The differentially expressed genes in DRG that influence neural regeneration after SNI
After sciatic nerve injury, microRNA-214 targets srGAP3 in rat DRG primary neurons. This relationship affects axon guidance and neural regeneration.
Neural Regeneration Research
Intranasal nerve growth factor repairs injured spinal cord neurons
Researchers found that intranasal administration of nerve growth factor increases its content and receptor in spinal cord neurons, improving locomotor behaviors after spinal cord injury. This study provides evidence for the use of intranasal nerve growth factor as a treatment for spinal cord repair.
Who are responsible for protecting against neuron and synapse injury in immature rats?
A study published in Neural Regeneration Research found that fructose-1,6-diphosphate reduces mitochondrial swelling and increases synaptic active zone length in hippocampal CA1 area. The compound has neuroprotective effects against repeated febrile convulsions-induced hippocampal neuron and synapse damage.
Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro
Researchers successfully silenced chemokine receptor 4 in SH-SY5Y cells, inhibiting neuroblastoma cell invasion. This approach may provide a new therapeutic strategy for blocking neuroblastoma metastasis.
Attenuated inhibition of neuron membrane excitability contributes to childhood depression
Research suggests that impaired inhibition of medium spiny neurons in the nucleus accumbens contributes to childhood depression. The study found that nomifensine can alleviate depressive behaviors by reducing neuron membrane excitability.
Intrathecal bumetanide has analgesic effects through inhibition of NKCC1
A study published in Neural Regeneration Research found that intrathecal bumetanide increases NKCC1 expression and decreases KCC2 expression in spinal cord neurons of rats with incisional pain. This suggests that intrathecal bumetanide may have analgesic effects through inhibition of NKCC1.
Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats
A study published in Neural Regeneration Research found that acupuncture and moxibustion can reduce neuronal edema in Alzheimer's disease rats. The treatment modality targets axin and β-catenin protein expression, a key pathway involved in Wnt signaling.
Chrysophanol attenuates injury to hippocampal neurons in lead-exposed neonatal mice
Chrysophanol alleviated hippocampal neuronal cytoplasmic edema and improved learning and memory abilities in lead-exposed neonatal mice. The compound also reduced oxidative stress markers and increased antioxidant defenses.
Age-related changes in lateral ventricular width and periventricular white matter by DTI
Researchers detected age-related changes in lateral ventricular width and periventricular white matter using DTI, which may correlate with cognitive and sensory motor deficits. The study published in Neural Regeneration Research found increases in fractional anisotropy value related to ventricle enlargement.
Does intravenous transplantation of BMSCs promote neural regeneration after TBI?
Intravenous transplantation of BMSCs has been shown to promote nerve cell regeneration in injured cerebral cortex, supplementing lost nerve cells. This study provides evidence for the potential use of BMSCs as a therapeutic option for traumatic brain injury treatment.
Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD
Researchers found that Zhichan decoction increased dihydroxyphenylacetic acid levels up to 10-fold after neural stem cell transplantation, promoting the differentiation of dopaminergic neurons. This study suggests a potential treatment for Parkinson's disease using traditional Chinese medicine.
What increases the neuronal plasticity of endogenous NSCs after focal cerebral ischemia?
Research by Dr. Hyung-Seok Kim reveals that early expressions of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous NSCs after focal cerebral ischemia. Additionally, neural precursor cells can be recruited from nearby areas to promote neurofunctional recovery.
Hippocampal neuron-related factor expression and neuronal injury after TBI
Research reveals the sequential expression of these factors after fluid percussion injury, suggesting a mechanism underlying hippocampal neuronal injury after TBI. The study provides new insights into the occurrence and development of hippocampal neuronal injury.
Signaling pathway for ginsenoside Rb1 promoting hippocampal neuronal neurite outgrowth
Research found ginsenoside Rb1 enhances PI3K/Akt and MAPK signaling pathways, promoting neuronal survival and neurite growth in the hippocampus. The study suggests potential anti-dementia effects of ginsenoside Rb1 in Alzheimer's disease.
Neuropeptide Y protects cerebral cortical neurons
Researchers found that Neuropeptide Y prevents excessive production of cytokines, reduces microglial reactivity, and inhibits N-methyl-D-aspartate current in rat cortical neurons. This study suggests a potential neuroprotective role for Neuropeptide Y in cerebral cortical neurons.
SWI assesses signal strength in different brain regions after acute hemorrhagic anemia
Researchers used SWI to evaluate signal strength in different brain regions after acute hemorrhagic anemia. The study found lower SWI signals in the frontal cortex, temporal lobe, and thalamus after bloodletting procedures compared to pre-bleed values.
Protective effect of α-synuclein knockdown on dopaminergic neurons
Knocking down α-synuclein in a methamphetamine-induced model of Parkinson's disease reduced depression manifestations, increased striatal dopamine and tyrosine hydroxylase levels, and decreased reactive oxygen species. This suggests that α-synuclein may exacerbate oxidative stress and apoptosis in dopaminergic neurons.
