Scientists at the Feinstein Institute have identified nine genetic markers that can increase a person's risk for schizophrenia. The study used a new mathematical approach to analyze genetic information, providing evidence of a recessive inheritance pattern. This discovery could lead to improved diagnosis and treatment options.
A recent study using PET scans shows that an experimental gene therapy can normalize brain function in Parkinson's patients. The treatment was found to alter brain activity in a favorable way, primarily affecting motor networks.
A new study found that green tea's EGCG ingredient can rescue mice from lethal sepsis, paving the way for clinical trials. The substance works by preventing HMGB1 from being released and activating immune cells.
Researchers have found that the vagus nerve directly communicates with the immune system, controlling inflammation. This discovery is leading to novel treatments for diseases such as sepsis and autoimmune conditions.
Researchers have identified two separate brain networks affected by Parkinson's disease, one regulating movement and the other cognitive function. The study found that standard treatments alter the motor network but not the cognitive network, highlighting the need for new treatments to target cognition.
Researchers at The Feinstein Institute for Medical Research have isolated MIF, a substance in semen that regulates sperm maturity and fertility. Elevated or low levels of MIF were found to be associated with infertility, while high levels were linked to autoimmune diseases.
A novel gene therapy technique has been found safe and effective in reducing worsening symptoms of Parkinson's disease in advanced patients. The treatment, which involves injecting genes into one side of the brain to restore a critical neurotransmitter called GABA, showed a 27% improvement in symptoms among participants.
Researchers at The Feinstein Institute for Medical Research have discovered a new gene that increases the risk of developing schizophrenia. The study, which analyzed over 500,000 genetic markers, found a significant link between a chromosomal region called PAR1 and the disease.
Researchers aim to identify genetic underpinnings of early-onset bipolar disorder, a mental illness affecting millions of Americans. The two-year study will analyze DNA from participants and their parents to develop more rational treatments.
Dr. Kevin J. Tracey's theory of the inflammatory reflex reveals a direct link between brain and immune system via the vagus nerve, providing a new approach to treating chronic inflammatory diseases. By manipulating brain activity, individuals may be able to 'think' their way to feeling better.
Researchers found a specific pattern of DNA sequence variations in the dysbindin gene associated with impaired cognition and intelligence. The study suggests dysbindin influences variation in human cognitive ability, but only explains a small proportion, about 3 percent.
Researchers found that galantamine, a drug already approved for Alzheimer's disease, can be used as an anti-inflammatory agent. By blocking the enzyme that destroys acetylcholine, galantamine stimulates nerve cells in the brain to release more of the chemical messenger.
David Eidelberg receives the prestigious Fred Springer Award for his work on mapping brain pathways and developing new diagnostic techniques. The award recognizes his pioneering efforts in viewing the brain at work, early diagnosis, and predicting treatment responses.
Researchers at Northwell Health's Institute for Medical Research have identified a crucial gene in type 1 diabetes development, which triggers the immune system to attack and kill beta cells. Blocking this protein may halt the harmful process and allow remaining beta cells to produce insulin.
Recent research in chronic lymphocytic leukemia (CLL) identifies genetic and protein markers that can predict patient outcomes. These new markers may enable earlier treatment, improving survival rates and altering the disease's progression.
Researchers using 'heavy water' tracked leukemia cell birth and death rates, revealing dynamic process with mortal cells that proliferate and die. The study found faster birth rates of leukemia cells correlate with poorer patient outcomes, paving the way for potential new methods of prediction and treatment guidance.
A study found that cancer patients receiving long-term bisphosphonate therapy were at risk of developing jawbone necrosis, a condition that can lead to bone death and require surgery. The condition is often associated with tooth extractions or other major dental work while on the drugs.
The NIH awards $1 million for research on Diamond Blackfan anemia, a genetic blood disorder linked to increased risk of adult cancers and birth defects. Researchers will broaden the DBA Registry of North America to gain insight into cancer susceptibility and develop new approaches for examining the origins of this disease.
Researchers discovered a genetic marker, PTPN22, associated with a two-fold increased risk of rheumatoid arthritis. The variant impairs immune regulation, leading to hyperresponsiveness and inflammation.
Researchers are collecting blood samples from hundreds of women to validate the novel approach. The test has received worldwide attention due to its potential for early detection and high survival rates. If successful, it could save thousands of lives annually.