Researchers found that antidepressant Zoloft accumulates in yeast cells, inducing autophagy and causing membrane distortions. This response supports the idea that depression may be linked to diminished BDNF secretions and suggests alternative targets for next-generation antidepressants.
A Princeton University study found that socioeconomic differences account for 80% of the life-expectancy divide between black and white men, and 70% for women. Socioeconomic factors such as income and education are significant contributors to the racial gap in mortality.
Astronomers have detected a cosmic effect that could provide insight into the forces behind the universe's formation, including dark energy and dark matter. The kSZ effect was seen in the movement of distant galaxy clusters, with velocities measured up to 600 kilometers per second.
Princeton scientists have identified unique neural activity sequences in the brain's posterior parietal cortex that help form short-term memories used for decision-making. These sequences correspond to whether a mouse turns left or right in a maze, allowing researchers to predict its future actions.
Researchers have developed long-lasting flu vaccines that target more constant proteins with less evolutionary flair, reducing the virus' ability to spread and mutate. These universal vaccines could make a bout with influenza less severe, making it easier to control the virus' spread.
Researchers from Princeton University and MIT found that projected increases in sea level and storm intensity brought on by climate change would make devastating storm surges more frequent. They developed a simulation tool that can predict the severity of future flooding an area can expect.
A family history of psychiatric conditions such as autism and depression may shape a person's intellectual interests. The study found that students interested in humanities or social sciences were more likely to report a family member with mood disorders or substance abuse, while those interested in science and technical majors were mo...
A recent study by Princeton researchers found that Hurricane Katrina survivors continued to experience poor mental health nearly five years after the storm. The study, which tracked low-income mothers in the New Orleans area before and after the disaster, showed a persistence of high levels of post-traumatic stress symptoms.
A Princeton University research team found that uninformed individuals can act as a counterbalance to minority groups, restoring majority rule. The study challenges the common notion that an outspoken minority can manipulate uncommitted voters.
A Princeton University study found that nighttime-lights imagery can pinpoint disease hotspots in urban areas with migratory populations. The technique accurately indicates fluctuations in population density, which is linked to the risk of epidemic.
Researchers at Princeton University have developed a technique to accelerate chemical discoveries by performing over 1,000 reactions per day using robotics. This approach enables the rapid exploration of new chemical combinations, potentially leading to breakthroughs in pharmaceuticals and other fields.
Researchers from Princeton University reject the prevailing theory that a single large meteorite caused the mass extinction event at the end of the Cretaceous period. Instead, they link the extinction to massive volcanic eruptions in western India known as the Deccan Traps, which were 3 times larger than France.
Invasive species like ship rats and non-native birds can become essential to ecosystems when native pollinators disappear. Researchers found that these 'alien' species perform similar functions as extinct native pollinators in New Zealand's North Island.
A new climate study found that daily weather variations have become more erratic and extreme, with significant fluctuations in sunshine and rainfall. This increase in variability could alter the distribution of heat and rainfall, affecting ecosystem stability and industries such as agriculture and solar-energy production.
The Princeton study suggests that savanna wildfires play a crucial role in maintaining the division between forests and savannas. The researchers found that regular fires prevent trees from establishing and savannas from turning into forest. However, human activities such as climate change, road construction, and fire prevention measur...
Researchers at Princeton University have developed a new model that simulates the seismic fallout of a giant meteorite strike, showing that the impact's effects are scattered and unfocused, resulting in less severe ground displacement and tsunamis. The model also provides new insights into the surface and interior details of other plan...
A Princeton University study found that people are more likely to yawn in winter than summer due to ambient temperatures. The researchers believe that yawning could serve as a method for regulating brain temperature.
Researchers at Princeton University and NYU have developed a method to detect the collision of stars with primordial black holes, which are believed to be a source of dark matter. The new technique uses existing solar observation methods to identify subtle vibrations in a star's surface caused by a passing black hole.
Researchers at Princeton University found that changes in gene activity consistently coincided with the worsening of a patient's condition. The study used blood samples from 168 blunt-force trauma patients and identified two sets of genes that showed massive fluctuations in expression as patients developed complications and neared death.
Researchers at Princeton University have matched brain activity with categories of words related to abstract ideas. The study reveals how the brain processes complex thoughts and identifies 'semantic threads' connecting related concepts.
Embryos avoid fatal chaos through a synchronized cell cycle mechanism triggered by the calcium wave, which sets cells to the same developmental timetable. The researchers' simulation shows that this rapid spread of oscillation is crucial for preventing disarray and ensuring the embryo's survival.
A new study published in Science found that high-ranking male baboons have higher stress-hormone levels than lower-ranking males, even during periods of stability. This suggests that life at the top has a real downside and being an alpha male comes at a cost.
A Princeton University research team has unraveled the mystery of how breast cancer tumors take root in the bone. The discovery highlights a specific protein called Jagged1 that sends destructive signals to cells, disrupting normal bone growth and paving the way for potential drug therapies.
Researchers create genetic sequences never seen in nature and produce substances sustaining life in cells almost as readily as natural proteins. The team's work represents a significant advance in synthetic biology, suggesting the construction of artificial genomes capable of sustaining cell life may be within reach.
Researchers at Princeton University discovered a gene, CCDC40, associated with congenital heart defects in humans. The gene controls right-to-left patterning and is also linked to respiratory disorders.
