Inflammation contributes to colon cancer
Researchers found that mice lacking Smad3 are acutely sensitive to bacterially-induced inflammation and cancer. Chronic inflammation stimulates cancer development.
Colon Cancer
Articles tagged with Colon Cancer
Study of human tissue reveals potential colon cancer biomarker
Researchers at the University of Cincinnati have identified a potential biomarker for predicting colon cancer risk and progression. They found genetic hotspots that regulate gene expression, which could be used to identify individuals at higher risk of developing aggressive colon cancer.
Newly identified gene powerful predictor of colon cancer metastasis
A newly identified gene MACC1 has been found to be a powerful predictor of colon cancer metastasis. Patients with low MACC1 levels have a longer life expectancy compared to those with high MACC1 levels.
Annals colonoscopy study underscores importance of quality standards
A recent study published in Annals of Internal Medicine concludes that screening colonoscopy is associated with fewer deaths from colorectal cancer, but primarily on the left side. The findings emphasize the need for skilled physicians to perform effective colonoscopies.
ASGE urges patients to seek a qualified endoscopist before undergoing a colonoscopy
A Canadian study found colonoscopy is associated with lower death rates from colorectal cancer, but raises concerns about detection of lesions on the right side of the colon. Patients are urged to seek a qualified gastrointestinal endoscopist to perform a thorough colonoscopy.
Colonoscopy significantly reduces death from left-sided colon cancer but not from right-sided
A new study by American College of Physicians reveals that colonoscopy strongly reduces mortality from left-sided colorectal cancer, while offering little benefit against right-sided cases. The researchers suggest factors such as incomplete examinations and varying tumor biology contribute to these limitations.
Light shines for potential early cancer diagnosis technique
A Northwestern University team developed partial-wave spectroscopy (PWS) to detect subtle abnormal changes in human colon cancer cells. The technique can identify cell nanoarchitecture and detect changes before conventional microscopy can.
Protein levels indicate risk of death in some colorectal cancer patients
Researchers found two insulin-related proteins that predict survival chances in colorectal cancer patients. High IGFBP-1 levels were associated with lower mortality rates, while high C-peptide levels increased the risk of overall death and other conditions.
Genomic signature of colon cancer may individualize treatment
Researchers have developed a model predicting recurrence in early-stage colon cancer patients and sensitivity to chemotherapy and targeted therapies. Gene expression analysis reveals specific patterns associated with higher cancer risk, enabling targeted treatments to prevent recurrences and improve survival rates.
Exercise and rest reduce cancer risk
A recent study found that regular physical activity can lower a woman's overall risk of cancer, but only if she gets a good night's sleep. The study, published by the American Association for Cancer Research, suggests that short duration sleep can undermine exercise's cancer prevention benefits.
Study helps clarify role of vitamin D in cancer therapy
Research reveals vitamin D's role in regulating colon cancer cell behavior by modulating gene expression and cytoskeleton structure. The study highlights a previously unknown pathway governing vitamin D's diverse effects on cancer cells.
Australia leads world first global effort to improve diagnosis of genetic disorders
A global initiative aims to collect information on every fault in every gene worldwide, standardizing the reporting of genetic mutations. The project has been published in the journal Science and involves international collaboration between researchers from Australia, China, Japan, and Kuwait.
Sibling study could lead to better treatments for inherited form of colon cancer
Scientists have discovered similarities in a region of chromosome 7q31 among siblings with colon cancer, suggesting a potential gene cause. Siblings sharing this genetic region tend to develop cancer 3.8 years earlier than non-sharing siblings.
Novel marker of colon cancer
Researchers have discovered a novel marker for colon cancer, revealing differentially expressed genes that can help identify diagnostic and therapeutic targets. The study's findings provide new insights into the progression of colon cancer and may lead to improved patient outcomes.
NCI awards VCU Massey Cancer Center $4.25M to study disparities in colon cancer diagnosis
The VCU Massey Cancer Center will conduct two studies to examine delays and disparities in colon cancer diagnosis and physician communication patterns based on race and gender. The first study focuses on appraisal delays, while the second study uses trained actors to simulate patient interactions with primary care physicians.
