A study by Boston Children's Hospital reveals that respiratory syncytial virus (RSV) causes significantly more acute respiratory illnesses, ED visits, and hospitalizations among young children compared to seasonal flu. RSV-related illnesses lead to increased missed workdays for parents.
A study by Boston Children's Hospital researchers suggests three optimal scenarios for school closures: single-day absentee rate of 5%, consecutive days of 4% or more absenteeism, and three consecutive days of 3% or more. Scenario #2 is preferred for its balance between sensitivity and specificity.
A large nationally representative study found that up to 20% of US children have suboptimal vitamin D levels, with Hispanic and black children at particularly high risk. The researchers recommend vitamin D supplements for all children, especially those in high latitudes, to improve health outcomes.
A study published in Nature Neuroscience reveals that Mst3b, an enzyme previously identified in the lab, is essential for regenerating damaged axons in both peripheral and central nervous systems. The findings suggest that activating Mst3b could lead to a possible treatment for brain and spinal cord injuries.
A new study has established that the CRAFFT diagnostic test can identify teens at risk of engaging in high-risk sexual behaviors, including unprotected sex and multiple partners. The test also found a significant association between substance use and increased odds of having sex without protection.
A $4.5 million grant will fund whole-genome sequencing of children with autism using new technologies. Researchers aim to discover noncoding DNA regions controlling gene activity and relate clinical autism to genetic variations in DNA and gene expression.
Scientists have created an implantable device that utilizes magnetism to control the release of medication, allowing for precise and repeatable dosing. The device uses nanoparticles that heat up when exposed to a magnetic field, causing the drug to be released into the body.
The introduction of new prenatal tests for Down syndrome has led to a steady decrease in births of babies with the condition since their introduction. Experts argue that existing tests may not be providing accurate information, leading to difficult conversations between physicians and expectant parents. To address this, researchers are...
Research highlights the negative impact of social stigma on LGBT teens' health, leading to substance use, risky behaviors, and suicidal ideation. Clinicians are called upon to provide high-quality, confidential care to address these disparities.
A growth factor called neuregulin1 can spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a heart attack. Researchers were able to restart the cell cycle with NRG1, stimulating cardiomyocytes to divide and make copies of themselves - even though they are not stem cells.
Researchers at Boston Children's Hospital have developed a drug-dispensing contact lens that can gradually release medication to the eye. The prototype lens dispensed antibiotic ciprofloxacin for up to 30 days in laboratory testing, with potential applications in conditions like glaucoma and dry-eye.
Researchers at Boston Children's Hospital developed a protein detectable in urine as a potential biomarker for appendicitis. The leucine-rich alpha-2-glycoprotein (LRG) marker showed near-perfect sensitivity and specificity, and was strongly elevated in diseased appendices.
Scientists have discovered a protein called prosaposin that inhibits tumor metastasis by blocking blood vessel growth. The study found that prosaposin significantly reduces lung and lymph node metastases in mice, increasing survival time.
A study published in Nature found that fat cells in bone marrow suppress blood production, making it harder for patients to recover from chemotherapy or radiation. Blocking this fatty infiltration could enhance blood recovery after transplant.
Researchers discover halofuginone, a compound from traditional Chinese medicine, inhibits Th17 cells and reduces disease pathology in mouse model of autoimmunity. Halofuginone may offer a new treatment option for autoimmune disorders with potential for oral administration.
A protein that maintains cell 'stemness' has been linked to various advanced human cancers, including liver cancer, ovarian cancer, and Wilm's tumor. Increasing its production can prevent mature tumor-suppressing microRNAs from maturing, leading to a more cancerous state.
Research in mice and human stem cells identified specific new therapeutic targets for treating cancer, including a gene called Dscr1 that suppresses angiogenesis and tumor growth. The study suggests that people with Down syndrome may benefit from an extra dose of one or more cancer-protective genes.
Researchers have discovered that a beating heart and blood flow are necessary for the development of the blood system, which relies on mechanical stresses to cue its formation. Compounds that modulate blood flow had a potent impact on the expression of a master regulator of blood formation, known as Runx1.
Researchers from Boston Children's Hospital use online surveillance tools to track emerging infectious diseases, providing up-to-the-minute information. HealthMap.org aggregates real-time data on swine flu outbreaks, highlighting the potential of internet mining for public health support.
A longitudinal study found that children who watched more adult-targeted TV during childhood were more likely to become sexually active earlier in adolescence. The study tracked 754 participants from age 6 to 18 and found a 33% increase in sex among those exposed to adult content over two sample days.
A new study evaluated the community's response to Indivo, a personalized health record system. The two-year study found that issues such as health literacy, accessibility, and privacy were relevant factors in PCHR adoption. Researchers advocate for continued evaluation of PCHRs and discussions on technical and policy approaches to adva...
Researchers at Children's Hospital Boston demonstrate that the brain can recognize objects quickly and consistently, even under different lighting conditions, size, and rotation. This finding could lead to advancements in teaching computers to see and improving brain-computer interfaces for individuals with visual impairment.
Researchers at Boston Children's Hospital have created a slow-release anesthetic drug-delivery system, showing promise for prolonged pain relief without toxicity in rats. The formulation, using liposomes to package saxitoxin, produced nerve blocks lasting two days or seven days when combined with dexamethasone.
A study from Boston Children's Hospital and Harvard Medical School found that low-income families with children who have chronic conditions are more likely to be enrolled in high-deductible health plans. The study analyzed data from 839 families who were switched from traditional plans to high-deductible plans, revealing a higher perce...
Researchers propose a platform model for health information infrastructure that would improve healthcare delivery, increase productivity and stimulate job growth. The model aims to support applications for clinical care, public health, and research, with key characteristics including data liquidity and substitutability of applications.
