Articles tagged with Colon Cancer
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A large cohort study found that high folate intake was associated with a reduced risk of colorectal cancer. The study also distinguished between natural and synthetic forms of folate and found no increased risk among participants consuming high levels of folate through supplements or fortification.
A Johns Hopkins team discovered that cancer cells exhibit a universal 'chaotic' pattern of methylation, leading to unpredictable gene function and increased randomness. This finding may require a new approach to cancer therapy, focusing on helping cancer cells return to normal instead of just killing them.
A new study by Brigham Young University researchers found that married individuals have a 14 percent lower risk of colon cancer death compared to unmarried patients. Married patients were also diagnosed at earlier stages of the disease and received more aggressive treatment, contributing to improved survival odds.
Scientists have discovered that niclosamide, a drug previously used to treat tapeworm infections, can silence a gene that triggers colon cancer metastasis. In mouse studies, the compound inhibited the formation of metastases in colon cancer cells.
Patients with mismatch repair defects have lower tumor recurrence rates, longer remissions, and improved overall and disease-free survival compared to those without the defects. The study suggests that these defects are associated with a reduced response to 5-FU therapy, particularly in patients with inherited defects.
A new study of U.S. veterans ages 70 and older found that healthy seniors benefit most from current colon cancer screening methods, while less healthy veterans may experience a net burden. The study highlights the need to target screening for those who are likely to benefit and re-evaluate screening for those who are not.
A new study by Henry Ford Hospital researchers found that nurse-driven, open-access colonoscopy programs are as effective and safe as traditional consultations with a gastroenterologist. The study compared outcomes of 15,901 patients in an open-access program to 6,861 patients who received outpatient consultation prior to screening.
Researchers at Tufts University have developed a device that can help reduce patient discomfort during colonoscopies by detecting and preventing 'looping' of the scope. The EFOST technology uses fiber optic bend sensors to create a visual image of the scope's position and shape, allowing doctors to make adjustments in real-time.
A survey of US primary care physicians found that making treatment recommendations changes the way physicians think about medical decisions. In scenarios involving colon cancer and avian influenza, physicians chose different treatments for themselves versus those they recommended to patients.
Researchers at Fox Chase Cancer Center found that naproxen and its derivative NO-naproxen reduce tumor formation in mutant mice. The data also suggests that naproxen blocks a key step in colon cancer formation, which could lead to the development of new chemopreventive agents.
CTC utilization has tripled in recent years, increasing access to colorectal cancer screening, and potentially saving lives through early detection of disease. The study suggests an opportunity for more people to be screened due to CTC's alternative to conventional optical colonoscopy.
Researchers found that the protein PUMA is responsible for inducing apoptosis in intestinal epithelial cells in response to inflammation, suggesting a promising target for ulcerative colitis therapies. Meanwhile, DNA methylation studies revealed targeted gene silencing and potential cancer-initiating events.
Research suggests that specific genes are silenced by DNA methylating enzyme Dnmt3b, similar to those found in human tumors. This targeted silencing may be an initiating event in cancer development.
A 40th anniversary Corvette was sold at a Barrett-Jackson auction to benefit the TGen Cancer Research Fund, named after Jackson family members who died from colon cancer. The sale raised over $250,000 for the fund, with all proceeds going towards life-changing research.
A research team at the University of Colorado Cancer Center has identified a new enzyme biomarker, ALDH1B1, present in nearly all colon cancer cells, which could help physicians diagnose colon cancer earlier and treat it more effectively.
A new clinical trial, sponsored by the National Cancer Institute, is testing whether rosuvastatin reduces the risk of recurrent colon cancer. The five-year study involves 1,740 patients and will determine if statins are effective in preventing colon cancer.
Researchers at Tel Aviv University discovered that curcumin amplifies the therapeutic activity of anti-inflammatory drugs used to treat colon cancer. This combination has already shown promising results in human clinical trials and may alleviate unwanted side effects.
Researchers at the University of Missouri have discovered biomarkers in mouse feces that can predict inflammation-associated colon cancer. This breakthrough could lead to a new method for detecting early-stage colon cancer in humans, potentially eliminating the need for colonoscopies.
A genetically tweaked probiotic has nearly eliminated colon inflammation in mice with colitis, halting disease progression by 95%. The novel probiotic strain may prove useful in colon cancer, another disease triggered by inflammation.
A new study led by researchers at WashU Medicine found that consistent exercise is associated with a lower risk of dying from colon cancer. The study analyzed data from over 150,000 men and women and found that those who exercised for at least 10 years had the lowest risk of colon cancer death.
