Researchers found that a small region of tissue at the front edge of what in humans would be the upper lip controls development of the upper half of the face. Facial tissues remain responsive to their environment for about nine weeks, or through most of the first trimester.
Researchers have identified the matchmaker protein SYG-1, which guides nerve cells to form synapses during embryonic development. This discovery may lead to new treatments for disorders such as chronic epilepsy and chronic pain, where synapse formation goes awry.
A new study found that providing integrated medical and health care services can reverse disparities in health outcomes between African Americans and whites. The research, published in the Journal of the American Geriatric Society, compared health status and survival rates of elderly African American and white participants enrolled in ...
A new study suggests that middle-aged mice burn fewer calories during exercise, contributing to weight gain. The researchers identified the serotonin 5-HT(2c) receptor as a potential target for therapy.
The article highlights the critical state of primary care in the United States, citing organizational and financial pressures that threaten its viability. The UCSF-led report proposes seven principles for reconstructing primary care, focusing on patient-centered care, adequate reimbursement, and improved education.
A comparative herbal study found that ephedra is hundreds of times riskier than other commonly used herbs, posing a risk 200 times greater than all other herbal supplements combined. The study's findings prompted calls for more stringent regulation or banning of the substance by the U.S. Food and Drug Administration.
Researchers found that a molecular sticking process stops the embryo's journey along the uterine wall and starts attaching it to the wall, creating a sticky environment. The discovery of L-selectin protein helps to understand human embryo implantation and may prove useful to treat infertility.
Researchers found that using interactive techniques, such as checking patient recall and comprehension, can improve diabetes control without requiring longer visits. This technique is underused by physicians but holds great potential for improving patient outcomes.
A study by UCSF researchers reveals that the human gene BOULE regulates meiosis in sperm development, a key step in creating sperm and eggs. The finding has significant implications for understanding infertility and developing new treatments, including drugs to assist immature sperm cells or block sperm maturation.
A meta-analysis of 29 trials found that cholinesterase inhibitors improved behavioral and functional status in patients with mild to moderate Alzheimer's disease. The study suggests potential benefits for improving quality of life and reducing caregiver burdens, but long-term research is needed to confirm these findings.
Researchers found that hormone therapy (HRT) significantly reduced the risk of developing type 2 diabetes among postmenopausal women with coronary heart disease and impaired fasting glucose. The study, published in Annals of Internal Medicine, suggests HRT may have metabolic benefits that outweigh the risks for certain high-risk groups.
A new study suggests that high levels of inflammatory protein CRP are strongly associated with an increased risk of ischemic heart disease. The research found that patients taking beta blockers and statins had less inflammation, indicating that treating inflammation may play a crucial role in preventing heart disease.
A recent study published in Archives of Internal Medicine found that individuals with depressive symptoms are more likely to experience unemployment or loss of income. The research suggests a significant economic impact of depression on employment and income, highlighting the need for increased awareness and treatment.
Physician participation in HMOs and IPAs has declined significantly, with 33% of specialists without HMO patients in 2001/2002. Kaiser Permanente stands out as the most stable employer for physicians, with higher satisfaction rates compared to other managed care networks.
A large randomized trial found no improvement in cognitive function among postmenopausal women with coronary disease after four years of hormone replacement therapy. The study provides no evidence regarding the effect of estrogen-only therapy on cognition, contradicting some previous studies that showed an improvement in younger women
A UCSF study of 239 men who have sex with men found no cases of HIV transmission through receptive oral sex. The study contradicts previous case reports and confirms the probability of zero transmission for this activity.
The new center will be equipped with a high-field MRI/MR spectroscopy system, allowing for early detection and monitoring of Alzheimer's disease. The center will also conduct research on newest drug treatments for neurodegenerative disorders.
Researchers discovered a key molecule regulating multiple genes in yeast and humans, potentially enabling rapid response to stress. The molecule, inositol polyphosphate, affects hundreds of genes by regulating enzymes that alter chromatin structure.
Researchers found that a cholesterol drug, atorvastatin, reduced paralysis and suppressed attacks in mice with multiple sclerosis. The study suggests that the drug could prevent progression to definite multiple sclerosis in individuals who have had a first attack.
The new guidelines identify five major areas of concern: insulin resistance, lipid metabolism, lactic acid disorders, bone disease, and abnormal body fat distribution. These metabolic complications may increase the risk of heart disease, stroke, and potentially fatal lactic acidosis.
The AIDS and Cancer Specimen Bank at UCSF is expanding its operations with new technologies and a central coordinating office. The bank now serves over one million specimens from around the world, including China, Thailand, and South America.
Researchers at UCSF used a new technique to decouple hormone pathways controlling reproduction and longevity in worms, finding that daf-2 activity can be turned on or off independently. This allows for the potential extension of lifespan without suppressing reproduction, offering a promising avenue for human aging research.
Researchers have developed a highly sensitive automated test for detecting prions in cattle, sheep, deer, and elk, significantly improving the accuracy and speed of detection. The test, an immunological probe, uses novel antibodies to reveal and measure infectious abnormal prion protein.
UCSF's Institute for Global Health has been awarded $4.5 million by the CDC to assist in global AIDS programs, focusing on training, technical assistance, and research in resource-constrained countries. The consortium will also establish regional coordinating centers in Brazil, India, and Zimbabwe.
A study published in the Journal of the National Cancer Institute found that 20% of mammogram-detected breast cancers are in situ lesions with unknown aggressiveness. The research highlights the need for further understanding of DCIS to identify which cases may progress to invasive cancer.
