A large-scale study published in the New England Journal of Medicine found that therapeutic hypothermia did not improve neurological outcomes in pediatric cardiac arrest patients. The study compared two treatment groups: therapeutic hypothermia and active normothermia therapy.
A new analysis of cases conducted in Northwell Health found that a surgical procedure may be more successful in preventing death than current drug therapies. The study revealed a mortality rate of 4.2% for patients who underwent surgery, compared to higher rates for those who did not.
A team of researchers used MakerBot's 3D printing technology to create a custom tracheal scaffolding, combining it with living cells to form a functional airway segment. The breakthrough has the potential to revolutionize tracheal repair and replacement procedures.
Araim Pharmaceuticals' ARA 290 peptide shows clinically significant pain reduction and improved metabolic control in type 2 diabetics. The novel agent is engineered to activate the innate repair receptor, which turns off inflammation and turns on the body's natural repair system.
A multinational trial of progesterone in severe TBI patients found no clinical benefits, with no difference in outcomes or mortality rates between groups. The study highlights the difficulty in demonstrating efficacy for this complex disease, and emphasizes the need for further research to find effective treatments.
Researchers at The Feinstein Institute for Medical Research have identified a brain network that measures placebo effects in Parkinson's disease patients. This breakthrough discovery has the potential to improve the accuracy of clinical trials by excluding subjects who are more likely to experience placebo effects.
A recent study by Northwell Health demonstrates that magnetic resonance imaging (MRI) guided biopsies can detect prostate cancer more accurately, with a detection rate twice as high as previous data. The new targeted approach uses MRI and transrectal ultrasound fusion to identify clinically significant prostate cancer.
A recent study by pediatricians found that children who played non-educational games on touch-screen devices had lower verbal scores upon testing. In contrast, playing educational games showed no significant difference in developmental scores.
A recent study found that nearly half of physicians surveyed believe ADHD stimulant medication diversion is common among teens, while most have never received training on the topic. This lack of knowledge and expertise can lead to ineffective prevention strategies, posing health risks to patients.
A review by Kevin J. Tracey, MD, and Clifford S. Deutschman argues that treatment for sepsis is nonspecific and limited to organ support, with no approved drugs targeting the condition. Instead, a new approach focusing on immunometabolic and neurophysiological mechanisms may be needed.
A recent German study on a new drug therapy for chronic lymphocytic leukemia (CLL) has been published in the New England Journal of Medicine. North Shore-LIJ Cancer Institute doctors highlight that most CLL patients are elderly with coexisting health issues, and the study found that subjects receiving obinutuzumab-chlorambucil had an a...
An international group of investigators has discovered new genetic variations and cell types involved in inherited susceptibility to rheumatoid arthritis. The study provides a definitive list of major common genetic variation involved in the disease, leading to potential new therapies.
Researchers at The Feinstein Institute for Medical Research have discovered a genetic overlap between schizophrenia and general cognitive ability. This finding provides molecular confirmation of the overlap, revealing that patients with schizophrenia also experience reduced cognitive abilities.
A study published online in Cancer found that increased inflammation in the prostate gland may predict a reduced risk of developing prostate cancer. The study's findings suggest that biopsies performed on prostates with high inflammation levels may indicate a lower risk for subsequent cancer detection.
A new guideline recommends most immunocompromised patients receive annual influenza shots, while those with cancer or undergoing chemotherapy should not. The guideline aims to provide 'one-stop shopping' for clinicians caring for immunocompromised patients.
Researchers at The Feinstein Institute for Medical Research have discovered a new genetic risk factor called NDST3 for schizophrenia and bipolar disorder. This genetic variant alters the expression of the gene, affecting neurodevelopmental processes, offering potential therapeutic targets for treatment.
Triferic effectively delivers iron to the body's bone marrow, maintaining hemoglobin levels without rapid flux, a safer alternative to current intravenous injection methods. The study demonstrated its effectiveness in preventing iron overload and iron deficiency in 300 patients with chronic kidney disease undergoing dialysis.
Researchers at The Feinstein Institute for Medical Research identified the cold-inducible RNA-binding protein (CIRP) as a key player in triggering inflammation during hemorrhagic shock and sepsis. Blocking CIRP activity may improve patient survival rates, according to preclinical studies.
Carl Nathan, MD, receives $20,000 prize for discoveries in immunology; monograph published in Molecular Medicine explores inspiration and purpose in scientific inquiry. The Anthony Cerami Award aims to document innovations and discoveries in medicine and healthcare.
A new study presented at ASTRO's Annual Meeting has identified the Common-Terminology-Criteria-for-Adverse Events (CTCAE) scale as a reliable method for assessing patient reactions to radiation therapy. The study found that using this standardized scale improved consistency among caregivers, enabling more uniform and effective care.
A new process called 'Smart Rounds' optimizes the safety and efficacy of radiation therapy by formalizing multidisciplinary reviews at the beginning of treatment planning. This leads to safer, more individualized radiation treatment plans and better utilization of medical resources.
Researchers used PET scanning to map changes in brain metabolism in Huntington's disease gene carriers, identifying a characteristic network of abnormalities. This finding enables the tracking of disease progression and will aid in evaluating the effects of new drugs before symptoms appear.
A recent study by pediatricians from the Cohen Children's Medical Center of New York found that over 90% of medical specialists who diagnose and manage ADHD in preschoolers do not follow treatment guidelines. The study suggests that many specialists are recommending medication as part of their initial treatment plan, despite guidelines...
Researchers used atomic force microscopy to measure the mechanical properties of single cells in articular cartilage. They found that vimentin protein plays a key role in maintaining cell integrity, and that adult tissue has higher mechanical properties than young or old tissue.
