Articles tagged with Engraftment
A new study has identified optimized immunosuppressive strategies that allow transplanted iPSC-CMs to survive without immune rejection in non-human primates. The researchers found a triple-drug regimen consisting of methylprednisolone, calcineurin inhibitors, and mycophenolate mofetil reliably prevents acute immune rejection.
A study published in the Journal of Clinical Immunology found alemtuzumab to be safe and effective in treating Asian patients with inborn errors of immunity after allogeneic hematopoietic cell transplantation. The drug was shown to improve overall survival rates, with 94.7% of patients surviving post-transplantation.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
Researchers at NTU Singapore successfully grew 'mini kidneys' in the lab, grafted them into live mice, and found a potential treatment for polycystic kidney disease by boosting autophagy. The study suggests that minoxidil could be used to reduce cysts in the novel mouse model.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
A recent study by the University of Alabama at Birmingham has identified 19 specific Bacteroides vulgatus genes that are linked to early colonization after fecal microbe transplants. These genes are part of a commensal colonization factor complex that promotes stable and resilient colonization in mice, suggesting their potential role i...
Researchers at Hollings Cancer Center have made a breakthrough in CAR-T-cell therapy by eliminating the need for lymphodepleting chemotherapy, which reduces the risk of severe side effects. In preclinical models, their method showed promising results in controlling cancer and creating memory cells trained on specific proteins.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
Researchers at Children's Hospital of Philadelphia have developed a custom-built application to automate the determination of engraftment after hematopoietic stem cell transplant. The tool has been shown to improve accuracy of reported engraftments, reducing errors in neutrophil and platelet engraftment reporting.
A study published in Nature Medicine found that higher levels of microbiota engraftment correlate with better clinical responses to FMT. The research used genomic sequencing and AI to analyze over 1,300 gut samples from donors and patients with various diseases.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
A new method has been developed to improve the quality of stem cell-derived cardiomyocytes, which can be used to treat heart attacks. The approach, tested in a mouse heart attack model, doubled the engraftment rate of injected cells, showing promise for repairing damaged heart tissue.
A new imaging test can detect bone marrow engraftment as early as days after a transplant, giving patients and doctors a more accurate assessment of the treatment's success. This breakthrough could help patients avoid painful biopsies and rapidly respond to potential complications, potentially saving lives.
A statistical model predicts which bacteria will engraft after fecal transplantation, providing a context for developing synthetic probiotics. The study found that recipient microbiome and immune state play roles in successful FMT, and new bacteria are acquired from both donors and recipients.
Researchers at Kyoto University discovered that heart cells differentiated from induced pluripotent stem (iPS) cells can be used to treat damaged hearts. The study found an optimal maturation stage for heart cells, which is crucial for improving patient outcomes and reducing the number of cells required for therapy.
Researchers at Boston Children's Hospital have identified epoxyeicosatrienoic acids (EETs) that enhance stem cell engraftment in zebrafish and mice. These compounds could improve bone marrow transplants by allowing the use of more umbilical cord blood units, increasing patient chances of finding a matched donor.
A phase I clinical trial found that ex vivo cultured cord blood stem cells showed improved engraftment rates and earlier hematopoietic recovery in patients with hematological malignancies. The study also developed a murine model of Ewing's sarcoma, revealing tumor origins in embryonic osteochondrogenic progenitors.
Researchers have developed a method to expand umbilical cord blood cells on mesenchymal precursor cells, speeding up the establishment of a new blood supply in patients. This approach has shown faster engraftment of white blood cells and platelets, resulting in improved patient outcomes.
The Society for Experimental Biology and Medicine (SEBM) recognizes the best papers published in 2011, with winners awarded in Clinical/Preclinical and Translational Research, Experimental Biology, and Interdisciplinary Research. The Interdisciplinary Research Award honors Nobel Laureate Dr. Alan MacDiamid.
A study on therapeutic cloning of hematopoietic stem cells showed promising results in generating compatible cells for long-term engraftment. Another study on transferring donor immunity across HLA barriers identified a safe and effective way to re-build immunity after bone marrow transplantation.