A global study has discovered over 10,000 previously unknown bacteria and viruses in public transit systems and hospitals worldwide. The researchers mapped urban antimicrobial resistance and identified potential city-specific signatures for some genes.
Researchers developed a unique pre-clinical model of long-term HIV infection using subset of human CD4 cells, excluding those prone to attacking mouse tissue. The model showed that memory CD4 cells can be infected and killed by HIV or protected by anti-HIV drugs, paving the way for T-cell based therapies
A new machine learning technique, MethSig, analyzes DNA methylation changes in tumor cells to infer which ones are driving tumor growth. The algorithm identifies a small number of cancer-driving events, consistent across patients and tumor types.
A new online application, Living Memory Home, offers a virtual and personal memorial space for mourners to deposit memories and feelings about their loss. The platform allows users to create a customized memorial space, share photos and messages, and reflect on both positive and negative memories and emotions.
Intellihealth, a medical obesity treatment platform co-founded by Dr. Katherine Saunders, was selected as the first winner of the Women at Weill investment competition. The company's software platform Evolve generates personalized treatment plans for patients and is integrated with Epic, a widely-used electronic health record system.
Dr. David Lyden, a Weill Cornell Medicine physician-scientist, has been inducted into the Association of American Physicians for his pioneering work on cancer metastasis and spread. His research reveals that tumors produce factors that prime distant organs to become hospitable sites for cancer growth.
A Weill Cornell Medicine team found rare variants of the virus in mothers' blood that can escape broadly neutralizing antibodies. These variants are associated with increased transmission risk to infants, suggesting vaccines or treatments need to be effective against them. Researchers propose high-dose combination therapy for pregnant ...
Researchers used advanced technology to create a detailed map of diseased lung tissue in severe COVID-19 patients. The study revealed that cells called alveolar epithelial cells are the main targets of infection by SARS-CoV-2, and provided new insights into the causes of damage.
The Diversity-Mentorship Collaborative program will provide innovative support for URM faculty, including research assistance and competitive career development awards. The grant aims to boost the number of URM faculty through recruitment, retention, advancement, and mentoring.
Researchers at Weill Cornell Medicine found that cancer cells can dodge chemotherapy by entering a state of hibernation, or senescence, which enables them to survive aggressive treatments. This discovery has implications for developing new drug combinations that could block senescence and make chemotherapy more effective.
Researchers at Weill Cornell Medicine have discovered that pregnant women can transfer protective COVID-19 antibodies to their babies while in the womb. The study found that most babies born to mothers with COVID-19 antibodies had detectable antibodies, suggesting a potential shielding effect.
A new study reveals that the Forkhead box protein O3 (FOXO3) gene helps preserve brain stem cells by preventing them from dividing until the environment is safe. This mechanism may contribute to the longevity of certain individuals and explain why exercise boosts mental sharpness.
Researchers found that a widely used cell type for brain research was misidentified as an endothelial cell, but could be reprogrammed to resemble one using gene expression manipulation. This study highlights the importance of rigorously evaluating stem cell models before embracing them.
A new study reveals a 'weak point' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease. The researchers found that interfering with the bacteria's process relieved gut inflammation in a mouse model of Crohn's disease.
A study by Weill Cornell Medicine found that COVID-19 transmission was extremely low among children and staff at North Carolina day camps, with only two cases linked to possible on-site transmission. The camps implemented strict safety measures, including masking, distancing, and frequent hand washing, which helped avoid viral spread.
Researchers found that common fungi in the gut teach the immune system to respond to more dangerous relatives, priming immunity against infection. The discovery offers a potential new therapy to combat deadly fungal infections.
A new computational method has been developed to analyze genetic and environmental interactions influencing disease risk, including body mass index and diabetes. The study found that prioritizing a smaller number of genetic variants in the genome improves analysis efficiency.
A randomized clinical trial found that azacitidine as a maintenance treatment significantly improves relapse-free survival and overall survival in patients with AML. Patients treated with oral azacitidine had a median relapse-free survival of 10.2 months, compared to 4.8 months for placebo recipients.
A study found that patients with more adverse social factors, such as low income and educational attainment, were significantly more likely to die of coronary heart disease. Using a simple count of these factors can help doctors estimate their patients' health risks and provide more aggressive treatment.
Drs. Sallie Permar and Stephen Patrick have been awarded the fifth annual Gale and Ira Drukier Prize in Children's Health Research for their groundbreaking research on neonatal viral infections and opioid epidemic's impact on pregnant women and infants. Their work has informed national policy and offers hope to untold expectant mothers.
Researchers have imaged the 'ball-and-chain' mechanism of ion channels using cryo-electron microscopy, providing new insights into their regulation. This discovery has significant implications for designing targeted therapies for disorders such as epilepsies and heart arrhythmias.
A preclinical study found that a human gene variant affects the brain's reward processing circuit and increases vulnerability to THC reward in adolescent females, leading to higher preference for cannabis. The study suggests genetic factors can contribute to increased susceptibility to cannabis dependence in select populations.
Researchers at Weill Cornell Medicine discovered that higher levels of protein adipsin in the blood protect against type 2 diabetes. Adipsin helps shield pancreatic beta cells, improving insulin production and preventing cell death.
Researchers have identified CEMIP as a key protein promoting brain metastasis in breast and lung cancers. By blocking CEMIP, it may be possible to prevent or treat brain metastases, which are a common cause of cancer deaths. High levels of CEMIP in primary tumors have been linked to a faster progression to brain metastasis.
Scientists have identified a link between gut microbiota and brain cell communication, revealing altered gene expression in immune cells that disrupts learning processes. Restoring gut microbiota at birth rescues learning deficits, suggesting early-life signals play a crucial role.
