Articles tagged with Colon Cancer
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A new Northwestern Medicine study found that patients treated by highly skilled surgeons have better long-term survival after surgery for colon cancer. The study showed a 70% lower risk of dying over five years compared to patients with less skilled surgeons.
A recent study published in JAMA Surgery found that low muscle mass and quality are linked to greater post-operative complications, hospitalization, and mortality in patients with colon cancer following colon resection surgery. The researchers followed 1,630 patients and used preoperative CT scans to analyze body composition.
A recent study published in iScience found that Δ9-tetrahydrocannabinol (THC) suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. THC treatment also prevented the development of colon cancers in mice.
Research finds that high androgen levels can cause intestinal stem cells to divide excessively and produce fewer mature epithelial cells, increasing the risk of tumor formation. The study's findings may have implications for treating or preventing colon cancers through androgen regulation.
A program using mail-in stool samples is shown to be an effective and cost-effective alternative to in-person colonoscopies for detecting colon cancer. The study identified nine best practices for implementing such programs, including patient navigation and high-quality testing kits.
A new small molecule treatment reduces colon cancer metastasis by locking up cancer cells' ability to change shape and move throughout the body. The treatment cut the rate of cancer metastasis in half, according to a study published in the Proceedings of the National Academy of Sciences.
Gut microbiome plays a crucial role in cancer growth, particularly in the colon where high levels of metabolites from antioxidant-rich foods accelerate bowel cancer. In contrast, small intestines have fewer bacteria and may convert cancer-driving proteins into super-suppressors.
Scientists have discovered that a steroidal sex hormone, ecdysone, drastically alters intestinal stem cell behavior, affecting gut growth and function. The study found that ecdysone stimulates stem cell growth and causes the gut to grow in size, leading to changes in its structure and function.
Research uncovering a new mechanism causing colorectal cancer found that abnormal Zeb2 expression undermines the integrity of the intestinal wall, allowing infiltrating bacteria to cause inflammation. Removing the microbiota or modulating the immune system can prevent cancer development.
Research from Newcastle University reveals that aspirin can significantly reduce the risk of bowel cancer in people with Lynch syndrome. The study found that taking two aspirins a day for two years reduced colon cancer by half, with protection lasting over 10 years.
A phase II clinical trial found that immunotherapy significantly shrinks or clears tumors in patients with non-metastasized colon cancer. In the MSI subtype, all 20 patients (100%) benefited from the therapy, while 25% of those with MSS tumors also responded well.
Researchers at UCI found that depriving colon cancer cells of glutamine causes them to adapt and become more invasive, but a modified version of the metabolite alpha-ketoglutarate inhibits key signaling pathways and curbs tumor growth
Researchers from IDIBELL and ICO conducted a pilot study to analyze intestinal microbiota genome in colon cancer patients. They used two sequencing methods, 16s and Shotgun, and found both techniques consistent, with complete sequencing more sensitive but not contradictory to single-gene sequencing.
Research finds that people with a history of cancer are at over two-fold risk of developing atrial fibrillation (AFib), a heart rhythm disorder. Prostate cancer is most strongly associated with AFib, followed by colon, lung and breast cancers.
Researchers at Mayo Clinic have found that combining density of immune cells with analysis of tumor budding can improve accuracy in predicting patient survival for patients with stage III colon cancer. This method provides important data on patient survival and may lead to personalized treatment recommendations.
A new study reveals that colon cancer is different in children, adolescents, and young adults, with younger patients more likely to have metastases outside the colon. The findings call for more intensive surveillance and treatment in those who have symptoms.
Expanding Medicaid in North Carolina would reduce colon cancers and improve access to care for men of all races, saving thousands of Black male lives. The study found that the state would save $5.1 million in cumulative cost savings by 2044.
Scientists identified a new biological pathway (RICTOR/mTORC2) as a potential therapeutic target for colon cancer. Targeting this pathway could enhance the effectiveness of chemotherapy treatments. The study also highlights the importance of SMAD4 gene mutations in colon cancer progression.
A study published in the International Journal of Cancer suggests that weight loss surgery may increase the risk of colon cancer. Patients who underwent such surgery had a higher risk of colon cancer compared to the general population, especially over time.
Researchers at Duke University Medical Center developed a new technique to visualize how pre-cancerous stem cells spread throughout the colon, illuminating key differences in their growth patterns. The study found that newborns are more sensitive to mutations, leading to rapid field cancerization and increased cancer risk.
