A new report from Weill Cornell Medicine emphasizes the importance of evaluating medication side effects and interactions in obesity treatment. Physicians are advised to prescribe alternatives that limit weight gain or aid in weight loss for patients with obesity.
New research uncovers a connection between Crohn's disease and spondyloarthritis, finding that IgA-coated E. coli bacteria trigger inflammation in Th17 cells. This discovery may lead to the development of diagnostic tools and therapies targeting both conditions.
A severely brain-injured woman regained the ability to communicate through eye movements, with researchers capturing the restoration process by measuring brain structure and function. The study suggests that other patients in chronic care facilities may harbor organized brain function, raising questions about diagnosis and treatment.
Researchers identified four unique depression subtypes based on brain connectivity patterns, providing potential biomarkers for diagnosis and treatment. These subtypes differ in clinical symptoms and response to transcranial magnetic stimulation therapy.
Researchers at Weill Cornell Medicine found that chemotherapy kills urothelial cancer cells but shapes their genetic evolution, leading to drug-resistant cell clones. This study provides a framework for understanding the biological basis of chemotherapy resistance in bladder cancer and may lead to improved diagnostics and treatments.
Researchers found that certain gut bacteria can shield the brain from stroke by directing immune cells to protect it. Modifying the microbiotic makeup of the gut may become a novel method to prevent stroke, particularly for high-risk patients.
Researchers have discovered a stress pathway in immune cells that play a role in certain forms of asthma. The IRE1α/XBP1 pathway helps eosinophils, a type of immune cell implicated in asthma, develop and survive. This finding suggests a potential new therapeutic target for treating asthma.
Ovarian cancer suppresses immune cells' ability to respond to tumor cells by activating a gene called XBP1. A novel therapy approach aims to restore dendritic cell function and trigger robust immune responses against ovarian tumors.
A study published in Nature Cell Biology reveals that exosomes secreted by pancreatic cancer cells contain MIF, which educates liver cells to produce a protein leading to fibrosis and tumor growth. This discovery could lead to targeted treatments and biomarkers for early detection.
A new study reveals that a tumor-secreted protein promotes the activation of Id1, leading to immune suppression and allowing cancer to grow and spread. Targeting Id1 may restore immune function and improve treatment outcomes for patients with melanoma and other advanced-staged cancers.
Researchers found that global changes in cancer cells' epigenome, which control gene expression, contribute to treatment resistance. The study suggests that these changes can be predicted using biopsies taken before and after treatment.
Researchers validated a previously reported molecular finding on triple negative breast cancer, but found it was limited to a single patient and could not be applied to further clinical work. The study highlights the importance of independent study validation and careful assay development.
Researchers and clinicians can design studies, create personalized treatment plans, and inform medical decisions with accurate genomic data. The NYC-CDRN aggregates over six million patients' medical data to study patterns and trends in cancer across a large patient population.
The National Institutes of Health has awarded a $6.2 million grant to Weill Cornell Medical College to tackle the global tuberculosis epidemic. The grant, worth up to $45.7 million over seven years, aims to develop new treatments and shorten therapy duration for patients with drug-resistant TB.
Researchers create first comprehensive map of NYC subway system microbes, finding mostly harmless bacteria, but also detecting disease-causing and treatment-resistant strains. The study provides baseline data for city-wide disease surveillance and bioterrorism threat mitigation.
A recent study from Weill Cornell Medicine found that nearly one in five nursing home residents experienced mistreatment from fellow residents, including verbal and physical abuse. The research suggests targeting interventions towards vulnerable individuals with dementia or mood disorders to address this widespread problem.
Scientists develop technology to visualize HIV protein motion in real-time, revealing key insights into the virus's ability to infect human immune cells. The study reveals three different conformations of the envelope trimer and provides a basis for developing effective therapies.
Substantial levels of HIV transmission are emerging among people who inject drugs in the Middle East and North Africa, with an estimated 626,000 individuals infected. High rates of HIV infection and hepatitis C virus among this population highlight the need for expanded harm-reduction programs and surveillance systems.
A study found that primary care physicians in team-based care models with electronic health records (EHRs) improved their quality of care more than those without EHRs. The patient-centered medical home (PCMH) model was associated with significant improvements in care, including better preventive screening and testing.
A gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of triple negative breast cancer, a particularly deadly strain. Targeting XBP1 may offer a new approach to treating this disease.
Research suggests that palliative chemotherapy can lead to more invasive medical procedures and a higher risk of death in intensive care units among advanced cancer patients. The findings highlight the need for clearer discussion of the harms and benefits of palliative chemotherapy at the end of life.
Researchers discovered that an RNA binding mechanism causes fragile X syndrome to occur when there are 200 or more CGG repeats in the gene. A drug that blocks this silencing mechanism can prevent fragile X syndrome, suggesting similar therapy is possible for other diseases.
Scientists at Weill Cornell Medical College have found that a twice-daily pill, idelalisib, can turn deadly blood cancer into a highly treatable disease. The study suggests that patients with CLL may avoid debilitating chemotherapy, leading to significant side effects and death.
The Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College will use precision medicine and cutting-edge approaches to spur breakthroughs in cancer treatment. The center's efforts will be supported by a $75 million gift, which also names the new flagship building.
A study found that psychiatrists are increasingly refusing to accept Medicare, Medicaid, or private insurance, leaving many patients without affordable mental health care options. The number of psychiatrists is also dwindling due to retirement and a lack of new medical students choosing the specialty.
Researchers found that 53% of men with ERG-positive HGPIN biopsies developed invasive prostate cancer, compared to 35% of those with ERG-negative biopsies. The discovery may help physicians monitor men at higher risk for cancer development and reduce unnecessary future biopsies.