The ADC does not reflect cytotoxic edema on the uninjured side after TBI
Researchers found that ADC values accurately reflect changes on the injured side but not on the uninjured side, indicating a delay in pathological changes. This study suggests that ADC measurements may not be reliable for detecting cytotoxic edema on the unaffected brain tissue after traumatic brain injury.
Citalopram increases the differentiation efficacy of BMSCs into neuronal-like cells
Researchers found that citalopram increases the efficiency of bone marrow stem cells (BMSCs) differentiating into neuronal-like cells. This improvement in cellular differentiation is associated with increased cell proliferation and survival while maintaining neuronal characteristics.
Why anandamide can increase intracellular Ca2+ concentration?
Researchers found that anandamide, a cannabinoid compound, directly causes Ca2+ influx and triggers an increase in intracellular Ca2+ concentration. The study discovered two independent mechanisms involving protein kinase C signaling pathway for anandamide's inhibitory effects on voltage-gated calcium channels.
Virtual reality interface device and brain neural networks in neurological diseases
Virtual reality interface devices reorganize brain neural networks in patients with chronic stroke and cerebral palsy, improving hand function and balance. This application enhances the quality of life for individuals with neurological diseases.
ADSCs transplantation promotes neurogenesis in Alzheimer's disease
Transplantation of adipose-derived stem cells (ADSCs) into APP/PS1 transgenic AD model mice promoted neurogenesis in the subgranular and subventricular zones. This improved cognitive function and reduced oxidative stress, providing evidence for AD treatment with ADSCs.
Substance P in hippocampus versus striatal marginal division for learning/memory function
Research by Yan Yu et al. found that substance P receptor neurokinin 1 is highly expressed in both hippocampus and striatal marginal division, affecting learning and memory function. The study suggests a similar role of the marginal division in learning and memory as the hippocampus.
An obstacle to the differentiation of adipose-derived stromal cells into astrocytes
Researchers found that adipose-derived stromal cells exhibit increased apoptotic rates and decreased viability when attempting to differentiate into astrocytes. This process is hindered by caspase-dependent apoptosis, a crucial strategy for increasing induction efficiency.
Inhibition of NgR expression reduces apoptotic retinal ganglion cells in diabetes
Inhibition of NgR expression reduces apoptosis of retinal ganglion cells in diabetic rats by inhibiting Rho kinase, indicating a potential therapeutic target for glaucoma and related diseases. Upregulation of NgR is associated with increased cell apoptosis and visual extinction.
Fusion protein of single-chain variable domain fragments and myasthenia gravis
A fusion protein composed of scFv and human serum albumin has been developed to target the acetylcholine receptor in myasthenia gravis. The protein showed a high inhibition rate (2.0-77.4%) for binding to acetylcholine receptors, indicating potential therapeutic efficacy.
How does miR-21 promote the differentiation of hair follicle-derived NCSCs into SCs?
Researchers found that microRNA miR-21 regulates the differentiation of neural crest stem cells (NCSCs) from human hair follicles into Schwann cells. By binding to the 3'-UTR of SOX2 mRNA, miR-21 down-regulates SOX protein expression, increasing SC differentiation capacity.
Nasal mucosal inhalation of AD vaccine attenuates Aβ1-42-induced cytotoxicity
A novel AD vaccine, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG, was administered via nasal mucosal inhalation to AD transgenic mouse models, producing strong T helper 2 humoral immune responses and reducing Aβ1-42-induced cytotoxicity. This approach offers a promising therapeutic strategy for Alzheimer's disease.
The optimal mitomycin C concentration for intact peripheral nerve structure and function
Researchers found that local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy without damaging peripheral nerve structures. However, high concentrations (> 0.7 mg/mL) may pose potential safety risks to peripheral nerves.
BMSCs with Nogo-66 receptor gene silencing for repair of spinal cord injury
Researchers successfully silenced the Nogo-66 receptor gene in BMSCs, blocking its inhibitory effect and promoting neuronal growth. This breakthrough enhances the therapeutic effects of BMSC transplantation for spinal cord injury repair, offering new hope for patients.
Thyroid hormone protects hippocampal cholinergic neurons in normal aged animals
Levothyroxine treatment improved cognitive and learning abilities in naturally aged mice by increasing choline acetyltransferase and acetylcholine levels. The supplement also enhanced superoxide dismutase activity and synapse function, suggesting a potential therapeutic strategy for age-related cognitive deficits.
Filiform needle acupuncture versus antidepressant drugs for poststroke depression
A meta-analysis of 17 clinical trials found that early filiform needle acupuncture significantly improved depression symptoms and was safer than conventional medications. This study provides evidence for the effectiveness of acupuncture in managing poststroke depression.
What aggravates hippocampal neuronal injury in acute cerebral ischemia?
Activation of extracellular signal-regulated kinase 1/2 was shown to protect against hippocampal neuronal injury in a rat model of diabetic cerebral ischemia. However, reduced extracellular signal-regulated kinase 1/2 decreased Ku70 activity and increased Bax expression, leading to increased lost hippocampal neurons.
