Researchers at MUSC and Cincinnati Children's have developed a novel colon organoid model with naturally occurring immune cells. The model has the potential to improve treatment outcomes for colon-related diseases such as cancer and IBD by providing a more complete human organoid system that can be used to model inflammation in the colon.
SourceMedical University of South Carolina·JournalCell Stem Cell·TypeExperimental study·DateNov 20, 2023
A team of researchers developed a gel delivery system that overcomes challenges in intratumoral therapy. The gel contains an imaging agent and can hold a high concentration of drug for slow release. In preclinical models, the treatment induced tumor regression and improved survival in immunotherapy-resistant colon and breast cancer.
SourceMass General Brigham·JournalAdvanced Healthcare Materials·TypeExperimental study·DateNov 13, 2023
A long-term study published in Environmental Epidemiology shows a slightly increased incidence of cancer, particularly colon, pancreas, and stomach cancer in men, as well as lymphoma in women. The researchers used new calculation methods to analyze radiation doses from Chernobyl fallout.
SourceUppsala University·JournalEnvironmental Epidemiology·TypeObservational study·DateNov 13, 2023
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
SourceUniversity of Gothenburg·JournalObesity·TypeObservational study·DateNov 6, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at Mainz University Medical Center aim to improve patients' quality of life by applying smart data technology to physical activity. The DECIDE project aims to provide individualized control of patients' daily physical activity, while the RELEVIUM project focuses on alleviating pain and weight loss in pancreatic cancer patie...
SourceJohannes Gutenberg Universitaet Mainz·DateNov 2, 2023
Researchers at Duke University developed an innovative antibody approach to target and kill tumor-promoting molecules found in cancer cells. The study revealed notable reductions in tumor growth and minimal side effects, making it a promising new treatment option for various types of cancer.
SourceDuke University·JournalImmunity·TypeExperimental study·DateOct 30, 2023
A large-scale prospective study identified significant variations in the gut microbiome of individuals who developed pre-cancerous colonic lesions. These findings suggest that the microbiome could act as a valuable tool to improve existing tests, advancing early detection methods for colorectal cancer.
A new study published in JNCCN found that intensive local-regional treatment to remove as much tumor as possible did not significantly impact overall quality of life for patients with metastatic colorectal cancer. However, the treatment was associated with a higher risk of adverse events.
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·TypeData/statistical analysis·DateOct 12, 2023
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
SourceTexas Tech University Health Sciences Center·DateOct 12, 2023
A new cancer drug candidate has been found to restore the effectiveness of the immune system in fighting tumors, including melanoma, bladder cancer, leukemia, and colon cancer. The drug works by lowering a toxic compound called MTA, which impairs normal functioning of immune cells and blocks immunotherapies.
SourceUniversity of Texas at Austin·JournalCancer Cell·TypeExperimental study·DateOct 9, 2023
Researchers developed a low-cost, ultrasensitive blood test to detect a highly specific biomarker for multiple common cancers. The test showed promise for early cancer detection and disease monitoring, detecting levels of the biomarker in the blood of patients with many types of cancers.
SourceMass General Brigham·JournalCancer Discovery·TypeExperimental study·DateOct 5, 2023
Researchers have developed an oral lipid nanoparticle drug that prevents tumor development in mice, demonstrating its potential as a treatment for colitis-associated cancer. The study, led by Georgia State University researchers, used M13-loaded nanoliposomes to target diseased tissue and reduce side effects.
SourceGeorgia State University·JournalPharmaceutics·TypeExperimental study·DateOct 3, 2023
A new poll found that 62% of people aged 50-80 disagree with using life expectancy as a factor in determining cancer screening guidelines. The majority also believes that some older adults should still receive cancer screenings even if guidelines don't recommend them.
SourceMichigan Medicine - University of Michigan·TypeSurvey·DateSep 28, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A Rice University-led team of researchers has been awarded $45 million to develop a new sense-and-respond implant technology that could improve immunotherapy outcomes for patients with difficult-to-treat cancers. The technology, called THOR, aims to provide real-time data from the tumor environment to guide more effective therapies.
