The Changing High-Risk Asthma in Memphis through Partnership (CHAMP) program significantly decreased healthcare use related to asthma by addressing access to care, fragmented care, and social needs. After one year of enrollment, results showed a 48% reduction in ED visits, 68% reduction in inpatient and observation visits.
The COVID-19 pandemic led to increased vacancies among pediatric and neonatal transport teams, with 62.1% reporting multiple team members leaving during the crisis. Compensation emerged as a primary concern for healthcare workers, highlighting the need for resilience training to reduce stress and promote retention.
A study by Le Bonheur Hospital found that high-flow nasal cannula (HFNC) treatment for mild to moderate bronchiolitis is associated with longer hospital stays and higher costs. HFNC usage outside intensive care units resulted in increased resource utilization for pediatric bronchiolitis patients.
The Le Bonheur Children's Heart Institute team will discuss the management of Patent Ductus Arteriosus (PDA) in premature infants at the 2022 PDA Symposium. The symposium aims to develop guidelines for managing PDA, with a focus on transcatheter closure in extremely low birth weight infants.
Researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center found no evidence of myocardial injury or myocarditis in athletes after COVID-19 infection. Most athletes had mild symptoms and normal cardiac test results.
Researchers at Le Bonheur Children's Hospital found that eosinophils modify the respiratory barrier during influenza A infection, helping to protect the airway. The study also suggests a potential antiviral role for eosinophils in SARS-CoV-2 (COVID-19) infections.
A recent study published in The Journal of Clinical Endocrinology & Metabolism found that non-Hispanic black patients with Type 1 diabetes and COVID-19 are almost four times as likely to present with diabetic ketoacidosis compared to white patients. The study highlights the importance of addressing social determinants of health, includ...
The article highlights the importance of pediatric nephrologists' involvement in caring for children with cancer, from diagnosis to treatment and beyond. Key findings include the increasing need for onco-nephrology expertise due to rising childhood cancer rates and advances in therapy protocols.
The study found that early PDA closure in extremely low birth weight infants with moderate to large PDA improved respiratory status, facilitated faster weaning off supplemental oxygen and ventilator support, and promoted normal weight gain. Delayed PDA closure and pulmonary hypertension were associated with worse respiratory outcomes.
Researchers are now able to use genomic alterations of tumors to determine prognosis and best treatment options for pediatric brain tumors. This approach has significantly changed the field of neurosurgery, enabling more effective treatment with fewer side effects.
Amali Samarasinghe, a researcher at Le Bonheur Children's Hospital and UTHSC, received the Charles and Amelia Gould Innovation Award to study eosinophils in asthma. The award aims to improve personalized approaches to therapy for children with asthma.
Laminin plays a crucial role in regulating interactions between migrating neural crest cells and the extracellular matrix. The study found that alterations in LAMR expression contribute to neural crest cell migration failure in Hirschsprung disease, leading to colonization of the distal colon when YIGSR is applied.
Researchers found that influenza A virus (IAV) infection leads to changes in eosinophil surface markers, antigen presentation, and survival. Eosinophils play an active role in resolving viral infections by recognizing IAV antigens and inducing epigenetic changes in CD8+ T-cells.
A randomized trial found that IV indomethacin was more effective in successfully closing hemodynamically significant PDAs in very low birth weight infants. The study showed a success rate of 55% for IV indomethacin versus 6% for IV acetaminophen.
Dr. Jeffrey A. Towbin, a researcher at Le Bonheur Children's Hospital, has received a NIH research project grant to identify modifier genes in cardiomyopathy. The study aims to understand how different genetic backgrounds affect the expression of myopalladin, a gene linked to the severity of cardiomyopathy.
Dr. Gosain's lab aims to establish a causative relationship between dysbiosis and Hirschsprung-associated enterocolitis, identifying key drivers of the disease and potential therapeutic targets.
A study published in Pediatrics found that black children are more than twice as likely to die after surgery, with increased risks of ventilator use, oxygen support, and wound infections. The authors developed race-specific models to predict surgical outcomes and suggest interventions to reduce mortality rates
Researchers have discovered that neural crest cells colonize the spleen during embryogenesis and persist into adulthood, displaying markers indicating a glial lineage. These cells are arranged anatomically adjacent to blood vessels, pericytes, and nerves, suggesting an astrocyte-like phenotype.
A clinical trial has shown that the infection caused by RSV can be effectively reduced after it has started, paving the way for a new treatment. The study found that the oral drug GS-5806 reduced viral load and improved symptoms in healthy adult volunteers infected with RSV.
A new drug, AL-8176, has been shown to safely reduce RSV viral load and clinical illness in healthy adult volunteers. The Phase 2 challenge study achieved primary and secondary endpoints of lower viral load and improvements in symptom scores.
A new drug, GS-5806, has been shown to safely reduce viral load and clinical illness in healthy adult volunteers infected with respiratory syncytial virus (RSV). The Phase 2a challenge study achieved primary and secondary endpoints, suggesting potential for clinical trials in naturally infected patients.
Dr. Jon McCullers reviews the co-pathogenesis of influenza viruses with bacteria, highlighting complex interactions leading to severe disease and increased morbidity. He calls for large-scale studies to unlock unanswered questions about co-infections and viruses to prevent future pandemics.
A recent study at Le Bonheur Children's Hospital found that Pedi-Flite improved outcomes for pediatric diabetic patients, reducing the need for hospital admissions. The system also saved over $760,000 by avoiding 439 ED visits and 115 admissions.
Researchers found that only one type of alveolar macrophage can fend off secondary bacterial infections, which are depleted during flu infections. The study aims to develop strategies for treatment and immunotherapies to supplement natural defenses.
Research by Dr. Robert Wyatt and his team provides insights into the molecular mechanism of IgA nephropathy, a common kidney disease in North America. The study's findings suggest noninvasive tests for diagnosis and monitoring, potentially leading to improved treatment outcomes for patients.
Researchers identify key findings in a large-scale study of individuals with int dup(15), including maternal and paternal duplications. The study found elevated levels of GABA and previously unknown sleep problems in affected subjects, providing significant insights into the disorder.
Dr. John DeVincenzo's research at Le Bonheur Children's Hospital is advancing our understanding of RSV replication, mutation, and treatment options. His lab has developed new techniques to detect minute sub-populations of viruses and assessed the effectiveness of RNA interference-based antiviral therapies.
A study by pediatric orthopaedic surgeons at Le Bonheur Children's Hospital found that spine-related injuries from ATVs are more common in older children and females, with a significant increase in non-contiguous spinal fractures. The researchers emphasize the need for parents to recognize ATV safety risks and take preventive measures.
Researcher Russell Chesney hypothesizes that 18th century London's crowded living conditions, poor diets, and low sunlight exposure contributed to high rates of rickets and tuberculosis in children like Tiny Tim. Improved nutrition, vitamin D from sunlight and cod liver oil could have prevented the boy's fatal condition