Articles tagged with Clinical Trials
A study found discrepancies between primary trial outcomes registered and published, with 31% of adequately registered trials showing evidence. Most discrepancies favored statistically significant results or omitted nonsignificant outcomes.
The MADIT-CRT study found that CRT-D therapy reduces the risk of heart failure or death by 34% compared to ICD-only therapy, with benefits seen across various patient sub-groups. This results validate a new indication for CRT-D therapy in preventing heart failure in at-risk patients.
Recent studies suggest that aspirin may not provide significant benefits for primary prevention in all diabetics. However, the European Society of Cardiology recommends its use for individuals with a high cardiovascular risk profile. Aspirin has been shown to reduce the risk of myocardial infarctions and strokes in this population, par...
Recent discoveries of genetic variants affecting coronary artery disease and heart attack risk are promising for preventing the condition. The variants increase risk by 10-30% and are common, making them useful in prevention algorithms.
The Aspirin for Asymptomatic Atherosclerosis study found no statistically significant difference in primary endpoint events between those subjects allocated to aspirin or placebo. Vascular events and all-cause mortality were similar in both groups, but major bleeding occurred more frequently in the aspirin group.
A new study by Johns Hopkins Medicine, Duke and Wake Forest suggests that disclosing financial conflicts of interest to research participants may not be sufficient. The study recommends establishing sound policy and practices for disclosure and management of financial interests.
Researchers advocate for clearer conflict of interest disclosures in clinical trials to ensure transparency and fairness. Key findings include the need for institutional review boards and study coordinators to play a larger role in disclosing financial relationships that may impact patient decisions.
Researchers found that presenting risk as natural frequencies and using bar charts helped participants make decisions consistent with their values. The studies also showed that different data presentations can be more persuasive, regardless of the participant's values. Healthcare providers should strive to maintain objectivity while re...
A new study published in JNCI finds that training methods for surgeons performing breast cancer sentinel lymph node resection are highly effective. The study evaluated three training methods and found a statistically significant positive association between procedural errors and false-negative rates.
A study published in BMC Medical Research Methodology found that general practitioners (GPs) are reluctant to participate in medical research due to administrative challenges. The researchers discovered that non-medical staff often handle first contact with surgeries, making it difficult for doctors to engage with the study.
Researchers present results from two Phase 1 clinical trials of TH-302, a hypoxia-activated prodrug, demonstrating partial responses in patients with relapsed/refractory lung cancer. The treatment showed manageable skin and mucosal toxicities, with minimal hematologic side effects.
A new study investigates the effects of the Khmer Rouge trials on Cambodians, finding that while most believe justice will be served, nearly 90% experience painful memories. The trials' impact on mental health remains uncertain, with higher rates of PTSD among those who remember torture and murder.
A new study finds that while most Cambodians believe the Khmer Rouge trials will deliver justice, over 87% of people who experienced torture during the regime say the trials will rekindle painful memories. The trial's impact on mental health is still unknown.
A recent study suggests that Khmer Rouge trials may exacerbate post-traumatic stress disorder (PTSD) symptoms in Cambodian survivors. The trial's impact on mental health is uncertain, as some respondents believe the trials will revive painful memories.
A study examining the effectiveness of universal intimate partner violence (IPV) screening found that it did not significantly reduce subsequent reports of IPV or improve quality of life. While some small benefits were observed, the authors conclude that screening is not enough to address IPV and recommend specific interventions to pre...
A phase I clinical trial enrolled its first patient only two days after FDA clearance, accelerating development of new cancer drugs. The joint effort between M.D. Anderson and AstraZeneca demonstrates how to shrink the time it takes to bring new therapies to patients.
A global breast cancer trial has recruited Chinese patients for the first time, evaluating the treatment's impact on cancer recurrence after mastectomy. Researchers aim to identify molecular fingerprints of each patient's cancer to determine the most likely candidates for radiotherapy.
Researchers at MIT's Picower Institute for Learning and Memory found that brain cells only change their responses after a successful behavior, but not after a failure. This study sheds light on the neural mechanisms underlying learning and memory, with implications for understanding how we learn and treating learning disorders.
A meta-analysis of 50,000 patients reveals GPs struggle to identify depression, resulting in missed diagnoses and misidentifications. Researchers recommend reassessment of suspected cases and multiple appointments for uncertain diagnoses.
A growing number of British academics claim that EU regulations are hindering their ability to conduct clinical research, with some facing delays of over 2 years due to excessive paperwork. Researchers argue that the current system requires lengthy protocols and multiple forms, leading to administrative burdens.
