Articles tagged with Colon Cancer
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Researchers developed a novel nanoparticle to deliver ARL67156, an enzyme inhibitor that prevents ATP degradation into adenosine, selectively targeting solid tumors. The treatment substantially suppressed tumor growth and resulted in prolonged survival in mouse models.
A new blood test has been developed to identify colon cancer patients who can safely avoid chemotherapy, reducing the number of patients treated with unnecessary treatment. The test assesses levels of circulating tumour DNA and could revolutionise chemotherapy treatment for colon cancer patients.
A new study found that circulating tumor DNA can identify stage II colon cancer patients who benefit from chemotherapy, sparing others the need for treatment. The study showed reduced use of chemotherapy without compromising survival rates.
A new study has identified persistent racial and ethnic disparities in five-year survival rates for younger adults with colorectal cancer. White patients had a higher five-year relative survival rate compared to Black, Hispanic, and Asian patients, regardless of disease stage.
A study of early-onset colon cancer found that five-year survival rates remained lower for Blacks and Hispanics compared to Whites, despite improvements in White survival over a 20-year span. The disparities persisted even among younger adults with localized disease.
A novel connection between genes involved in mitosis and glucose metabolism was found by researchers at Nagoya University. They demonstrated a gene bypass process using evolutionary repair experiments, suggesting that suppressing both Plk1 and CK1 could be more effective in cancer treatment.
A new study from University of Gothenburg found that men with high childhood BMI are at an elevated risk of obesity-related cancer, even if their weight is normal in young adulthood. The study analyzed data from 6,565 men born between 1945 and 1961 and found a persistently increased risk of adult obesity-related cancer.
A study published in Gastroenterology found that artificial intelligence reduced the rate of missed precancerous polyps in colorectal cancer screening by twofold compared to standard colonoscopy. The AI detection method identified smaller, flatter polyps and improved false negative rates.
A study at Karolinska Institutet has revealed that a subgroup of innate lymphoid cells (ILCs) can accumulate in the intestinal mucosa of patients with inflammatory bowel disease (IBD). These immature cells can be influenced by gut environment factors, leading to increased cell division and cytokine production.
Researchers found that APC gene mutations in colon cancer patients disrupt T lymphocyte migration to tumors, making it harder for the immune system to combat cancer. The study provides new insights into the mechanisms of antitumor immune defense.
The American Association for Cancer Research (AACR) has announced the recipients of its 2022 Scientific Achievement Awards and Lectureships, recognizing Tony Hunter, Christina Curtis, John E. Dick, Kevan M. Shokat, and Lee M. Ellis for their groundbreaking contributions to cancer research.
Scientists have identified two proteins, CB7H3 and B7H4, as potential targets for new immunotherapies against colon cancer. Blocking these proteins slowed the growth of tumors and allowed immune cells to attack cancer cells. The study also found a link between microbiota and tumor growth in colon cancer.
Researchers develop innovative non-contact agitation technology to assess motility and invasive capacity of cancer cells in tissue sections. The study reveals significant increases in Rac/Cdc42 activity in tumor areas, with stronger correlations found in advanced cancer stages.
Researchers at TTUHSC will investigate common mechanisms of resistance and sensitivity in alternate telomere lengthening (ALT) cancers, with a focus on targeting ATM kinase inhibitors for therapy. The team aims to develop clinical trials for patients with ALT+ cancers.
Researchers have created a new type of colon tattoo ink that is more biocompatible and less prone to diffusion than existing inks. The ink uses metal-derived nanoparticles and polymers to adhere to the submucosal surface in the colon, allowing for better identification and removal of complex polyps and tumors.
A new analysis of cases in the National Cancer Database finds that younger patients (less than 50 years old) with acute appendicitis are at increased risk of developing cancer of the appendix. The study suggests that patients under 40 may want to undergo surgery to rule out cancer.
A new study found that nearly one-third of older adult female survivors of colorectal, endometrial, and ovarian cancer experience quality-of-life-impacting challenges with physical activity due to chronic lower extremity lymphedema. The researchers urge the medical community to include regular lymphedema assessments in survivorship care.
A new study found that dual-eligible patients for Medicare and Medicaid have poorer outcomes and higher costs after cancer surgery, even in high-quality hospitals. These patients are more likely to experience complications, longer hospital stays, and lower chances of going home instead of a nursing facility.
