A new study reveals that prostate cancer develops through periodic bursts of genetic mutations, causing complex DNA reshuffling. This process, dubbed 'punctuated cancer evolution,' may lead to more accurate diagnosis and effective treatment in the future.
A new study published in NEJM finds that sofosbuvir achieves a response rate of 93% for genotype 2 and 61% for genotype 3 patients. This represents a significant improvement over traditional interferon-based treatments, which often have limited efficacy in these patient populations.
The Feil Family Brain and Mind Research Institute aims to develop advanced personalized therapeutic solutions for patients with devastating brain diseases, such as Alzheimer's disease and Parkinson's disease. The institute will conduct bench-to-bedside research to test novel therapeutics in cutting-edge clinical trials.
A recent study reveals that 41% of the human genome is covered by longer DNA patents, which could lead to a loss of individual genomic liberty. The study also found that short sequences from patents cover virtually the entire genome, even outside of genes.
Two studies by Weill Cornell Medicine researchers propose new treatments for beta-thalassemia, HFE-related hemochromatosis, and polycythemia vera. The discovery reveals a crucial role of macrophages in regulating iron production and red blood cell production, offering new avenues for therapy.
Researchers at Weill Cornell Medicine developed a new method to expand adult hematopoietic stem cells outside the human body, overcoming a major technical hurdle. This breakthrough could lead to fewer donor cells being needed for transplantation and make bone marrow banking possible.
Current quality measures for outpatient settings neglect critical areas of high-quality care, including safety and effectiveness. Dr. Tara Bishop suggests revisiting quality measurement to include these neglected areas, which could improve patient care and safety.
A multi-center analysis shows fully covered self-expanding metal stents can effectively resolve painful and potentially life-threatening benign biliary strictures. The study found that 91.6% of patients had symptom relief after metal stent removal, with successful stricture resolution rates varying by patient group.
Weill Cornell researchers argue that ACOs may not be improving population health as intended, as their focus is often solely on medical care for patients within their geographic area. The authors emphasize the importance of clearly defining population health to formulate effective healthcare and social service policies.
A new clinical study, funded by the NIH, aims to discover novel biomarkers and therapeutic treatments for patients with chronic fatigue syndrome. The four-year study will use advanced neuroimaging and clinical evaluations to expand scientific understanding and improve diagnostics.
Researchers at Weill Cornell Medicine have made a breakthrough in treating diffuse large B-cell lymphoma by targeting the master regulatory transcription factor Bcl6. By shutting down this protein, patients may experience fewer side effects and improved treatment outcomes.
Dr. Lewis Cantley, a pioneer in cancer research, has made significant breakthroughs in understanding the PI3K pathway and its role in cancer development. His work has led to revolutionary treatments and continues to advance precision medicine for cancer diagnosis and treatment.
Researchers at Weill Cornell Medical College and Cornell University have developed bioengineered ears that can grow cartilage over a three-month period. The study's breakthrough could provide a new solution for children born with congenital ear deformities, as well as individuals who have lost part or all of their external ear.
Researchers at Weill Cornell Medicine found that a copper-depletion compound, tetrathiomolybdate (TM), prevents cancer recurrence and metastasis progression. The study's findings are promising for high-risk triple-negative breast cancer patients with no current visible breast cancer.
A new study reveals that amyloid peptides build-up in brain's blood vessels accelerates cognitive decline by limiting oxygen-rich blood and nutrients. Researchers identify CD36 as a key protein in the buildup of Aβ40 in blood vessels, promoting cerebral amyloid angiopathy (CAA).
The Sixth Starr Cancer Consortium Grant Competition awarded $5 million to five collaborative cancer research projects at Memorial Sloan-Kettering, The Rockefeller University, and Weill Cornell Medical College. These projects aim to deepen understanding of cancers and transform detection and treatment through innovative approaches.
A study of 17 clinical trials found that 70% of men taking Cialis for 12 weeks could ejaculate most of the time and reach orgasm, compared to 30% in the placebo group. The benefits were seen across all levels of ED severity.
A team of researchers has found significant errors in a previously published study claiming to identify awareness in vegetative state patients using bedside EEG technology. The reanalysis questions the validity of the original study's statistical methodology and findings.
Researchers at Weill Cornell Medical College found that less than half of black patients with uncontrolled hypertension were prescribed a diuretic drug, despite its proven benefits and low cost. The study highlights the need for physicians to follow established guidelines and prescribe diuretics as recommended for this population.
A new study by Weill Cornell Medicine reveals that the accuracy of quality measures in electronic health records can vary widely. The researchers found that automated reports generally performed well but underestimated certain measures, such as asthma prescriptions and diabetes cholesterol control.
A Weill Cornell study reveals that a specific miRNA, miR-708, acts as a metastatic tumor inhibitor and can be restored to stop the spread of aggressive breast cancer. Synthetic miR-708 delivery has blocked metastatic outgrowth in mice, making it a promising therapeutic target.
A generic HIV treatment strategy could save nearly $1 billion annually by replacing brand-name drugs with generics, but may diminish effectiveness. The switch would also increase the risk of treatment failure due to a more complicated regimen.
Weill Cornell and Tres Cantos Open Lab collaborate to investigate TB drug permeability into Mtb bacteria using metabolomics technology. The goal is to identify broader chemical principles for transforming potential potent compounds into active drugs.
A study by Weill Cornell Medicine shows that EHRs can improve patient care, but only when combined with sustained high-intensity technical assistance. Small physician practices in underserved areas of New York City need more technical support to effectively use EHR technology.
Researchers from Weill Cornell Medicine and others have successfully reprogrammed scar tissue in rats' hearts using a cocktail of three genes. The addition of a VEGF gene enhances this effect, improving heart function and reducing scar tissue.
Experts recommend developing and implementing evidence-based appropriateness criteria to prioritize patients most in need of elective procedures, such as joint replacement surgery. This could help combat increasing healthcare costs while enhancing access and quality, according to Weill Cornell researchers.
A 10-year follow-up study shows promising outcomes for patients who received gene therapy to rebuild their blood vessels. The five- and 10-year survival rates were comparable to those of patients treated with traditional medical therapy, with some cases showing improved outcomes.
A consensus statement published in Annals of Surgical Oncology calls for heated chemotherapy after colon cancer surgery to optimize patient survival. The treatment, known as HIPEC, has shown promising results with a median survival of greater than 20 months compared to six-month survival with traditional intravenous chemotherapy.