Articles tagged with Colon Cancer
Researchers found that Bacteroides fragilis and Escherichia coli bacteria work together to create a microenvironment that induces chronic inflammation and DNA damage, supporting tumor formation. This discovery could lead to more effective screening and prevention strategies for colon cancer.
Researchers identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells. The enzyme, GalNAc-T6, attaches sugar molecules to proteins, affecting cell-cell adhesion and leading to abnormal tissue formation. This discovery may lead to new therapies for colon cancer.
A new UCLA study found that a high-cholesterol diet can accelerate the formation of tumors in the colon by speeding up intestinal stem cell division. The research identified a molecular pathway that could serve as a new target for colon cancer treatment.
A recent study by Texas Tech University Health Sciences Center El Paso aims to identify the most accurate stool test for detecting colorectal cancer. The research consortium will compare four different fecal immunochemical tests (FITs) to determine their effectiveness in detecting blood in the stool, a common early sign of cancer.
Research from MD Anderson Cancer Center finds improved adherence to surgical treatment guidelines, but chemotherapy guideline adherence remains largely unchanged. Informed patient-physician discussions are crucial for better survival outcomes and quality care.
A Kaiser Permanente study found that live phone calls are significantly more effective at reminding patients to complete and return at-home fecal screening tests for colon cancer. Phone calls outperformed other reminder strategies, including text messages and letters, especially among Spanish-speaking patients.
Researchers have identified a new genetic marker, BRF1, associated with up to 1.4% of hereditary colon cancer cases. The finding allows for personalized follow-up programs and potential prevention of early onset cancer in mutation carriers.
Researchers found that pigs fed a high-calorie diet supplemented with purple-fleshed potatoes had lower levels of inflammation-linked protein IL-6, compared to those on a standard diet. This study suggests that whole foods containing macronutrients and phytonutrients may be effective in preventing colon cancer.
A new study reveals that the IGPR-1 protein plays a critical role in colon tumor growth and drug resistance, identifying it as a potential target for treatment. Blocking IGPR-1 with an antibody or shRNA inhibits tumor growth, suggesting significant therapeutic potential.
A recent ESMO 2017 Congress session has ignited debate on the optimal duration of adjuvant chemotherapy for colon cancer, with experts weighing in on the pros and cons of shortening treatment from six to three months. The IDEA study suggests that three months provides a similar benefit but with reduced side effects.
Researchers at VCU Massey Cancer Center have found a potential cure for colon cancer by targeting the gene CtBP with a drug called HIPP, which reduces pre-cancerous polyps by half and increases mouse lifespan. This breakthrough may also extend to other cancers depending on the same mechanism.
The University of Arizona researchers will investigate NHE8's role in gastrointestinal diseases, including IBD and colon cancer. They aim to understand how this protein affects goblet cell function, gut microbiome balance, and epithelial cell proliferation.
A Berlin study of patients with early-stage colon cancer has found that the MACC1 gene and DNA repair mechanisms can help determine prognosis and predict response to chemotherapy. Patients with low MACC1 levels and proficient mismatch repair status have a higher five-year survival rate.
A new study has found a link between adolescent obesity and an increased risk of developing colon and rectal cancer in adulthood. The study analyzed data from over 1.7 million Israeli males and females, finding that being overweight or obese at age 17 was associated with a significantly higher risk of colorectal cancer.
Researchers identified significant gene mutations and differences in the upper digestive tract that could help develop tailored treatment options for cancer patients. The study found a set of frequently mutated genes in small bowel adenocarcinomas, which may affect therapy choice and targeting.
A simple blood test measuring carcinoembryonic antigen (CEA) levels could change treatment options for 17% of stage 2 colon cancer patients. The test may improve survival rates and quality of life for thousands with the disease.
Researchers found that grape-based compounds resveratrol and grape seed extract effectively killed colon cancer cells and suppressed tumors in mice. The combination of these compounds was found to be non-toxic to healthy cells, making them a promising approach for colon cancer prevention and treatment.
Researchers have discovered a way to increase the effectiveness of doxorubicin in treating colon cancer while minimizing its toxic side effects. The new combination therapy uses aldose reductase inhibitors to block oxidative signals that drive cancer growth.
In a clinical trial of 86 patients with colorectal and other cancers, scientists found that half respond to pembrolizumab due to mutations in their tumors. This could lead to a new standard-of-care including mismatch repair deficiency testing to identify patients who may benefit from immunotherapy.
University of Guelph researchers discover Ruby Ring onion variety has highest levels of quercetin and anthocyanin, compounds known for their anti-cancer properties. The study reveals red onions can activate pathways that encourage cancer cell death and disrupt communication between cells.