Researchers are developing implantable electrical devices to target specific cells in the body and control diseases like inflammatory and autoimmune conditions. Initial results show that it is possible to manipulate neural signals specific to different inflammatory mediators.
A new protein, CALHM1, has been identified as a key regulator of the sense of taste. The discovery, made by Philippe Marambaud at the Feinstein Institute for Medical Research, sheds light on the mechanisms of communication between the brain and the senses.
The Northwell Health system has received a federal grant to train Hampton University students on the racial disparities in prostate cancer treatments. The program aims to improve treatment outcomes for African American men, who are disproportionately affected by the disease.
Researchers found that people with mild cognitive impairment and Alzheimer's disease struggle to process semantic information, leading to broader implications for daily functioning. Semantic processing deficits may be slowed through training, and could contribute to decline in activities of daily living.
Researchers at The Feinstein Institute for Medical Research have discovered that extract from mung bean can reduce the release of HMGB1, thereby increasing survival rates in mice. This finding has promise for the treatment of sepsis in humans.
The Feinstein Institute will conduct a two-year study to evaluate the physical, mental, and socioeconomic impact of the 9/11 attacks on responders. The study aims to identify health issues among WTC responders and develop prevention strategies.
The Feinstein Institute has received a $9.3 million federal grant to train clinicians on better care for patients with schizophrenia. The three-year grant will educate providers on new mental health protocols and technology resources to deliver more-effective treatments.
Researchers identified a genetic marker, microRNA, that differs in expression between African American and Caucasian women with breast cancer. The study found that African American patients overexpressed only six microRNAs, while Caucasian patients expressed 20 microRNAs, suggesting potential connections to treatment outcomes.
A retrospective analysis of 104 potential living kidney donors found that morbid obesity impedes kidney donation, with only three out of 23 morbidly obese donors able to successfully lose weight and donate. The study highlights the need for larger studies to assess the impact of obesity on kidney donation and explores ways to increase ...
A study published in Archives of General Psychiatry identified a gene, MC4R, that increases weight gain in patients treated with commonly-used antipsychotic drugs. Patients who carry the recessive variant of this gene gained up to 20 pounds during a 12-week trial.
Glioblastoma is an incurable disease with a one-year survival rate. Researchers at the Feinstein Institute are presenting new data on potential treatments, including pharmacological inhibition of microglia and PDZ-RhoGEF.
A genetic marker in blood can determine if a patient with ovarian cancer will benefit from chemotherapy after surgery. This discovery offers hope to patients diagnosed at stage III of the disease, who have a poor prognosis without effective treatment.
A collaborative study identified 5 novel genetic variation regions linked to Crohn's disease in Ashkenazi Jewish individuals, which have a two-to-four times higher prevalence compared to non-Jewish Europeans. These findings could lead to the discovery of new treatments for this debilitating disorder.
A new clinical trial demonstrates the effectiveness of adaptive radiotherapy in treating head and neck cancer, requiring only one or two replans to maintain treatment quality. The study found that ART keeps radiation tightly fitted to a patient's body, offering individualized treatment with minimal burden.
A new study found that women with BRCA1 or BRCA2 mutations inherited from their fathers tend to be diagnosed with breast cancer a decade earlier than those who inherit the genes from their mothers. The research analyzed 130 patients and discovered significant differences in age of diagnosis based on parent-of-origin effects.
A study published in The American Journal of Industrial Medicine found that WTC first responders suffer from asthma at more than twice the rate of the general U.S. population, with rates doubling between 2002 and 2005. Researchers tracked 20,834 responders who received medical screenings from 2002 to 2007, comparing their results to US...
Researchers identified a new type of T cell that can produce acetylcholine, a neurotransmitter that blocks inflammation. This discovery suggests a novel approach to treating inflammatory and autoimmune diseases by targeting the nerves and T cells.
A double-blind trial demonstrated a 23% improvement in motor symptoms among patients receiving gene therapy for advanced Parkinson's disease, compared to a 12% improvement in those receiving sham surgery. The study suggests a potential breakthrough in treating this progressive movement disorder.
A perinatal safety initiative led by Northwell Health has significantly reduced adverse obstetrical outcomes, including returning to the operating room and birth trauma, from 2% to 0.8% over a two-year period.
A new study by Long Island Jewish Medical Center and The Feinstein Institute for Medical Research found that fine particles of pollution can increase the risk of sudden cardiac arrest. For every 10ug/m3 rise in small particle air pollution, there was a four-to-ten percent increase in out-of-hospital cardiac arrests.
A new experimental thyroid drug, Eprotirome, lowers cholesterol levels without causing the classic thyroid risks to the heart and bone. It also reduced lipoprotein A levels by 33%.
Researchers found a link between the MET proto-oncogene and reduced cancer risk in people with schizophrenia, suggesting an intriguing relationship between cancer-related genes and schizophrenia susceptibility. The study suggests that the gene's activation mechanism may be similar to its role in autism.
A new study by Louis Potters and colleagues found that permanent prostate brachytherapy is an effective treatment option for younger patients diagnosed with prostate cancer, with success rates comparable to older patients. The study analyzed data from 2,119 patients and showed that age didn't impact the long-term therapeutic outcome of...
Researchers at Northwell Health have identified a new risk factor gene, REL, associated with rheumatoid arthritis. The study found that this gene is common in people in North America and may confer an important survival advantage.
A multi-center study found that antidepressant citalopram had no significant effect on reducing repetitive behaviors in children with autism spectrum disorder. The study included 149 children aged five to 17 and tested the treatment over a 12-week period.
Researchers identified a new anatomical path through which the brain and spleen communicate, enabling the immune system to respond to disease. The study suggests that stimulating the vagus nerve can suppress inflammation-producing molecules in the spleen, potentially leading to new treatments for sepsis.