contraceptives significantly improved pain and behavioral changes in women compared to standard 28-day birth control pills. The study also showed a significant decrease in moderate to heavy bleeding days among women who received the continuous birth control regimen.
Researchers found that women with Caesarean deliveries for their first child have lower fertility rates in subsequent pregnancies compared to those giving birth vaginally. The study of nearly 600,000 births shows a 12% reduction in the number of children born after a first C-section.
Researchers at Yale University have successfully created new neurons using uterine stem cells, which increased dopamine levels and partially corrected Parkinson's disease symptoms in mice. This breakthrough has significant implications for the development of a potential human treatment.
Researchers at Yale University found that exposure to DES alters HOXA10 gene expression, leading to uterine cancer and fertility problems in female offspring. Long-term effects of similar substances like BPA on reproductive health remain a concern.
Research at Yale University reveals a link between grhelin, the hunger hormone, and decreased fertility. Grhelin's impact on reproductive health is seen in mice bred with low ghrelin levels, producing smaller litter sizes and altered uterine development.
Pittsburgh researchers present study findings on preeclampsia, a condition affecting 5% of first pregnancies, and elevated maternal cardiovascular risk persisting after preterm birth. Researchers also explore healthcare provider conversations about substance use during pregnancy.
Researchers have discovered that an enzyme called MMP-2 is necessary for ovarian cancer to attach itself to new sites, and that blocking its production can slow the spread of the disease. In a mouse study, early treatment with an MMP-2 inhibitor reduced tumor growth by 68% and nearly doubled survival time.
Obese women should not be encouraged to gain at least 15 pounds during pregnancy, according to Saint Louis University obstetrician Raul Artal. Engaging in physical activity and proper diet can help prevent health issues like hypertension and diabetes.
A Kaiser Permanente study found that one-third of women experience pelvic floor disorders, including incontinence and prolapse. The study, which surveyed over 4,000 women aged 25-84, highlights the need for education and access to experts in female pelvic medicine.
The NHLBI has published its first US clinical practice guidelines for von Willebrand Disease, a condition that affects 1 in 100 to 1,000 people. The guidelines provide recommendations for screening, diagnosis, and treatment of the three major types of VWD, emphasizing proper diagnosis and treatment to prevent complications.
The study found a 50% decline in cystic fibrosis births and a decrease in severe gene mutations, suggesting that prenatal carrier screening may be reducing the number of affected births. The authors attribute the decline to the gradual implementation of preconception and prenatal screening for CF.
A new study using neurophysiology technology will track pelvic floor damage in women before, during, and after pregnancy. The goal is to determine if vaginal birth affects pelvic floor strength and coordination, or if other factors like pregnancy itself play a role.
A large-scale study published in the American Journal of Obstetrics & Gynecology found a strong link between physical abuse during pregnancy and premature births. Researchers surveyed 2660 Caucasian women and discovered that 24% of mothers of preterm newborns had experienced physical abuse, compared to 8% of those with term births.
Researchers have discovered a link between viral infection, particularly from the herpes group, and pregnancy-induced hypertensive disease and pre-term birth. The study found viral nucleic acid in heel-prick blood samples of 1326 newborn babies, including over 400 with cerebral palsy.
Researchers at the University of Leeds have made a breakthrough in diagnosing pre-eclampsia, a condition that affects up to 15% of pregnancies. A user-friendly diagnostic kit is being developed to test pregnant women, with potential savings estimated at £500m for the NHS.
Researchers at Yale School of Medicine have developed a blood test that detects early stage ovarian cancer with 99% accuracy, building on previous work showing 95% effectiveness. The new platform uses six protein biomarkers instead of four, increasing specificity from 95 to 99.4%.
A multi-center study of 500 women found that more women preferred the contraceptive ring over the skin patch due to lower complication rates and higher satisfaction. The ring was also reported to have fewer side effects compared to the patch.
A study by Yale University researchers has identified a gene, ENPP1, linked to preterm birth and low birth weight in Hispanic women. The study found that this variant of the gene may be associated with deranged energy metabolism, a possible explanation for preterm births.
Researchers at Yale School of Medicine implemented clinical patient safety interventions to standardize communication and interpretation of fetal monitoring, leading to a 60% decrease in adverse events over 2.5 years. The staff's perception of the safety climate also increased by 30%.
