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Goethe University Frankfurt


Optimized perception in the twilight zone

Research at Goethe University Frankfurt reveals that the human brain prepares for dawn and dusk by reducing resting activity in the visual cortex, allowing it to process weak visual stimuli more effectively during these times. This mechanism may have provided an evolutionary advantage in the pre-industrial era.

SourceGoethe University Frankfurt·JournalNature Communications·DateApr 10, 2018

Cause of severe genetic disease identified

Mutations in p63 protein lead to severe genetic disease AEC syndrome, which resembles Alzheimer's, Parkinson's or ALS more closely than other syndromes. The research lays groundwork for causal therapies by showing that protein aggregates underlie the disorder.

SourceGoethe University Frankfurt·JournalProceedings of the National Academy of Sciences·DateFeb 2, 2018

How massive can neutron stars be?

Astrophysicists have determined that the maximum mass of neutron stars cannot exceed 2.16 solar masses through a combination of theoretical and observational research. The result was achieved by applying universal relations to data on gravitational-wave signals and electromagnetic radiation from merging neutron star events.

SourceGoethe University Frankfurt·JournalThe Astrophysical Journal Letters·DateJan 17, 2018

In the footsteps of Jacques Cousteau

A team of researchers led by Eberhard Gischler analyzed the Blue Hole stalactite recovered in 1970, revealing concentric layers that detail climate conditions since the last ice age. The study provides new insights into paleo-environmental conditions and storm patterns.

SourceGoethe University Frankfurt·JournalJournal of Sedimentary Research·DateDec 18, 2017

New active ingredients from the toolbox

Researchers at Goethe University Frankfurt have successfully designed non-ribosomal peptide synthetases to produce completely new natural products. This breakthrough enables the creation of novel therapeutics and peptides with improved yields and modified structures, offering new avenues for biotechnology and drug development.

SourceGoethe University Frankfurt·JournalNature Chemistry·DateDec 13, 2017

Interstellar space probes: Where's the brakes?!

A theoretical physicist at Goethe University Frankfurt proposes using magnetic sails to decelerate interstellar spacecraft, enabling them to collect data from nearby stars and planets. The concept involves creating a strong magnetic field that reflects ionized hydrogen in the interstellar medium, slowing down the probe.

SourceGoethe University Frankfurt·JournalJournal of Physics Communications·DateNov 17, 2017

Zooming in on protein teamwork

Researchers at Goethe University Frankfurt have developed a new super-resolution optical microscopy technique that makes dimerization of membrane receptors visible. The study reveals ligand-specific receptor dimerization and improves our understanding of the decision between cell life or death.

SourceGoethe University Frankfurt·JournalScience Signaling·DateNov 3, 2017

Why does an anesthetic make us lose consciousness?

Researchers at Goethe University Frankfurt discovered that anesthetics decrease local information generation in specific brain areas, which can lead to reduced signal transmission and consciousness loss. This finding challenges the previous assumption that anesthetics disrupt signal transmission between brain areas.

SourceGoethe University Frankfurt·JournalPLOS Computational Biology·DateJun 13, 2017

Precise insight into the depths of cells

Scientists at Goethe University Frankfurt have combined two advanced fluorescence microscopy techniques to observe cells with high-resolution imaging. The new technique, called csiLSFM, allows for three-dimensional insight into a cell's interior with sub-100nm resolution.

SourceGoethe University Frankfurt·JournalProceedings of the National Academy of Sciences·DateMay 24, 2017

New hope for slow-healing wounds

Researchers at Goethe University Frankfurt have developed light-inducible microRNA inhibitors that can target specific genes involved in slow-healing wounds. By injecting these inhibitors into the skin of mice, they were able to improve wound healing by blocking a particular microRNA that is frequently found in diabetes patients.

SourceGoethe University Frankfurt·JournalNature Communications·DateMay 19, 2017

How cells combat Salmonella

A team of researchers has discovered an inflammatory signaling platform that cells use to defend against Salmonella infections, which may lead to the development of new antibiotic treatments. The study found that protein chains relay pro-inflammatory signals to trigger degradation of bacteria and restrict their proliferation.