A recent study by City of Hope researchers highlights the limitations of Signatera, a popular liquid biopsy test for detecting colorectal cancer recurrence. The study found that standard-of-care CT scan plus CEA blood draw test was more effective in identifying early disease recurrence.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
A meta-analysis of 280,660 cases of colorectal cancer and 14,139 cases of adenoma found that taller individuals have a higher risk of developing colorectal cancer and precancerous colon polyps. The study suggests that adults over 4 inches (10 cm) above the average U.S. height may be at increased risk.
Researchers have found that statins can inhibit the formation of tumors and metastases in animals with increased MACC1 expression. A study analyzing data from over 300,000 patients prescribed statins also showed a correlation between statin use and reduced cancer incidence.
A recent observational study of 1,011 patients with stage III colon cancer found no significant association between eating unprocessed red meat or processed meat after diagnosis and increased risk of recurrence or mortality. The study's results provide new insights into the relationship between dietary choices and colon cancer outcomes.
Researchers discover that chemotherapy triggers the secretion of mucins in colorectal cancer cells, forming a physical barrier that prevents drugs from reaching their intended target. The study found potential new biomarkers for disease prognosis and a promising treatment strategy using NCX blockers like SN-6.
USC researchers will use $18.5 million funding to study colorectal cancer in Hispanic patients, aiming to close the gap in understanding the disease and developing effective treatments. The project aims to improve patient engagement in genomic research and develop culturally relevant educational materials.
Researchers discovered a bacterial toxin that can accelerate colon cancer in mice, sharing similarities with human tumors. The study's findings suggest a potential link between transient food poisoning and colorectal cancer development, highlighting the need for further epidemiological studies.
Researchers at Case Western Reserve University are developing an AI tool to analyze medical images and determine which rectal cancer patients require surgery. By using radiomics and machine learning techniques, the team hopes to identify patients who can avoid invasive surgery and opt for chemotherapy or radiation therapy instead.
Researchers found that adding a specific bacterium to the gut microbiome of mice with colon cancer increased immune cell activity and reduced tumor size. The study suggests leveraging gut microbiota to enhance anti-tumor immunity in advanced colon cancer, offering a promising new approach for treatment.
Researchers at Princeton University have discovered a new compound that can disable the MTDH gene, which is essential for cancer progression and metastasis. The compound shows promise in treating major human cancers, including breast, prostate, lung, and colon cancers.
Researchers from the University of Copenhagen have discovered a natural substance, a flavonoid, that can inhibit cancer cells' ability to defend themselves against chemotherapy by targeting efflux pumps. This could lead to more effective treatment and potentially even combat antibiotic resistance.
A Mount Sinai study reveals that young adult cancer patients exhibit distinct genetic hallmarks and immune system responses compared to their older counterparts. These findings suggest personalized treatment approaches for young adults with various types of cancers.
Researchers created a novel humanized mouse model to study hyperprogressive disease (HPD) and hyperprogression (HP) in mismatch repair-deficient colon cancer. The study found accelerated tumor growth after PD-1 blockade with pembrolizumab administration, and identified changes in human cytokine profiles.
A survey of adults shows low colonoscopy rates during the pandemic, but home-based fecal occult blood testing increased by 30% among respondents. The study highlights the need for tailored screening options to address patient concerns and improve colorectal cancer screening rates.
A new deep learning algorithm can accurately predict the status of molecular pathways and key mutations in colorectal cancer from routine histology images. The algorithm, which doesn't require manual annotations, has been shown to be significantly more accurate than current methods.
A Mayo Clinic expert suggests that people with serrated polyps, which are flat and difficult to spot during colonoscopies, should be checked more frequently for bowel cancer. The presence of serrated polyps alone or with adenomas increases cancer risk, similar to adenomas alone, according to a new study.
A research team at TUM has discovered that the protein TIMP1 is associated with a significantly higher risk of liver metastasis and death in male patients, particularly those with pancreatic, colon, and melanoma cancers. This finding may lead to improved diagnosis and targeted therapy options for men.
Researchers developed novel scoring tools to predict colon cancer risk in average-risk individuals, especially useful in low-screening countries. The tools consider factors like age, smoking history, and aspirin use to determine personalized risk.
Researchers found that antidepressants inhibit the growth of pancreatic and colon cancers in mice by blocking a mechanism used by cancer cells to evade the immune system. The findings suggest a promising approach for combining antidepressant drugs with immunotherapy to treat incurable cancers.
Researchers analyzed data from over 3,200 brain metastatic tumors and discovered that different types of cancer tend to spread to specific parts of the brain. The study's findings may help predict where a particular cancer will metastasize and inform treatment strategies.
