Researchers found that the deltaFosB gene regulator protects against depression by boosting neurons' activity when glutamate binds to AMPA receptors. Boosting deltaFosB calms neurons, enabling individuals to pursue goal-directed behavior despite stress.
A new study suggests that magnetic stimulation therapy produced significant antidepressant effects in a subgroup of treatment-resistant patients, with remission rates of 14% compared to 5%. The treatment has few side effects and may be an effective alternative for those who don't respond to current medications.
Researchers have found a specific genetic cause of schizophrenia that impairs communication between the brain's decision-making and memory hubs. Engineered mice with this mutation show difficulty with working memory tasks, highlighting the importance of connectivity in learning and memory.
A nationally representative survey found that about 13% of American children and teenagers have a mental disorder, with lower socioeconomic status linked to higher rates. Mental health services are often underutilized, particularly among minority youth, highlighting the need for increased access and support.
Researchers successfully blocked a conditioned fear memory in humans for at least a year using a noninvasive technique that exploits the reconsolidation window of emotional memories. The method, inspired by animal studies, shows promise for treating anxiety disorders like PTSD by altering emotional memories during their recall.
Children with poor reading skills showed increased brain connectivity after intensive training, making significant gains in reading and potentially leading to improved treatments for developmental conditions like autism. The study suggests that behavioral training can enhance brain function and improve communication between brain regions.
A study funded by NIMH found that a combination of medication and structured parent training significantly reduced serious behavioral problems in children with autism. The treatment protocol showed greater benefits compared to medication alone, including a lower dose of medication needed for symptom control.
A clinical trial has begun testing a novel compound, STX107, that selectively targets the synaptic defect underlying Fragile X syndrome. The study aims to evaluate safety and tolerability in healthy volunteers, with potential progression to phase 2 trials in adults and pediatric safety assessments.
The NIMH is launching a large-scale research project to explore the effectiveness of early and aggressive treatment in reducing symptoms of chronic schizophrenia. The Recovery After an Initial Schizophrenia Episode (RAISE) project aims to develop and test interventions that incorporate diverse treatment approaches and are tailored to i...
A study by the National Institute of Mental Health found that teenage girls' brains activate more in social emotion circuitry as they age, indicating a shift towards approach rather than avoidance. This may reflect resilience to psychosocial stress among healthy female adolescents.
Genome-wide studies identify a vast array of genetic variation that may account for at least one third of the genetic risk for schizophrenia. The studies found a shared chromosomal neighborhood between schizophrenia and bipolar disorder, implicating an area of Chromosome 6 in immunity and gene expression regulation.
A new analysis of data from 14 studies found a strong association between stressful life events and depression risk. However, the presumed high-risk version of the serotonin transporter gene did not show an increased risk for major depression alone or in interaction with stressful life events.
A study funded by NIH found citalopram to be no more effective than a placebo in reducing repetitive behaviors in children with autism spectrum disorders. The medication was associated with increased side effects, challenging its use as a treatment option.
A two-year grant from NIMH will support the adaptation and assessment of an HIV intervention designed for young, heterosexual Latino couples. The program aims to increase condom use, monogamous relationships, and decrease risky sexual behaviors.
The National Institute of Mental Health is using Recovery Act funds to evaluate the effectiveness of a new training program for telephone crisis counselors. The training, which began in 2008, aims to assess the benefits of the training and shape telephone-based suicide prevention services across the country.
Researchers have identified a previously unknown form of potassium channel, Isoform 3.1, implicated in schizophrenia and linked to abnormal brain activity. Inhibiting this protein may correct disorganized brain activity without cardiac side effects associated with existing antipsychotic medications.
Researchers found that individuals with autism tend to stare at people's mouths rather than their eyes due to the attraction of audiovisual synchrony. This phenomenon is more pronounced in toddlers with autism, who exhibit a strong preference for lip-sync, whereas unaffected peers focus on socially meaningful movements.
The NIH will commit $60 million in ARRA funds to support autism research, focusing on diagnostic screening tools, early interventions, and adapting pediatric treatments for older children. The grants will promote economic recovery by creating biomedical jobs and supporting innovative projects.
A new study funded by the National Institutes of Health has identified three effective treatments for childhood anxiety disorders: a combination therapy with psychotherapy and antidepressant medication, cognitive behavioral therapy, and an antidepressant medication alone. The study found that 81% of children in the combination treatmen...
Researchers discovered an electromagnetic biomarker that predicts a patient's response to ketamine, a fast-acting antidepressant. Increasing activity in the anterior cingulate cortex hub near the front of the brain while viewing flashing frightful faces correlates with improved symptoms after receiving ketamine.
A new study found that newer atypical antipsychotic medications were not more effective than an older conventional antipsychotic in treating child and adolescent schizophrenia. The study also revealed potential metabolic side effects, particularly with olanzapine, which may lead to serious health issues.
The NIH has funded a network of nine centers to use high-tech screening methods to identify small molecules as probes to investigate cell functions and develop new therapies. The goal is to increase the pace of development and use of chemical probes, which have become invaluable tools for exploring biologic processes.
A large genetic analysis implicates machinery involved in sodium and calcium balance in brain cells in bipolar disorder. Variation in two genes showed the strongest association with bipolar disorder.
Researchers discovered a mechanism in mouse brains that may explain why human mothers develop depression after childbirth. The study found that a GABA receptor subunit fluctuates during pregnancy and postpartum, impairing the brain's ability to adapt to hormone fluctuations.