SourceGoethe University Frankfurt·JournalNature Microbiology·DateMay 10, 2017

Tracing down linear ubiquitination

Researchers developed a novel technology to tackle the 'secret ubiquitin code' by enabling systematic analysis of linear ubiquitination targets. This breakthrough will improve understanding of linear ubiquitination's role in diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.

SourceGoethe University Frankfurt·JournalNature Methods·DateMar 20, 2017

An utter shambles

Researchers found that parenting by ADHD parents is less adequate, with more criticism and household chaos. However, they also rated their relationship to children more positively than non-ADHD parents. The study suggests a complex interplay between these factors and recommends future research on designing parent training programs.

SourceGoethe University Frankfurt·JournalJournal of Attention Disorders·DateMar 10, 2017

More individual therapy for blood cancer patients

Researchers from Goethe University Frankfurt discovered a novel biomarker, SAMHD1, that enables accurate prediction of therapy responders and non-responders in acute myeloid leukaemia (AML) patients. This biomarker can guide cytarabine-based chemotherapies to only those patients likely to respond, sparing others from toxic side effects.

SourceGoethe University Frankfurt·JournalNature Medicine·DateJan 10, 2017

New chemistry of life

Researchers at Goethe University Frankfurt discovered a new ubiquitination mechanism in Legionella bacteria that affects cellular processes and causes cell death. This mechanism reveals a broader role of ubiquitin in regulating life processes and may lead to new strategies for developing antibacterial agents.

Did LIGO detect black holes or gravastars?

The LIGO Scientific Collaboration detected gravitational waves that could have been caused by the collision of two black holes. Researchers used theoretical models to test whether these signals could also be produced by gravastars, hypothetical objects proposed as an alternative to black holes.

SourceGoethe University Frankfurt·JournalPhysical Review D·DateOct 19, 2016

Giraffes more speciose than expected

Scientists have reclassified giraffes into four distinct species based on genetic analysis, revealing new insights into their biology and conservation needs. The study highlights the urgent need for protection efforts to safeguard these endangered animals in Africa.

SourceGoethe University Frankfurt·JournalCurrent Biology·DateSep 8, 2016

The Genesis Project: New life on exoplanets

Gros has investigated the possibility of bringing life to planets with temporary habitability, proposing an automated gene laboratory on board a probe. The Genesis mission could be achieved within decades with interstellar unmanned micro spacecraft, potentially allowing for the development of complex life forms.

SourceGoethe University Frankfurt·JournalAstrophysics and Space Science·DateSep 2, 2016

Alzheimer fibrils at atomic resolution

A European and US research team has successfully determined the structure of the most disease-relevant beta-amyloid peptide 1–42 fibrils at atomic resolution. The findings simplify the targeted search for drugs to treat Alzheimer's dementia, offering hope for a potential cure in the next decade.

SourceGoethe University Frankfurt·JournalProceedings of the National Academy of Sciences·DateAug 4, 2016

How yeast cells regulate their fat balance

Researchers at Goethe University Frankfurt discovered how yeast cells measure and adapt to the availability of saturated and unsaturated fatty acids in foodstuffs, which opens up new possibilities to understand membrane lipid production and distribution. This finding paves the way for targeting hormone-producing cells with more precision.

SourceGoethe University Frankfurt·JournalMolecular Cell·DateJun 23, 2016

When will a neutron star collapse to a black hole?

Physicists have found a simple formula for the maximum mass of neutron stars, which depends on their rotation rate. The research, published in Monthly Notices of the Royal Astronomical Society, suggests that rotating neutron stars can support masses up to 20% higher than non-rotating ones.

SourceGoethe University Frankfurt·JournalMonthly Notices of the Royal Astronomical Society·DateApr 7, 2016

Light signals from living cells

Researchers from Goethe University and MIT have developed a new method to deliver protein markers with nanometre precision into living cells. The technique, called cell squeezing, uses high pressure to incorporate fluorescent probes with an efficiency rate greater than 80 percent.

SourceGoethe University Frankfurt·JournalNature Communications·DateFeb 4, 2016