A study of nearly 1,600 tumor samples found that CT-X genes are expressed in half of ER-negative and triple-negative breast cancers. This suggests a potential new therapy approach for these aggressive breast cancer types. Researchers plan to initiate clinical trials based on the findings.
A study by Dan Barouch and colleagues at Beth Israel Deaconess Medical Center found no correlation between Ad5 neutralizing antibodies and T-cell immune responses. The researchers suggest using rare serotype vectors to develop HIV-1 vaccines that are not suppressed by baseline vector-specific neutralizing antibodies.
A Kaiser Permanente study found that a reminder program using electronic health records and personalized outreach increased mammography rates among women aged 50-69. Mammography rates jumped from 63% to over 80%, with 75% of women completing their screenings within 10 months.
Two large studies using DHA showed mixed results, with no benefit in people with mild to moderate Alzheimer's but a positive result in healthy older adults. The findings highlight the need for earlier detection and diagnosis of Alzheimer's disease, as well as further research on genetic interactions.
A new study suggests that partnering with local physicians, conducting educational seminars, and utilizing community outreach are effective tools in recruiting people for Alzheimer's clinical studies. In contrast, patient registries and internet recruiting were found to be less successful strategies. The study also explores the importa...
A study of nearly 20,000 patient records found that African-American breast, ovarian, and prostate cancer patients die earlier than others with similar treatment, suggesting biological or host genetic factors as the cause. The survival gap persists even after controlling for socioeconomic factors.
A clinical trial shows that quadriplegics can operate a powered wheelchair using a tongue drive system, which detects movement of a magnetic tracer attached to the tongue. The system allows for intuitive control with minimal prior training, enabling users to play computer games and navigate obstacles with ease.
A study published in BMC's open access journal Trials found that 93% of RCTs published in Chinese medical journals between 1994 and 2005 were flawed, casting doubt on their reliability. Researchers investigated clinical trials on 20 common diseases and found that only 7% met recognized standards for authentic randomization.
A Phase II trial shows that a low dose of oral interferon alpha preserves beta cell function in patients with newly diagnosed type 1 diabetes, delaying the need for insulin. The study found significant improvement in preserving insulin-producing beta cell function compared to placebo, offering hope for managing the disease.
The European Society of Human Reproduction and Embryology (ESHRE) has launched an international study to investigate the efficacy of polar body screening in preimplantation genetic testing. The study aims to determine whether this novel method offers a possible solution for improving IVF treatment outcomes.
The American Thoracic Society and European Respiratory Society have released standardized definitions and measurement recommendations for assessing asthma control, severity, and exacerbations. The guidelines provide a framework for clinicians to diagnose and manage asthma, with a focus on improving patient outcomes.
A landmark study demonstrates a significant reduction in heart failure or death in patients with heart disease who received CRT-D versus ICD-only. The MADIT-CRT trial showed a 29% decrease in mortality and heart failure symptoms, improving survival and outcome for patients with severe heart disease.
A study published in The Lancet Oncology found that combining HPV testing with routine liquid-based cytology (LBC) screening in the UK did not increase the detection of cervical cancer. However, HPV testing detected cases of precancerous cervical cells in the first round of screening, but this effect was not sustained over two rounds.
A recent study published in the Journal of Religion examines medical studies on intercessory prayer, finding that scientists' personal beliefs influenced the outcomes. The research highlights the evolution of American religious demographics and the development of clinical trials.
The BrainGate2 pilot clinical trial is taking place at Massachusetts General Hospital, extending prior safety and feasibility research of the BrainGate Neural Interface System. The trial aims to help patients with spinal cord injury, stroke, muscular dystrophy, ALS, or limb loss turn their thoughts into actions.
A new clinical trial has begun at Massachusetts General Hospital to expand restorative neurotechnology research for patients with paralysis. The trial aims to harness brain signals to control assistive devices, such as computers and prosthetic limbs, for people with spinal cord injuries, ALS, or limb loss.
Researchers at UNSW found that internet-based therapy programs are as effective as face-to-face treatments for depression. The Sadness program required minimal clinician contact, making it convenient for patients to access treatment without stigma or location barriers.
Allogeneic stem cell transplantation provides significant overall and relapse-free survival benefits for adult patients with intermediate- and poor-risk acute myeloid leukemia in first complete remission. However, its benefit varies by cytogenetic risk, with no significant advantage for good-risk AML.
The DuraHeart system is designed for severe left-ventricular heart failure, helping patients sustain life while awaiting a heart transplant. The device, developed by Terumo Heart Inc., has been successfully implanted in three US patients.
A large-scale trial found that surgical treatment for degenerative spondylolisthesis provides significantly greater relief from pain compared to non-operative approaches. Patients who underwent surgery reported better function, less pain, and higher satisfaction than those who chose not to have surgery.
