Articles tagged with Colon Cancer
Researchers found that Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells, suggesting a potential treatment for colon cancer. The study reveals that AS-induced apoptosis and autophagy are mediated by reactive oxygen species.
Researchers compared tumor biology in patients with early-onset and average-onset colorectal cancer, finding no significant differences in terms of tumor location, symptoms, or genetic makeup. The study suggests that early-onset colorectal cancer is not biologically distinct from average-onset cases, and more aggressive treatment may n...
A study found that total vitamin D intake of 300 IU per day or more was associated with a 50% lower risk of developing young-onset colorectal cancer. Higher dietary vitamin D intake was linked to a reduced risk of colon polyps detected before age 50.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
A study published at ESMO World Congress on Gastrointestinal Cancer 2021 suggests a link between antibiotic use and an increased risk of colon cancer, particularly in people under 50 years old. The research found that quinolones and sulfonamides/trimethoprim were associated with cancers in the first part of the colon.
Patients enrolled in the US military's universal health care system experienced improved colon cancer survival rates compared to those in the general population. The study found a 26% lower risk of death among Black patients, highlighting the positive impact of universal healthcare on racial disparities in cancer outcomes.
A new Arizona State University study has shown that high fat diets can trigger a molecular cascade of events leading to colon cancer through intestinal stem cells. The research found that PPARs, specifically PPAR delta and alpha, play a crucial role in elevating cancer risk by stimulating the metabolism of fats.
A new study found that higher red meat intake and lower educational attainment are associated with an increased risk of colorectal cancer in people under 50. The research also linked lower fiber and folate intake to a stronger link between rectal cancer and early-onset cases.
Research finds inflammasomes play a role in inflammation and intestinal barrier integrity. Obesity-associated colon cancer is linked to increased gene expression levels of certain proteins, including NLRP3 and IL1B.
A Mayo Clinic study found that 15.5% of patients with colorectal cancer had inherited gene mutations, which can be detected through universal testing and broader gene panels. This discovery has the potential to lead to targeted cancer therapies and earlier disease detection in families.
A long-term study published in PLOS ONE found that bariatric surgery does not increase the risk of colorectal cancer in obese individuals. After a median follow-up period of 22 years, there were 57 cases of colorectal cancer in the surgery group and 67 in the control group, suggesting no association between the two.
A team at Washington University in St. Louis has developed an imaging technique using acoustic resolution photoacoustic microscopy co-registered with ultrasound and paired with deep learning to differentiate between residual tumors and healthy tissue in rectal cancer patients after chemotherapy and radiation. This technique shows promi...
A new study found that delaying colonoscopies after abnormal at-home screenings by over 12 months increases the risk of colorectal cancer diagnosis and death. The odds of being diagnosed with late-stage colon cancer increased by approximately 33% at 16 months.
African-Americans are more likely to develop cancerous lesions on the right side and suffer from colorectal cancer at a younger age due to unique biological aging patterns. The research found that the right side of the colon in most African-Americans had suffered epigenetic changes contributing to their increased cancer risk.
Researchers discovered that the cancer stem cells' ability to form tumors is regulated by a molecular switch called Mll1. Blocking this enzyme can specifically target cancer stem cells, offering hope for more effective treatments. Clinical trials are underway to evaluate the use of Mll1 inhibitors in head and neck tumors.
Scientists have developed a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. The treatment has shown promise in treating aggressive subtypes of cancers with specific mutations in genes called RAS or NF1.
Researchers at City of Hope developed a cancer-killing virus called CF33 that targets hard-to-treat tumors and stimulates an immune response. The oncolytic virus demonstrates increased PD-L1 expression in tumor cells and causes them to die, leading to lasting anti-tumor immunity.
A new study published in the Journal of the American College of Surgeons suggests that Medicaid expansion under the Affordable Care Act may lead to earlier diagnoses of colon cancer. Researchers found improved access to care and enhanced surgical care for patients with colon cancer in states that implemented Medicaid expansion.
A new Northwestern Medicine study found that patients treated by highly skilled surgeons have better long-term survival after surgery for colon cancer. The study showed a 70% lower risk of dying over five years compared to patients with less skilled surgeons.
A recent study published in JAMA Surgery found that low muscle mass and quality are linked to greater post-operative complications, hospitalization, and mortality in patients with colon cancer following colon resection surgery. The researchers followed 1,630 patients and used preoperative CT scans to analyze body composition.