A high-salt diet may negatively affect cognitive function by causing a deficiency of nitric oxide, which is vital for maintaining vascular health in the brain. This can lead to the accumulation of tau deposits, contributing to dementia and cognitive impairment.
Weill Cornell Medicine establishes a transformative scholarship program to eliminate medical education debt, covering tuition and living expenses. The $160M initiative will support up to two-thirds of the institution's medical student body, empowering them to focus on their passions and talents without financial burden.
A new study by Weill Cornell Medicine found that states with comprehensive prescription drug monitoring program mandates saw a 8.92% reduction in opioid prescriptions and 17.75% fewer emergency department visits compared to those with weak or no mandates.
Researchers at Weill Cornell Medicine have illuminated the basic mechanism of Piezo proteins, which function as sensors in the body for mechanical stimuli. The discovery provides insights into the roles of Piezo proteins in human diseases and potential new therapeutic strategies.
Long-term spaceflight causes significant changes to gene expression, immune system, and DNA repair systems. The study provides insights into the effects of prolonged space travel on astronaut health and may help scientists develop treatments or prevention strategies.
Researchers found that modulation of immune system during pregnancy is similar in women with and without lupus. In healthy pregnancies, key immune genes are quieted after embryo implantation, while those with preeclampsia or complications show downregulation of these genes.
A new AI approach analyzes time-lapse images of embryos to predict pregnancy potential, improving IVF success rates and minimizing multiple pregnancies. Researchers used a large dataset of human embryos to train an algorithm that can classify embryo quality with high accuracy.
A study by Weill Cornell Medicine found that consuming high-fructose corn syrup causes mice with colon cancer to develop larger tumors. The researchers discovered a molecular mechanism by which the sweetener fuels tumor growth and suggest blocking this effect could lead to new cancer treatments.
High-need, high-cost patients account for 50% of US healthcare spending. Patients identify care management, telemedicine, and home health visits as beneficial solutions to prevent ED overuse. Care management helps with appointment scheduling and reminders, while home-based services enhance patient convenience and comfort.
Research by Weill Cornell Medicine scientists reveals that the nervous system can dampen excessive inflammation in the gut and lungs, which may lead to new treatments for diseases like asthma and inflammatory bowel disease. The study also found that beta-adrenergic receptors play a crucial role in controlling the immune response.
A new study by Weill Cornell Medicine researchers found that levetiracetam is more effective than phenobarbital in treating nonsyndromic epilepsy in U.S. infants, with 40% of treated infants experiencing no further seizures within three months.
A team of researchers has discovered that chromosomal instability can cause cancer cells to leak DNA, leading to a chronic inflammatory response that enables their spread. This finding opens up new possibilities for targeting metastasis in cancer treatment.
A high-salt diet reduces resting blood flow to the brain and causes dementia in mice, according to a new study. The study found that mice fed a high-salt diet developed dementia even when blood pressure did not rise, suggesting a direct link between salt intake and cognitive impairment.
Researchers at Weill Cornell Medicine have identified a type of white blood cell that regulates the gut fungal population and protects against harmful fungi. This discovery sheds light on the mechanisms leading to ASCA generation, suggesting patients with certain gene variants may benefit from antifungal therapy.
Researchers found that menopause triggers metabolic changes in the brain, increasing the risk of Alzheimer's disease. The study used PET imaging to measure glucose metabolism in the brains of 43 healthy women aged 40-60, revealing lower levels of glucose metabolism in post-menopausal women.
Dr. Fine's laboratory uses cerebral organoids to model glioma growth and response to therapies, offering a more accurate representation of clinical disease. The award supports his personalized brain-cancer models, which may lead to precision medicine treatment strategies.
A new study from Weill Cornell Medicine reveals that nerve cells in the gut play a crucial role in triggering an immune response to infection. The researchers found that these nerve cells communicate with immune system cells through a protein called neuromedin U, enabling them to rapidly respond to threats.
A new dissolvable device made from polyethylene glycol and dihydroxyacetone has shown promise in preventing intestinal damage during surgical incisions. The flexible material can be left behind in the abdominal cavity, protecting vital structures until the final sutures are made.
Researchers used mathematics and MRI to better understand how neurological disorders affect brain connections. They discovered sub-networks called eigenmodes, which communicate information between brain regions.
Researchers from NewYork-Presbyterian and Weill Cornell Medicine call for increased adoption of fluoroless catheter ablation to reduce radiation exposure. The procedure uses high-frequency sound waves to create a precise image of the heart, guiding treatment with computerized three-dimensional mapping systems.
Researchers at Weill Cornell Medicine have developed a method to generate healthy blood-forming stem cells from readily available cells lining blood vessels. This breakthrough enables the creation of an unlimited supply of new, healthy blood cells for transplantation, which may help cure patients with genetic and acquired blood diseases.
The WorldQuant Initiative combines advanced molecular profiling technologies with quantitative methods to analyze genomic data, enabling the prediction of disease risk and outcomes. Researchers will leverage predictive tools to improve diagnosis and treatment for various illnesses.
Researchers found that fecal microbiota transplantation increased bacterial populations resembling healthy donors and reduced inflammatory response. Clinical improvements were seen in 35% of patients and clinical remission in 15%. Further studies are needed to determine long-term effects and optimal delivery methods.
According to a large international study, one out of four children in ICUs develops delirium. The prevalence nearly doubles after five days, highlighting the need for routine monitoring.
A multicenter study found that scalp cooling reduced hair loss in certain breast cancer patients undergoing non-anthracycline adjuvant chemotherapy. The study, published in JAMA, showed that 67% of patients retained half or more of their hair after treatment.