New telemonitoring systems provide a more interactive experience for patients with heart failure, offering education, feedback, and advice on adjusting therapy. These systems have shown promise in reducing mortality and hospitalization rates, but service integration is crucial to fully realizing their benefits.
The AGA Institute will present exciting data on treatments for Clostridium difficile infection, hepatitis C, and Crohn's disease. The late-breaking session includes studies on optimized therapies and new technologies, which may become the standard of care in the near future.
Research suggests music can reduce pain and encourage better oral feeding in premature babies, leading to calmer infants and parents. The studies found preliminary evidence of therapeutic benefits, including improved physiological measures and behavioral states.
A randomised controlled trial of 2518 patients found no significant reduction in deep vein thrombosis with compression stockings. In fact, skin complications were more common in those who received the stockings. The study's findings challenge national stroke guidelines and recommend revising treatment protocols.
Researchers at Mayo Clinic have found that patients with chronic lymphocytic leukemia (CLL) can tolerate high doses of green tea extract EGCG, leading to a significant reduction in lymphocyte count. The study also showed that many participants experienced regression of CLL symptoms, particularly those with enlarged lymph nodes.
Researchers at Karolinska Institutet are making rapid progress in stem cell therapy, with a first-in-human study initiated for Parkinson's disease. The study uses the drug product sNN0031, which has shown long-lasting recovery and new cell formation in animal models. Additionally, a treatment for ALS entered clinical trials last year.
The FIELD study found that fenofibrate significantly reduced the risk of first diabetes-related amputations in patients with type 2 diabetes. The treatment also showed a significant reduction in minor amputations without large-vessel disease, while major amputation risks did not differ between groups.
The NIH has launched a new program to develop therapeutics for rare and neglected diseases, providing funding for preclinical research and product development. The program aims to stimulate research collaborations with academic scientists and improve the drug development process.
A large, multi-national clinical trial program has demonstrated the effectiveness and safety of pirfenidone in slowing the deterioration of lung capacity in IPF patients. The treatment resulted in a clinically meaningful reduction in the percentage of patients with an absolute decline in lung function.
A two-week course of eszopiclone increases CPAP usage among OSA patients, with sustained benefits at six months. The study suggests that this intervention could represent a significant clinical benefit for these patients.
Two recent studies by the University of Cincinnati team found that LAM patients are more likely to participate in clinical trials due to a shared cause and altruism. The research also shows that CT scans given to young women with a collapsed lung can be cost-effective and beneficial in diagnosing the disease.
The American Pain Society has issued a new clinical practice guideline for low back pain, recommending noninvasive treatments over interventional procedures and shared decision making. The guideline provides eight recommendations to help determine the best way to treat patients with persistent back pain.
Research found that lower levels of alpha-beta peptide 1-42, tau, and phosphorylated tau 181 in cerebrospinal fluid are associated with a faster rate of cognitive decline among individuals with mild dementia. The study suggests that these biomarkers may be useful as entry criteria for clinical trials of disease-modifying therapies.
A randomized trial found acupuncture to be as effective in treating chronic low back pain as usual care, with simulated and standard acupuncture showing similar benefits. The study suggests that the mind-body connection and physiological effects may play a role in the therapeutic effect of acupuncture.
A proteomic analysis of 50 participants from the Women's Health Initiative hormone replacement therapy trial reveals estrogen upregulates proteins involved in major body processes. The study found changes in serum levels of proteins affecting coagulation, metabolism, osteogenesis, and blood vessel morphogenesis.
A large clinical trial found that long-term treatment with Gamunex improves and maintains physical and mental component scores in patients with CIDP. Improvements were observed in all domains, including physical functioning, role-physical, social functioning, and mental health.
A head-to-head clinical trial will enroll approximately 400 patients at three world-class sites to compare Telesso's novel guide-wire assisted peripheral IV catheter with the industry standard. The trial aims to reduce safety risks, lessen patient pain and discomfort, and provide cost savings.
A survey of 2,400 practicing clinicians found that only 65% were aware of at least one major clinical trial on complementary and alternative medicine (CAM) therapies. Clinicians who were aware of CAM trials reported greater ability to interpret evidence and acceptance of its value.
Research found that children with sickle cell disease are less likely to receive transcranial Doppler ultrasound screenings due to limited lab access, despite increased overall screening rates.
A clinical trial found that regular exercise significantly improved the quality of life for patients with chronic heart failure, reducing the risk of death and hospitalization. The study also revealed that exercise was well-tolerated and safe, with participants reporting fewer physical and social limitations.