A recent study published in iScience found that Δ9-tetrahydrocannabinol (THC) suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. THC treatment also prevented the development of colon cancers in mice.
Research finds that high androgen levels can cause intestinal stem cells to divide excessively and produce fewer mature epithelial cells, increasing the risk of tumor formation. The study's findings may have implications for treating or preventing colon cancers through androgen regulation.
A program using mail-in stool samples is shown to be an effective and cost-effective alternative to in-person colonoscopies for detecting colon cancer. The study identified nine best practices for implementing such programs, including patient navigation and high-quality testing kits.
A new small molecule treatment reduces colon cancer metastasis by locking up cancer cells' ability to change shape and move throughout the body. The treatment cut the rate of cancer metastasis in half, according to a study published in the Proceedings of the National Academy of Sciences.
Gut microbiome plays a crucial role in cancer growth, particularly in the colon where high levels of metabolites from antioxidant-rich foods accelerate bowel cancer. In contrast, small intestines have fewer bacteria and may convert cancer-driving proteins into super-suppressors.
Scientists have discovered that a steroidal sex hormone, ecdysone, drastically alters intestinal stem cell behavior, affecting gut growth and function. The study found that ecdysone stimulates stem cell growth and causes the gut to grow in size, leading to changes in its structure and function.
Research uncovering a new mechanism causing colorectal cancer found that abnormal Zeb2 expression undermines the integrity of the intestinal wall, allowing infiltrating bacteria to cause inflammation. Removing the microbiota or modulating the immune system can prevent cancer development.
Research from Newcastle University reveals that aspirin can significantly reduce the risk of bowel cancer in people with Lynch syndrome. The study found that taking two aspirins a day for two years reduced colon cancer by half, with protection lasting over 10 years.
A phase II clinical trial found that immunotherapy significantly shrinks or clears tumors in patients with non-metastasized colon cancer. In the MSI subtype, all 20 patients (100%) benefited from the therapy, while 25% of those with MSS tumors also responded well.
Researchers at UCI found that depriving colon cancer cells of glutamine causes them to adapt and become more invasive, but a modified version of the metabolite alpha-ketoglutarate inhibits key signaling pathways and curbs tumor growth
Researchers from IDIBELL and ICO conducted a pilot study to analyze intestinal microbiota genome in colon cancer patients. They used two sequencing methods, 16s and Shotgun, and found both techniques consistent, with complete sequencing more sensitive but not contradictory to single-gene sequencing.
Research finds that people with a history of cancer are at over two-fold risk of developing atrial fibrillation (AFib), a heart rhythm disorder. Prostate cancer is most strongly associated with AFib, followed by colon, lung and breast cancers.
Researchers at Mayo Clinic have found that combining density of immune cells with analysis of tumor budding can improve accuracy in predicting patient survival for patients with stage III colon cancer. This method provides important data on patient survival and may lead to personalized treatment recommendations.
A new study reveals that colon cancer is different in children, adolescents, and young adults, with younger patients more likely to have metastases outside the colon. The findings call for more intensive surveillance and treatment in those who have symptoms.
Expanding Medicaid in North Carolina would reduce colon cancers and improve access to care for men of all races, saving thousands of Black male lives. The study found that the state would save $5.1 million in cumulative cost savings by 2044.
Scientists identified a new biological pathway (RICTOR/mTORC2) as a potential therapeutic target for colon cancer. Targeting this pathway could enhance the effectiveness of chemotherapy treatments. The study also highlights the importance of SMAD4 gene mutations in colon cancer progression.
A study published in the International Journal of Cancer suggests that weight loss surgery may increase the risk of colon cancer. Patients who underwent such surgery had a higher risk of colon cancer compared to the general population, especially over time.
Researchers at Duke University Medical Center developed a new technique to visualize how pre-cancerous stem cells spread throughout the colon, illuminating key differences in their growth patterns. The study found that newborns are more sensitive to mutations, leading to rapid field cancerization and increased cancer risk.
Researchers found that two genes, HNF4A and HNF4G, help burn dietary fat in intestinal stem cells, which may increase cancer risk on a high-fat diet. Altered stem cell functions can lead to colon cancer.
A team of scientists has identified a specific gene, eIF2B5, that is essential for the survival of colon cancer cells with APC mutations. Inhibiting this gene causes programmed cell death in mutated cells but not in healthy cells, providing a promising new target for antitumor therapies.