A Princeton scientist has recast two well-known math problems as physics questions, providing new tools for solving challenges in data compression, gravitational waves, and more. The reformulation offers insights into the role of randomness and disorder.
Researchers have created a material that exhibits dual electronic properties, acting as both a normal superconductor and a metal at low temperatures. This discovery could enable the development of energy-efficient quantum computers with fault-resistant capabilities, but significant technical hurdles remain to be overcome.
A Princeton University study found that wild Scottish sheep with stronger immunity lived longer, but were less fertile, and vice versa. The research suggests a balance between strong and weak immune responses in the population.
Researchers have identified key genes controlling reproductive lifespan in roundworms, which may lead to the development of fertility-preserving treatments for women. The study's findings suggest that quality over quantity is a limiting factor in human reproduction, and that similar genes are shared between humans and worms.
Fibroblasts, a type of connective tissue cell, have been found to be metabolically active during quiescence, producing proteins that help replenish other cells. This discovery could lead to new strategies for attacking tumors and improving overall health.
A Princeton University-led team has developed a system to produce realistic movie simulations of earthquakes based on complex computer models. The movies will be made available worldwide within hours of an earthquake, providing researchers with enhanced understanding and tools to improve maps of the Earth's interior.
Researchers at Princeton University have developed 3D computer simulations of supernovae explosions, providing new insights into the universe. The simulations match massive blow-outs observed by astronomers and may lead to a better understanding of the physics involved.
Princeton researchers uncover ancient sponge-like creatures with fossilized shells dating to 650 million years ago, rewriting the timeline of life on Earth. The discovery provides direct evidence that animal life existed before and survived a severe 'snowball Earth' event.
Seemingly redundant portions of the fruit fly genome contribute to normal development by ensuring genes are turned on and off at the appropriate times. The discovery sheds light on the potential importance of 'junk DNA' in understanding developmental disorders.
Princeton researchers have found unique electrons that can bypass obstacles and flow efficiently on surfaces of certain materials, potentially revolutionizing electronics. This discovery opens the door to creating faster integrated circuits by leveraging the flow of surface electrons.
Princeton University researchers are developing a new method for studying brain connectivity using genetically engineered viruses. The viruses, designed by Lynn Enquist's team, travel through the nervous system, tracing connections between neurons and reporting on their activity. This approach has significant implications for understan...
Researchers have detected subatomic particles, known as geoneutrinos, which could help understand the Earth's internal heat and its impact on geological events like earthquakes and volcanoes. The discovery has significant implications for predicting such events in the future.
Researchers at Princeton University found that a chemical signal called cAMP can induce coordinated movement in cells, leading to the formation of groups. This discovery has implications for understanding collective behavior in humans and other organisms, from white blood cells to organ development.
Research at Princeton University found that caloric restriction impairs long-term memory in early adulthood but does not further decline it with age. In contrast, reducing insulin signaling improves learning ability and maintains it better with age. The study has implications for treating cognitive decline associated with aging.
Researchers found a large shift in the carbon cycle during the Cryogenian period, which may have been triggered by the Sturtian glaciation. The disturbance could have led to the accumulation of organic carbon in the ocean and had far-reaching effects on Earth's climate.
Researchers have devised a method to identify genetic material responsible for complex traits in millions of yeast cells, shedding light on the missing heritability problem. By studying regions of the genome that cause specific traits in offspring, scientists can detect subtle patterns previously undetectable.
A Princeton University-led team tracked fever and sickness behaviors in song sparrows using radio transmitters, discovering that different populations respond differently to infection. The study's findings may aid in forecasting where diseases will take hold, including West Nile virus.
Researchers found that rats fed high-fructose corn syrup gained significantly more weight than those with table sugar, leading to abnormal increases in body fat and triglycerides. The study highlights the link between high-fructose corn syrup consumption and obesity, particularly in the context of metabolic syndrome.
A group of 27 scientists and conservationists warn that allowing ivory sales in Tanzania and Zambia could lead to increased poaching and threaten the recovery of African elephants. The countries have not met the convention's standards for taking part in legal ivory trade, and China and Japan are major consumers of illegal ivory.
A team of Princeton University scientists tested Albert Einstein's theory of general relativity at cosmic scales, concluding it works as well in vast distances as in local regions. They analyzed over 70,000 galaxies and demonstrated that the universe follows Einstein's rules up to 3.5 billion light years from Earth.
A Princeton University-led research team discovered that protein competition for an enzyme provides a mechanism to integrate different signals directing early embryonic development. This competition influences which signals are sent to cells, establishing a biochemical mode of signal integration.
A team of scientists is researching self-cannibalizing cancer cells to develop new therapies. Cancer cells can stop proliferating and consume themselves when stressed, allowing them to survive enormous amounts of stress.
Jason Petta's discovery enables control of single electrons, achieving rapid manipulation without disturbing surrounding trillions. This breakthrough paves the way for future high-capacity quantum computers.
Researchers observe complex electron patterns resembling fractals in a gallium arsenide semiconductor, revealing the transition point where it becomes magnetic. The findings suggest that magnetism arises from localized interactions within these fractal puddles.
A new study finds that Earth's polar ice sheets are susceptible to significant melting under moderate global warming scenarios, potentially leading to a 6-9 meter sea level rise. This could result in permanent submersion of low-lying coastal areas and hundreds of millions of people being displaced.