Researchers discovered a significant increase in rare deletions and duplications of genetic material in people with schizophrenia, affecting 13.1% of cases and 10.4% of controls. Two new sites on Chromosomes 1 and 15 were implicated as potent risk factors for the disorder.
Researchers found that autism mutations may disrupt specific genes vital to the developing brain, which are turned on and off by neuronal activity. Disruption of this refinement process may be a common mechanism of autism-associated mutations.
A study found that people with nonfamilial schizophrenia harbor eight times more spontaneous mutations than healthy controls, primarily affecting brain development pathways. This suggests that rare genetic variations contribute to the vulnerability of individuals without a family history of the illness.
A recent study published in the American Journal of Psychiatry estimates that major mental disorders result in significant losses of human productivity, with individuals with serious mental illness earning approximately $22,545 per year. The total economic burden is attributed to lost earnings and increased likelihood of unemployment.
Researchers at NIMH found that brain activity responds to social hierarchy, influencing motivation and health. The ventral striatum activates equally for monetary rewards and changes in rank.
The NIH has awarded grants to researchers studying early brain development, social interactions, rare genetic variants, and potential environmental risk factors for autism. Researchers at Yale and Wayne State University aim to identify novel treatments using buspirone and explore the relationship between genes and physical traits.
Studies find that rare genetic deletions and duplications in schizophrenia patients disrupt genes involved in brain development, potentially implicating hundreds of genes. The findings support a new approach for discovering genes associated with the disorder.
Research reveals that past child abuse increases PTSD symptoms in adults, with certain gene variations amplifying the risk. The study identifies a key gene, FKBP5, which plays a crucial role in regulating stress-response systems.
A recent study published in JAMA found that teenagers with difficult-to-treat depression who switched to another antidepressant medication and added psychotherapy showed significant improvement. The results suggest that a combination approach may be more effective than traditional treatment strategies for adolescents with treatment-res...
A new technique allows researchers to identify the specific neural connections and molecular tags that sustain a particular fear memory in mice. The study reveals how proteins called AMPA receptors strengthen memories by becoming part of the synapses encoding them.
Research identifies genetic variations that shield adults from depression caused by childhood trauma. The study discovered that certain gene variations help regulate the response to stress, protecting against moderate to severe depression in adulthood.
Researchers found a link between a specific gene variant and autism, particularly when inherited from mothers. The study suggests that the CNTNAP2 gene may play a role in brain cell development and differentiation.
A large study found that identifying youth with risk factors for psychosis can lead to accurate predictions, with a 65-80% accuracy rate. Combinations of risk factors include social decline, family history, unusual thoughts, and past drug abuse. This ability to predict psychosis will help determine the most effective time to intervene.
A study funded by the National Institute of Mental Health found that premenopausal women with mild depression have lower bone mass than their nondepressed peers. Bone thinning was especially prevalent in hip bones, increasing the risk of fractures and other costly injuries as they age.
Youth with ADHD exhibit delayed brain maturation in frontal cortex areas, which can affect higher-order executive control functions. However, the delay is most pronounced in regions at the front of the brain's outer mantle, supporting ability to control thinking, attention, and planning.
A study found that a specific brain mechanism promotes resilience to stress in mice, potentially leading to improved treatments for stress-related mental illnesses. The research identified key components of the mechanism and found similarities with human brain function.
Researchers have identified epigenetic mechanisms involved in schizophrenia, pointing to potential new targets for medications. The GAD1 gene's role in producing the neurotransmitter GABA is also linked to brain development abnormalities.
A recent clinical trial funded by the NIH found that combining psychotherapy and antidepressant medication is the most effective treatment for adolescents with major depressive disorder. The TADS study showed improved recovery rates compared to using medication or therapy alone.
Researchers identified two genes linked to suicidal thinking during antidepressant treatment, with certain versions increasing the risk by 2-15 fold. The findings may lead to genetic testing and individualized treatments for depression.
A study published in the Journal of the American Medical Association found that workplace depression screening and enhanced treatment can significantly improve employee health and productivity. Employees who received intervention were 40% more likely to have recovered from their depression and worked an average of two more hours per week.
A new study shows that tamoxifen, a breast cancer medication, dramatically reduces manic symptoms of bipolar disorder more quickly than many standard medications. Tamoxifen blocks an enzyme called protein kinase C, which is thought to be over-active during the manic phase.
A global survey found that fewer people in less developed countries with mental disorders sought services compared to those in high-income countries. The U.S. population used services the most at 18%, while Nigeria had the lowest rate at 1.6%.
The study found that the number of office visits resulting in a bipolar disorder diagnosis for youths ages 19 and younger increased from 25 per 100,000 people in 1994-1995 to 1,003 per 100,000 people in 2002-2003. In contrast, adults saw a rise from 905 per 100,000 people to 1,679 per 100,000 people over the same period.
Researchers created OCD-like behaviors in mice using genetic engineering and reversed them with antidepressants and targeted a key brain circuit. The study suggests new strategies for treating the disorder by understanding the role of the SAPAP3 gene in glutamate-mediated communications.
A specific gene variant associated with attention deficit hyperactivity disorder (ADHD) may also predict better clinical outcomes and higher IQ in teens. The variant, called the 7-repeat version of the dopamine D4 receptor gene, is linked to thinner brain areas controlling attention but confers advantage only among youth with ADHD.
A study by the National Institute of Mental Health found that people with a variation in the GRIK4 gene are more likely to respond to citalopram, an antidepressant medication. Researchers also discovered that variations in another gene, HTR2A, make people more likely to respond as well.