Neuroprotective effects of low concentration of lithium
The study found that low concentrations of lithium carbonate had a protective effect on SH-SY5Y cells, with reduced expression levels of pyruvate kinase 2 and calmodulin 3. Additionally, western blot analysis revealed increased expression of stress proteins GRP94 and HSP27.
Houshiheisan maintains stabilization of the internal environment of neurovascular units
The Houshiheisan compound prescription effectively suppresses abnormal amyloid precursor protein accumulation and reduces amyloid substance deposition. It maintains the stabilization of the internal environment of neurovascular units, minimizing injury to these units in the ischemic penumbra.
3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia
Researchers found that 3-n-butylphthalide improved neuronal morphology in the cerebral cortex and hippocampus, reducing oxidative stress caused by chronic cerebral ischemia. The compound also inhibited amyloid beta accumulation and improved cholinergic function in rats with chronic cerebral ischemia.
Rat versus mouse models of focal cerebral ischemia for neural regeneration studies
Researchers studied rat and mouse models of focal cerebral ischemia to develop high-quality rodent models of stroke. They found optimal methods for middle cerebral artery occlusion in rats (0.40-0.45 mm, 18-20 mm thread insertion length) and mice (0.15-0.18 mm, 9-11 mm thread insertion length).
Gene therapy and the regeneration of retinal ganglion cell axons
Researchers investigate gene therapy as a potential treatment to improve viability and regenerative capacity of injured adult retinal ganglion cells. Studies using modified viral vectors introduce genes into injured visual pathway cells, aiming to promote long-distance axon regeneration.
Outcomes of cerebral motor cortex neurons after rTMS or tDCS
Researchers found that non-invasive brain stimulations, including rTMS and tDCS, can regulate the activities of cerebral motor cortex neurons. These findings suggest potential therapeutic benefits for individuals with central nervous system injuries or damage.
Disappearance of unaffected motor cortex activation by rTMS in a cerebral infarct patient
Research by Jeong Pyo Seo and Sung Ho Jang found that repetitive transcranial magnetic stimulation (rTMS) reduces activation in the unaffected motor cortex of patients with cerebral infarct. This effect was observed after just two weeks of treatment, suggesting potential drawbacks to this therapy for stroke recovery.
Dental pulp stem cells promote the survival and regeneration of retinal cells after injury
Researchers discovered that dental pulp stem cells can protect retinal ganglion cells from death and promote regeneration of their axons. The study found that these stem cells naturally express neurotrophic factors, providing a potentially limitless source of growth factors for injured neurons.
Visualization of peripheral nerve regeneration
Researchers at National Taiwan University have reviewed treatment options and imaging tools for peripheral nerve repair, contributing to knowledge in the field. The study proposes several imaging tools that may help visualize peripheral nerve regeneration in vivo and in real-time.
Electrical stimulation of fastigial nucleus and cellular apoptosis in injured region
The study found that electrical stimulation of the fastigial nucleus can increase Ku70 expression, leading to decreased Bax protein and reduced mitochondrial apoptosis. Injured brain tissue showed co-localization of Ku70 with Bax.
A VLSM study on motor cortex neuron injury and lower limb dysfunction in chronic stroke
A VLSM study found that neuronal injury in the corona radiate, caudate nucleus and putamen of patients with chronic stroke can predict walking speed. The study suggests that VLSM may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.
Stem cells in neurodegeneration: challenges and future neurotherapeutic prospects
Inhibition of Rho-associated kinase (ROCK) and subsequent cofilin dephosphorylation can promote neurite outgrowth in PC12 cells, a key step towards treating neurodegenerative disorders. Additionally, mesenchymal stem cell transplantation has shown promise in repairing and protecting damaged brain tissue after traumatic injury.
HSP90 is a potential target for ameliorating skeletal muscle abnormalities in PD
Researchers found exercise training significantly reduces HSP90 overexpression in PD rats, suggesting a potential therapeutic target for skeletal muscle abnormalities. This study supports the use of HSP90 inhibitors as a new treatment option for PD-related muscle issues.
Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by DBI?
Researchers found that apolipoprotein E-derived therapeutic peptide improves synaptic stability and learning memory performance after diffuse brain injury. Apolipoprotein E mimetic peptide also reduces neuronal apoptosis by suppressing the ERK1/2-Bax mitochondrial apoptotic pathway.
Neuronal activation by acupuncture at Yongquan and sham acupoints for DOC: A PET study
Acupuncture at Yongquan acupoints induced stronger neuronal activation than sham points, increasing synaptic activity in areas involved in conscious thought. This may explain the improvement of patients with disorder of consciousness.
Effect of repeated-pulse transcranial magnetic stimulation at the Guangming point on EEGs
Researchers found that repeated-pulse transcranial magnetic stimulation at the Guangming point evokes distinct patterns in electroencephalogram signals compared to other nearby points. This study suggests a potential therapeutic application of this stimulation technique for modulating brain activity.
Acrylamide exposure impairs blood-cerebrospinal fluid barrier function
Researchers found that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. This damage may underlie acrylamide-induced neurotoxicity and central and peripheral neuropathy.