Researchers found that two genes, HNF4A and HNF4G, help burn dietary fat in intestinal stem cells, which may increase cancer risk on a high-fat diet. Altered stem cell functions can lead to colon cancer.
A team of scientists has identified a specific gene, eIF2B5, that is essential for the survival of colon cancer cells with APC mutations. Inhibiting this gene causes programmed cell death in mutated cells but not in healthy cells, providing a promising new target for antitumor therapies.
A preliminary study found that most elderly patients with stage II and III colon cancer survive short-term surgery, but those with unplanned hospital admissions and open operations face higher mortality rates. Experienced surgeons who perform high-volume procedures also reduce the risk of death.
Researchers found complex patterns of mutations, including changes in cancer genes, and a huge variability of mutations in healthy colon tissue. The study provides insight into how a healthy cell becomes a cancerous one and identifies new mutational signatures in normal colon cells.
Researchers found that disrupting the PTPN2 gene boosts anti-tumor immunity, enabling cancer clearance in animal models. Deleting the gene stimulates production and fitness of T-killer cells, which are critical in warding off tumors.
A Norwegian study found that being overweight before age 40 significantly increases the risk of several types of cancer, including endometrial cancer by 70%. Obesity is also linked to an increased risk of postmenopausal breast, renal-cell and colon cancers.
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Researchers at George Washington University found a connection between specific bacteria in the microbiome and the development of colon cancer. The study suggests that altered microbial profiles may be used to identify risk for colon cancer, particularly in younger patients.
New studies show that KRAS gene mutations, common in colorectal and other cancers, vary in disease severity depending on the specific mutation and tissue location. The findings suggest that precision medicine approaches must be tailored to individual mutant forms of KRAS.
Researchers at UMass Amherst discover that consuming fried foods can exacerbate conditions of the colon, including colonic inflammation and tumor growth. The study suggests that eating fried foods may make diseases like IBD more aggressive in susceptible individuals.
Researchers at Johns Hopkins Kimmel Cancer Center found that taking a single course of antibiotics may boost the risk of developing colon cancer a decade later. The study, published in the journal Gut, highlights the need for judicious use of antibiotics and careful stewardship.
Researchers at the University of Arizona Cancer Center successfully repeated findings from a study that challenged current approaches to colon cancer treatment. The team validated therapeutic targeting of LRP6 as a potential strategy for blocking progression of colon cancer, offering new hope for patient care.
Researchers at the University of Minnesota Medical School have identified a cellular mechanism that contributes to drug resistance in colon cancer. The study found that KRAS proteins can transfer between cancer cells via long, thin extensions called tunneling nanotubes, leading to more aggressive and invasive cancer behavior.
A new iPad app, mPATH-CRC, will be tested in North Carolina and Kentucky clinics to increase colorectal cancer screenings. The project aims to determine the optimal way to implement technology-based programs to improve medical care delivery.
Researchers from the University of Missouri School of Medicine found no significant difference in colonoscopy detection rates between moderate and deep sedation methods. Moderate sedation, typically used in colonoscopies, was found to be equally effective as deep sedation in detecting pre-cancerous polyps.
A researcher is using a $2.3 million grant to study the mechanisms by which bacteria in the colon may trigger cancer development. The goal is to develop prevention strategies, such as probiotics, to stop the triggering of the immune response.
Early-onset colorectal cancer incidence has been increasing rapidly in Western US states, despite low rates of smoking and physical inactivity. The study found that rates rose faster for rectal tumors than colon tumors, with average increases exceeding 2.5% per year in ten states.
Researchers found that strawberry tree honey reduces colon cancer cell proliferation and colony formation ability by regulating EGFR and MAPKs signaling pathways. The study also showed that the honey inhibits cell cycle, induces apoptosis, and suppresses key genes involved in tumor growth.
The study found significant increases in colon and rectal cancer incidence among young adults in several high-income countries, including Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the UK. The incidence of colon cancer increased significantly each year in people aged 0-49 years, while rectal cancer incidence was most...
A novel colorectal cancer vaccine has demonstrated positive phase I results, with patients showing no signs of serious adverse events and activation of immune cells. The vaccine was found to be safe and effective in a small sample of human subjects, paving the way for further testing to determine its potential as a treatment.
Researchers analyzed colon cancer proteins and genes, uncovering novel biological mechanisms and potential new therapeutic strategies. The study provides a systematic catalog of proteins produced by colon cancer tumors and adjacent normal tissues, including insights into unexpected gene behavior.