Mayo Clinic estimates new, tiny, super-sensitive probe could cut colon polyp removal in half
Researchers at Mayo Clinic developed a probe that can detect cancerous cells in the colon with 90% accuracy, reducing the need for unnecessary polyp removal. The probe-based confocal laser endomicroscopy system could potentially cut colon polyp removal in half.
Breakthrough optical technology to assess colon cancer risk, accuracy
Researchers developed a fiber optic technology to measure blood levels in the colonic lining, detecting an early increase in blood supply associated with proximity to neoplasia. The findings suggest this technology could be a valuable screening tool for enhancing polyp detection and improving colon cancer prevention.
Colon cancer link to obesity uncovered
A new JAMA study reveals a genetic link between obesity and colon cancer risk, showing those with a common genetic variant of ADIPOQ carry up to 30% reduced risk. This finding may lead to improved screening and early detection for colon cancer through lifestyle changes such as diet and exercise.
Black Americans are at higher risk for colon polyps
A new study published in JAMA found that black Americans have a higher occurrence of colon polyps compared to white patients. The research suggests that black men and women are at greater risk for serious polyps, emphasizing the importance of regular screening among this demographic.
Cancer-causing gut bacteria exposed
A team of scientists has discovered that a molecule produced by a common gut bacterium activates signaling pathways associated with cancer cells. The research, published in the Journal of Medical Microbiology, sheds light on the way gut bacteria can cause colon cancer.
Virtual colonoscopy as good as other colon cancer screening methods
A nationwide study confirms virtual colonoscopy's accuracy in detecting colorectal cancers and pre-cancerous polyps as high as traditional colonoscopy. This minimally invasive procedure has been endorsed by the American Cancer Society, offering a safe and non-invasive screening option for millions of Americans.
How often to screen for colon cancer? NEJM study finds 5-year risk extremely low
A large study found that rescreening average-risk individuals after a normal initial colonoscopy every five years is sufficient to determine the optimal screening interval. The study's findings contradict previous recommendations of 10-year screenings and may impact screening costs and individual follow-up rates.
UC Davis doctors use multimedia to increase colorectal cancer screening among Hispanics
Researchers at UC Davis have developed an interactive multimedia computer program to provide personalized education on colorectal cancer screening. The program aims to increase screening rates among Hispanic patients, who are less likely to receive screenings compared to non-Hispanic whites.
Researchers identify cancer-causing gene in many colon cancers
Scientists at Dana-Farber Cancer Institute have identified a previously unsuspected gene, CDK8, as a cancer-causing gene in many colon cancers. The study suggests that blocking CDK8 may be useful against tumors driven by overactive beta-catenin.
Early stage colon cancer characterized by inactivation of gatekeeper gene
A Singaporean research team reports that the RUNX3 gatekeeper gene is inactivated at an early stage of colon cancer. The study suggests that reactivating this gene could lead to a diagnostic test and therapeutic target. This finding builds upon previous knowledge of tumor suppressor genes disrupting APC, leading to cancer development.
Evaluation of quality measure for colon cancer care suggests considerable improvements needed
A study published in the Journal of the National Cancer Institute found that only 38 percent of U.S. hospitals were compliant with the guideline to examine 12 or more lymph nodes in colon cancer patients by 2004-2005, despite being recommended since 1997. Compliance increased from 15% to 38% over the eight-year period.
US hospitals 'flunk' colon cancer
A Northwestern University study found that over 60% of US hospitals do not comply with the recommendation to examine 12 lymph nodes after colon cancer surgery, leading to improved survival rates when more nodes are checked.
Colon cancer linked to unequal gene activity
Researchers found that a subtle difference in gene activity is responsible for one in every 10 colon cancer cases. The study identified a specific gene, TGFBR1, which normally protects against cancer, and its abnormal expression increases the risk of colon cancer nearly nine times.
Worldwide gulf in cancer survival between 31 countries and between black and white people in USA
A comprehensive study of 31 countries found significant variations in cancer survival rates, with the US and Europe experiencing lower survival rates compared to other regions. The study reveals a racial gap in cancer survival between black and white populations in the US, with blacks facing a 7-14% lower survival rate.
'Smothered' genes combine with mutations to yield poor outcome in cancer patients
Researchers at Johns Hopkins Medicine identified a deadly combination of gene activity in breast and colon cancers, leading to poor patient outcomes. The study found that epigenetic changes contribute to cancer aggressiveness by disrupting normal biochemical pathways.
