Scientists have recreated the conditions of the Earth's mantle, where diamonds form, by simulating extreme pressure and heat. They found that the sediments represent a plausible source of potassium for the saline fluid inclusions in diamonds.
Researchers at Goethe University have developed a novel method for producing new peptide drugs, using fragments of natural NRPS systems as building blocks. The approach enables the easy production of peptides in excellent yield, with applications for modifying clinically relevant drugs and producing peptide libraries.
A new SFB will analyze the influence of non-coded RNAs on cardiovascular system processes. The collaboration aims to find new therapeutic target molecules for cardiovascular diseases.
Researchers are developing a top-down lithography method to create complex tissues and their anatomical microstructures. This approach uses light sheet illumination and special hydrogels to form branched chain structures that serve as a matrix for cell colonization.
The project aims to deepen early career researchers' understanding of the value of science for its own sake and foster their interest in conceptual fundamental research. The PAPA programme will provide an educational programme, intensive education and supervision, workshops, and a mentoring programme to support the scholars.
A new form of psychotherapy developed for teens and young adults has been shown to effectively reduce psychological stress. The treatment, which consists of 30-26 sessions over four to five months, demonstrated improved symptoms of post-traumatic stress disorder and other mental disorders.
The new project, led by Professor Vinzenz Hediger, investigates war destruction and reconstruction in non-fiction film from 1949 to 1953. The team analyzes public spaces such as marketplaces and squares in various European countries.
Researchers have discovered a novel biosynthesis pathway for aryl polyene pigments in bacteria, produced via a unique complex of proteins. These pigments exhibit anti-oxidative properties similar to carotenoids but are formed differently.
The Event Horizon Telescope project has captured the first-ever image of a black hole, located at the heart of galaxy Messier 87. The image reveals a ring-like structure with a dark central region, confirming our understanding of general relativity.
Researchers at Goethe University are investigating the development of synthetic drugs from natural substances, economic mechanisms in the Internet, and the connection between social inequality and societal stability. The EU has funded three projects: SYNPEP, POLAR, and COOKIES, which aim to improve our understanding of these issues.
Bacteria can create a wide range of derivatives from simple basic structures through mechanisms similar to pharmaceutical research. This diversification allows them to counteract unknown competitors and exhibit a wide range of biological activity.
A research team at Goethe University Frankfurt has successfully simulated the capture of protons by heavy elements in the universe. By using an ion storage ring, they were able to create conditions similar to those found in stellar explosions and neutron stars, allowing them to study the formation of heavy elements in detail.
Franz-Ulrich Hartl and Arthur L. Horwich's pioneering discoveries on assisted protein folding highlighted the importance of cellular quality assurance. They elucidated key aspects of the chaperone machinery and its role in neurodegenerative diseases, such as Alzheimer's dementia and Parkinson's disease.
Scientists have discovered that the direction of laser light hitting a molecule determines its chiral form. This breakthrough could lead to more efficient production of molecules with uniform chirality for pharmaceuticals. The research was conducted using the planar formic acid molecule and the reaction microscope method.
Dorothee Dormann's work reveals similarities in ALS and FTD pathogenesis, highlighting the role of protein FUS in disease progression. Her research aims to identify molecular targets for therapy and explore common mechanisms with other neurodegenerative diseases.
The Goethe University co-ordinates a mega-project on cybersecurity and data protection, with a total grant of €16 million. The project aims to establish international standards in cybersecurity and boost the effectiveness of Europe's security capacities.
Professor Marjan van den Akker is appointed as endowed chair for polypharmacy and health services research, focusing on frequent disease combinations and their medical treatment. She aims to improve care for patients with multimorbidity by developing and evaluating interventions.
In a study by Goethe University Frankfurt researchers, male amphipods demonstrated choosiness in their mating behavior. The degree of choosiness was found to be influenced by population density in their natural environments.
The protection of extraterrestrial life is not stipulated in international space research agreements. However, launching miniature interstellar probes poses a risk to habitable but sterile oxygen planets. Research suggests that these planets are unlikely to support life due to the corrosive effect of free oxygen.
Researchers are studying Bronze Age activity in the Urals to understand demographic processes and settlement structures. They are analyzing palaeogenetic techniques, archaeological excavations, geophysical surveys, material culture, and archaeobotany to find answers about population genetics, cultural transformation, and demography.
Scientists have discovered a way to create artificial edge states in topological insulators using ultracold quantum gases in optical lattices. This breakthrough could lead to increased stability and energy efficiency in mobile devices, as well as the development of more efficient lasers.
Fuchs-Schündeln's ERC project aims to analyze heterogeneous labor market outcomes, exploring effects of maternity leave policies and increasing female presence in occupations on relative wages. The €1.6m grant will fund four subprojects involving macro- and microeconomic methods.
The formation of secondary particulate matter in the atmosphere is still not fully understood. Alexander Vogel's research aims to identify its sources and improve air quality by analyzing molecular fingerprints from atmospheric samples.
A team of scientists has identified a previously unknown protein structure that enables the controlled intake of potassium ions into cells. The discovery, published in Nature Communications, reveals a complex mechanism involving two inter-subunit half-channels and challenges existing theories on potassium transport.
Professor Alexander Krot will work at Goethe University Frankfurt for six months, building on his research on the formation of the first solid bodies of our solar system. His work aims to provide fundamental insights into the childhood of the solar nebula, shedding light on the early formations in the solar system.