A global study analyzed six clinical trials with over 12,800 patients, finding that 3 months of chemotherapy was nearly as effective as 6 months in patients with lower recurrence risk and caused fewer side effects. The study suggests a new standard for personalized chemotherapy in colon cancer.
A study found that black persons are 31% more likely than white persons to develop interval colorectal cancer, a type of cancer that develops after a negative colonoscopy result. The risk is highest for distal colon and rectal cancer, and is not explained by differences in physician quality.
Research suggests overweight boys may be at increased risk of colon cancer as adults if they remain overweight. However, those who lose weight and achieve a healthy BMI by young adulthood appear to have similar risk profiles. The study highlights the importance of maintaining a healthy weight in childhood.
Patients with stage III colon cancer who reported a healthy lifestyle had a 42% lower chance of death and a trend for lower cancer recurrence risk than those with less healthy lifestyles. A healthy diet, regular physical activity, and maintaining a healthy body weight were all important factors.
Patients with stage III colon cancer who consumed two ounces or more of tree nuts per week had a 42% lower chance of cancer recurrence and 57% lower chance of death than those who did not eat nuts. This benefit was consistent across known factors that can influence cancer recurrence.
The Illinois Colon CARES portal, launched by UChicago Medicine and the Center for Asian Health Equity, aims to increase access to colorectal cancer screenings for uninsured and vulnerable populations. The initiative seeks to enhance communication across health systems and provide timely results to patients.
Researchers at Johns Hopkins Kimmel Cancer Center discover that cancer cells hijack the DNA repair machinery to sustain their growth. By inhibiting this mechanism, they found potential targets for anticancer drugs and ways to track cancer recurrence.
Researchers at the University of Maryland School of Medicine found that CHD4, a protein that usually prevents mutation, can become a protector of cancer cells. The protein plays a key role in DNA damage repair and may be linked to cancer progression.
Researchers at Scripps Research Institute uncover how a protein called angiomotin regulates the Hippo-YAP pathway, a key signaling system in cells that controls cell growth and division. The study sheds light on the protein's role in cancer development and provides new insights into the mechanisms underlying diseases such as fibrosis.
Researchers have developed a novel technology to correct disease-causing aberrations in the chemical tags on DNA that affect gene expression. The tool uses DNA methylation editing to model mutations associated with colon cancer and restore proper methylation patterns in stem cells derived from patients with Angelman syndrome.
Researchers at MIT have developed a new CRISPR-based model for colon cancer that enables rapid simulation of the disease's progression and testing of new treatments. The model uses genetic mutations with CRISPR to recreate human-like tumors in mice, providing a valuable tool for scientists studying colon cancer.
A study reveals that cognitive stimulation and social interactions increase lifespan in mice with colon tumors through a wound repair response. Environmental enrichment also reduces inflammation, improves tumor vasculature, and promotes immune cell activity to defend against cancer.
A new analysis reveals that dialysis patients are being screened at a higher rate than their counterparts without kidney failure, with the healthiest patients being more likely to receive screening. The findings suggest that there is substantial over-screening among patients on dialysis, and physicians should carefully evaluate patient...
Researchers found a significant association between sulfide-producing bacteria and increased risk of colon cancer in African-Americans. The study also revealed that Bilophila wadsworthia, a bacterium producing hydrogen sulfide, was more abundant in African-Americans with colon cancer than healthy counterparts.
Researchers developed a predictive risk model combining genetic and lifestyle information to classify population into groups according to colon cancer risk. Lifestyle influences cancer risk more than genetics, making it a modifiable factor in disease prevention.
Researchers at the University of Illinois Chicago report that increasing expression of cytokine LIGHT in mice with colon cancer activates the immune system's natural cancer-killing T-cells. This leads to a significant decrease in tumor burden, including primary tumors and metastatic tumors in the liver.
A recent study found a significant increase in colorectal cancer incidence rates among young adults, including those in their early 50s. Rectal cancer rates are rising even faster, with three in ten diagnoses now in patients under 55.
Current smokers with colon cancer are 14-21% more likely to die within five years compared to never smokers. Smoking prevention and cessation efforts may improve survival rates from colon cancer.
Virginia Tech researchers have discovered that modifying IRAK-M protein can significantly reduce inflammation and cancer progression in pre-clinical animal models. The team's findings suggest that designing therapeutics targeting IRAK-M could be a viable strategy for preventing these diseases.
Two renowned medical researchers, Sanford Markowitz and Mukesh K. Jain, receive $6.7 million awards from the National Institutes of Health (NIH) to advance studies on colon cancer and age-related cardiovascular risks.
