A newly discovered compound has been identified as a potential diagnostic marker for zinc status, which can help detect the harmful effects of zinc deficiency in blood vessel cells. This discovery may lead to faster and easier methods for detecting low zinc levels in the body.
A new study published in The FASEB Journal found that consuming twice the recommended daily allowance of protein helps prevent muscle loss and promotes fat loss. Tripling protein had no additional benefits.
Researchers have discovered that a small protein chemokine called CCL26 plays a crucial role in the development and severity of asthma. CCL26 induces a greater migration of eosinophils in asthmatic airways compared to healthy volunteers, making it a potential target for new treatments.
Research suggests that fetal stress can disrupt genetic imprinting patterns, leading to chronic disease later in life. The study found high rates of IGF2 gene expression from both alleles in cord blood, associated with increased disease susceptibility.
Researchers have discovered that two receptors of leukotriene B4 play opposing roles in inflammation, with BLT1 promoting and BLT2 weakening inflammation during an allergic reaction. This finding suggests new approaches to developing anti-asthma and anti-COPD drugs.
Research in mice suggests that obese fathers' changes to microRNAs increase the risk of daughters being overweight/obese and both sons and daughters developing diabetes-like diseases. Fathers' diet and body composition at conception may affect future child's health.
Research published in the Journal of Leukocyte Biology found that excessive mast cells lead to delayed wound healing due to overproduction of IL-10. The study provides a potential therapeutic target for future drug development.
A study published in The FASEB Journal found that moderate paternal exposures, such as cigarette smoking, increase the number of mutations transmitted to children and potentially future generations. DNA mutations were more frequent in families with low-income fathers who smoked cigarettes.
Researchers found that DHA is converted into maresin 1 (MaR1), which inhibits inflammation and shifts macrophage phenotype, providing a potential lead for new drugs to treat chronic inflammation.
The FASEB MARC Program has announced the recipients of its travel awards for the June 2013 FASEB Science Research Conferences. This year, five awards totaling $8,000 were conferred to promote the entry of underrepresented minority students, postdoctorates, and scientists into the basic science community.
Researchers discovered that compounds derived from polyunsaturated fatty acids (omega-3s) reduce inflammation in acutely injured blood vessels, promoting better artery healing after procedures like angioplasty and bypass surgery. These naturally occurring compounds could improve long-term results of cardiovascular procedures.
Researchers have developed a new gene delivery method using magnetically targeted nanoparticles that can effectively deliver genes to injured arteries without causing side effects. The technique, which uses stents as a platform for magnetic guidance, shows promise in overcoming current limitations of gene therapy vectors.
Researchers discovered that severe trauma injuries or burns lead to defective neutrophils, which contribute to septic complications. Measuring neutrophil motility could become a biomarker for predicting risk of septic complications and personalizing treatments.
Researchers at Stanford University and Akira University in Japan have discovered a new hormone called R-spondin2 that promotes follicle development and stimulates ovary growth. The hormone, produced by human female eggs, may lead to new infertility treatment options when used with traditional Follicle Stimulating Hormone (FSH).
Patients with advanced kidney disease undergoing hemodialysis are at high risk of heart attacks due to uremic toxins. New research identifies oral adsorbent AST-120 as a potential treatment to delay kidney disease progression and prevent future heart attacks.
Scientists identify five epigenetic biomarkers associated with better weight loss response in obese adolescents participating in the EVASYON weight loss program. These biomarkers may help predict an individual's response to weight loss intervention and offer therapeutic targets for enhancing its effects.
Researchers developed a new compound called PC-KUS that reduces hydrogen peroxide accumulation in the hair follicle, reversing gray hair. The treatment also works on vitiligo, a skin condition causing loss of pigment, with successful repigmentation outcomes observed.
Researchers found that stimulating the CB2 receptor in white blood cells weakens HIV-1 infection. Synthetic compounds may make current therapies more effective and provide protection against certain complications. The discovery holds promise for fighting other viral diseases.
A zebrafish study suggests that riboflavin, a form of vitamin B2, can mitigate the toxic effects of cyanide poisoning. The research, published in The FASEB Journal, also identifies new biomarkers that may be clinically useful for diagnosing cyanide exposure and developing antidotes.
A study found that a Mediterranean diet causes a decrease in total cholesterol and LDL cholesterol levels. Each individual has a unique microbial profile, like a fingerprint, which remains true even after diet manipulation.
A new study found that menus displaying the minutes of brisk walking needed to burn food calories led to fewer calories ordered and consumed compared to menus without calorie labels. The study, conducted by Texas Christian University researchers, suggests a more effective strategy for encouraging reduced calorie intake in restaurants.
A team of researchers from Stephen F. Austin State University has confirmed that the Neches River rose-mallow is a unique species using genetic fingerprint analyses. The plant's DNA profile shows distinct differences from other related species, making it eligible for government-funded restoration efforts.
A new study by the University of Texas Health Science Center suggests that inflammation plays a significant role in the development of Parkinson's disease. The researchers found that exposure to an experimental inflammatory agent caused changes in brain tissue similar to those associated with PD, highlighting the potential for therapeu...
Researchers found that adolescents are less sensitive to the aversive effects of MDPV bath salts and exhibit different physiological responses, such as lower dopamine levels and decreased body temperature. These findings suggest that adolescents may be more vulnerable to the use and abuse of these drugs.
A research team led by Nalini Santanam is investigating the epigenetics of pain in endometriosis, with preliminary findings suggesting that epigenetic markers may play a role in the disease's development. The team hopes to find new biomarkers for diagnostics and personalized treatment approaches.
