A recent study from Weill Cornell Medicine found that nearly one in five nursing home residents experienced mistreatment from fellow residents, including verbal and physical abuse. The research suggests targeting interventions towards vulnerable individuals with dementia or mood disorders to address this widespread problem.
Scientists develop technology to visualize HIV protein motion in real-time, revealing key insights into the virus's ability to infect human immune cells. The study reveals three different conformations of the envelope trimer and provides a basis for developing effective therapies.
Substantial levels of HIV transmission are emerging among people who inject drugs in the Middle East and North Africa, with an estimated 626,000 individuals infected. High rates of HIV infection and hepatitis C virus among this population highlight the need for expanded harm-reduction programs and surveillance systems.
A study found that primary care physicians in team-based care models with electronic health records (EHRs) improved their quality of care more than those without EHRs. The patient-centered medical home (PCMH) model was associated with significant improvements in care, including better preventive screening and testing.
A gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of triple negative breast cancer, a particularly deadly strain. Targeting XBP1 may offer a new approach to treating this disease.
Research suggests that palliative chemotherapy can lead to more invasive medical procedures and a higher risk of death in intensive care units among advanced cancer patients. The findings highlight the need for clearer discussion of the harms and benefits of palliative chemotherapy at the end of life.
Researchers discovered that an RNA binding mechanism causes fragile X syndrome to occur when there are 200 or more CGG repeats in the gene. A drug that blocks this silencing mechanism can prevent fragile X syndrome, suggesting similar therapy is possible for other diseases.
Scientists at Weill Cornell Medical College have found that a twice-daily pill, idelalisib, can turn deadly blood cancer into a highly treatable disease. The study suggests that patients with CLL may avoid debilitating chemotherapy, leading to significant side effects and death.
The Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College will use precision medicine and cutting-edge approaches to spur breakthroughs in cancer treatment. The center's efforts will be supported by a $75 million gift, which also names the new flagship building.
A study found that psychiatrists are increasingly refusing to accept Medicare, Medicaid, or private insurance, leaving many patients without affordable mental health care options. The number of psychiatrists is also dwindling due to retirement and a lack of new medical students choosing the specialty.
Researchers found that 53% of men with ERG-positive HGPIN biopsies developed invasive prostate cancer, compared to 35% of those with ERG-negative biopsies. The discovery may help physicians monitor men at higher risk for cancer development and reduce unnecessary future biopsies.
Researchers have discovered a rare genetic variation that increases triglyceride levels, contributing to the risk of heart disease and other disorders. The ApoE R145C variant is estimated to affect up to 36 million sub-Saharan Africans worldwide.
A team of scientists found a consistent signature of brain activity in patients with severe brain injuries who regained consciousness after using Ambien. The unique electroencephalography (EEG) pattern points to a neural circuit switched on by the drug, which may help identify other patients who could respond.
Weill Cornell Medical College will receive a $500,000 grant from MasterCard to support research into female cancers. The grant aims to develop personalized care and address various types of women's cancers.
A team of researchers has identified a family of enzymes crucial for cancer growth in p53 mutant cells. Targeting these enzymes with novel agents may prevent the growth of p53 mutant cancers, benefiting patients with breast, ovarian, lung, colorectal, and brain tumors. The study suggests that inhibiting Type 2 PIP kinases could shut do...
Researchers at Weill Cornell Medicine and TSRI have determined the atomic-level structure of the tripartite HIV envelope protein, known as Env. The findings provide a detailed picture of the complex protein and its sites of vulnerability that could be targeted by future vaccines.
Researchers studied Brachyury gene's role in regulating notochord development, finding CRM mutations affect timing of gene expression. This can lead to birth defects and cancer by delaying critical developmental processes.
Researchers have identified a variant of common soil-based pathogen Clostridium perfringens type B as a potential multiple sclerosis trigger. The bacterium produces a toxin that targets damaged tissues in MS patients, with levels of epsilon toxin antibodies found to be 10 times higher in MS patients than healthy controls.
Researchers at Weill Cornell Medicine discovered that blood vessel cells can release beneficial molecules to repair and regenerate organs. The study found that endothelial cells possess tissue-specific genes that code for unique growth factors and adhesion molecules.
A study found that a single nucleotide polymorphism in the BDNF gene leads to shrinkage of neurons from the hippocampus, reducing connectivity between brain cells. The discovery offers mechanistic insight into why some depression and anxiety runs in families.
Researchers at Weill Cornell Medicine discovered that pretreating patients with low doses of azacitidine, a targeted drug, can enhance chemotherapy's ability to kill cancer cells. This approach has the potential to change the standard of care for patients with diffuse large B-cell lymphoma and may be applicable to other tumor types.
A study by Weill Cornell Medicine found that patients and health organizations favor electronic communications, but physicians face barriers such as lack of compensation and increased workload. The study identified successful examples of medical groups using electronic communication to improve access to care and communication with pati...
Researchers have discovered how an experimental drug can completely eradicate human lymphoma in mice after just five doses by gumming up the powerful master regulatory transcription factor Bcl6. The study provides a promising new strategy to treat diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma.
A new finding by Weill Cornell Medical College researchers could improve the safety and performance of reprogrammed cells. The study found that an enzyme called activation-induced cytidine deaminase (AID) helps in the process of changing adult human cells into induced pluripotent stem cells (iPS cells). These iPS cells can be developed...
Researchers found a dose-dependent reduction of beta amyloid in the blood and brain of IVIG-treated patients with the ApoE4 genotype. Biomarker analyses also showed increases in anti-oligomer and anti-fibril antibodies in IVIG-treated patients.