A team of researchers has created a microdevice that uses magnetism to remove pathogens from the bloodstream, showing promise as a potential treatment for sepsis. The device, developed by Chong Wing Yung and Don Ingber, achieved over 80% clearance of fungi in contaminated human blood.
A study by Children's Hospital Boston found that half of glass-table injuries could have been prevented or less severe with safety glass. Tempered glass can significantly reduce these types of injuries, which often result in severe lacerations and disfiguring scars.
A longitudinal study of infants found that TV viewing before age 2 does not improve language and visual motor skills. Maternal, child, and household characteristics are more influential in a child's cognitive development.
Researchers developed a statistical model using genetic information from 569 patients, predicting an individual's lifetime risk of cardioembolic stroke with 86% accuracy. The model identifies interactions between multiple genetic factors and provides a network of predictive factors contributing to stroke.
A study by Boston Children's Hospital researchers has identified lipocalin 2 as a protein that triggers the epithelial to mesenchymal transition in human breast cancer cells, increasing invasiveness and metastasis. The protein is detectable in urine samples, suggesting it may be used for prognostic testing.
A large study of 704 babies found no cases of bacterial meningitis in children with simple febrile seizures. The researchers suggest that lumbar punctures may not be necessary for well-appearing children who have had a single, uncomplicated seizure.
Children's researchers found that ER stress and unfolded-protein response block leptin action in the brain; chemical chaperones can re-sensitize the brain to leptin, leading to significant weight loss. Leptin-sensitizing agents may bring new hope for obesity treatment
Researchers silenced genes that prevent mature neurons from regenerating, causing them to recover and re-grow vigorously after damage. Up to 50% of injured neurons survived, and up to 10% showed significant re-growth of axons over long distances.
A recent study published in Cancer Cell reveals a potential therapeutic approach for MLL-AF4 leukemias, a subtype of acute lymphoblastic leukemia that accounts for 70% of infant cases. By inhibiting the histone-modifying enzyme DOT1L, researchers hope to reverse cancer-promoting genes and improve treatment outcomes.
Researchers developed a new diagnostic marker called procalcitonin to identify infants at high risk for serious bacterial infections. The test showed high sensitivity and was able to establish a threshold value to identify low-risk infants.
Neuroscientists identified Npas4 as the first known master switch to orchestrate inhibitory synapse formation and maintenance. This factor regulates over 200 genes involved in calming down over-excited cells, restoring balance that's thought to go awry in neurologic disorders.
Researchers discovered that a rare genetic disorder, tuberous sclerosis complex, may be linked to neurological disorders such as autism, epilepsy, and mental retardation. The study found that abnormal neuronal structure can lead to excess brain connections, which may contribute to these conditions.
Researchers at Boston Children's Hospital have discovered a new mechanism of immunity that could lead to the development of a more effective pneumococcal vaccine. The study identified specific protective T-cells called TH17 cells, which release protein IL-17 to kill pneumococcus in the nose, significantly reducing the risk of infection.
Abnormal tumor blood vessels are 'leaky' and 'twisty', hindering chemotherapy drug delivery. Researchers identify a key factor: tumor capillary cells' inability to sense mechanical forces, leading to irregular vessel formation. Normalizing these forces may improve therapy effectiveness.
Researchers at Boston Children's Hospital have developed 20 disease-specific stem cell lines for conditions such as Parkinson's Disease, Down Syndrome, and Muscular Dystrophy. These lines were created using the iPS technique and will be made available to researchers worldwide.
Scientists at Boston Children's Hospital have identified the Otx2 protein as a key factor in triggering brain plasticity, allowing the brain to rewire and adapt. This discovery has implications for understanding developmental disorders like autism and potential treatments for improving learning and cognitive function.
Researchers identified five gene variants that could predict sickle cell disease severity and offer potential therapeutic targets. These variants influence fetal hemoglobin levels, which affect symptom severity in the disease.
A study of Middle Eastern families with a high incidence of autism identified six new genes involved in the brain's ability to form new connections. The findings suggest that autism may stem from disruptions in experience-dependent learning, which is essential for learning and memory.
A worksite-based program called Talking Parents, Healthy Teens teaches parents how to get past their inhibitions and fears when discussing sensitive topics. The program has significant and immediate effects on parents' behavior, leading to more conversations about sexual topics with their children.
Lodamin, a novel oral angiogenesis inhibitor, has shown promising anticancer results in mice, demonstrating its potential as a preventive therapy for patients at high risk of cancer. The drug selectively accumulates in tumor tissue, blocks angiogenesis, and inhibits primary tumor growth without apparent side effects.
A new group of stem cells in the epicardium can regenerate cardiomyocytes, smooth muscle cells, endothelial cells, and fibroblasts. This finding advances the hope of recapitulating developmental events to regenerate injured heart tissue, with potential applications for treating adults with heart failure.
Pediatric cardiac surgeons used stereoscopic glasses to visualize the heart in real-time during surgeries, resulting in improved accuracy and speed. The new technique showed a 44% reduction in time spent on anchor placement compared to traditional 3D ultrasound guidance.
Researchers found that stem cells differentiate through the collective behavior of multiple genes in a network, leading to just a few endpoints. The findings also suggest that cell populations maintain built-in variability that nature can harness for change under the right conditions.
A recent study analyzing data from 443 patients who received implants found that ICDs are life-saving, but also deliver more inappropriate shocks to children than adults. Inappropriate shocks can be unpleasant and may be caused by difficulties in differentiating normal increases in heart rate from abnormal rhythms.
Researchers discovered a genetic cause for a rare form of inherited iron deficiency anemia, which may provide insights into iron deficiency in the general population and suggest new treatment approaches. The study identified a gene mutation in the TMPRSS6 protein, leading to excessive hepcidin production and impaired iron absorption.