Researchers have identified new genetic markers to detect Lynch syndrome-associated colorectal cancer with 92% accuracy. The discovery could lead to a non-invasive screening option using stool samples, reducing the need for annual colonoscopies and invasive tests.
SourceMayo Clinic·JournalCancer Prevention Research·DateSep 20, 2023
New research from Cold Spring Harbor Laboratory suggests that high tumor mutation burden does not guarantee an effective immune response in patients with mismatch repair deficiency. The study found that tumors with identical mutations across all cells responded to immunotherapy, while those with subclonal mutations did not.
SourceCold Spring Harbor Laboratory·JournalNature Genetics·DateSep 14, 2023
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers have characterised a specialised type of immune cell that plays a key role in protecting and repairing the healthy human gut. Depletion of these cells is linked to inflammatory bowel disease (IBD) progression, with potential implications for treatment options.
SourceThe Francis Crick Institute·JournalScience·TypeObservational study·DateSep 14, 2023
A team of scientists at VCU Massey Cancer Center discovered a previously unknown interaction between proteins that supplies energy to tumor cells, holding significant implications for colon cancer treatments. By blocking heat shock protein 27 activity, researchers confirmed a decrease in mitochondrial function and death of cancer cells.
SourceVirginia Commonwealth University·JournalCell Reports·DateSep 12, 2023
Mayo Clinic researchers found that cells expressing PD-1 and PD-L1 within a certain distance of each other can predict the success of immunotherapy in patients with colorectal cancer. This spatial analysis may help select patients most likely to benefit from treatment, improving outcomes and minimizing unnecessary treatments.
SourceMayo Clinic·JournalClinical Cancer Research·DateAug 31, 2023
Researchers found that mutations in blood stem cells can promote the development of colitis-associated colon cancer (CAC) by increasing blood vessel formation. Blocking certain drugs, such as axitinib, inhibited CAC tumor growth in mice with clonal hematopoiesis, suggesting potential therapeutic strategies.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 24, 2023
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
SourceMichigan Medicine - University of Michigan·JournalBMC Health Services Research·TypeData/statistical analysis·DateAug 17, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers used base editors to introduce specific combinations of activating and inactivating mutations into healthy organoids, creating realistic models for various types of cancer. This allows for further investigation into the development and treatment of cancer, with potential applications including testing new drugs.
SourceHubrecht Institute·JournalNature Communications·TypeExperimental study·DateAug 17, 2023
A large long-term study found that good cardiorespiratory fitness in young men is associated with a significantly lower risk of developing nine specific cancers, including a 40% reduced risk of liver cancer. Higher fitness was also linked to lower risks of rectal, pancreatic, and bowel cancers.
SourceBMJ Group·JournalBritish Journal of Sports Medicine·TypeObservational study·DateAug 15, 2023
Researchers have engineered bacteria that can detect tumor DNA in a live organism, using CRISPR technology. The bacteria, Acinetobacter baylyi, were designed to respond to specific DNA sequences associated with cancer, allowing for early detection and potentially preventing disease progression.
SourceUniversity of California - San Diego·JournalScience·TypeExperimental study·DateAug 10, 2023
A new study published in JNCCN found that the adoption of clinical research results led to a significant increase in the use of shorter adjuvant chemotherapy periods, with CAPOX becoming more widely used. The study also revealed disparities in treatment patterns, with Black patients being more likely to receive shorter chemotherapy reg...
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateAug 7, 2023
A new study found that 81% of women report persistent GI symptoms years after diagnosis, with abdominal bloating and gas being the most common. The analysis also showed that severe GI symptoms are linked to poor quality of life, social activities, and body image satisfaction.
SourceOhio State University·JournalPLOS ONE·DateAug 1, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers found that expression of transcription factors contributes to different subtypes of colorectal cancers. The degree of DNA methylation varies across tissue types, with some cancers having high and others low frequency of methylation gains. Studying transcription factor expression may help determine overall survival in patien...