A team led by Dr. Sjoerd van Wijk is exploring M1-deubiquitinating enzymes and their interactions with death receptors to better comprehend programmed cell death regulation. This research may lead to insights into human diseases, such as cancer development and bacterial invasion.
A neuronal circuit in nematode worms modulates locomotion by dopamine and neuropeptide signaling, findings that may provide insights into food-motivated behavior in humans. The study suggests that similar inhibitory balancing mechanisms may be present in mammals.
The ORA project investigates the connection between citizens and parliament, essential for democracy. The team, led by Professor Thomas Zittel, will analyze legislators' behaviors to understand if geographic ties offer an alternative to collective representation by political parties.
Robert Tampé's €1.5 million Koselleck project aims to elucidate key mechanisms of antigen processing in MHC-I complexes, which could lead to new therapy options for infections and autoimmune diseases.
The European Joint Programme and Goethe University will develop tools to integrate and standardize patient data for rare disease research. The university will receive the largest funding sum of all participating German institutions, with a focus on developing open-source registration platforms.
Scientists discovered that developing brain networks act locally to build globally, with spontaneous activity patterns correlating between distant populations of neurons. This finding suggests that long-range order originates from neural activity driven by short-range connections.
Scientists have successfully explained the structure and function of docking domains in peptide natural products. This breakthrough allows researchers to redesign docking domain interactions, modulating the product spectrum of a rhabdopeptide-synthesizing NRPS. The discovery has promising implications for creating new substances.
Cuttlefish control camouflage by directly acting on skin cells called chromatophores, producing local changes in contrast. Through statistical analysis of chromatophore output, researchers inferred motor neuron activity and higher levels of control, peering into the brain's camouflage system.
Researchers developed an imaging signature to detect subclinical cardiac injury in lupus patients, revealing inflammation as the underlying pathophysiological mechanism. The new diagnostic method using cardiac magnetic resonance (CMR) improves detection and monitoring of heart involvement without radiation or contrast agents.
Researchers discovered that endothelial cells instruct neurons on their correct positioning in the cerebral cortex through laminin secretion. This finding highlights the importance of neurovascular communication in brain development and may hold key to treating dementia and mental illness.
A social-psychological study at Goethe University Frankfurt reveals that while social class influences behavior, the communication situation plays a more significant role in shaping behavior towards counterparts from different social classes. The study found that individuals exhibit solidarity with those from lower social classes and a...
Researchers have made significant breakthroughs in treating hereditary angioedema with the new drug BCX7353. The medication has been shown to significantly reduce attack frequency and improve quality of life by up to 75% compared to placebo, offering a convenient oral administration without severe side effects.
Researchers at Goethe University Frankfurt have created a new process to produce highly functionalized organochlorosilanes, ideal crosslinkers for various applications. The process enables the production of inorganic-organic hybrid materials with unique properties.
Researchers set limits on neutron star sizes by analyzing billions of theoretical models, refining estimates to within 1.5 kilometers. The study also explores the possibility of 'twin stars' with exotic properties, which are statistically rare and unlikely to be deformed during mergers.
Researchers found that frequent nerve signals strengthen dendritic spines in adult-born neurons, allowing them to connect with the existing neural network. This process is crucial for learning and memory formation in the hippocampus.
Scientists from Goethe University Frankfurt and the Frankfurt Institute for Advanced Studies have developed a novel simulation code, ExaHyPE, to calculate gravitational waves on exascale supercomputers. This breakthrough allows for more accurate simulations of black hole mergers and other astrophysical phenomena.
Scientists at Goethe University Frankfurt reveal atomic details of Legionella's enzymatic weapon and develop the first inhibitor. The discovery has implications for tackling antibiotic-resistant bacteria, which threaten global health and economic stability.
Scientists warn of increased infectious diseases transmitted through vectors in the coming decades. The Asian tiger mosquito, introduced via trade and tourism, has not yet filled its ecological niche globally, posing a threat to regional health.
Dr. Anna Possner will join the Goethe University in Frankfurt to investigate the impact of low-level clouds on Earth's surface temperature. Her research focuses on semi-transparent parasols that reflect sunlight but have a minimal effect on heat emission, and she aims to improve understanding of their influence.
The US is predicted to lose its lead as the country with the most Nobel Prizes due to declining productivity. According to an empirical study, the US will be surpassed by Germany in 2025 and France in 2028. The UK remains a strong contender with a high success rate per capita.
Researchers at Goethe University Frankfurt found that single cells in the innermost layer of blood vessels proliferate after injury and contribute to the formation of new vessels. This process, known as clonal expansion, is thought to play a significant role in tissue damage repair, such as in diabetes or heart attacks.
A recent study published in Environmental Research Letters found that limiting global warming to 1.5°C would reduce flood hazards globally by 21%, whereas a 2°C limit would increase flood risks by an average of 11% across 21% of the world's land area.
Astronomers used computer simulations to create images of accreting supermassive black holes in different gravity theories. They found that even highly non-Einsteinian black holes could mimic the appearance of standard black holes, highlighting the need for new techniques to distinguish them.
Scientists at Goethe University Frankfurt explore cryobiology's social and biological impacts, including 'suspended life', and study immune defense mechanisms to understand pathogens' evasion strategies.
Chemotherapy-induced DNA damage triggers apoptosis in oocytes due to p63 activation. Researchers found that inhibiting specific enzymes can prevent this process, offering new hope for fertility preservation.