A new study from the University of Michigan Comprehensive Cancer Center found that chemotherapy delays are common among patients with surgical complications after colorectal cancer surgery. The study, which analyzed data from 17,108 patients, suggests that surgical complications can have long-term impacts on quality of care.
A Vanderbilt University Medical Center researcher has identified a new lead for compounds that block the Wnt signaling pathway, implicated in over 90% of sporadic colon cancers. The approved anti-parasite drug pyrvinium was found to inhibit Wnt signaling and cell proliferation in cultured colon cancer cells.
Research review finds that regular physical activity can significantly reduce the risk of developing around two dozen health conditions, including some cancers and dementia. Healthy adults should aim for 150 minutes of moderate intensity exercise per week, with strength-training sessions and balance exercises also recommended.
Researchers found that FAK inhibitor Y15 effectively blocked colon cancer cell growth and viability in mice. The study showed promise for a new therapy by decreasing tumor growth and promoting apoptosis in mice treated with Y15.
Researchers identified two small-molecule inhibitors that effectively targeted FAK, an enzyme present in certain cancers. These inhibitors, Y11 and Y30, inhibited colon cancer-cell growth and decreased tumor formation, offering a potential for more effective and less toxic cancer therapies.
A study at Memorial Sloan-Kettering Cancer Center found that introducing colon cancer screening during routine mammography screening increased minority access to preventive care. The research introduced colon cancer screening to women living in Harlem, resulting in similar colonoscopy findings as the general population.
A University of Illinois study shows that sulforaphane, a powerful cancer-fighting agent in broccoli, can be released by bacteria in the lower gut and absorbed into the body. This discovery raises the possibility of enhancing the activity of these bacteria to increase broccoli's cancer-preventive power.
Research by Michigan State University found that high doses of fish oil can induce severe colitis and colon cancer in mice. The study suggests that establishing dietary guidelines for omega-3 consumption is necessary to prevent harm, particularly in individuals with inflammatory bowel disease.
Although overall cancer mortality is decreasing in the EU, incidence has increased by almost 20% since 2002. Cancer prevention efforts are struggling to keep pace with economic crises, which threaten to worsen occupational exposure to carcinogens.
Researchers at Dana-Farber Cancer Institute found that multivitamin use did not impact colon cancer outcomes in patients with stage III colon cancer. Multivitamin use had no beneficial effect on patients' survival rates but may have a small association with survival benefits for younger patients and those who are obese.
CDX2 is an identity gene that tells a cell it is in the epithelial tissue of the intestine, enabling it to perform its job correctly. Cancer cells deactivate this gene, leading researchers to identify five anti-cancer genes and discover CDX2's role in suppressing colon cancer.
A new analysis found that rectal cancer rates are rising among young people under 40, with a 3.8% annual increase between 1984 and 2005. The study suggests that endoscopic evaluation should be considered for individuals presenting with rectal bleeding or other signs of the disease.
Researchers at Tel Aviv University discovered that low hemoglobin levels can indicate a potential for colon cancer years before it's diagnosed. A continuous long-term decline of more than 0.28 grams per decilitre over a four-year period may serve as a warning of illness on the horizon.
A UNC physician authored an editorial on a cost-effectiveness study comparing colonoscopy and computed tomographic colonography (CTC) for colon cancer screening. The analysis concluded that CTC is not cost-effective compared to colonoscopy if reimbursed at the same rate.
A study published in The Journal of the National Cancer Institute found that computed tomographic colonography (CTC) screening every five years is not cost-effective if reimbursed at the same rate as colonoscopy. However, CTC would be cost-effective if it enticed 25% more individuals to screen.
Researchers at Tel Aviv University are developing a new clinical approach to prevent cancer recurrence after surgery by blocking stress responses. The treatment involves combining two widely available medications to boost the immune system and prevent tumor metastasis, with promising results in animal studies.
Researchers have developed a new technique combining flexible sigmoidoscopy with optical technologies to detect colon cancer more accurately in women. The test identified subtle changes in tissue that indicate the presence of cancer, providing hope for improving discrepancies in screening accuracy between men and women.
A study found that smoking is associated with molecularly defined DNA changes and a subtype of colorectal cancer that emerges more frequently among older women. The researchers suggest that epigenetic modifications may play a role in the development of smoking-related colorectal carcinogenesis.
A Kaiser Permanente Center for Health Research study found that simple, automated telephone reminders can increase colon cancer screening rates by 30 percent. The study, which involved nearly 6,000 members in Oregon and Washington, showed that people were more likely to get screened after receiving automated reminders.
