Researchers found that failed synchronization of the womb's clock with the mother's body clock can lead to miscarriage or infertility. The study also suggests that subtle synchronization defects may increase the risk of complications during pregnancy.
A computer model developed by scientists can predict how the liver stores fat in response to various situations, including drug treatment. This knowledge could help researchers understand and treat diseases, as well as develop new drugs with fewer side effects.
A study published in The FASEB Journal found that the androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice. Researchers discovered this association by comparing female mice with and without the androgen receptor.
Research in The FASEB Journal suggests that fenofibrate may become a viable treatment option for relieving pain, stimulating appetite, reducing nausea, and preventing depression. The study found that fenofibrate activates cannabinoid receptors, which could lead to the development of new drugs targeting these receptors.
Chronic alcohol consumption compromises the skin's protective immune response, leading to increased illness and bacterial burden. Restoring IL-17 levels improves skin injury and bacterial clearance defects in mice with Staphylococcus aureus skin infections.
The FASEB MARC Program conferred $1,850 to 1 student and postdoctoral awardee from underrepresented groups, aiming to increase their engagement in biomedical research. The program seeks to promote diversity and inclusion in the scientific community.
The FASEB MARC Program awarded Crystal Rogers from the California Institute of Technology $1,000 to attend the West Coast SDB Regional Meeting. The program aims to increase diversity in biomedical research by supporting underrepresented groups.
Researchers found that M-MDSCs can inhibit both T cell and B cell proliferation, leading to improved symptoms in arthritic mice. The study suggests a potential role for M-MDSCs in treating autoimmune diseases like arthritis.
The FASEB MARC Program has announced the travel award recipients for EB 2015, promoting diversity in biomedical research. The program aims to increase the number and competitiveness of underrepresented groups in biomedical and behavioral research.
A recent study suggests that helping fetuses achieve optimal weight before birth may prevent metabolic problems like high cholesterol, diabetes, and obesity in grandchildren. Researchers found that low birthweight infants may pass on their risk of metabolic disease to their own children and grandchildren.
A new study published in The FASEB Journal found that nitrate supplementation can lower hemoglobin levels in normoxic animals and improve liver oxygenation. Researchers also discovered that higher doses of nitrate can increase erythropoietin expression, which may have implications for conditions like polycythemia.
Intermediate filaments of vimentin 'insulate' mitochondria in cancer cells from destruction, preserving energy reserves. This discovery may lead to the development of new drugs that effectively treat cancer.
The FASEB MARC Program has selected four students and postdoctorates from underrepresented groups to receive travel awards. The awards totaled $7,400 and aim to promote diversity in the biomedical research community. The recipients include Hamid Hussaini, Ibrahim Osumanu, Isavannah Reyes, and Kimberly Herard.
The FASEB MARC Program has awarded $2,000 to two students from underrepresented groups to attend the American College of Sports Medicine Northwest Regional Chapter Meeting. The program aims to increase diversity in biomedical research by promoting participation and engagement among young scientists.
The FASEB MARC Program has awarded travel grants to 1 recipient, Chih Ching Wu from San Jose State University, totaling $1,850. The program aims to increase diversity in biomedical and behavioral research by supporting underrepresented groups.
The FASEB MARC Program has awarded 7 travel grants totaling $12,950 to students and post-docs from underrepresented groups attending the 2015 IHCM Short Course. The program aims to increase diversity in biomedical research by promoting participation of young scientists.
Researchers discovered a new way to shrink ovarian cancer tumors by inhibiting abnormal angiogenesis. Using a naturally occurring protein inhibitor called 3TSR, the approach improved chemotherapy drug delivery and resulted in significant tumor regression and survival.
Research published in The FASEB Journal suggests that spaceflight conditions can induce changes in B lymphocyte production in bone marrow, leading to premature aging of the immune system. A ground-based model simulating low-gravity conditions found similar effects in mice as those observed in elderly mice on Earth.
Researchers developed a new test using magnetic resonance imaging to measure the function of retinal blood vessels and light-detecting cells. This breakthrough enables doctors to detect eye problems earlier, including macular degeneration and after childhood injuries, and may slow disease progression.
Researchers discovered that a low-energy nanosecond laser therapy can reverse the pathological and molecular changes in age-related macular degeneration. The treatment does not cause retinal damage, and it may also be effective on other eye diseases like diabetic macular oedema.
A new study found that HIV penetrates the blood-brain barrier by relying on proteins expressed by mature monocytes. These proteins could serve as a target for preventing HIV from reaching brain cells. The research aims to shed light on novel mechanisms for improving drug delivery to the brain.
Researchers have developed a treatment that extends telomeres in human cells, which could lead to longer and healthier lives. The treatment uses modified mRNA encoding TERT, resulting in rapid lengthening of telomeres and increased cell division capacity.
Researchers found that γδ T cells contribute to systemic insulin resistance in obese mice by promoting low-grade inflammation in fat tissue. The study suggests that targeting γδ T cells may provide a new avenue for treating or preventing type 2 diabetes caused by obesity.
Research found that melanoma cells with higher levels of melanin have increased mitochondrial Complex II function and reactive oxygen species production. Triggering hyperpigmentation in these cells also led to increased ROS generation and complex II activity.
Research in the FASEB Journal found that cold temperatures can induce cells to change from white to brown fat, which may help treat type 2 diabetes. About 30% of cells that appear white before cold stress rapidly turn into brown adipocytes.
