A randomized clinical trial found that participants treated at non-stigmatizing 'accessible care' centers were nearly three times more likely to be cured of hepatitis C than those referred out to local clinicians. The study suggests that expanding and supporting accessible care models could help eliminate the disease.
A preclinical study suggests that SARS-CoV-2 infection can cause ferroptosis in pacemaker cells, leading to cardiac arrhythmias. Researchers used animal models and human stem cell-derived pacemaker cells to demonstrate the virus's impact on these cells.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
Researchers at Weill Cornell Medicine have found that an enzyme called ART1 can modify a receptor on tumor-fighting immune cells, triggering their death. Blocking ART1 increased the presence of these immune cells within tumors and slowed or stopped tumor growth in animal models.
Researchers at Weill Cornell Medicine found that certain Candida albicans yeast strains produce a potent toxin called candidalysin, which damages immune cells and triggers pro-inflammatory responses. The study suggests a possible way to personalize treatments for IBD patients by targeting these high-damaging strains.
A new study by Weill Cornell Medicine and colleagues found that most COVID patients regain consciousness after removal of respiratory support, but may take weeks to recover. The study also showed that patients who experienced low blood oxygen levels during treatment took longer to recover consciousness.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
A study published in Nature Communications reveals the precise molecular structure of siponimod, a multiple sclerosis drug, and its interactions with S1P receptors. This knowledge may lead to the development of more targeted therapies that reduce side effects.
Researchers at Weill Cornell Medicine have identified a protein called HDP1 that plays a critical role in activating genes required for the development of male and female stages of the malaria parasite. Without HDP1, parasites are unable to assemble mature gametocytes, leading to their death and inability to infect mosquitoes.
A preclinical study by Weill Cornell Medicine researchers reveals that a specific group of fungi residing in the intestines can protect against intestinal injury and influence social behavior in mice. The findings suggest a novel signaling system connecting fungi in the gut to their host's cells, including immune cells and neurons.
Researchers found that disulfiram protected rodents from immune-mediated lung injury in models of SARS-CoV-2 coronavirus infection and TRALI, a rare lung failure syndrome. Disulfiram blocks NETs formation, which can cause lung damage and blood clots.
Researchers discovered a key growth factor protein, HB-EGF, produced by immune-regulating cells that protects the gut against inflammatory bowel disease. ILC3s produce HB-EGF to counteract TNF-induced inflammation and maintain gut barrier function.
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
Scientists at Weill Cornell Medicine developed a new imaging technique to capture bacteriorhodopsin's motions in response to light on a millisecond time scale. This study reveals the protein's kinetics, including the speed of transitions between open and closed states, which informs optogenetics research.
Melanoma cells release small packages containing the protein NGFR, which primes nearby lymph nodes to form new vessels and encourage cancer spread. This process, called lymphangiogenesis, may help doctors determine which patients need more aggressive treatment.
A team of Weill Cornell Medicine investigators created a comprehensive atlas, called Tau interactome, that maps all the Tau protein's interactions with other proteins in human neurons. They found that mutations diminish Tau-mitochondrial protein interaction may hamper energy production and lead to cognitive decline.
Researchers found that even unrelated vaccines can provide cross-protection against multiple pathogens, reducing caseloads and hospital usage. Vaccinating vulnerable populations with other vaccines during the pandemic can have a substantial impact.
A study from Weill Cornell Medicine and Cornell University reveals that targeting protein ATF4 and its related metabolic protein SIRT3 can trick lymphoma cells into starving themselves, slowing their growth.
A new study found that COVID-19 vaccination during pregnancy elicits high levels of antibodies in both mother and baby, regardless of when it occurs. The research suggests that pregnant women should not delay vaccination until late pregnancy, as it is likely to be beneficial for themselves and their babies.
Researchers identify a previously overlooked site on the HA protein, known as the 'anchor epitope', which can neutralize a wide range of influenza strains. This discovery has significant implications for the development of universal influenza vaccines and antibody therapies.
Researchers at Weill Cornell Medicine discovered that deleting the EtfD Mtb enzyme renders Mycobacterium tuberculosis unable to sustain an infection in mice. The enzyme plays a critical role in fatty acid breakdown, making it an attractive target for TB treatment.
Weill Cornell Medicine researchers have developed a new approach to analyze genetic mutations associated with spina bifida, shedding light on this complex birth defect. The study uses machine learning to identify genes and molecular pathways relevant to neural tube closure.
Researchers grew 'mini-brains' from stem cells of patients with and without schizophrenia, finding reduced gene expression in patient samples that stymied brain cell development. Replacing the missing genes restored normal brain cell production, suggesting a potential target for therapy.
Researchers have found that depleting copper levels in the body can greatly reduce the ability of cancer cells to metastasize, including aggressive breast cancer. The discovery provides hope for developing more effective treatments for high-risk triple-negative breast cancer.
Researchers at Weill Cornell Medicine are studying breast cancer as a series of inflection points to identify potential intervention points and develop therapeutics for triple negative breast cancer. The goal is to create a large repository of organoids from tissue samples to study gene expression, epigenetic changes, and immune response.
A recent study found that nearly a quarter of home health care workers rate their general health as fair or poor, with 1 in 5 reporting poor mental health. Factors contributing to poorer health include low household income, cost barriers, and history of depression.
Investigators at Weill Cornell Medicine identified significant age-related differences in tumor characteristics across various cancers, suggesting potential for personalized treatment approaches. They found that tumors from younger patients showed advanced signs of aging and more mutations associated with aggressive disease.