Researchers at UNC Chapel Hill discovered a link between altered gut microbiota and colon cancer, finding higher bacterial diversity and richness in individuals with adenomas. The study suggests that manipulating the microbiota through diet could help prevent colon cancer.
Researchers found APC plays a crucial role in renovating the actin cytoskeleton by triggering actin assembly, offering a second way mutations in APC could lead to cancer. The study suggests APC's impact on the cytoskeleton may contribute to cancer development, especially when its actin-binding section is mutated.
Patients with stage II colon cancer treated after 1995 had longer time to recurrence, but improved overall survival. Stage III colon cancer patients treated after 1995 also showed improved overall survival without change in time to recurrence compared to those treated before 1995.
Researchers found that specific bacterial signatures were associated with polyps, early lesions that can develop into colon cancer. The study suggests the development of non-invasive screening tests and diet-based prevention regimens to reduce CRC risk.
A meta-analysis found that the G allele of PPAR-γ gene polymorphism 34 C>G decreases colon cancer risk, indicating its potential as an early diagnosis and treatment target. The study confirms previous data linking the polymorphism to CRC risk.
A large study found no association between coffee, tea, or sugar-sweetened soft drinks and colon cancer risk. High tea consumption was linked to a modest increase in risk, but the connection is unclear.
A recent study published by Mayo Clinic has found that older women with diabetes are at a more than doubled risk for certain types of colorectal cancer. The research team analyzed data from over 37,000 participants and identified associations between diabetes and specific molecular markers.
Researchers at Henry Ford Hospital discovered a pill that halves the required liquid intake for colonoscopy prep, improving bowel preparation quality and patient tolerance. The pill, lubiprostone, was added to an electrolyte mix, reducing volume requirements.
A new study has found that genetically short-circuiting the ability of cancer stem cells to absorb a key nutrient can kill many colon cancer cells. The approach targets tumor cell 'factories' and could potentially reduce recurrence rates of colon cancer. However, further research is needed to ensure the treatment does not harm normal s...
Research suggests that epigenetics plays a key role in the development of degenerative diseases. Environmental influences can alter gene expression, which can be passed on to offspring and impact life and death. HDAC inhibitors, found in foods like broccoli and garlic, may help prevent cancer by silencing tumor suppressor genes.
Researchers from Oregon State University are exploring the link between epigenetics, diet, and disease prevention. They found that HDAC inhibitors, found in foods like broccoli and garlic, can stop degenerative processes and turn off tumor suppressor genes.
Scientists developed a urine test for detecting colon cancer by analyzing chemical differences in human urine samples. The study identified 16 substances associated with colon cancer, offering potential for an alternative screening method to colonoscopy.
Researchers at Fox Chase Cancer Center have found that a new form of naproxen, called nitric oxide-donating naproxen (NO-naproxen), can block early molecular changes leading to colorectal cancer development while reducing gastrointestinal toxicity. This novel agent may be more effective than standard naproxen in inhibiting tumor growth.
A blood test measuring C-reactive protein (CRP) levels may help assess colon cancer risk, according to a Vanderbilt University Medical Center study. High CRP levels were found to be associated with a 2.5-times greater risk of colon cancer in women.
Researchers discovered that specific inflammasome components protect against colitis and cancer in mice. Mice lacking these components developed more severe colitis and larger tumor burdens, highlighting the complex role of inflammasomes in human disease.
A research group at Case Western Reserve University found that Recql5 mutation had an important impact on tumorigenesis in the mouse GI tract. The study also suggested that Recql5 may be an important candidate for a colon cancer biomarker, and its expression was recently shown to affect sensitivity to camptothecin-based anticancer drugs.
A combination of Vitamin A acetate and TRAIL kills precancerous colon polyps while sparing normal tissue, providing a potential new avenue for chemoprevention. The regimen, tested in mouse models and human colon cancer tissue, appears to address the issue of continuous long-term therapy required for current chemopreventive drugs.
Researchers developed a vaccine targeting an abnormal protein MUC1, found in both IBD and colon cancer. The vaccine delayed IBD development and reduced inflammation, reducing cancer risk.
A large-scale study of 10,000 adults found that virtual colonoscopy identifies more unsuspected cancers outside the colon than within it. The majority of these cancers were detected at an early stage and have positively affected survival.
A study found that new chemotherapy agents for metastatic colorectal cancer improve life expectancy by 6.8 months and increase lifetime medical costs by $37,100, equating to a cost of $66,200 per year of life gained.
A new study found that older patients with stage III colon cancer are less likely to receive chemotherapy after surgery due to concerns about adverse events. However, the study discovered that when they do receive chemotherapy, it is less toxic and of shorter duration compared to younger patients, resulting in fewer adverse events.