$1.8M awarded for metastatic colon cancer research
The American Association for Cancer Research has awarded $1.8 million to three researchers to study genetic signatures, epigenetic staging, and individualized therapy for metastatic colon cancer. The grants aim to accelerate the discovery of new treatments and improve patient outcomes.
NCI grant launches clinical trials for colon cancer screening
A Northwestern University biomedical engineer has developed optical technology that can detect colon cancer early and is now being tested in large-scale clinical trials. The tests aim to predict the presence of colon cancer with adequate sensitivity, potentially leading to a routine screening test.
Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show
Researchers at Thomas Jefferson University have developed a new type of colon cancer vaccine that reduces the spread of disease in mice. The vaccine targets mucosal cells and induces an immune response against cancer, leading to fewer metastases and prolonged survival.
Weight-loss surgery can cut cancer risk
A recent study published by Dr. Nicolas Christou of the McGill University Health Centre (MUHC) suggests that bariatric surgery reduces the risk of developing cancer by up to 80% in morbidly obese patients. The research, which compared over 1,000 patients who underwent bariatric surgery with those who did not, found significant decrease...
Study links vitamin D to colon cancer survival
A new study by scientists at Dana-Farber Cancer Institute found that patients diagnosed with colon cancer who had abundant vitamin D in their blood were less likely to die during a follow-up period. The researchers identified 304 participants and followed them until death or 2005, whichever occurred first.
Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s
Researchers at Columbia University's Mailman School of Public Health discovered that the prevalence of pre-cancerous masses in the colon is similar between patients aged 40-49 and 50-59. The study suggests that starting colon cancer screening at age 40 may help decrease its prevalence and save more people from the disease.
Family history of colorectal cancer linked with reduced risk of cancer recurrence
A family history of colorectal cancer is associated with a significant reduction in cancer recurrence and death, especially among patients receiving chemotherapy treatment. The study found that having more affected first-degree relatives further increased the protective effect, suggesting a distinct underlying molecular mechanism.
Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s
A new study found that the prevalence of pre-cancerous masses in the colon is similar between average-risk patients aged 40-49 and 50-59. This suggests that colon cancer screening may be feasible at an earlier age, potentially reducing incidence and saving lives.
Smokers with advanced colon cancer may face higher odds of disease recurrence
Research at Dana-Farber Cancer Institute reveals that smokers with stage III colon cancer have a 22% increased risk of recurrence or death compared to never-smokers. A 20+ pack year smoking history before age 30 was found to be particularly harmful, increasing the risk by 37%
To fight the cancer before the tumor grows
Researchers at Heidelberg University Hospital have discovered a new approach to immunize against certain types of cancer. They found that immune cells react strongly to modified proteins in tumor cells with DNA repair defects, which are present in around 15% of all tumors.
What identifies cancer cells causing relapse and metastasis? Not CD133
A recent study has cast doubt on CD133's status as a colon cancer stem cell marker, finding that the protein is expressed by most cells in colon tumors, not just stem cells. Both CD133+ and CD133- cells can initiate tumors when transplanted into mice.
New technology may mean immediate diagnosis for patients with GI diseases
A new real-time microscopic technique called confocal laser endomicroscopy (CLE) can identify suspicious patterns and precancerous cells, potentially eliminating the need for biopsies in many cases. CLE was found to be accurate in detecting gastrointestinal conditions with an overall accuracy rate of 91%.
New method proposed for determining which patients should get treatment for colorectal cancer
A new study suggests that the depth of cancer penetration in the bowel wall affects survival rates, and proposes changes to current guidelines. Patients with thin lesions confined to the bowel wall have better survival outcomes than those with thicker cancers.
Discovery of a novel mechanism for the development of colon cancer
Researchers at the University of Helsinki have identified a novel mechanism by which harmless colon polyps acquire malignant tumor properties, driven by abnormal PROX1 protein production. Removing PROX1 from cancer cells reverses their malignant behavior, suggesting it as a promising target for future therapies.
AMPK signaling: Got food?
Scientists discovered that when food supplies dwindle, mammals activate the AMPK signaling pathway to conserve energy. The study reveals a link between cancer and diabetes, suggesting that type 2 diabetes drug metformin may also antagonize tumor growth.
