Scientists at University at Buffalo used chitinase to identify the extracellular transport signal of cholera toxin, a crucial step in understanding how bacteria cause disease. The researchers found that only a portion of a specific region of the protein was essential for its secretion.
A study suggests that insulin can suppress a pro-inflammatory transcription factor that promotes clot formation in blood vessels. Insulin infusion reduced levels of tissue factor and plasminogen activator inhibitor-1, key players in the development of human and mouse atherosclerosis.
A team of UB researchers has discovered a novel peptide in human saliva with potent antimicrobial activity against various types of bacteria and fungi, including drug-resistant strains. The peptide, labeled MUC7 20-mer, shows activity at very low concentrations and little toxicity to mammalian cells.
A study of German subjects found periodontal disease bacteria in carotid artery samples, supporting the 'infectious burden' hypothesis that oral infection plays a role in atherogenesis. The study also identified multiple types of bacteria, suggesting a complex relationship between gum disease and cardiovascular disease.
Researchers from the University at Buffalo School of Dental Medicine found no relationship between long-term exposure to dental aerosols and respiratory illness among dental students. The study, which analyzed data from over 800 students, suggests that breathing in mists spun off by drills may not cause respiratory problems.
Research found that people who habitually sleep more than 8 hours a night and those who need daytime naps have a 50% increased risk of dying, with nearly three times the risk from stroke. The study suggests an underlying sleep disorder may be to blame.
A UB team has demonstrated a breakthrough in three-photon pumped frequency upconversion, producing fluorescent emissions with higher energy than the laser's pumping photon. This process enables efficient light production for applications such as optical imaging, bioimaging, diagnostics and photodynamic therapy of deep tissue tumors.
University at Buffalo researchers have developed reusable chemical sensors that can detect hundreds of chemicals in an area smaller than a dime. The new technology uses pin-printing to create xerogel-based sensors, which are rigid materials with intricate networks of nanoscopic pores.
Researchers developed a detailed hazard map for Pico de Orizaba, Mexico's highest mountain, using advanced technologies and computer simulations. The map reveals three levels of hazard based on probability, enabling local authorities to prepare for various events such as landslides, mudflows, and eruptions.
Researchers at the University at Buffalo have performed simulations that mimic hydrocarbon combustion, demonstrating a defining feature of combustion and gaining insights into the two-way interaction between chemistry and turbulence. The work aims to develop more realistic models of fluid mechanics and chemistry involved in combustion.
A study of 2,600 Americans found that between 1-2% have a compulsive gambling problem, with rates higher among minorities and lower-income individuals. Problem drinkers are 23 times more likely to also have a gambling issue.
UB researchers found that Ritalin can cause long-lasting changes in brain cell structure and function, similar to other stimulant drugs. The study suggests that Ritalin's effects may outlast the initial dose, leading to concerns about its long-term impact on the brain.
Theoretical physicists at UB have developed a system that can reduce the amplitude of physical impact by 95-98 percent, and harness dissipated energy into usable thermal energy. The research has potential applications in bridge, ship, and building protection, as well as harnessing energy from natural phenomena.
Researchers investigating cumulative effect of maternal cocaine use on infants' mental development, examining interactions with environment, family violence, and substance co-use. The study aims to understand how children develop self-regulation and control impulses.
Researchers at the University of Buffalo have discovered that cells 'wiggle' at high speeds when exposed to voltage changes, without relying on special proteins or lipids. This fundamental property of cells opens up new avenues for studying cell motility and its potential applications in medicine.
A new study by University at Buffalo researchers found that insulin can reduce pro-inflammatory components in the bloodstream while increasing anti-inflammatory components. The results suggest that insulin may have anti-atherosclerotic effects and potentially reduce the risk of heart attack, contrary to previous assumptions.
A UB study found that Mexican Americans who primarily speak Spanish and are less 'Americanized' are significantly less active during leisure time. This disparity is associated with acculturation, which affects physical activity habits.
Research finds that fathers' alcohol abuse and depression are associated with emotional and behavioral problems in children, including anxiety and depression. The study also highlights the importance of considering maternal depression when evaluating the effects of paternal alcohol abuse.
A study by UB researchers found that more than half of survivors diagnosed with uncontrolled high blood pressure still had hypertension, and 46% of those with dangerously high cholesterol continued to have high levels. This highlights the need for improved secondary prevention strategies in the US population.
A study published in Ethnicity and Disease found that cocaine use and hypertension are major risk factors for brain hemorrhage in young African Americans. The researchers also discovered that the incidence of intracerebral hemorrhage is nearly 50 times higher in African Americans than in white patients.
Researchers found a significant association between chronic respiratory disease and periodontal disease in the Third National Health and Nutrition Examination Survey. Poor oral health worsens respiratory function and may increase risk of serious lower-respiratory-tract infections.
Researchers at the University at Buffalo have developed a computer program that can analyze handwriting and determine authorship with high accuracy. The software uses scientific criteria to quantify performance and increase confidence in identifying writers, which is essential for admitting handwriting evidence in U.S. courts.
A specific protein isolated from Chilean tarantula venom shows promise as a basis for new drugs to prevent atrial fibrillation, a major cause of death following a heart attack. The research demonstrates the physiological function of mechanosensitive ion channels in the heart for the first time.
A new study from the University at Buffalo reveals that obese individuals carry a massive oxidative load that increases their risk of heart disease. Severe calorie restriction decreases free radical production by over 50%, reducing the risk of developing heart disease without medication.
The Hauptman-Woodward Medical Research Institute and University at Buffalo have received $3.13 million to develop new methods for determining protein structure, crucial for designing new drugs. Researchers will use X-ray crystallography and NMR spectroscopy to determine protein structures.
