Articles tagged with Colon Cancer
Researchers discovered that mutations in the PIK3R1 gene, particularly R348, can activate ERK and JNK signaling cascades, enabling tumor growth. Targeted therapies may need to focus on these mutant tumors, offering a potential new approach for treating endometrial and colon cancers.
University of Minnesota researchers have identified microRNAs miR-182 and miR-503 that contribute to the development of colon polyps into cancerous tumors. By targeting these microRNAs, physicians may be able to provide earlier and more specialized treatment for patients with a higher risk of colon cancer.
Researchers at Thomas Jefferson University have discovered a novel approach to killing colon cancer cells by using an antibody that targets the GUCY2C receptor, which is over-produced and exhibited on the surface of cancer cells. The immunotoxin selectively destroys colon cancer cells while sparing surrounding tissue.
A subset of stage III colon cancer patients with CpG island methylator phenotype (CIMP) showed improved overall survival when treated with irinotecan-based therapy. Patients with CIMP-negative tumors experienced significant harm from the addition of irinotecan, resulting in lower overall survival rates.
A study by researchers at the University of Kansas reveals a new function for APC in protecting against chronic colitis-induced inflammation and tumor development. The team found that functional nuclear APC is necessary to suppress Wnt signaling pathway, controlling goblet cell differentiation.
A new method has been developed to produce artificial anti-cancer molecules with properties similar to those of the body's natural defense systems. The molecules have proved effective against colon cancer cells in laboratory tests and show promise for further research.
A study published in Nature found that regulatory DNA regions preceding genes play a crucial role in tumor development, with altered function leading to gene mutations and cancer progression.
A group of scientists have revealed the structure of two proteins involved in liver and colon cancers, opening up research opportunities for drugs that can inhibit cancer cell growth. By blocking a specific region of these proteins, it is possible to prevent tumour cell reproduction without affecting other life-sustaining functions.
Researchers at the University of Granada found that colon cancer patients suffer from reduced physical function, fatigue, and loss of muscle strength due to treatment. This can lead to a significant decline in quality of life, affecting up to 40% compared to healthy individuals.
Researchers discover synthetic triterpenoids suppress colon cancer onset by impeding inflammation and increasing 15-hydroxyprostaglandin dehydrogenase gene expression. Oral administration in mice shows promise for chemoprevention, with potential to delay or halt colon cancer development.
A team of scientists has discovered that the colon has a safety mechanism to restrict adenoma formation and growth. The study found that an increase in BMP production limits the self-renewal capacity of adenoma stem cells, thus impeding rapid development.
African-Americans with colon cancer are half as likely to have a genetic marker linked to better outcomes compared to Caucasian patients. The study also found that African-Americans are more likely to have right-sided colon cancer, which is easier to miss with screening.
A meta-analysis of 43 studies found that sedentary behavior increases the risk of colon, endometrial, and lung cancers. The risk increases with sitting time, even among physically active individuals, suggesting a detrimental impact on cancer prevention.
A new study by Northwestern University found that community-based outreach programs can significantly increase colorectal cancer screening rates among low-income and minority populations. By using a combination of automated reminders, mailed letters, phone calls, and personal outreach, the program was able to nearly double screening ra...
Researchers have identified four new genes that increase familial breast cancer risk, with RINT1 also linked to a broad spectrum of gastrointestinal and gynecological cancers. The study has significantly expanded the panel of genes known to account for increased breast cancer occurrence within families.
The Myriad myRisk test detects significantly more deleterious mutations than single cancer tests and helps solve the overlap dilemma among hereditary cancer syndromes. The test evaluates 25 clinically significant genes associated with eight major hereditary cancers.
Researchers engineered a bacterial toxin to attach to tumour cells, forcing the immune system to recognize and attack cancer. The engineered toxin significantly reduced human colon cancer tumours in mice with minimal metastasis.
Researchers at Albert Einstein College of Medicine will study how aging and poor nutrition interact to cause colon cancer mutations. They will use novel techniques, including single-cell whole-genome sequencing, to understand the development of tumors and identify new approaches for preventing and detecting colon cancer.
A study found that aspirin lowers colorectal cancer risk in people with high 15-PGDH gene levels, but not those with low levels. The research team analyzed data from nearly 128,000 participants and discovered a link between 15-PGDH and the anti-cancer effects of aspirin.
Researchers have identified PPAR delta as a crucial molecule linking dietary fats to colon cancer progression. The study found that deleting PPAR delta in a mouse model of colon cancer stopped key steps required for tumor growth, providing new clues for developing therapeutics.