Researchers have discovered a rare genetic variation that increases triglyceride levels, contributing to the risk of heart disease and other disorders. The ApoE R145C variant is estimated to affect up to 36 million sub-Saharan Africans worldwide.
A team of scientists found a consistent signature of brain activity in patients with severe brain injuries who regained consciousness after using Ambien. The unique electroencephalography (EEG) pattern points to a neural circuit switched on by the drug, which may help identify other patients who could respond.
Weill Cornell Medical College will receive a $500,000 grant from MasterCard to support research into female cancers. The grant aims to develop personalized care and address various types of women's cancers.
A team of researchers has identified a family of enzymes crucial for cancer growth in p53 mutant cells. Targeting these enzymes with novel agents may prevent the growth of p53 mutant cancers, benefiting patients with breast, ovarian, lung, colorectal, and brain tumors. The study suggests that inhibiting Type 2 PIP kinases could shut do...
Researchers at Weill Cornell Medicine and TSRI have determined the atomic-level structure of the tripartite HIV envelope protein, known as Env. The findings provide a detailed picture of the complex protein and its sites of vulnerability that could be targeted by future vaccines.
Researchers studied Brachyury gene's role in regulating notochord development, finding CRM mutations affect timing of gene expression. This can lead to birth defects and cancer by delaying critical developmental processes.
Researchers have identified a variant of common soil-based pathogen Clostridium perfringens type B as a potential multiple sclerosis trigger. The bacterium produces a toxin that targets damaged tissues in MS patients, with levels of epsilon toxin antibodies found to be 10 times higher in MS patients than healthy controls.
Researchers at Weill Cornell Medicine discovered that blood vessel cells can release beneficial molecules to repair and regenerate organs. The study found that endothelial cells possess tissue-specific genes that code for unique growth factors and adhesion molecules.
A study found that a single nucleotide polymorphism in the BDNF gene leads to shrinkage of neurons from the hippocampus, reducing connectivity between brain cells. The discovery offers mechanistic insight into why some depression and anxiety runs in families.
Researchers at Weill Cornell Medicine discovered that pretreating patients with low doses of azacitidine, a targeted drug, can enhance chemotherapy's ability to kill cancer cells. This approach has the potential to change the standard of care for patients with diffuse large B-cell lymphoma and may be applicable to other tumor types.
A study by Weill Cornell Medicine found that patients and health organizations favor electronic communications, but physicians face barriers such as lack of compensation and increased workload. The study identified successful examples of medical groups using electronic communication to improve access to care and communication with pati...
Researchers have discovered how an experimental drug can completely eradicate human lymphoma in mice after just five doses by gumming up the powerful master regulatory transcription factor Bcl6. The study provides a promising new strategy to treat diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma.
A new finding by Weill Cornell Medical College researchers could improve the safety and performance of reprogrammed cells. The study found that an enzyme called activation-induced cytidine deaminase (AID) helps in the process of changing adult human cells into induced pluripotent stem cells (iPS cells). These iPS cells can be developed...
Researchers found a dose-dependent reduction of beta amyloid in the blood and brain of IVIG-treated patients with the ApoE4 genotype. Biomarker analyses also showed increases in anti-oligomer and anti-fibril antibodies in IVIG-treated patients.
A study by Weill Cornell Medicine found that even healthy-looking smokers have damaged airway cells with characteristics similar to those in aggressive lung cancer. The researchers discovered that these cells express human embryonic stem cell genes, which are normally only active in developing embryos.
A non-invasive urine test using a three-gene signature can diagnose acute rejection and predict kidney transplant patients at risk weeks to months before symptoms appear. The test helps tailor immunosuppressive drug doses for optimal organ care.
A Weill Cornell study reveals nearly half of hospital admissions and deaths in Tanzania are due to hypertension and stroke. The researchers attribute the rise to urbanization, industrialization, and dietary changes.
A Weill Cornell study found that over 1 million Americans who had quit smoking took up the habit again after 9/11, resulting in a 2.3% increase in adult smokers nationwide. The study estimates the cost to government at $530-830 million due to increased Medicare and Medicaid use, productivity losses, and decreased tax revenue.
Researchers propose a new framework for evaluating surgical procedures and implantable devices using clinical trials, observational databases, and registries. The framework aims to address the current lack of evidence-based research in surgery and device fields, where innovative techniques need to be evaluated.
A Weill Cornell study reveals that faulty wiring occurs when RNA molecules embedded in a growing axon are not degraded, interfering with new signals meant to guide the axon. This knowledge may lead to new therapies and strategies to correct faulty pathways.
A study reveals a unique form of childhood asthma connected to impaired sphingolipid synthesis, bypassing typical allergen and inflammation pathways. This discovery may lead to precision medicine approaches for treatment.
Researchers discovered that inhibiting powerful protein EZH2 with new agents may supply broad benefit for lymphoma patients. The study found that EZH2 is a key driver of cancer in B-cells, and its inhibition can help treat follicular lymphoma and diffuse large B-cell lymphomas.
Researchers at Weill Cornell Medical College have developed an anti-cocaine vaccine that prevents the drug from reaching the brain and producing a high. The vaccine works by generating antibodies against cocaine, rendering it ineffective, and has shown promising results in non-human primates.
Scientists at Weill Cornell Medicine have discovered two key proteins that work to block cancer's spread by generating a microenvironment that prevents cancer cells from settling and growing in distant organs. The study suggests that therapeutic proteins could offer a new treatment strategy for metastatic cancer.