Researchers discovered vitamin E can alleviate symptoms of nonalcoholic steatohepatitis (NASH) in mice, a common complication of obesity. The study suggests that supplementation with vitamin E may have significant public health benefits.
A team of researchers studied human cells sent to space, finding that the immune system weakens and bacterial virulence enhances under microgravity conditions. The study also found altered gene expression related to rheumatoid arthritis, tumor growth, and wound repair.
Researchers discovered that eating mushrooms containing vitamin D2 can effectively increase and maintain vitamin D levels in healthy adults. The study found that mushroom powder was as effective as taking supplemental vitamin D2 or vitamin D3.
Researchers investigated whether caffeine affects cognitive performance in children and teens, finding sex differences in responses to caffeine on certain tasks. Additionally, a study on food pairing found that consuming caffeinated beverages with flavored foods increased preference for those foods.
Research finds an association between a rare pregnancy condition called chorangiosis and full-blown malaria in pregnant women. The study suggests that active malarial infection enhances blood vessel growth in the placenta, potentially leading to complications like low birth weight.
Dr. Lawrence Witmer's Visible Interactive Dinosaur (VID) project aims to digitally recreate the tissues stripped away by time, creating the most realistic dinosaur renderings. The project has dual purpose of helping paleontologists and educating the public about physiology and anatomy.
A study found that low-dose aspirin slowed the growth of two breast cancer lines in lab tests and reduced tumor growth in mice. The compound also inhibited tumor cells from spreading and enhanced the effect of tamoxifen, a common drug therapy for hormone-receptor positive breast cancer.
A study by Dr. Susan K. Wood found that social stress can lead to inflammatory changes in the brain, increasing vulnerability to depression and heart disease. The research identified specific genes and proteins involved in this process, shedding light on potential targets for treatment.
Dr. Johnathan D. Tune has been recognized with the Henry Pickering Bowditch Lecture Award for his groundbreaking work investigating the mechanisms connecting obesity, diabetes, and heart disease. His research, conducted using obese pigs, has identified key targets to potentially treat or slow down heart disease.
Antibiotic overuse and misuse are creating conditions for the emergence of superbugs in border communities like Eagle Pass, Texas. Collaborating with officials to develop an outreach model to mitigate antimicrobial resistance, scientist Subburaj Kannan emphasizes the need for government action and public awareness.
A study found that intranasal delivery of neuropeptide Y reduced anxiety, depressive-like behavior, and hyper-arousal in rats exposed to single prolonged stress. This provides proof-of-concept for potential non-invasive prophylactic treatment for PTSD.
Researchers investigated the recreational use of HIV antiretroviral drug efavirenz, which is commonly used to treat HIV. Studies found that its diversion for psychoactive effects can lead to adverse neuropsychiatric complications and potentially create resistant strains of the virus.
A new website application called Dietary Analysis Tool for Athletes (D.A.T.A.) has been validated as accurately recording dietary intake. The digital tool generates a report immediately after the recall, providing quick feedback for athletes and sports health professionals.
Millions of Americans experience abnormality of smell function, affecting daily life. Researchers have discovered a crucial balance between anti-inflammatory and pro-inflammatory cytokines in nasal mucus, which may lead to new treatments for patients with smell loss.
A novel gene therapy approach using nanoparticles to deliver GDNF may halt Parkinson's disease progression and reverse symptoms. This non-invasive method bypasses the blood-brain barrier, enabling continuous production of GDNF in brain cells.
Researchers developed a novel therapy for endothelial barrier damage using multifunctional perfluorocarbon nanoparticles and anti-inflammatory drug delivery. The therapy demonstrated the evolution and severity of endothelium damage in correlation to animal fat-diet consumption.
Rats fed a berry diet for 2 months showed significant protection against radiation-induced aging, with improved autophagy and reduced toxic protein accumulation. Berries may help alleviate age-related cognitive decline and neurodegenerative diseases like Alzheimer's and Parkinson's.
Scientists can now better study human disease using induced pluripotent stem cells (IPS), which can generate any cell type. This technology reduces the risk of organ/tissue rejection in cell transplants and allows for the correction of mutations in IPS cells.
Physiology's enduring relevancy is highlighted through Dr. Joyner's research on complex bodily functions like blood pressure and blood flow during exercise. The redundancy in human systems complicates genetic explanations for diseases, leading to a comeback of multi-directional thinking in physiology
Four talented Dedham students from Maine's Aspirnaut science-outreach program have made a groundbreaking discovery about a novel chemical bond in animal tissues. This bond is essential for the genesis of animal tissues and has been found to be present in another lineage of multicellular organisms, highlighting its evolutionary importance.
A new study published in The FASEB Journal found that PubMed Central's public accessibility of biomedical articles draws readership away from journals, weakening their ability to build communities and communicate research findings. Over time, this effect increases, posing a threat to the perceived value of journal subscriptions.
New research reveals that fish oil can enhance the function of white blood cells called B cells, contradicting previous assumptions of its only immunosuppressive properties. This discovery may lead to the use of fish oil among those with compromised immune systems.
New research using mice shows that disrupting our internal clocks can lead to a complete absence of 24-hour bodily rhythms, resulting in immediate weight gain. Proper sleep patterns are critical for healthy metabolic function, and even mild impairment in circadian rhythms can have serious health consequences.
Research published in The FASEB Journal found that sildenafil promotes healthy expansion and browning of white adipose tissue. This is achieved through the inhibition of cyclic GMP breakdown, which reduces pro-inflammatory hormones and shifts fat storage to 'brown' type.
The FASEB MARC Program has announced the travel award recipients for the 2013 American College of Sports Medicine Northwest Chapter Meeting, aiming to promote diversity in the basic science community. The program aims to increase the number and competitiveness of underrepresented minorities in biomedical research.