Researchers identified a significant association between genetic mutations in the TLR4 gene and inflammatory injury to the placenta, increasing the risk of preterm birth. Women with this mutation were five times more likely to experience placental inflammation, while babies with the mutation faced nearly five times the risk.
Researchers have developed a successful test vaccine that prevents the development of prostate cancer in 90% of young mice. The vaccine targets prostate stem cell antigen (PSCA), which is over-expressed in early-stage prostate cancers, and has been shown to mount an immune response against the protein.
A study found that only 65% of Illinois public school sex education teachers covered the four basic topics required for comprehensive instruction. Additionally, 30% of teachers had never received sex-education training, and most lacked confidence in teaching these topics without such training.
A recent study by Yale University researchers found that IVF twin pregnancies have a higher prevalence of congenital heart disease (CHD) compared to singletons. The study, which examined almost 2,000 patients, revealed a three-fold increase in CHD among IVF twins.
Researchers identify genetic mutations in MTHFR and Factor V as significant contributors to blood clots and tissue injury in the placenta. These mutations may lead to increased risks of preterm birth, intrauterine growth restriction, and preeclampsia.
A new study suggests that taking folic acid supplements for at least one year before pregnancy can significantly reduce the risk of premature birth. The research found a 50-70% decrease in early preterm deliveries, with the greatest reduction seen in very early premature births.
A Kaiser Permanente study found that high doses of caffeine daily during pregnancy increase the risk of miscarriage, particularly among women consuming coffee, tea, and hot chocolate. Women who consumed over 200mg of caffeine per day had twice the miscarriage risk compared to those with no caffeine intake.
A study published in the American Journal of Obstetrics & Gynecology found that 23% of neonates born between 23 and 32 weeks gestation have positive umbilical blood cultures for genital mycoplasmas, a frequent cause of congenital fetal infection. These infections are associated with increased risk of neonatal systemic inflammatory resp...
A University of South Florida fetal surgeon successfully treated a rare condition where placental blood vessels block the birth canal and can rupture during labor. The laser procedure sealed off the abnormal fetal blood vessels, eliminating prolonged hospitalization and allowing the pregnancy to progress with a vaginal delivery.
Researchers from University of Missouri and Imperial College London found that chemical markers on cancer and HIV-infected cells can fool the immune system, making it ineffective against vaccines. The study suggests that vaccines may be unlikely to work due to these shared sequences.
Researchers at USC suggest epigenetics plays a role in male infertility, with abnormal DNA methylation linked to low sperm counts. The study finds high levels of methylation in sperm DNA from men with fertility issues, potentially leading to new treatments for male infertility.
Direct-to-consumer genetic testing poses risks of misleading patients and physicians due to lack of regulation. Physicians recommend consulting with doctors before ordering tests, as results may not be clinically valid or accurately interpreted.
A Phase 2 study found that eltrombopag elevated platelet counts to a safe level in over 75% of chronic ITP patients within two weeks, reducing bleeding symptoms. The therapy also showed similar incidence and severity of adverse effects compared to the placebo group.
Researchers argue that improved understanding of placental function and dysfunction can lead to novel screening tests. These tests could identify high-risk pregnancies and prevent devastating events like stillbirth. Despite the prevalence of stillbirths, research in this area is underfunded.
A combination of common anti-HIV drugs tenofovir and emtricitabine with nevirapine during labor significantly reduces the risk of HIV-positive pregnant women developing resistance to a class of drugs, potentially improving future treatment options.
A common medication used to stop preterm labor is associated with increased risk of brain damage and intestinal problems in premature infants. However, use of the medication has not been linked to other serious complications. Obstetricians are now advised to limit its use to cases where babies are at greatest risk.
A study published in Obstetrics & Gynecology found that women who followed a combination of five or more lifestyle factors experienced significantly lower rates of infertility due to ovulatory disorders. The key factors included dietary choices and physical activity, with higher scores associated with a lower risk of infertility.
A new study published in JAMA found that antiretroviral drug therapy and non-physician care, such as nursing, are essential in saving the lives of HIV-infected African children. The research showed significant improvements in CD4 cell counts and weight-for-age scores among children treated with antiretrovirals.