Researchers found a cellular signaling system that responds to THC and anandamide regulates sperm functions required for fertilization in humans. Heavy marijuana users may jeopardize fertility by overloading this natural signaling system.
University at Buffalo chemists found that nitric oxide is highly reactive with ethanol, making it a potentially more insidious pollutant. The study's findings provide new insights into how solvation affects chemical reactions and could help scientists better tailor lab experiments.
A new UB study reveals a significant association between breast cancer risk and physical characteristics of insulin resistance, including abdominal fat distribution and higher-than-normal male and female sex hormones. Women with increased waist-to-hip ratio and oily skin are at greater risk of developing breast cancer.
Massive sheets of lava produced by flood basalt eruptions generated intense heat, pushing ash and gas into the upper atmosphere and causing dramatic global-scale climate shifts. These events are now believed to have contributed to mass extinctions, including those that wiped out dinosaurs.
A recent study found that 57% of women who drank in bars reported experiencing verbal or physical aggression. Women should be aware of their own risky behaviors and the bar environment's impact on aggression.
Researchers at the University at Buffalo have found that a combination of fish oil and vitamin E reduces inflammation-inducing cytokines in mice with rheumatoid arthritis. This study suggests that these nutrients may delay symptoms and improve function for patients with this disease.
A University at Buffalo study has found that people with severe gum disease are twice as likely to suffer a stroke due to blocked arteries. Periodontal disease was associated with an increased risk for cerebrovascular events, particularly non-hemorrhagic strokes.
A prospective study of 10,786 Italian women found a 40% lower risk of breast cancer in premenopausal women with the C-2 estrogen metabolism pathway, which produces less active by-products. Lifestyle changes such as physical activity and a low-fat diet high in cruciferous vegetables may shift estrogen metabolism from high-risk to low-risk.
A recent UB study found no association between high-normal iron levels and risk of death due to cardiovascular disease, coronary heart disease or heart attack. However, black men with low levels of excess iron were at three times the risk of death from any cause.
Children born prematurely are 3 to 4 times more likely to be educational underachievers than full-term children. Targeted educational intervention programs can help maximize their academic potential. The study controlled for age, race, maternal education, and foster-care placement.
Researchers found that children with a parent who had a premature heart attack showed structural and functional abnormalities in their arteries as young as 6 years old. These changes included thickened vessel walls and decreased reactivity, which can lead to atherosclerosis and increase the risk of heart disease.
The University at Buffalo is leading a $10 million DARPA project to develop specific ferromagnetic materials for use in spintronics. The goal is to create magnetic semiconductors and prototype devices to exploit electron spin properties, enabling new functions in data processing, storage, and communications.
Researchers at the University at Buffalo found that impaired pulmonary function was associated with increased risk of mortality over a nearly 30-year period. The study showed that individuals with poorer lung function were more than twice as likely to die, highlighting the importance of regular lung function testing
Elaine M. Hull receives a $602,759 Independent Scientist Award to expand her research on hormone and neurotransmitter interactions in the brain. She aims to clarify how gonadal hormones influence neurotransmitter release in the medial preoptic area, essential for male copulation in all vertebrate species.
A study published in The Journal of Clinical Endocrinology and Metabolism found that excess glucose consumption stimulates the generation of free radicals, which can damage cells lining blood vessels. The researchers also observed a decrease in levels of a-tocopherol, a powerful antioxidant.
Insulin reduces expression of molecule promoting inflammation and clogging of arteries, increasing production of vasodilator nitric oxide. The study's findings indicate insulin may have an antiatherosclerotic role, potentially protecting people at risk of CVD.
Anthony Auerbach, a University at Buffalo biophysicist, has been awarded a $2.7 million Jacob Javits Neuroscience Investigator Award to continue his distinguished research on cell communication and synapses. His focus will be on understanding acetylcholine receptors, proteins that facilitate chemical messages across brain synapses.
The University at Buffalo will host a global conference on environmental health, bringing together over 500 researchers and experts from around the world. The conference aims to assess the worldwide disease burden caused by environmental problems and build connections among health centers in Pan America and globally.
A recent UB study found that the 'healthy worker effect' can skew results of health studies involving workers, particularly among female nuclear-weapons workers. The study suggests that this bias must be taken into account to obtain accurate results, emphasizing the need for appropriate comparisons and consideration of unexposed workers.
A University at Buffalo study found that a woman's biology, specifically age at first menstruation and first live birth, are major predictors of resolved fertility in fertile women, not lifestyle habits. Women over 30 at first live birth were three times more likely to take longer than a year to conceive.
A study by Scott Coffey found that cocaine withdrawal symptoms are relatively mild and decrease steadily over time, with improvements in depression, anxiety, and energy levels.
A UB study found that obese children are more likely to have high levels of triglycerides and low levels of protective cholesterol, increasing the risk of heart disease later in life. The research, which analyzed data from over 4,000 children, suggests that monitoring body mass index is crucial for early detection of dyslipidemia.
A new study by the University at Buffalo has found that African Americans and Mexican Americans experience significantly poorer oral health than white Americans. The research, based on national data from 1988-94, shows that nearly half of African American men and one-third of African American women had periodontal disease, compared to ...
A University at Buffalo study found that men with testicular cancer are two-thirds less likely to have fathered a live infant and nine times more likely to have been diagnosed as infertile than healthy controls. The research contradicts earlier findings that showed no relationship between fertility and testicular cancer diagnosis.
A University at Buffalo study shows that exercise training improves muscle function and protects against injury in aging animals. Regular exercise can help prevent frailty in seniors by strengthening muscles and reducing the risk of injury.