New research suggests CD39, an enzyme capable of clearing high levels of adenosine triphosphate from the bloodstream, significantly improves survival of mice in severe sepsis. This discovery holds promise for effective treatment and reduction of costs associated with septic patients in intensive care units.
The FASEB MARC Program has announced the winners of its travel award recipients for the APS Professional Skills Training Course. Eight students and postdoctorates from underrepresented groups received a total of $9,600 to attend the course in Orlando, FL.
Scientists discovered that SPLUNC1 binds to pulmonary lipids to fight lung infection, keeping airways flexible and hydrated. This finding brings the protein closer to becoming a viable therapy for asthma and COPD patients.
A component of the plant Glycyrrhiza uralensis has been shown to inhibit the development of metabolic disorders by stopping the activation of NLRP3, a protein involved in disease process. Isoliquiritigenin attenuates high-fat diet-induced obesity, type 2 diabetes and hepatic steatosis in mice.
Research published in The FASEB Journal suggests that low birth weight in rats can lead to reduced co-enzyme Q levels in the aorta, but supplementing with extra CoQ may prevent age-associated damage and heart disease. This study provides potential steps towards developing a diagnostic test for blood co-enzyme Q levels.
Research published in the Journal of Leukocyte Biology suggests that poor eating habits alter gene expression, leading to persistent effects on the immune system and increased risk of cardiovascular disorders. Even after successful treatment of atherosclerosis, the immune system's function remains altered.
Scientists discovered a link between the body's circadian clock and bladder function, finding that disruptions to the daily cycle can cause overactive bladder. The study suggests that altering peripheral clock genes through receptor activators can regulate bladder contractions.
New research suggests that low-dose BPA exposure in infants may lead to an increased risk of food intolerance in adulthood. A study involving rats found that perinatal exposure to BPA affected developing immune systems, predisposing offspring to food intolerance.
Researchers found that peripheral tissue clocks can synchronize with the environment independently of the brain's master clock, leading to a revised model of circadian entrainment. This discovery opens new avenues for understanding and addressing circadian-related disorders.
A new single-domain antibody called FC5 has proven able to cross the blood-brain barrier, opening doors to new treatments for brain diseases. This breakthrough technology allows for the delivery of larger molecules into the brain, targeting conditions such as Alzheimer's, Parkinson's, and cancer.
New research suggests that differences in DNA methylation patterns and gene activity established in the womb underpin the link between birth size and disease risk. The study found that being overweight at birth may be better than being underweight for future health.
The FASEB MARC Program has awarded $5,550 to students and postdoctoral researchers from underrepresented groups at the AMP 2014 Annual Meeting. The program aims to increase diversity in biomedical research through travel awards and mentorship opportunities.
The FASEB MARC Program has announced the travel award recipients for the RECOMB/ISCB Conference, with Brittany Baur and Leanne Whitmore selected to receive awards. The program aims to increase diversity in biomedical research by supporting underrepresented groups.
Researchers have successfully developed a synthetic version of the sperm protein PAWP, which induces calcium oscillations and oocyte activation in human and mouse eggs. This breakthrough raises hopes for improved IVF success rates and better understanding of fertilization events.
A new study published in the FASEB Journal reveals never-before-detected gene activity and sex differences in human skeletal muscle. The research found that men have approximately 400 more active genes than women, providing a reference for future studies on muscle disease and dysfunction.
New research suggests that early exposure to THC may cause long-term damage to the immune system, leading to increased risk of autoimmune diseases and chronic inflammatory conditions. Studies involving adolescent mice found that THC treatment resulted in severe alterations of immune responses in adulthood.
Researchers developed a new blood test called the lymphocyte genome sensitivity (LGS) test, which can detect some cancers earlier than ever before. The test analyzes white blood cells exposed to UVA light and measures their DNA damage, allowing for early cancer detection and identifying those at risk of developing cancer.
The FASEB MARC Program has announced the winners of its 10 travel awards, totaling $18,500, to promote diversity in biomedical research. The recipients include students and postdoctorates from underrepresented groups, recognized for their participation at the SACNAS National Conference.
The FASEB MARC Program has announced travel award recipients for the Society of Leukocyte Biology Joint Meeting. This year, 1 student and postdoctoral researcher received a total of $1,850 to encourage participation from underrepresented groups in biomedical research.
The FASEB MARC Program has selected recipients for the 2014 APS Intersociety Meeting. The program aims to increase underrepresented groups in biomedical research. A total of $1,850 was awarded to 1 participant.
New research found an epigenetic link between a mother's diet and an offspring's risk of future obesity. Excess methylation on the Pomc gene blocks its expression, leading to delayed satiety response and increased food intake.
Researchers found that macrophages from the lungs of old mice had different responses to infections than those of young mice, but these changes were reversed by ibuprofen. The study suggests that reducing inflammation with diet, exercise, and/or drugs may help prevent or reduce diseases in the elderly.
A study published in The FASEB Journal identifies a salamander skin peptide called tylotoin that promotes wound healing by enhancing keratinocyte proliferation and releasing essential growth factors. This discovery could lead to the development of new treatments for human wounds.
A new study published in The FASEB Journal found that identical twins who eat fast food have similar levels of metabolites, regardless of weight. This suggests that genetics and gut microbiota play a crucial role in the development of Type 2 diabetes.
Researchers have developed a novel strategy to diagnose diabetic retinopathy by detecting the early molecular changes caused by diabetes on the endothelium of retinal vessels. This allows for early detection and potential intervention to prevent irreversible structural damage.