A study by UT Southwestern Medical Center found that popular web information on colorectal cancer screening materials are written beyond the recommended sixth-grade reading level and fail to address key risks and barriers. Only half of the sites discussed colorectal cancer risk in the general population, while only a quarter specifical...
A study published in JAMA Surgery found that patients over 65 have a higher risk of complications and longer hospital stays after colorectal cancer surgery compared to younger patients. The study analyzed over 1 million patients with colorectal cancer and found that mortality rates improved across all age groups during the decade studied.
A study published at The Wistar Institute Cancer Center found that bacterial virulence proteins can suppress DNA repair proteins in epithelial cells, leading to genetic mutations that favor tumor development. This research opens the possibility of modifying colon cancer risk by altering gut bacteria populations.
A new study has identified PLAC8 as a critical protein involved in the spread of colon cancer. Elevated levels of PLAC8 have been linked to abnormal cell behavior, leading to faster tumor growth and increased invasiveness.
A new NIH study reveals that obesity primes the colon for cancer, with frequent exercise and calorie control shown to lower the risk. The research suggests that molecular signals in the gut lead to cancer progression in obese mice, highlighting the importance of a healthy lifestyle in preventing colorectal cancer.
A study of 999 patients found that low-dose aspirin use after colon cancer diagnosis was associated with improved overall survival, particularly among those with HLA class I antigen expression. The molecular mechanisms underlying this effect are not fully understood.
A team identified p38 as a dual role in colon cancer, both protecting the epithelial barrier and promoting tumour growth. Treatment with a p38 inhibitor reduced tumour size in mice.
A new non-invasive genetic test detected 92% of colon cancer cases, outperforming a traditional fecal immunochemical test in asymptomatic participants. The test's high sensitivity could lead to increased screening rates and reduced deaths from colorectal cancer.
A recent study found that colon cancer incidence rates have dropped by 30 percent in the US among adults 50 and older due to widespread colonoscopy adoption. Colonoscopy use has almost tripled among adults ages 50-75, leading to significant declines in mortality rates as well.
A pilot study found that mailing free stool tests to patients' homes increased colon cancer screening rates by nearly 40% among uninsured and low-income patients. The test, called FIT, is simple, cost-effective, and can be done at home.
The study reveals that beta-catenin increases in certain types of T cells, causing chronic inflammation in the intestine and colon, leading to cancer. The researchers also found that beta-catenin signaling alters the balance between pro-inflammatory and anti-inflammatory T cells.
A Michigan State University study found that obese men are more likely to have colorectal polyps, precancerous growths linked to colon cancer. The research showed a significant association between elevated leptin levels, higher body mass index, and larger waistlines with an increased risk of having these polyps.
A new evidence review finds that fecal immunochemical tests (FITs) detect about 79% of colorectal cancers and correctly identify 94% of patients without cancer. The test is simple, can be done at home, and can save lives, making it a great tool for assessing which patients have cancer and which do not.
Researchers found that fiber activates Gpr109a receptors, which reduce inflammation in the colon and prevent cancer. Mega-doses of niacin may also help protect the colon and prevent conditions like ulcerative colitis and Crohn's disease.
Cancer death rates have declined by 20% over the past two decades, with middle-aged black men experiencing a 50% reduction in mortality. The American Cancer Society estimates that there will be 1,665,540 new cancer cases and 585,720 cancer deaths in 2014.
Researchers decoded cell messages in zebrafish embryos to understand abnormal colonic cell growth, a common precursor to colon cancer. The discovery provides new insights into pathways fueling low-calcium-related cell growth and potential therapies to prevent colon cancer.
The John S. Dunn Foundation awards seed grants to researchers at Rice University's BioScience Research Collaborative to support new collaborations in cancer diagnosis and treatment, vascular health, and plant-inspired energy conversion. The grants aim to foster interdisciplinary and multi-institutional research.
A study by Arizona State University researchers links CXCR2 to tumor formation, growth, and progression in colon cancer. The genetic culprit is implicated in recruiting immune cells that evade the immune response, providing a new clue for developing therapeutic targets.
Researchers found that patients surveyed at federally supported community health centers generally reported high-quality care, with excellent or very good ratings for overall quality of services, clinician care, and referrals. The study also found that higher patient ratings of access to care and patient-centered communication were ass...
Researchers at the McGill University Health Centre have identified genetic changes in the colon lining that could be used as biomarkers for early diagnosis of colorectal cancer. The study, published online in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.
