A study found that healthcare providers and women have different priorities when it comes to contraception. For women, safety and side effects are top concerns, while providers focus on method usage and effectiveness. The mismatch between these priorities underscores the need for shared decision-making processes.
Researchers found that early palliative support services significantly reduced depression and feelings of overwhelm among family caregivers, improving overall quality of life. The study suggests that timely intervention can better equip caregivers to cope with the demands of caring for patients with advanced cancer.
Research confirms BRCA2 gene mutations increase lung cancer risk by 1.8 times in smokers and double the risk for some individuals. The study also identified associations with CHEK2 and TP63 genes, highlighting potential targets for early screening and treatment.
The study found that physician-led ACOs are more likely to have comprehensive care management programs and advanced IT capabilities. These organizations also tend to measure and report financial and quality performance at the clinician level.
Practitioners can use shared decision making and motivational interviewing to adapt approaches for different clinical situations.
Researchers identified potentially actionable mutations in cancers of the appendix using next-generation DNA sequencing. KRAS and GNAS mutations were found to be common alterations in both low-grade appendiceal mucinous neoplasm (LAMN) and adenocarcinoma tumors.
Researchers at Dartmouth's Norris Cotton Cancer Center have discovered a new epigenetic mechanism that distinguishes normal blood stem cells from blood cancers. This finding holds promise for developing targeted treatments that preserve healthy stem cells while killing leukemia cells.
Researchers developed a new gene expression analysis approach to identify cancer-associated genes from microarray data, outperforming traditional methods. The variance-based approach identified high variation in adjacent 'normal' tissue samples and preferentially selected genes specifically associated with cancer.
Dartmouth researchers found tweens who participate in coached team sports are less likely to try smoking. Participating in other clubs was also associated with lower risk of trying drinking.
Dartmouth has been awarded a grant to serve as a Lead Academic Participating Site in the National Clinical Trials Network, aiming to streamline clinical trial operations and improve access to new treatments. The network's goals include faster trial design, optimal use of scientific innovations, and expanded patient participation.
Researchers found that false-positive mammograms have a temporary and limited impact on women's overall health and well-being. The study also showed that women who experience a false positive may actually be more likely to use breast cancer screening in the future.
A new study by Dartmouth investigators finds Medicare's current risk-adjustment methodology is flawed and ineffective in adjusting for population differences. The researchers suggest using wealth and health indices as an alternative to explain regional mortality rates, outperforming the current diagnosis-based method.
As the US population ages, Alzheimer's disease is projected to increase from 3 million in 2011 to over 10 million by 2050, affecting broad-based national policies. The annual cost of care for people over 70 is estimated at $157-$215 billion, with costs expected to reach $1.2-$1.6 trillion by 2040.
A national survey of over 2,500 teens and young adults found a strong association between liking music with alcohol brand references and increased binge drinking. The study suggests that policy interventions targeting these references could help reduce teen alcohol consumption.
Researchers at Dartmouth's Geisel School of Medicine identified a potential therapeutic target for glioblastoma multiforme, a deadly form of brain cancer. The study found that STK17A protein is induced in response to DNA damage and is correlated with poorer outcomes.
Researchers at Dartmouth found that disrupting VISTA, a protein preventing overreaction, enhanced the immune system. This discovery may lead to new cancer treatments using the immune system.
A new study by Dartmouth researchers found that young people are increasingly influenced by tobacco marketing, with exposure to coupons and websites associated with increased smoking rates. Black and Hispanic youth are disproportionately affected.
Researchers at Dartmouth developed a more accurate and safer treatment for pancreatic cancer by analyzing pre-treatment CT scans. The study found that blood volume in tumors is a key predictor of treatment response, making PDT easier, faster, and more effective.
A study by Dartmouth researchers found that fast food giants' advertisements for healthier kids' meals frequently go unnoticed by young viewers. Only one-half of the target audience correctly identified milk in McDonald's ads and sliced apples in Burger King's ads, highlighting poor communication about nutritional value.
A new study found that certain genetic variants, such as ALDH2 and VCAM1, can predict bladder cancer recurrence in patients. These variants can help identify high-risk patients who require more frequent screenings and aggressive treatment, improving quality of life for all bladder cancer patients.
Researchers at Dartmouth's Norris Cotton Cancer Center have compiled a review of genetic-based testing in breast cancer diagnosis and treatment. Genomic testing enables personalized therapy, increasing precision and success rates for patients.
Researchers have developed a novel approach to treating CLL by disrupting the activity of the NF-kappaB pathway, which ensures survival and resistance of CLL cells. This approach may lead to re-sensitization of CLL cells to conventional chemotherapy and novel agents.
Researchers question the effectiveness of using financial incentives to change hospital behavior, citing potential drawbacks such as neglecting population health. They recommend broadening the scope of readmissions programs to include admissions and incentivizing broader goals.
Researchers at Norris Cotton Cancer Center have developed an antibody that targets the ProAVP surface marker in small-cell lung cancer. The antibody, MAG-1, significantly slows tumor growth in mice and has shown promise as a potential treatment for recurrent small-cell lung cancer.
Researchers have successfully activated an immune system response in mice by applying localized heat to tumors, which then targeted and eliminated other tumor sites. This innovative approach uses iron-oxide nanoparticles and magnetic energy to kickstart the immune system against metastatic tumors.
A study published in Journal of Medical Internet Research found that doctor jokes posted on Facebook received significant likes and were often successful. The researchers analyzed over 33,000 Facebook users and identified 263 who posted a joke referencing doctors, with the majority being successful.