The MacArthur Foundation is funding Pathfinder International to implement a range of interventions, including the non-pneumatic anti-shock garment, to treat postpartum hemorrhaging in developing countries. The program aims to reduce maternal mortality by addressing the leading cause of maternal death, postpartum hemorrhage.
A 6-year study found that using 3D/4D imaging to guide embryo placement resulted in a 10.04% increase in pregnancy rates for IVF patients, with an overall rate of 40.34%. The new technique targets the Maximal Implantation Potential (MIP) Point, where embryos typically implant and develop in natural pregnancies.
A study found that two-thirds of women are interested in stopping their periods but lack understanding of the medical implications. Physicians, however, believe continuous oral contraceptive therapy is medically safe and acceptable, sparking a need for better patient-physician dialogue.
Researchers found that vaginal progesterone gel reduced the need for intensive care and decreased hospital stays for premature infants. The treatment may also help prevent early preterm birth among women with a short cervix, according to the study's results.
According to a study published in Fertility and Sterility, nearly 60% of IVF procedures performed on women over 35 result in successful pregnancies. The researchers found an excellent pregnancy rate for patients undergoing single blastocyst transfer, with 62.2% conceiving and 51.1% having pregnancies beyond the first trimester.
A Saint Louis University study suggests severely obese women should lose weight during pregnancy, while obese women who are pregnant should gain less weight. Limiting weight gain reduces the risk of preeclampsia, cesarean delivery, and has babies with normal birth weights.
A new study published in the New England Journal of Medicine found that multiple corticosteroid injections in pregnant women are linked to an increased rate of cerebral palsy among children. The study suggests that exposure to repeat courses should be limited to minimize this risk.
A multi-center study found that repeated courses of steroids given to premature babies may increase the risk of cerebral palsy. The study, led by Dr. Ronald Wapner, followed 556 infants and found that six out of 248 who received multiple steroid courses had been diagnosed with cerebral palsy.
A study found that half of women prescribed medications linked to birth defects do not receive contraceptive counseling. Women filling prescriptions for these medications are no more likely to use contraception than other women, highlighting the need for increased awareness among physicians and women who may become pregnant.
The Oregon Health & Science University School of Medicine is part of a national team researching ways to preserve or restore fertility in women with cancer. Researchers are studying methods to freeze and store ovary tissue and grow follicles in culture, aiming to help young cancer patients have children.
Most women who think they have a vaginal yeast infection actually don't, according to Saint Louis University researcher Susan Hoffstetter. Women are often misdiagnosed and treat themselves with anti-fungal medicine, worsening symptoms.
A national team of scientists is investigating fertility preservation for women with cancer through the $20 million program. MU researcher John Critser will receive funding to study cryopreservation methods of human eggs, aiming to improve efficiency and challenges in the process.
The Oncofertility Consortium seeks to alter the medical world's approach to female cancer patients, promoting a new consciousness to protect their reproductive health. Researchers will investigate fertility threats posed by cancer treatment and develop strategies to improve communication with newly diagnosed patients.
Researchers found that Metformin improves glucose uptake and survival of early embryos in mice with insulin resistance. The drug may benefit women with type 2 diabetes or polycystic ovary syndrome trying to conceive. Improved embryo quality could lead to more successful pregnancies.
The first comprehensive national survey of older adults' sexual attitudes and behaviors found that most people ages 57-85 consider sex an important part of life. However, nearly half reported at least one sexual problem, including lack of desire, vaginal dryness, or erectile dysfunction.
The article challenges the routine use of ultrasound as a screening procedure for chromosome abnormalities, suggesting that foetal 'nuchal thickness' measurements are not supported by scientific data. This could lead to the 'loss' of normal babies in attempts to prevent Down's syndrome and trisomy 18.
A team of U-M researchers, including gynecologists and engineers, will use the grant to examine damage to pelvic muscles during vaginal deliveries. They aim to develop preventive strategies to reduce injury rates, which affect up to 300,000 women per year.
A recent study from the University of Pittsburgh found that bacterial vaginosis (BV) risk escalates when even one partner is African-American, increasing preterm birth risks. BV affects up to 50% of women in some populations and can lead to herpes and other STIs.
A study published in the Journal of Women's Health found that few older women with significant risk factors for lifetime exposure to HIV showed interest in being tested. The study, which analyzed data from 514 women aged 50-95, found that only 22% of participants expressed interest in HIV testing.