Younger patients with colon cancer are nearly 2 to 8 times more likely to receive postoperative chemotherapy than older patients, yet no added survival benefit is seen for these patients. The study's findings suggest overtreatment of young and middle-aged adults with colon cancer.
A study by Osaka University reveals that colorectal cancer cells can survive under glucose-depletion conditions by maintaining TCA cycle activity and ATP production. Key proteins GLUD1 and SLC25A13 play pivotal roles in nutritional stress and are associated with tumor aggressiveness.
The ColoCare study, led by Huntsman Cancer Institute, aims to identify elements that impact colorectal cancer patients' survival and recovery. The study analyzes health and lifestyle factors to predict patient outcomes and determine the most effective treatments.
Researchers at St. Jude Children's Research Hospital discovered that NLRC3 protein plays a central role in inhibiting colon cells from becoming cancerous. The study found that deleting the protective NLRC3 protein exacerbates colon cancer development, but also identified key molecular components of its tumor suppressing pathway.
Researchers developed a model system to study ARID1A's tumor-suppressing effects on colon cancer. They found that ARID1A functions as a principal tumor suppressor by regulating active enhancers.
A recent study published in the American Journal of Roentgenology found that CT scans have good sensitivity for detecting colon cancers with tumors beyond the bowel wall, but struggle with identifying nodal involvement. Thin-slice CT may be an effective tool in this area.
A new study published in JAMA Oncology found that left-sided primary tumor location is associated with a nearly 20 percent reduced risk of death. This difference was independent of many clinical factors like tumor stage and receipt of adjuvant chemotherapy.
Scientists have discovered a metabolic fingerprint in feces that matches changes in tumor tissues, suggesting a potential new diagnostic tool for early detection of colorectal cancer. The method uses ultrasensitive technology to identify molecules in the feces of mice and humans, with promising results for noninvasive testing.
Researchers at UT Southwestern Medical Center have identified a small molecule called TASIN-1 that selectively kills cells with a mutation precursor to colon cancer while sparing normal cells. The findings could eventually help with both prevention and intervention efforts for colon cancer.
Researchers at the Research Institute of McGill University Health Centre (RI-MUHC) have discovered that some cancer cells can draw blood from existing mature blood vessels, allowing them to continue spreading. This breakthrough could lead to more personalized treatment options and improve the lives of patients with colon cancer.
Boston University researchers have identified a new strategy to treat colon cancers driven by the mutant KRAS gene. The study found that inhibiting MEK and TAK1 genes suppresses the growth of these cancer cells, providing a potential avenue for precision medicine.
Researchers at Georgia State University have developed edible ginger-derived nano-lipids that effectively target and deliver chemotherapeutic drugs to colon cancer cells. These nanovectors, modified with folic acid, show high-affinity binding to tumor tissues and inhibit tumor growth while reducing side effects.
Researchers discovered 15 gene mutations that contribute to more aggressive colon cancer in African-Americans, resulting in higher recurrence and metastasis rates. These findings explain the disparity in colorectal cancer rates and death rates between African-Americans and other groups.
A new study found no clear common characteristic of microbe populations in obese individuals, disappointing those hoping for a solution to weight loss through gut bacteria alteration. The researchers suggest that a more complex relationship exists between the microbiome and health, warranting further investigation.
Researchers developed a hydrogel patch that delivers gene therapy, chemotherapy, and thermal ablation to treat colon cancer. The patch achieves complete tumor remission in non-resected tumors and prevents recurrence when applied after surgery.
Scientists have identified a rare genetic alteration in the MSH3 gene that is associated with a new form of hereditary colon cancer. The discovery has significant implications for diagnosis and treatment, as it offers a clear diagnosis for some cases of polyposis and allows for targeted surveillance and prevention.
The study found treating colon cancer cells with a combination of curcumin and silymarin resulted in increased cell death and inhibition of cell multiplication. The researchers believe phytochemicals could provide an alternate therapeutic approach to cancer treatments.
Researchers are working to identify demographic and clinical factors that distinguish individuals under 50 with colon cancer from those without the disease. The study aims to develop a risk-based screening system, potentially including blood stool tests or other less invasive tests for high-risk groups.
Researchers have found an association between adjuvant chemotherapy and improved survival in stage 2 colon cancer patients, contradicting current clinical guidelines. The study analyzed 153,110 patients with stage 2 colon cancer and found that those who received adjuvant chemotherapy survived longer than those who did not.
A new rat study suggests that a specific strain of gut microbiota may reduce colon cancer risk and increase survival rates. The research found that rats with LEW microbiota developed significantly fewer tumors than those with other strains, providing new insight into the role of gut microbiota in cancer development.