A new study suggests that impaired autophagy may contribute to the development of post-partum depression in pregnant women. The researchers found lower levels of messenger RNA associated with autophagy in blood samples from women who went on to develop PPD.
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
A new automated screening tool can accurately identify patients at high risk of developing progressive scarring of the lungs, a condition called idiopathic pulmonary fibrosis (IPF). The tool uses machine-learning algorithms to analyze patient electronic health records and detects IPF risk automatically.
Researchers have discovered how a common blood stem cell mutation, DNMT3A R882, alters gene activity and produces abnormal blood cells that increase cancer risk. The study found that the mutant cells produce more red blood cells and platelets, leading to higher cardiovascular disease risks.
A new study reveals that aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson's disease through a cellular waste-ejection process called lysosomal exocytosis. This process can lead to the deaths of neurons and ultimately result in the characteristic symptoms of the disease.
A new preclinical model of thymic cancer reveals how a common mutation sparks tumor formation and identifies potential targets for therapy. The model, developed by Weill Cornell Medicine researchers, shares molecular characteristics with human thymic tumors, paving the way for new treatments.
A new study identifies PDIA3 as a molecule targeted by the immune system in response to stress, contributing to liver damage in type 2 diabetes and obesity. Elevated levels of antibodies for PDIA3 have been found in people with these conditions, but improving diet and weight can reverse this liver condition.
A new analysis shows that combining two anti-platelet drugs can reduce the risk of graft failure after coronary artery bypass surgery, but also increase the risk of bleeding. The study found a significant reduction in graft failure rates with dual therapy, but more bleeding events requiring medical attention.
Researchers at Weill Cornell Medicine found that disrupting circadian clocks leads to increased fat cell growth and insulin production. Stress and other factors can throw the body's 'clocks' out of rhythm, contributing to weight gain.
Researchers found no significant differences in placental health indicators, birth weights, or Apgar scores between vaccinated and unvaccinated women. Vaccination against COVID-19 was shown to be safe during pregnancy, protecting both mothers and babies from severe illness.
Researchers found that mothers who didn't transmit HCMV to their infants had higher levels of antibody-dependent cellular phagocytosis, suggesting a non-neutralizing immunity mechanism. This finding has implications for the development of effective HCMV vaccines.
A new study found that individual details of a memory are parsed and stored elsewhere, in the prefrontal cortex. This separation ensures that exposure to any cue is sufficient to activate the prefrontal cortex for recall of the whole memory.
Researchers at Weill Cornell Medicine discovered that chemokines can form DNA-bound nanoparticles that induce chronic, dysfunctional immune responses. This new mechanism may play a central role in autoimmune diseases such as scleroderma and lupus, where inflammation goes awry.
Establishing complete trauma care programs accessible to all road injury victims could save 200,000 lives annually, according to a study. Clinical interventions such as early resuscitation and interventional radiology are the most effective measures to reduce deaths related to road traffic injuries.
A multicenter prospective study shows that 88% of isolated LCH skull lesions in children resolve spontaneously without surgery. The study supports a nonsurgical approach, avoiding the risks associated with removal.
A new study found that post-operative atrial fibrillation (POAF) is associated with a higher risk of hospitalization for heart failure among patients undergoing cardiac and non-cardiac surgery. POAF may be an early marker for heart failure, and its presence could contribute to the development of the condition.
A large clinical trial found treating anal precancerous lesions reduces the risk of developing anal cancer in people with HIV by 57%. The study highlights the need for screening and treating high-grade squamous intraepithelial lesions (HSIL) as the standard of care for older HIV+ individuals.
The study found that autologous stem cell transplantation (ASCT) was underutilized in community settings, but maintenance therapy after standard therapy improved outcomes for patients over 65. Maintenance rituximab after bendamustine and chemotherapy regimens also significantly extended times to disease progression and overall survival.
Researchers have developed a new method to assess the three-dimensional structure of the human genome, revealing that groups of simultaneously interacting regulatory elements may affect gene expression. The study found that cooperative groupings of DNA elements occurred around genes associated with cell identity.
A recent study published in the New England Journal of Medicine found that COVID-19 vaccine immunity against new infection appears to wane rapidly, whereas people with a prior-infection were moderately protected from Omicron. Natural immunity provided strong and durable protection against severe illness.
A new preclinical study by Weill Cornell Medicine researchers shows that naturally-produced IgG antibodies in breast milk can protect infants from infection-induced diarrheal illness. These antibodies enhance infant immunity against bacterial pathogens causing gastrointestinal diseases.
A new cell therapy has been developed to target and eliminate leukemia stem cells that cause disease relapse. The treatment uses genetically engineered T cells with a chimeric antigen receptor that recognizes specific markers on these cancer cells.
Researchers have identified a previously unrecognized form of hormone therapy-resistant prostate cancer and found promising drug targets to treat it. The discovery opens the door to developing therapies that specifically target this disease, which accounts for approximately a quarter of castration-resistant prostate cancers.
A study by Weill Cornell Medicine investigators has revealed the cause and potential precision therapies for a type of aggressive blood cancer called diffuse large B cell lymphoma (DLBCL). The research found that SETD2 gene mutations can lead to an accumulation of DNA damage, causing cancer cells to grow uncontrollably.