A study by Weill Cornell Medicine found that even healthy-looking smokers have damaged airway cells with characteristics similar to those in aggressive lung cancer. The researchers discovered that these cells express human embryonic stem cell genes, which are normally only active in developing embryos.
A non-invasive urine test using a three-gene signature can diagnose acute rejection and predict kidney transplant patients at risk weeks to months before symptoms appear. The test helps tailor immunosuppressive drug doses for optimal organ care.
A Weill Cornell study reveals nearly half of hospital admissions and deaths in Tanzania are due to hypertension and stroke. The researchers attribute the rise to urbanization, industrialization, and dietary changes.
A Weill Cornell study found that over 1 million Americans who had quit smoking took up the habit again after 9/11, resulting in a 2.3% increase in adult smokers nationwide. The study estimates the cost to government at $530-830 million due to increased Medicare and Medicaid use, productivity losses, and decreased tax revenue.
Researchers propose a new framework for evaluating surgical procedures and implantable devices using clinical trials, observational databases, and registries. The framework aims to address the current lack of evidence-based research in surgery and device fields, where innovative techniques need to be evaluated.
A Weill Cornell study reveals that faulty wiring occurs when RNA molecules embedded in a growing axon are not degraded, interfering with new signals meant to guide the axon. This knowledge may lead to new therapies and strategies to correct faulty pathways.
A study reveals a unique form of childhood asthma connected to impaired sphingolipid synthesis, bypassing typical allergen and inflammation pathways. This discovery may lead to precision medicine approaches for treatment.
Researchers discovered that inhibiting powerful protein EZH2 with new agents may supply broad benefit for lymphoma patients. The study found that EZH2 is a key driver of cancer in B-cells, and its inhibition can help treat follicular lymphoma and diffuse large B-cell lymphomas.
Researchers at Weill Cornell Medical College have developed an anti-cocaine vaccine that prevents the drug from reaching the brain and producing a high. The vaccine works by generating antibodies against cocaine, rendering it ineffective, and has shown promising results in non-human primates.
Scientists at Weill Cornell Medicine have discovered two key proteins that work to block cancer's spread by generating a microenvironment that prevents cancer cells from settling and growing in distant organs. The study suggests that therapeutic proteins could offer a new treatment strategy for metastatic cancer.
A new study reveals that prostate cancer develops through periodic bursts of genetic mutations, causing complex DNA reshuffling. This process, dubbed 'punctuated cancer evolution,' may lead to more accurate diagnosis and effective treatment in the future.
A new study published in NEJM finds that sofosbuvir achieves a response rate of 93% for genotype 2 and 61% for genotype 3 patients. This represents a significant improvement over traditional interferon-based treatments, which often have limited efficacy in these patient populations.
The Feil Family Brain and Mind Research Institute aims to develop advanced personalized therapeutic solutions for patients with devastating brain diseases, such as Alzheimer's disease and Parkinson's disease. The institute will conduct bench-to-bedside research to test novel therapeutics in cutting-edge clinical trials.
A recent study reveals that 41% of the human genome is covered by longer DNA patents, which could lead to a loss of individual genomic liberty. The study also found that short sequences from patents cover virtually the entire genome, even outside of genes.
Two studies by Weill Cornell Medicine researchers propose new treatments for beta-thalassemia, HFE-related hemochromatosis, and polycythemia vera. The discovery reveals a crucial role of macrophages in regulating iron production and red blood cell production, offering new avenues for therapy.
Researchers at Weill Cornell Medicine developed a new method to expand adult hematopoietic stem cells outside the human body, overcoming a major technical hurdle. This breakthrough could lead to fewer donor cells being needed for transplantation and make bone marrow banking possible.
Current quality measures for outpatient settings neglect critical areas of high-quality care, including safety and effectiveness. Dr. Tara Bishop suggests revisiting quality measurement to include these neglected areas, which could improve patient care and safety.
A multi-center analysis shows fully covered self-expanding metal stents can effectively resolve painful and potentially life-threatening benign biliary strictures. The study found that 91.6% of patients had symptom relief after metal stent removal, with successful stricture resolution rates varying by patient group.
Weill Cornell researchers argue that ACOs may not be improving population health as intended, as their focus is often solely on medical care for patients within their geographic area. The authors emphasize the importance of clearly defining population health to formulate effective healthcare and social service policies.
A new clinical study, funded by the NIH, aims to discover novel biomarkers and therapeutic treatments for patients with chronic fatigue syndrome. The four-year study will use advanced neuroimaging and clinical evaluations to expand scientific understanding and improve diagnostics.
Researchers at Weill Cornell Medicine have made a breakthrough in treating diffuse large B-cell lymphoma by targeting the master regulatory transcription factor Bcl6. By shutting down this protein, patients may experience fewer side effects and improved treatment outcomes.
Dr. Lewis Cantley, a pioneer in cancer research, has made significant breakthroughs in understanding the PI3K pathway and its role in cancer development. His work has led to revolutionary treatments and continues to advance precision medicine for cancer diagnosis and treatment.
Researchers at Weill Cornell Medical College and Cornell University have developed bioengineered ears that can grow cartilage over a three-month period. The study's breakthrough could provide a new solution for children born with congenital ear deformities, as well as individuals who have lost part or all of their external ear.
Researchers at Weill Cornell Medicine found that a copper-depletion compound, tetrathiomolybdate (TM), prevents cancer recurrence and metastasis progression. The study's findings are promising for high-risk triple-negative breast cancer patients with no current visible breast cancer.
A new study reveals that amyloid peptides build-up in brain's blood vessels accelerates cognitive decline by limiting oxygen-rich blood and nutrients. Researchers identify CD36 as a key protein in the buildup of Aβ40 in blood vessels, promoting cerebral amyloid angiopathy (CAA).