Researchers found that increasing astrocytic mGluR3 levels enhanced memory in older females, while reducing these levels impaired memory in young females. In males, reducing mGluR3 enhanced memory, and increasing the receptor had no effects.
Research led by Weill Cornell Medicine found that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. This new understanding suggests a unified model for colorectal cancer initiation where damage to intestinal crypts causes a decrease in aPKC protein expression.
Researchers developed a high-resolution sensor to track real-time dynamics of ATP levels in cells and within subcellular compartments. The iATPSnFR2 sensor has high sensitivity across a wide range of ATP concentrations, enabling accurate tracking of ATP levels and their dynamics.
A Weill Cornell Medicine study found that over 15-fold more Haitians have early-onset heart failure than previously thought, with elevated blood pressure being the leading risk factor. The research suggests a shift in focus to early prevention and treatment of cardiovascular diseases in low-income countries.
Researchers discovered that maternal blood cytokines, such as XCL1, play a crucial role in fetal brain development and offspring behavior. Elevated XCL1 levels during pregnancy are associated with improved emotional regulation and reduced anxiety in male mice.
Researchers at Weill Cornell Medicine have discovered a way to boost protective effects of sphingolipids in blood vessels, slowing the development and progression of coronary artery disease. The study suggests revising current views on ceramides' role in the disease, instead finding that their levels remain stable in endothelial cells.
A new study reveals that gut microbiota significantly impacts host amino acid and glucose metabolism, leading to a second liver-like function. The research identifies specific bacterial metabolic genes responsible for depleting amino acids, which can be targeted to treat conditions such as type 2 diabetes and inflammatory bowel disease.
Researchers developed a powerful new technique to generate dynamic structural data of proteins. They applied it to Glt Ph, revealing previously unseen structural states and uncovering the basis of wanderlust kinetics. The approach opens up possibilities to track protein structure in real-time.
Researchers found that severe intraoperative anemia is a significant contributor to higher female mortality rates after heart bypass surgery. Women tend to arrive in surgery with lower red blood cell counts and smaller body size, making them more susceptible to anemia's effects.
A clinical trial found that a nasal spray called etripamil effectively and safely treated recurrent episodes of paroxysmal supraventricular tachycardia (PSVT) in patients. The study showed that two-thirds of participants experienced relief within an hour, with an average time needed for symptom relief being 17 minutes.
Researchers at Weill Cornell Medicine have assembled a comprehensive atlas of messenger RNA variants in the mouse and human brain, revealing intricate patterns of gene expression and its relationship to major brain disorders. The study provides valuable insights into brain development, neuron specialization, and disease mechanisms.
Weill Cornell Medicine scientists developed a human neuron model that simulates tau protein aggregate spread, a process driving cognitive decline in Alzheimer's disease. The model identified novel therapeutic targets, including the UFMylation cascade, which can potentially block tau spread.
Researchers at Weill Cornell Medicine have developed a novel method to create grafts that accurately replicate the human ear's anatomy and biomechanical properties. The new technique uses 3D printing and tissue engineering to produce cartilage-containing structures that mimic the ear's shape, flexibility, and elasticity.
Researchers at Weill Cornell Medicine have identified mutations in the ARID1A gene that drive follicular lymphoma transformation into a more aggressive form. These mutations make patients highly susceptible to experimental BAF-inhibitor drugs, offering new hope for early intervention therapies.
A team of researchers at Weill Cornell Medicine has discovered a critical protein sensor called SEL1L that regulates collagen clearance from tissue. This finding provides new insights into the development of therapeutic strategies for diseases like lung fibrosis, which currently have no effective treatments.
A recent study analyzed 306,800 US suicide deaths between 2003 and 2020 and found that physical health concerns were a significant risk factor for suicide. The largest subgroup of individuals who died by suicide had no documented mental health issues or antidepressant use.
Researchers mapped the evolution of urinary tract cancer cells using single-cell resolution, revealing stable molecular characteristics despite metastasis. The study provides new avenues for personalized treatment strategies and targeted therapies.
A new study found that peer-coaching is effective in controlling high blood pressure, particularly among younger Black patients. Participants under 60 who received peer coaching experienced a medically significant reduction in systolic blood pressure compared to those receiving enhanced usual care. The study also showed promise for pra...
Researchers found that specialized nursing facility clinicians (SNFists) can decrease the likelihood of nursing home residents experiencing stressful hospitalizations. Care from SNFists also improved the quality of life in their last days, with a 6% decreased risk of hospitalizations due to various reasons. The study suggests increasin...
Researchers found that gut bacteria in newborns produce serotonin, promoting the development of immune cells called Tregs. This helps prevent allergic reactions and autoimmune diseases. The study suggests that unique gut bacteria may supply neurotransmitters needed for critical biological functions during early development.
A study published in JAMA found that three months of social worker follow-up support improved HIV clinic attendance and antiretroviral therapy initiation, but did not reduce mortality after one year. The intervention, known as Daraja, was highly effective at addressing barriers to care such as stigma and lack of social support.
Researchers deciphered the male breast cancer genome, identifying gene mutations and molecular profiles that could impact diagnosis and treatment. The study found mutations in genes known to drive cancer growth and structural variants impacting other cancer-associated genes.
Researchers at Weill Cornell Medicine found that patients with drug-resistant tuberculosis (TB) respond similarly to those with drug-sensitive TB when treated with bedaquiline-based second-line medications. The study suggests that treatment duration for drug-resistant TB may be shortened, potentially reducing mortality rates.
A new genetic signature of 140 genes may predict enhanced disease-free survival in patients with non-small cell lung cancer treated with immunotherapy and low-dose radiation. The signature is associated with aggressive tumor growth but also increased immunity and tissue repair after treatment.