Scientists successfully blocked cancer-fighting gene silencing protein UHRF1, restoring hundreds of protective genes in human colon cancer cells. The findings suggest a new strategy for fighting cancers by targeting this protein.
Researchers developed a novel cell model of aging-related colon cancer risk by combining genetic and epigenetic factors. The model shows that epigenetic changes are essential for cancer initiation, and can be used to assess cancer risk in human lab-grown cells.
A team of University of Wisconsin-Madison scientists has identified four blood-based fingerprints associated with pre-cancerous forms of colon cancer. The findings may lead to a minimally-invasive blood test to increase screening rates and reduce overtreatment.
Researchers at Oregon State University discovered that two hop-derived compounds inhibit liver and colon cancer cell growth effectively similar to xanthohumol. These non-estrogenic derivatives offer promising alternatives for future preclinical studies.
Starting colorectal cancer screening at age 45 rather than 50 would decrease U.S. cancer deaths by as much as 11,100 over five years and cases by up to 29,400. Screening a greater number of older adults would avert nearly three times as many diagnoses and deaths at a lower cost.
A study by Weill Cornell Medicine found that consuming high-fructose corn syrup causes mice with colon cancer to develop larger tumors. The researchers discovered a molecular mechanism by which the sweetener fuels tumor growth and suggest blocking this effect could lead to new cancer treatments.
Researchers found that early-life microbiota play a crucial role in regulating immune responses and preventing colon cancer in adulthood. The absence of microbiota in early life can lead to enhanced pro-inflammatory gene expression and an accumulation of immune cells that suppress tumor growth.
A study published in EMBO Reports found that the common oral bacterium F. nucleatum accelerates colon cancer growth by inducing the production of protein Annexin A1, which stimulates cancer cell growth. This discovery may help predict aggressive colon cancers and identify new treatment targets.
Research published in The Journal of Physiology suggests that exercise may play a role in inhibiting the growth of colon cancer cells. After high-intensity interval training (HIIT), growth was reduced and inflammation increased, indicating a potential anti-cancer effect. This study highlights the importance of regular physical activity...
Researchers at UMass Amherst have discovered a novel therapeutic target, CYP monooxygenase pathway, that could prevent or treat colon cancer. The study found that certain fatty acid metabolites, such as epoxyoctadecenoic acids (EpOMEs), increase inflammation and tumor growth in the colon.
The study found a substantial increase of 230% in colon cancer screenings among Medicaid patients post-ACA expansion. Additionally, data showed a 9.3% rise in early-stage colon cancer diagnosis and a 27% decrease in risk of death.
Researchers at Penn State College of Medicine identified 10 synthetic cannabinoid compounds that effectively inhibited the growth of seven types of human colon cancer cells. These compounds work through alternative mechanisms, not relying on traditional marijuana receptors, and hold promise for developing drugs to treat cancer.
A study published in Cell Reports reveals a critical connection between chronic inflammation and the development of colon cancer. Researchers found that persistent inflammation leads to increased levels of myeloid-derived suppressor cells and interleukin-10, which ultimately silence tumor suppressors and contribute to cancer growth.
Colorectal cancer mortality rates are projected to decrease in most countries, but increase in Europe, North America, and Oceania. The number of deaths is expected to rise globally by 60.0% and 71.5% until 2035.
Researchers found that it took a year or more from first spotting a symptom to beginning treatment for 10% of patients in England, Northern Ireland, and Wales. The time to diagnosis varied significantly across countries, with Denmark performing the best.
A systematic review and meta-analysis found that racial differences in colorectal cancer incidence are not due to biological factors. The study suggests that screening should begin at age 50 regardless of race, with consideration for individual risk factors and preferences. Improved access to screening is crucial to reducing disparitie...
Researchers report a 100% major pathological response rate in early-stage colon cancers with mismatch repair deficiencies treated with nivolumab and ipilimumab. The regimen was well-tolerated, and patients underwent radical resection without delays.
A new study found that inflammatory proteins in the colon increase incrementally with weight in humans, leading to pro-cancerous changes. The study also suggests that NSAIDs may lower the levels of these pro-inflammatory proteins, reducing cancer risk.
Researchers at CWRU School of Medicine are exploring the role of long noncoding RNAs in colon cancer. They have identified potential targets for treatment, including lincDUSP, and found that depleting its levels can slow tumor growth.