Researchers at Goethe University and Harvard Medical School develop screening method for active ingredients to treat Batten disease, a devastating disorder affecting vision and motor abilities. The breakthrough uses innovative microscopy technology and identifies biomarkers for potential drug intervention.
Researchers at Goethe University Frankfurt have created two interlocking rings of DNA, measuring 18 nanometers in size, which are suitable as components of molecular machines. The catenan structure is freely pivotable and can be used to arrange and study proteins or other molecules that are too small for direct manipulation.
Researchers at Goethe University Frankfurt have elucidated a new signaling pathway in the immune system that regulates inflammation and chronic dermatitis. The discovery provides new avenues for therapeutic intervention and potential targeted therapy for patients with unclear origin.
Women's fertility is affected by chemotherapy due to oocyte quality control, which differs from male germ cells. The protein p63 plays a key role in this process.
Researchers analyzed a major forest commons management program in Ethiopia, finding that groups with higher shares of conditional cooperators were more successful in managing their forests. These groups also spent more time monitoring their forest to deter free riding.
A novel lab-on-chip device has been developed to screen sensitive membrane proteins in parallel, utilizing a nano-fabricated chip with 50,000 nanopores. This technology preserves protein structure without organic solvents or solid support, enabling simultaneous analysis and preserving fragile protein function.
Dr. Stephan Grill's innovative laser-assisted method enables non-invasive measurement of mechanical forces in living cells, opening new avenues for understanding interactions between mechanics and biochemistry in cell biology. The Paul Ehrlich Prize recognizes his outstanding contributions to the field.
Professor Cesare Montecucco has won the prestigious Paul Ehrlich and Ludwig Darmstaedter Prize for his significant contributions to understanding bacterial diseases. The award recognizes his research on tetanus, botulism, anthrax, and Helicobacter pylori-associated diseases.
Researchers grew two populations of neurons in microfluidic platforms, forming synaptic connections and enabling manipulation with drugs or neurotransmitters. The system allows for visualization and control of synapse dynamics, shedding light on memory formation and pharmaceutical development.
Particle No. 30, named Orion and Sirius, have been identified as the most likely interstellar candidates discovered to date. The discovery was made by a team of researchers using non-destructive X-ray analysis techniques.
Researchers discovered a magnetometer system in the upper beak of birds, composed of over 500 dendrites that encode the magnetic field information. This system helps birds create a magnetic map for spatial orientation, contradicting previous myths about iron-based magnetoreception.
Researchers found a simple intervention involving monthly follow-up phone calls improved depression care in primary practice. The trial evaluated 626 patients with depression, highlighting the potential of practice-based health care assistants to recognize and react to deteriorating symptoms.
Researchers at Goethe University Frankfurt identified a soluble Notch inhibitor, EGFL7, which blocks neural stem cell self-renewal and promotes differentiation into neurons. The findings offer potential medical applications in tissue development and neurodegenerative diseases.
A research team at Goethe University Frankfurt has identified two proteins, Fcj1 and Su e/g, that regulate the shape of mitochondria's inner membrane. The protein Fcj1 promotes negative curvature, while the Su e/g protein induces positive bending, leading to the formation of cristae junctions.
Scientists at Goethe University report a paradigm shift in immune response regulation, revealing the crucial role of linear ubiquitin chains in nuclear factor kappa B activation. This finding may lead to structure-based drug design for targeting the NF-κB pathway in diseases such as cancer and inflammation.
Researchers have determined the structure of a protein within its natural environment, Escherichia coli, for the first time using nuclear magnetic resonance (NMR) spectroscopy. This milestone advances our understanding of molecular biology and opens new avenues for investigating protein interactions in living systems.
A team of scientists has identified two proteins that may act as receptors for autophagosomes, the cell structures responsible for removing misfolded proteins and damaged organelles. This discovery sheds light on how autophagy works and could lead to new drug development.
Researchers at Goethe University Frankfurt have discovered an enzyme that enables yeast cells to ferment xylose into ethanol, a waste sugar in the cellulosic ethanol production process. This single-step conversion technology has the potential to increase biofuel production efficiency and reduce competition with food and feed production.
A team of scientists has successfully determined the structure of DFPase, an enzyme from the squid Loligo vulgaris that can rapidly detoxify chemical warfare agents like Sarin. The study used neutron diffraction and provides essential information about the reaction mechanism of DFPase.
Long-term measurements of atmospheric gases suggest that air masses are moving more slowly than expected, potentially impacting ozone layer recovery. Researchers urge further study to understand the exact mechanisms behind this phenomenon and its implications for climate models.
Researchers developed a new class of anti-inflammatory drugs with fewer side effects than aspirin, targeting the later stage of arachidonic acid biosynthesis. These dual mPGES-1/5-LO-Inhibitors effectively target both prostaglandins and leukotrienes, promising more effective results for inflammatory reactions.
Researchers found that cancer cells use apoptosis inhibitors to prevent programmed cell death while also controlling cell migration. This discovery challenges current treatment strategies and highlights the need for more targeted approaches.
Researchers at Goethe University Frankfurt aim to improve heart healing after a heart attack by promoting cellular regeneration. Micro-RNAs may hold the key to discovering new inhibitors to regulate protein synthesis and activate stem cells.
The CLOUD experiment aims to understand the role of cosmic rays in cloud formation and climate change. By simulating cosmic ray intensity, researchers plan to uncover details of aerosol and cloud formation mechanisms.
The 9th International Kimberlite Conference at the Goethe University Frankfurt explores the science of diamonds, their inclusions, and their significance for geoscientists. The conference features over 500 participants from 37 countries, with a focus on basic scientific research, diamond production, and industry.
Researchers discovered how filopodia extensions are generated and integrated with lamellipodia/ruffles in human cancer cells. The study reveals a complex interplay between these actin-based structures, suggesting that suppression of filopodia is needed for efficient cell migration.
Researchers at Goethe University Frankfurt have discovered two gatekeeper proteins, Rpn13 and an ubiquitin receptor, on the proteasome. This finding has significant implications for cancer research, as it may lead to the development of targeted drugs that can block protein breakdown and prevent tumor cell proliferation.
Researchers at Goethe University Frankfurt have made the first measurement of entangled states in nitrogen, resolving a long-standing debate on electron localization. The study uses COLTRIMS technology to probe the pathways of two electrons, demonstrating that electron location can only be determined for the complete system.
Researchers at Frankfurt's Research Center for Neurotechnology have developed new artificial vision systems using neural organization principles. These systems aim to combine individual functions to form a functioning whole, leading to potential applications in intelligent security and autonomous vehicles.
Researchers at Goethe University Frankfurt discovered that domestic chickens possess a magnetic sense of direction, orienting themselves by the Earth's magnetic field. This ability is thought to have evolved before migration and may be common to all birds.
Researchers at Goethe University Frankfurt have identified a novel Ub conjugation reaction that allows for more efficient manipulation of key proteins in the treatment of cancer and other diseases. This discovery provides a basis for novel therapeutic approaches that are more specific than existing drugs like Bortezomib.