Two approved weight-loss drugs have been linked to serious harms, including memory and depression problems, and cardiovascular risks. Researchers question the FDA's decision to approve these medications without more definitive evidence.
A study found that telemedicine can reduce hospitalizations for nursing home residents by 5.3-9.7%, saving Medicare millions of dollars per year. The key to successful implementation lies in engagement, as simply making telemedicine available does not guarantee its use.
Researchers at Dartmouth have developed a protocol to harvest and culture mouse melanoma cells, which are rare in human form but prevalent in mice. This breakthrough allows for more accurate modeling of human melanoma, potentially leading to new treatments.
A new biological pathway-based computational model, called PHPN, mines large publicly available disease datasets to find shared genetic connections between diseases. The model offers a visual representation of the relationships between diseases and phenotype's at the systems level.
The Choosing Wisely campaign has sparked discussion on low-value services, but more work is needed to include common and costly services. The campaign's lists have been criticized for only including low-impact services for physicians and patients to question.
A systematic review found that patient decision support interventions have inconsistent results in reducing healthcare spending, with some studies predicting savings ranging from $8 to $3,068 per patient. The impact on treatment utilization rates was mixed and the quality of economic analyses varied.
Researchers have made refinements to a technique combining MRI and near-infrared spectroscopy (NIRS) to improve image quality and accuracy in detecting breast cancer. The new design allows for increased coverage of the chest, providing improved visibility for 'hard-to-see' areas, and has shown promising results in clinical trials.
Researchers have successfully used the Cherenkov effect to capture and visualize radiation beams entering or exiting the human body. This breakthrough technology enables doctors to see the dose of radiation to the skin and detect errors in dosage, potentially reducing side effects like skin reactions during breast cancer treatment.
Researchers found that coevolution between humans and H. pylori bacteria reduced gastric cancer risk in people of African descent, but not in Amerindian descent. The study suggests that the interaction between H. pylori and human ancestry influenced disease risk, with high African-strain infection leading to worse outcomes.
A new analysis reveals steady progress against cancer's burden, despite underestimation due to other disease advancements. Researchers measured years of life lost to cancer and found increased longevity offsetting progress.
Lynch syndrome increases the risk of colon and endometrial cancers. Screening all endometrial cancers for this genetic mutation can lead to early detection and improved patient outcomes for women at high risk.
Researchers developed a new statistical model, NOIA, which showed increased power for detecting genetic effects and interactions in cutaneous melanoma. The study identified significant associated genes HERC2, MC1R, and CDKN2A, providing new insights into the influence of gene-gene interactions on melanoma risk.
Dartmouth researcher Scott Williams found that a person can have multiple DNA mutations in different parts of their body, resulting in varying genotypes. These discoveries challenge traditional views on human uniqueness and may impact forensic analysis, paternity testing, and genetic screening.
A Dartmouth researcher found that oxygen can keep dying heart cells alive by providing spikes of oxygen. This discovery could lead to new treatments for congestive heart failure, which is often caused by cell death due to lack of oxygen. The research suggests that controlled breathing exercises may also have health benefits.
The National Institutes of Health has awarded a $5.9 million grant to the Geisel School of Medicine at Dartmouth for its Lung Biology Center of Biomedical Research Excellence. This funding supports cystic fibrosis research and translates basic science into clinical applications.
Researchers at Dartmouth's Geisel School of Medicine discovered that cyclin A plays a crucial role in ensuring faithful chromosome segregation during cell division. In contrast to normal cells, cancer cells often fail to correct errors, leading to abnormal numbers of chromosomes and resistance to chemotherapy treatments.
A study published in Nature reveals that attention operates at the synapse level to sharpen signals and selectively boost relevant information. The results have implications for improving screening and treatments for people with attention deficits resulting from brain injury or disease.
Researchers are studying the evolution and biology of human pregnancy, genetic factors contributing to preterm birth, and racial disparities in preterm birth rates. The study aims to identify potential targets for further research and address environmental factors such as drinking or smoking.
The Geisel School of Medicine at Dartmouth has launched a handbook for rural health care ethics, addressing the gaps in resources for regional clinicians. The guide covers case studies and personal ethical challenges faced by healthcare professionals in rural settings.
Researchers have discovered a connection between gene expression and the development of lung disease in scleroderma patients. The study suggests that a specific gene profile may predict which individuals are at risk of developing lung complications, providing potential targets for new treatments.
A Dartmouth study found that adjuvant radiotherapy can prevent tumor recurrence in patients with borderline-malignant and malignant phyllodes tumors after breast-conserving surgery. The treatment was effective in controlling the growth of tumors in nearly 80% of cases.
A Dartmouth study has found that patients taking immunosuppressive drugs such as glucocorticoids may be at higher risk of developing bladder cancer. The research examined the long-term use of glucocorticoids in 786 bladder-cancer patients and 1,083 control subjects, revealing a potential link between the two.
Researchers develop method to target genes in Toxoplasma gondii, a parasite responsible for malaria and diarrhea. The breakthrough enables the creation of safe and effective genetically modified vaccines and drug therapies.
A Dartmouth-led study of young U.S. teens found that owning alcohol-branded merchandise is associated with an increased risk of transitioning from susceptibility to binge drinking. The study also discovered that teens who own these items are more likely to develop positive attitudes towards drinking and initiate alcohol use.