A preliminary study found that most elderly patients with stage II and III colon cancer survive short-term surgery, but those with unplanned hospital admissions and open operations face higher mortality rates. Experienced surgeons who perform high-volume procedures also reduce the risk of death.
Researchers found complex patterns of mutations, including changes in cancer genes, and a huge variability of mutations in healthy colon tissue. The study provides insight into how a healthy cell becomes a cancerous one and identifies new mutational signatures in normal colon cells.
Researchers found that disrupting the PTPN2 gene boosts anti-tumor immunity, enabling cancer clearance in animal models. Deleting the gene stimulates production and fitness of T-killer cells, which are critical in warding off tumors.
A Norwegian study found that being overweight before age 40 significantly increases the risk of several types of cancer, including endometrial cancer by 70%. Obesity is also linked to an increased risk of postmenopausal breast, renal-cell and colon cancers.
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Researchers at George Washington University found a connection between specific bacteria in the microbiome and the development of colon cancer. The study suggests that altered microbial profiles may be used to identify risk for colon cancer, particularly in younger patients.
New studies show that KRAS gene mutations, common in colorectal and other cancers, vary in disease severity depending on the specific mutation and tissue location. The findings suggest that precision medicine approaches must be tailored to individual mutant forms of KRAS.
Researchers at UMass Amherst discover that consuming fried foods can exacerbate conditions of the colon, including colonic inflammation and tumor growth. The study suggests that eating fried foods may make diseases like IBD more aggressive in susceptible individuals.
Researchers at Johns Hopkins Kimmel Cancer Center found that taking a single course of antibiotics may boost the risk of developing colon cancer a decade later. The study, published in the journal Gut, highlights the need for judicious use of antibiotics and careful stewardship.
Researchers at the University of Arizona Cancer Center successfully repeated findings from a study that challenged current approaches to colon cancer treatment. The team validated therapeutic targeting of LRP6 as a potential strategy for blocking progression of colon cancer, offering new hope for patient care.
Researchers at the University of Minnesota Medical School have identified a cellular mechanism that contributes to drug resistance in colon cancer. The study found that KRAS proteins can transfer between cancer cells via long, thin extensions called tunneling nanotubes, leading to more aggressive and invasive cancer behavior.
A new iPad app, mPATH-CRC, will be tested in North Carolina and Kentucky clinics to increase colorectal cancer screenings. The project aims to determine the optimal way to implement technology-based programs to improve medical care delivery.
Researchers from the University of Missouri School of Medicine found no significant difference in colonoscopy detection rates between moderate and deep sedation methods. Moderate sedation, typically used in colonoscopies, was found to be equally effective as deep sedation in detecting pre-cancerous polyps.
A researcher is using a $2.3 million grant to study the mechanisms by which bacteria in the colon may trigger cancer development. The goal is to develop prevention strategies, such as probiotics, to stop the triggering of the immune response.
Early-onset colorectal cancer incidence has been increasing rapidly in Western US states, despite low rates of smoking and physical inactivity. The study found that rates rose faster for rectal tumors than colon tumors, with average increases exceeding 2.5% per year in ten states.
Researchers found that strawberry tree honey reduces colon cancer cell proliferation and colony formation ability by regulating EGFR and MAPKs signaling pathways. The study also showed that the honey inhibits cell cycle, induces apoptosis, and suppresses key genes involved in tumor growth.
The study found significant increases in colon and rectal cancer incidence among young adults in several high-income countries, including Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the UK. The incidence of colon cancer increased significantly each year in people aged 0-49 years, while rectal cancer incidence was most...
A novel colorectal cancer vaccine has demonstrated positive phase I results, with patients showing no signs of serious adverse events and activation of immune cells. The vaccine was found to be safe and effective in a small sample of human subjects, paving the way for further testing to determine its potential as a treatment.
Researchers analyzed colon cancer proteins and genes, uncovering novel biological mechanisms and potential new therapeutic strategies. The study provides a systematic catalog of proteins produced by colon cancer tumors and adjacent normal tissues, including insights into unexpected gene behavior.
Scientists successfully blocked cancer-fighting gene silencing protein UHRF1, restoring hundreds of protective genes in human colon cancer cells. The findings suggest a new strategy for fighting cancers by targeting this protein.