Researchers at Johns Hopkins Medicine have identified DNA sequence changes associated with schizophrenia symptoms, including delusions. Additionally, they discovered 'jumping genes' in colon cancer cells that could be used as biomarkers to monitor disease progression.
Researchers will investigate the mechanism of estrogen receptor beta (ERbeta) in colon cancer development, with a goal to develop novel prevention and therapy strategies. The study aims to clarify how estrogen influences colon cancer development using unique models and data.
A study found that older patients who underwent laparoscopic colon cancer resection were less likely to be discharged to a nursing facility than those with open surgical procedures. Patients between 70-75 years old had the lowest risk of discharge, while those over 85 were eight times more likely.
Researchers have found that erectile dysfunction drugs can protect the colon from inflammation and damage, potentially preventing or treating colon cancer. The drugs activate a tumor suppressive pathway in the gut, reducing excessive cell proliferation.
Researchers discovered that aspirin improves survival in patients with colon cancer whose tumour cells express Human Leukocyte Antigen class I (HLA class I), a cell-surface protein involved in the immune system. The study found that HLA class I could be used to predict which patients benefit from aspirin therapy.
A meta-analysis found that diabetic patients have an increased risk of developing both breast and colon cancer. The study also showed that diabetic patients are at a higher risk of dying from these cancers, with a 23% increased risk for breast cancer and a 38% increased risk for colon cancer compared to non-diabetic patients.
A large study found that colonoscopy screening can prevent up to 40% of colorectal cancers, with more frequent intervals recommended for those with a personal history of adenoma or family history of colorectal cancer. The study also suggests that sigmoidoscopy alone is insufficient for reducing the incidence of proximal colon cancer.
A new method uses a combination of techniques to detect genetic variations that initiate colon cancer. The technique achieved high sensitivity and was able to detect APC variations in 41 out of 80 samples, including previously unknown variations.
University of Illinois scientists have found that lifelong exposure to genistein, a bioactive component in soy foods, protects against colon cancer. The study suggests that a diet rich in soy genistein represses signals through epigenetic modifications, reducing the number of pre-cancerous lesions and abnormal cell growth.
A McMaster University study found that financial incentives for Ontario surgeons led to an increase in the use of laparoscopic colon cancer surgery. The research suggests that this may not result in significant improvements in patient outcomes, despite potential benefits such as shorter hospital stays and smaller visible scars.
Researchers have discovered genetic processes that cause specific types of bowel cancer and identified effective drugs targeting these genes. The findings offer the opportunity to develop personalized treatment based on a person's genetic profile, with promising results for alternative second- or third-line treatments.
Researchers at UTMB found that colon cancer cells produce large amounts of hydrogen sulfide, which they use to make energy and grow. Blocking the production of this compound, CBS, was shown to curb tumor growth in mice.
A large study found that regular aspirin use is associated with a lower risk of BRAF-wild-type colorectal cancer, but not BRAF-mutated cancer. The researchers also observed a significant risk reduction for BRAF-wild-type cancer with increasing aspirin tablets per week and longer duration of use.
A new study shows that using a quarterly report card improves colonoscopy quality indicators. Colonoscopy procedures have higher adenoma detection rates (53.9%) and cecal intubation rates (98.1%) after implementing the program, with increased detection of proximal adenomas.
A US study found that reducing unnecessary and high-dose pediatric CT scans could lower the overall lifetime risk of future imaging-related cancers by 62 percent. The research suggests that eliminating unnecessary imaging and lowering doses for the highest-dose scans could prevent thousands of future cancers.
Researchers found that the percentage of emergency bowel surgeries varies wildly from state to state, with some states having 7% mortality rates compared to less than 1% in others. The study suggests that analyzing potential contributing factors may help decrease these rates and improve outcomes.
A large-scale study has shown that immunological stool tests are more sensitive than enzyme-based tests in detecting colon cancer and precancerous lesions. The tests detected about twice as many cancer cases and three times as many advanced precancerous lesions, with a higher specificity rate.
A novel transcriptome-based classification of colon cancer has been developed, improving disease stratification based on clinicopathological variables and common DNA markers. The analysis identified six molecular subtypes associated with distinct clinical and pathological characteristics.
A study of over 310,000 bowel cancer patients in six countries found that UK patients were more likely to be diagnosed at a later stage than others, resulting in lower survival rates. Improved diagnostic investigation and treatment are seen as key factors to increase UK survival rates.
A new study found that one out of four colonoscopies paid for by Medicare is potentially inappropriate, based on current screening guidelines. The researchers suggest that older adults are less likely to benefit from early detection due to the slow progression of colon cancer.