New research suggests that PSA screening has remarkably favorable tradeoffs, particularly for Black men, who disproportionately bear the burden of prostate cancer mortality and morbidity. The study's findings support the use of PSA screening for high-risk groups, including Black men, and highlight the need to revise clinical guidelines...
Researchers at Weill Cornell Medicine found that tumors recruit nearby cells called fibroblasts to work as their enablers by releasing lactate. This finding suggests that future drug treatments could target this defense mechanism to help cancer patients.
A new study by Weill Cornell Medicine investigators found that T cells' genetic program and developmental path affect their response to immunotherapy. The results suggest that infiltrating T cells don't all meet the same fate in every tumor, with long-lived memory programs correlating strongly with overall survival
A recent study by Weill Cornell Medicine and Dana Farber Cancer Institute reveals that CDC7 is replaceable by CDK1 in cell division, opening up new avenues for cancer therapies. The finding highlights the complex molecular orchestration of the cell cycle and suggests a powerful new strategy against cancer.
A new study by Weill Cornell Medicine investigators found that adult vaccination rates and social determinants of health impacted children's mental health during the pandemic. Stress surrounding the pandemic decreased in children after vaccinations were rolled out for adults in December 2020.
Research from Weill Cornell Medicine found that less prostate cancer screening has reduced overdiagnosis, but increased incidence of high-grade and metastatic disease. The study analyzed over 438,000 men with newly diagnosed prostate cancer between 2010 and 2018.
A preclinical study suggests that astrocyte abnormalities may contribute to repetitive behaviors and memory deficits in autism spectrum disorders. Researchers grew human astrocytes from patients with ASD and transplanted them into healthy mice, which developed repetitive behaviors but not social deficits.
Researchers tracked brain cell activity in zebrafish during seizures, finding that seizures arise from an excess of excitatory over inhibitory neuron activity in confined regions. The findings suggest a nuanced role for both excitation and inhibition in seizure origins.
Inhibiting a key signaling pathway in brain-resident immune cells may calm brain inflammation and slow Alzheimer's disease. The NF-κB pathway's activation triggers inflammatory activation of microglia, leading to tau tangle formation and spread.
Researchers at Weill Cornell Medicine discovered that cancer cells suppress a key enzyme in propionate metabolism, increasing production of methylmalonic acid (MMA) and causing cells to become more aggressive. This metabolic change may hold the key to understanding how tumors metastasize and developing novel therapies.
A new study found that hysteroscopic and laparoscopic sterilization procedures have higher-than-expected failure rates of five to six percent at 5 years post-procedure. The study, led by Dr. Aileen Gariepy, used Medicaid claims data to compare the effectiveness of these methods.
A randomized clinical trial found that participants treated at non-stigmatizing 'accessible care' centers were nearly three times more likely to be cured of hepatitis C than those referred out to local clinicians. The study suggests that expanding and supporting accessible care models could help eliminate the disease.
A preclinical study suggests that SARS-CoV-2 infection can cause ferroptosis in pacemaker cells, leading to cardiac arrhythmias. Researchers used animal models and human stem cell-derived pacemaker cells to demonstrate the virus's impact on these cells.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
Researchers at Weill Cornell Medicine have found that an enzyme called ART1 can modify a receptor on tumor-fighting immune cells, triggering their death. Blocking ART1 increased the presence of these immune cells within tumors and slowed or stopped tumor growth in animal models.
Researchers at Weill Cornell Medicine found that certain Candida albicans yeast strains produce a potent toxin called candidalysin, which damages immune cells and triggers pro-inflammatory responses. The study suggests a possible way to personalize treatments for IBD patients by targeting these high-damaging strains.
A new study by Weill Cornell Medicine and colleagues found that most COVID patients regain consciousness after removal of respiratory support, but may take weeks to recover. The study also showed that patients who experienced low blood oxygen levels during treatment took longer to recover consciousness.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
A study published in Nature Communications reveals the precise molecular structure of siponimod, a multiple sclerosis drug, and its interactions with S1P receptors. This knowledge may lead to the development of more targeted therapies that reduce side effects.
Researchers at Weill Cornell Medicine have identified a protein called HDP1 that plays a critical role in activating genes required for the development of male and female stages of the malaria parasite. Without HDP1, parasites are unable to assemble mature gametocytes, leading to their death and inability to infect mosquitoes.
A preclinical study by Weill Cornell Medicine researchers reveals that a specific group of fungi residing in the intestines can protect against intestinal injury and influence social behavior in mice. The findings suggest a novel signaling system connecting fungi in the gut to their host's cells, including immune cells and neurons.
Researchers found that disulfiram protected rodents from immune-mediated lung injury in models of SARS-CoV-2 coronavirus infection and TRALI, a rare lung failure syndrome. Disulfiram blocks NETs formation, which can cause lung damage and blood clots.
Researchers discovered a key growth factor protein, HB-EGF, produced by immune-regulating cells that protects the gut against inflammatory bowel disease. ILC3s produce HB-EGF to counteract TNF-induced inflammation and maintain gut barrier function.
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
Scientists at Weill Cornell Medicine developed a new imaging technique to capture bacteriorhodopsin's motions in response to light on a millisecond time scale. This study reveals the protein's kinetics, including the speed of transitions between open and closed states, which informs optogenetics research.
Melanoma cells release small packages containing the protein NGFR, which primes nearby lymph nodes to form new vessels and encourage cancer spread. This process, called lymphangiogenesis, may help doctors determine which patients need more aggressive treatment.