A new study published in Clinical Gastroenterology and Hepatology found that computer-aided detection can improve colonoscopy quality by reducing the miss rate, with a relative reduction of nearly a third when used in conjunction with standard-of-care colonoscopy. The study suggests that artificial intelligence may be an important tool...
Researchers found that the gene TCF-1 regulates specific Treg cells, leading to more severe and inflammatory colon cancers. Without TCF-1, these cells become activated and gain a gut-homing feature, resulting in harsher cancer outcomes.
Research at UTHealth School of Public Health in Houston found that infants born to obese mothers have a heightened risk of developing colorectal cancer later in life. The study also linked timing and magnitude of maternal weight gain during pregnancy, as well as birth weight, to increased risk of the disease.
Researchers found that Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells, suggesting a potential treatment for colon cancer. The study reveals that AS-induced apoptosis and autophagy are mediated by reactive oxygen species.
Researchers compared tumor biology in patients with early-onset and average-onset colorectal cancer, finding no significant differences in terms of tumor location, symptoms, or genetic makeup. The study suggests that early-onset colorectal cancer is not biologically distinct from average-onset cases, and more aggressive treatment may n...
A study found that total vitamin D intake of 300 IU per day or more was associated with a 50% lower risk of developing young-onset colorectal cancer. Higher dietary vitamin D intake was linked to a reduced risk of colon polyps detected before age 50.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
A study published at ESMO World Congress on Gastrointestinal Cancer 2021 suggests a link between antibiotic use and an increased risk of colon cancer, particularly in people under 50 years old. The research found that quinolones and sulfonamides/trimethoprim were associated with cancers in the first part of the colon.
Patients enrolled in the US military's universal health care system experienced improved colon cancer survival rates compared to those in the general population. The study found a 26% lower risk of death among Black patients, highlighting the positive impact of universal healthcare on racial disparities in cancer outcomes.
A new Arizona State University study has shown that high fat diets can trigger a molecular cascade of events leading to colon cancer through intestinal stem cells. The research found that PPARs, specifically PPAR delta and alpha, play a crucial role in elevating cancer risk by stimulating the metabolism of fats.
A new study found that higher red meat intake and lower educational attainment are associated with an increased risk of colorectal cancer in people under 50. The research also linked lower fiber and folate intake to a stronger link between rectal cancer and early-onset cases.
Research finds inflammasomes play a role in inflammation and intestinal barrier integrity. Obesity-associated colon cancer is linked to increased gene expression levels of certain proteins, including NLRP3 and IL1B.
A Mayo Clinic study found that 15.5% of patients with colorectal cancer had inherited gene mutations, which can be detected through universal testing and broader gene panels. This discovery has the potential to lead to targeted cancer therapies and earlier disease detection in families.
A team at Washington University in St. Louis has developed an imaging technique using acoustic resolution photoacoustic microscopy co-registered with ultrasound and paired with deep learning to differentiate between residual tumors and healthy tissue in rectal cancer patients after chemotherapy and radiation. This technique shows promi...
A long-term study published in PLOS ONE found that bariatric surgery does not increase the risk of colorectal cancer in obese individuals. After a median follow-up period of 22 years, there were 57 cases of colorectal cancer in the surgery group and 67 in the control group, suggesting no association between the two.
A new study found that delaying colonoscopies after abnormal at-home screenings by over 12 months increases the risk of colorectal cancer diagnosis and death. The odds of being diagnosed with late-stage colon cancer increased by approximately 33% at 16 months.
African-Americans are more likely to develop cancerous lesions on the right side and suffer from colorectal cancer at a younger age due to unique biological aging patterns. The research found that the right side of the colon in most African-Americans had suffered epigenetic changes contributing to their increased cancer risk.
Researchers discovered that the cancer stem cells' ability to form tumors is regulated by a molecular switch called Mll1. Blocking this enzyme can specifically target cancer stem cells, offering hope for more effective treatments. Clinical trials are underway to evaluate the use of Mll1 inhibitors in head and neck tumors.
Scientists have developed a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. The treatment has shown promise in treating aggressive subtypes of cancers with specific mutations in genes called RAS or NF1.
Researchers at City of Hope developed a cancer-killing virus called CF33 that targets hard-to-treat tumors and stimulates an immune response. The oncolytic virus demonstrates increased PD-L1 expression in tumor cells and causes them to die, leading to lasting anti-tumor immunity.
A new study published in the Journal of the American College of Surgeons suggests that Medicaid expansion under the Affordable Care Act may lead to earlier diagnoses of colon cancer. Researchers found improved access to care and enhanced surgical care for patients with colon cancer in states that implemented Medicaid expansion.