A new study suggests that individuals with low income are frequently misdiagnosed and lack access to effective treatment for eating disorders. Researchers offer guidelines for therapists to make accommodations for these patients, including providing government or local food resources and engaging with local food banks.
An experimental mRNA vaccine against CMV elicited promising immune responses, outperforming a previous vaccine candidate in preventing the virus from infecting epithelial cells. The new vaccine may protect adults against CMV, potentially preventing women from passing the infection to their babies during pregnancy.
Researchers at Weill Cornell Medicine have developed a mouse model that illuminates the process of histological transformation, where adenocarcinoma transforms into aggressive small cell lung cancer. The study suggests targeting Myc proteins as potential therapeutic approaches for this deadly type of cancer.
A new study published in Nature Communications has provided structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum. The research suggests that the drug, TDI-8304, can selectively target and kill resistant parasites, offering hope for more effective treatments against ...
A new study finds that SARS-CoV-2 can infect dopamine neurons, causing them to lose their ability to grow and divide, leading to inflammation and potentially severe neurological symptoms. Researchers discovered three drugs that may block or rescue infected dopamine neurons from senescence.
A drug screening system modeling cancers with lab-grown tissues called organoids helped uncover a promising target for future pancreatic cancer treatments. Researchers identified an existing heart drug, perhexiline maleate, that powerfully suppresses the growth of pancreatic tumor organoids.
Researchers at Weill Cornell Medicine found lipid-signaling microdomains in condensates, previously thought to function primarily in cell membranes. These discoveries may lead to a better understanding of neurodegenerative diseases like ALS and Alzheimer's disease.
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
A phase 3 trial found that tirzepatide promotes additional weight loss and preserves metabolic health when continued, but discontinuation leads to significant weight regain. Researchers suggest chronic treatment may be necessary for sustained weight loss and improved cardiometabolic risk factors.
Researchers at Weill Cornell Medicine discovered a genetic variant in the GIP receptor that may help individuals resist obesity. The variant enhances insulin release and glucose metabolism, allowing mice with the variant to process sugar more efficiently and stay leaner.
Researchers tested removing race information from cardiovascular risk calculators and found no impact on patients' risk scores. Adding social determinants of health also didn't have an effect, suggesting that measuring traditional risk factors can accurately predict risk without using race.
Researchers at Weill Cornell Medicine found that controlling high blood pressure may not prevent cognitive declines due to immune protein IL-17. Increased levels of IL-17 in the brain suppressed blood flow and induced cognitive impairment in a preclinical model.
Researchers used AI-selected natural images and synthetic images to probe visual processing areas of the brain, finding that predicted maximal activator images significantly activated targeted areas. The study suggests individualized models for each subject can improve understanding of visual system organization across populations.
A team of researchers at Weill Cornell Medicine used an AI-based approach to uncover patterns among social determinants of health and their impact on children's health outcomes. The analysis found statistical associations between four broad patterns in social determinants and outcomes relating to child developmental health.
Researchers at Weill Cornell Medicine found that partnering with local religious leaders increased the adoption of family planning methods in Tanzania. The approach, which involves workshops and training for faith leaders, led to a 19% rise in contraceptive uptake in communities where religious leaders participated.
A team at Weill Cornell Medicine mapped the location and spatial features of blood-forming cells in human bone marrow, confirming hypotheses and providing a powerful new means to study diseases. The method, which uses artificial intelligence, identified and determined the positions of about 1.5 million cells in archival samples.
A new resorbable scaffold has been shown to be more effective than traditional angioplasty in treating severe artery blockages in the lower leg. In a large clinical trial, patients who received the scaffold had a 74% chance of avoiding adverse events, compared to 44% for those who underwent angioplasty.
A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a new mechanism for insulin regulation in type 2 diabetes. The preclinical discovery provides a new chemical tool for probing the biology of diabetes and could lead to better treatments.
A preclinical study by Weill Cornell Medicine researchers reveals that activating a pathway to promote cell division can expand insulin-producing cells without impairing their function. The study's findings support the concept that beta cell mass can be expanded without compromising function.
A phase 1 trial of the radiopharmaceutical 225AC-J591 demonstrated promising antitumor activity against advanced metastatic prostate cancer, reducing PSA levels by at least half for 47% of patients. The treatment was well-tolerated, with only temporary low blood cell count side effects.
Researchers at Weill Cornell Medicine have discovered a new mechanism that makes some cancers treatment-resistant, involving the shuttling of messenger RNAs from the nucleus to the cytoplasm. The approach targets this mechanism with a combination of approved chemotherapies, showing promise in treating persistent cases.
A study published in Annals of Neurology found that receiving clot-busting drug treatment in a mobile stroke unit (MSU) increases the likelihood of averting strokes and complete recovery compared to standard hospital emergency care. Patients treated by an MSU had faster treatment times, with nearly one-third recovering within 24 hours.
A new study finds that certain gut-dwelling fungi amplify excessive inflammation in severe COVID-19 and cause long-lasting changes in the immune system. Patients with these fungi may benefit from specialized treatments targeting the fungi or immunological changes they instigate.
Mental health crises among children and adolescents requiring emergency department care skyrocketed during the pandemic and have stayed elevated despite a return to normalcy. Studies found increased rates of youth mental health-related visits, including anxiety, depression, substance use disorder, and eating disorders.
Researchers at Weill Cornell Medicine have discovered that a tiny chemical modification on mRNAs, known as m6A, is key to the formation of stress granules during cell stress. Longer mRNAs dominate stress granules because they have high levels of m6A, which triggers their sequestration.
Researchers found that adding dendritic cell boosting therapy to radiation and CTLA4 inhibitor combination produced synergistic effect, eliciting tumor regression. This approach resulted in complete or almost complete elimination of targeted tumors.