A new protein variant called CLIP-170S allows cancer cells to dodge chemotherapy drugs, rendering them ineffective. Researchers discovered this variant in more than 60% of patients with gastric cancer and are exploring a combination therapy involving imatinib to overcome resistance.
Researchers found that packaging neurotransmitters into synaptic vesicles is a major source of energy consumption, even when the vesicles are filled and inactive. The process, known as proton efflux, continues to consume energy due to a 'leaky' energy threshold set by evolution.
A study by Weill Cornell Medicine scientists found that blocking a signaling pathway in brain immune cells can protect against Alzheimer's disease features in a preclinical model. The results suggest a new strategy to block the development of the disease or slow its progression.
Researchers discover a unique subset of group 3 innate lymphoid cells that circulate in the bloodstream and infiltrate the brain, sparking inflammation in conditions like MS. Countering their activity could be a new therapeutic strategy for such conditions.
A study by Weill Cornell Medicine investigators found that antibodies secreted in the gut help control pathogenic forms of gut fungi like Candida albicans. However, patients with Crohn's disease often have impaired antibody function, leading to an overgrowth of harmful fungi.
A recent study by Weill Cornell Medicine found that nursing homes acquired by private equity companies have lower quality of care and higher Medicare costs. Residents at these facilities were 11% more likely to have emergency room visits and hospitalizations, resulting in $1,080 higher annual Medicare costs.
A new study found that a simple surgical technique called posterior left pericardiotomy significantly reduces the risk of atrial fibrillation in patients undergoing cardiac surgery. The procedure, which involves draining excess fluid and small clots from the heart sac, was associated with a 56% lower incidence of irregular heart rhythm...
A study at Weill Cornell Medicine reveals how drugs can affect membrane-spanning proteins, causing unwanted side effects. The researchers found that membrane-associated drugs can interact with these proteins in multiple ways, leading to changes in membrane characteristics.
A study found that arginine treatment improved outcomes in cancer patients with brain metastases, showing a complete or partial response in nearly 78% of patients. The amino acid may be useful as an anticancer therapy when combined with radiotherapy or other treatments.
A new study suggests that greater cumulative estrogen exposure in life may counter the brain-shrinking effect of menopause. Women with longer reproductive years, more children, and hormone therapy showed increased gray matter volume in certain brain areas. This protective effect may help reduce Alzheimer's risk in women.
A preclinical study found that female mice are more susceptible to binge drinking due to a brain circuit called the bed nucleus of the stria terminalis (BNST). The BNST is more excitable in females, requiring stronger inhibition to curb excessive alcohol consumption. This natural 'brake' mechanism may also contribute to sex differences...
Researchers found that COVID-19 patients with high blood sugar levels were more likely to develop severe lung dysfunction, require mechanical ventilation, and die. The study also suggests that SARS-CoV-2 may disrupt fat cells' production of adiponectin, a hormone regulating blood sugar levels.
Researchers at Weill Cornell Medicine have profiled individual cells from patients' brain tumors in unprecedented detail, revealing distinct states and programming marks that could be targeted with future drugs. The study offers insights into glioma dynamics and may lead to better detection, staging, monitoring, and treatment methods.
A study by Weill Cornell Medicine identified Oct2 as the key determinant of B-cell humoral immune response, suggesting that the destiny of antibody-producing cells is predetermined. This discovery may lead to new insights into tissue development and cancer development.
Researchers at Weill Cornell Medicine identified club cell factors that inhibit immunosuppressive cells in tumors, leading to increased antitumor T cells and improved effectiveness of PD1 immunotherapy. A
Researchers identified a crucial epigenetic regulator, PRC1, that contributes to uveal melanoma progression. By inhibiting PRC1, they transformed indolent cells into the more metastatic subtype, highlighting new treatment strategies and challenging current clinical testing methods.
A preclinical study found that high-fructose diets alter villi in the small intestine, leading to increased nutrient absorption and weight gain. Fructose's primary metabolite promotes elongation of villi and supports intestinal tumor growth.
Researchers at Weill Cornell Medicine found that defective red blood cells with retained mitochondria contribute to lupus inflammation. The study provides a new piece to the lupus puzzle and could lead to targeted therapies for patients.
In a phase 2 clinical trial, sacituzumab govitecan (SG) demonstrated sustained tumor shrinkage in 27% of patients with advanced urothelial carcinoma. The treatment also showed improved overall survival and reduced progression compared to standard chemotherapy.
A new cancer vaccine strategy showed promise in a proof-of-concept study, reducing tumor burden and improving overall survival in an animal model of Lynch syndrome. The vaccine targets specific neoantigens produced by cancer cells, stimulating a robust immune response.
A study found that male children with Crohn's disease experience worse growth due to factors like infliximab use and poor growth at symptom onset. In contrast, female patients tend to grow better regardless of disease severity or medication interventions.
Scientists at Weill Cornell Medicine developed a computational technique that greatly increases the resolution of atomic force microscopy, revealing atomic-level details on proteins and biological structures. The new method allows researchers to study biological molecules under physiologically relevant conditions, providing high-resolu...
Researchers found two gene variants associated with an increased risk of triple negative breast cancer (TNBC) in African American women. The ANKLE1 gene variant is protective against TNBC, but a version found in African Americans may be oncogenic. A mutation in the Duffy gene also increases TNBC risk in African American women.