A large-scale clinical trial found that patients treated with the two-drug regimen had a much higher rate of major liver injury compared to those taking isoniazid. The study confirms CDC recommendations for frequent monitoring of patients, highlighting the importance of laboratory testing to detect early liver injury.
Researchers discovered a blocking enzyme that reduces anxiety without sedation, improving cognitive abilities and alertness. The study suggests a new route for treating anxiety without the side effects of existing anti-anxiety drugs.
A UCSF study found that macrophages from human lymphoma patients can cause mouse lymphoma when injected into mice. This contradicts the current understanding of macrophages' role in fighting disease. The researchers believe HIV-infected macrophages can become neoplastic and stimulate lymphoma growth.
Researchers have developed a new technique to detect corrupted tumor suppressor genes affected by DNA methylation, which could lead to new therapies. The study found that DNA methylation primarily affects different genes than those damaged by deletion or mutation, suggesting a previously unrecognized source of therapeutic targets.
A recent UCSF-led study found that fluoroquinolones were widely prescribed to patients discharged from the hospital despite narrow-spectrum antibiotics being appropriate. The study highlights the serious erosion of effectiveness due to overuse and increasing bacterial resistance, particularly in cystic fibrosis patients.
The Bill & Melinda Gates Foundation is funding a study at UCSF to test diaphragms as an HIV prevention method. The diaphragm holds promise for preventing HIV transmission, particularly in women, who are disproportionately affected by the disease.
Researchers found that 40% of rejected lungs could have been candidates for transplantation, more than doubling the number of potentially suitable donor lungs. The study highlights the need for a prospective assessment of selection of donors for lung transplantation to potentially save thousands of lives.
A study of internal tobacco industry documents reveals that companies profited from both tobacco and nicotine replacement therapies, undermining efforts to combat smoking addiction. Researchers argue that such financial conflicts of interest should be made public to ensure greater corporate responsibility.
Researchers found no difference in cosmetic appearance between sutured and non-sutured hand cuts after three months. Patients treated conservatively reported less pain and shorter treatment times compared to those who received sutures.
A recent study found that the suicide attempt rate is high among urban gay men, with younger generations experiencing earlier attempts. Researchers attribute this trend to increased anti-gay harassment and lack of social support among young LGBTQ+ individuals.
A new drug has been developed to combat botulism by potently neutralizing the toxin. The antibody cocktail is capable of binding to a different part of the toxin molecule, blocking more of the toxin surface than single antibodies. This approach could be scaled up for mass production and stockpiling to prevent or treat botulism.
The Prodisc implant aims to alleviate lower back pain and maintain spine mobility by replacing damaged discs. Researchers will compare its safety and effectiveness to spinal fusion surgery in a randomized clinical trial.
A recent study by UCSF researchers reveals that lower literacy is associated with worse health outcomes for diabetes patients, even after accounting for other factors. Patients with inadequate health literacy are more likely to experience complications such as diabetic retinopathy and have poorer blood sugar control.
A study of over 1,000 passengers flying between San Francisco and Denver found that recirculated cabin air did not cause more colds than fresh air. The researchers suggest that being on a plane packed with people may be the primary factor in transmission of colds.
A new study suggests that growth hormone therapy can significantly enhance human thymic function and increase the production of new T cells in HIV-infected patients. This could potentially help preserve and restore their immune systems. However, more research is needed to confirm these findings and ensure the benefits outweigh the risks.
A new study found that 96% of HIV-positive MSM with STIs had received healthcare in the previous six months, highlighting the need for regular screening and effective risk reduction messages. The study also revealed high rates of co-infections with HSV-2 and syphilis among HIV-infected men.
Research finds that two-thirds of adolescent girls in Zimbabwe are involved with older men due to economic need, increasing risk of HIV. The study suggests promoting economic self-sufficiency through education and vocational training can help reverse the epidemic.
A study in Zimbabwe found that women are willing to use diaphragms as a potential HIV prevention method. Diaphragms may increase the effectiveness of new microbicides designed to prevent HIV acquisition, according to principal investigator Nancy Padian.
A community-based intervention implemented in Albuquerque from 1997-98 found that young gay men reported a 12% decrease in unprotected anal intercourse, reversing baseline increases. The study suggests that empowering communities to establish healthy environments with peer support can effectively reduce HIV risk behavior.
A study published in JAMA found that nearly 28% of newly infected people have a strain of HIV resistant to at least one class of antiretroviral drugs, highlighting the need for new treatment options. The research also shows that drug-resistant viruses take longer to control with current treatments.
A long-term study of hormone therapy in postmenopausal women with heart disease found no reduction in heart attack risk and increased blood clot risk. The therapy also showed a higher risk of gallbladder disease requiring surgery.
Researchers found genetically engineered mice lacking the A/C receptor had 8-12% lower blood pressure than normal mice. Blocking this subtype may offer a new approach to treating high blood pressure with reduced side effects.
Researchers identified a new cholesterol disorder caused by mutations in the CYP7A1 gene, leading to elevated cholesterol levels and increased risk of heart disease. The study found that carriers of the mutation had significantly higher cholesterol levels and were more likely to develop gallstones.
A new study suggests that Btx-B may be effective in treating face wrinkles, with a faster onset of action but shorter duration compared to type A. The low-dose study found that patients injected with Btx-B experienced rapid wrinkle reduction within 48 hours, but the effect did not last as long as type A.
Researchers identify Beta-gamma dimer as key molecule in the brain's response to alcohol, which amplifies dopamine release and contributes to cravings. Blocking this molecule may prevent excessive drinking and provide a novel target for medications.