Inherited cancer mutation is widespread in America
A recent study found that the American Founder Mutation, a common cause of Lynch syndrome, is older and more prevalent than thought. The new research includes 32 additional families and estimates that the mutation is present in 32,150 Americans.
USC study finds evidence of gender-related differences in development of colon cancer
A USC study found that specific gene variants linked to colon cancer result in opposite survival outcomes for men and women. Women with certain variants had higher overall survival rates, while men with the same variants had lower survival rates.
Colon cancer risk perception associated with screening behavior
A study found that women's perceived risk of colon cancer is associated with their screening behavior, with higher risks detected in Latinas and lower risks in Asian women. Women with a family history of cancer were more likely to undergo screenings.
UCI study finds effective colon cancer prevention treatment
Researchers at UCI have developed a new colon cancer prevention treatment using a combination of DFMO and sulindac, reducing the risk of reoccurring colorectal polyps by up to 95%. The treatment has shown promise in reducing the incidence of advanced adenomas and other forms of colon cancer.
Vitamin D and calcium influence cell death in the colon, researchers find
Researchers at Emory University found that supplementing diet with calcium and vitamin D increased levels of protein Bax, which controls programmed cell death in the colon. This increase may push pre-cancerous cells into programmed cell death, potentially reducing colon cancer risk.
Digestive process affects anti-cancer activity of tea in gastrointestinal cells
A study found that digestion alters the structure of tea catechins and their anticancer activity. Digestion significantly reduced anticancer activity in colon cancer cells but had little effect on black tea. The findings suggest that better understanding digestion's impact on tea can lead to changes in product formulation and preparation.
African Americans less likely than whites to get colonoscopy despite family history of colon cancer
Despite having a family history of colon cancer, African Americans are less likely than whites to receive recommended colonoscopy screenings. The study found that only 27.3% of African Americans with a family history underwent the screening within the past five years.
Cancer detected earlier, faster, with new medical imaging, Stanford study finds
Researchers at Stanford University School of Medicine developed a new medical imaging technology that can detect early stages of colon cancer without a biopsy. The technique uses a short protein attached to fluorescent beacon to identify cancerous cells, allowing doctors to pick up the earliest possible cancers.
Burroughs Wellcome Fund grants $9.75 million towards translational researchers
The Burroughs Wellcome Fund has awarded $9.75 million to 13 translational researchers through its Clinical Scientist Awards in Translational Research. These awards support established physician-scientists exploring scientific questions, applying knowledge at the bedside, and bringing insights back to the laboratory.
Case Western Reserve University researchers identify colorectal cancer gene
Case Western Reserve University researchers identified genes associated with hereditary components of colorectal cancer in a genome-wide scan. The study found susceptibility genes on chromosomes 1p, 15q, and 17p, which may lead to better cancer screening strategies.
Higher body mass index means higher risk of several cancers
A meta-analysis of 221 datasets found that a 5kg/m2 increase in BMI raises the risk of oesophageal adenocarcinoma, thyroid cancer, colon and kidney cancers in men, and endometrial, gallbladder, and oesophageal adenocarcinoma in women. The study also found stronger associations between increased BMI and colon cancer in men.
Smokers might benefit from earlier colon cancer screening
A new study suggests that smokers may benefit from earlier colon cancer screening due to their increased risk of developing the disease. The research found that current smokers were diagnosed with colon cancer approximately seven years earlier than people who never smoked.
Ludwig Institute for Cancer Research receives NHMRC's largest 2009 grant
The Ludwig Institute for Cancer Research in Melbourne received a $20 million NHMRC grant to develop new ways of detecting and treating colon cancer, the most common form of cancer in Australia. The research will focus on five key projects relating to genetic causes, biomarkers, and therapies for colon cancer.
Expression patterns of microRNAs appear altered in colon cancer, and associated with poor outcomes
A study found that microRNA expression patterns are differentially expressed in colon tumor tissues, with certain miRNAs associated with poor survival and treatment outcomes. The researchers identified miR-21 as a potential diagnostic biomarker for colon adenocarcinomas and survival prognosis.
TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
Researchers found that a TNF-alpha antagonist can stop inflammation-induced colon cancer in mice with ulcerative colitis. The study used mice treated with azoxymethane and dextran sulfate sodium, which developed tumors due to increased TNF-alpha expression.