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Genome-wide association studies mislead on cardiac arrhythmia risk gene

Scientists from the University of Chicago discovered that DNA variants in SCN10A regulate SCN5A expression, suggesting a primary role for SCN5A in cardiac arrhythmia risk. The study highlights the importance of evaluating functional targets of genome-wide association study hits to avoid costly implications.

SourceUniversity of Chicago Medical Center·JournalJournal of Clinical Investigation·DateMar 20, 2014

Top cardiac electrophysiology congresses join forces

The European Society of Cardiology and the European Heart Rhythm Association will hold a joint Congress annually from 2014 to 2017, featuring four main topics: electrophysiology, devices, non-invasive EP, and basic science. The agreement aims to improve scientific collaboration and quality among cardiac electrophysiology communities.

SourceEuropean Society of Cardiology·DateJun 13, 2012
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Fish oil prevents potentially deadly decline in heart rate variability

A randomized controlled trial found that fish oil supplementation prevented a reduction in heart rate variability in elderly subjects exposed to indoor air pollutant particles. In contrast, soy oil supplements showed a marginal, nonsignificant protective effect against the negative impact of particulate matter on heart rate variability.

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateDec 15, 2005

SOFA study reveals no effect of fish oil on life-threatening cardiac arrhythmia

A European multi-centre study found that eating fish oil did little to reduce the risk of heart rhythm problems, cardiac arrest or arrhythmia in patients with an increased risk. The Study on Omega-3 Fatty acids and ventricular Arrhythmia (SOFA) investigated the effect of taking fish oil capsules on life-threatening cardiac arrhythmia i...

SourceEuropean Society of Cardiology·DateSep 5, 2005

New cardiac arrhythmia syndrome identified

An international team has defined a previously undescribed inherited cardiac arrhythmia syndrome caused by mutations in the ankyrin-B gene. The syndrome, distinct from Long QT Syndrome, is characterized by abnormal heartbeats and increased risk of sudden death, particularly among young people.

SourceDuke University Medical Center·JournalProceedings of the National Academy of Sciences·DateMay 31, 2004

Mutation causes specific arrhythmia and sudden cardiac death

A study published in Nature reveals a specific gene mutation causing inherited Long QT Syndrome, leading to fatal cardiac arrhythmias and sudden death. Researchers identified the E1425G mutation in ankyrin-B, a protein crucial for heart muscle cell function.

SourceDuke University Medical Center·JournalNature·DateFeb 5, 2003
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