SourceJohns Hopkins Medicine·JournalProceedings of the National Academy of Sciences·DateJul 27, 2023
A new study reveals that the cellular chaperone protein GRP78 migrates to the nucleus under stress and alters gene activities, allowing cancer cells to become more mobile and invasive. This discovery offers potential new approaches for cancer treatment, including down-regulating GRP78 activity or preventing it from binding to ID2.
SourceKeck School of Medicine of USC·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJul 24, 2023
Researchers identified a new mechanism by which cancer hijacks enzyme substrate motif mutations, enabling tumor growth and therapy resistance. The study found that colorectal cancer hijacks BUD13 mutations to inactivate a key tumor suppressor, Fbw7.
SourceUniversity of North Carolina Health Care·JournalJournal of Experimental Medicine·DateJul 3, 2023
A collaborative study by researchers at the University of Ottawa and McMaster University has made a groundbreaking discovery linking different types of cancers to their embryonic origins. The team found that drugs targeting specific embryonic pathways can effectively treat various tumors, including brain, colon, and leukemia cancers.
SourceUniversity of Ottawa·JournalCell Chemical Biology·TypeData/statistical analysis·DateJun 28, 2023
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A study by Regenstrief Institute has identified seven risk factors for early onset colorectal cancer in males, providing a framework for clinicians to consider screening recommendations for younger men. The model may help estimate relative risk and identify individuals at higher risk for colorectal cancer.
SourceRegenstrief Institute·JournalCancer Prevention Research·DateJun 27, 2023
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJun 26, 2023
Researchers have discovered abnormalities in the DNA instruction code that lead to the aggressive spread of colorectal cancer. By studying DNA methylation levels, they identified unique gene regions associated with liver metastasis and found a link between these changes and cancer cell aggression.
SourceUniversity of Otago·JournaliScience·TypeRandomized controlled/clinical trial·DateJun 26, 2023
A new study published in the Journal of the American College of Surgeons found that people who live in historically redlined areas are less likely to be screened for breast, colorectal, and cervical cancer. The legacy of redlining continues to contribute to significant disparities in cancer screening rates.
SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateJun 15, 2023
Researchers found specific bacterial species significantly associated with the development of tubular adenomas and sessile serrated adenomas. The study suggests a potential opportunity to intervene through diet or probiotics to prevent colorectal cancer.
SourceMass General Brigham·JournalCell Host & Microbe·TypeObservational study·DateMay 31, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateMay 30, 2023
Research reveals both metabolically healthy and unhealthy obesity types linked to increased risk of various obesity-related cancers, with stronger association in metabolically unhealthy obesity. Metabolically unhealthy women face higher risks for endometrial, liver, and kidney cancers.
SourceEuropean Association for the Study of Obesity·DateMay 13, 2023
A new study found that being overweight or obese during early and middle adulthood increases the risk of gastrointestinal cancers in later life. The research also suggests that frequent aspirin use does not modify this increased risk.
SourceOhio State University Wexner Medical Center·JournalJAMA Network Open·TypeData/statistical analysis·DateMay 10, 2023
Researchers have highlighted the importance of stromal vitamin A pathway in regulating IL-6 expression in colorectal cancer-associated fibroblasts. The study found that disrupting retinol-mediated IL-6 expression could be a potential approach to target CAFs during CRC treatment.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 3, 2023
A recent study led by Dr Rachael Rigby from Lancaster University found that delays in stoma reversal surgery do not impact on risk of complications or commensal microflora loss, atrophy, or scarring. However, a higher degree of microflora loss is associated with an increased risk of complications.
SourceLancaster University·JournalGut Microbes·TypeExperimental study·DateApr 20, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Scientists have created a new method to model liver cancer tumor subtypes using CRISPR-Cas9, discovering that specific gene isoforms can lead to different cancer subtypes. This platform could help researchers develop new therapeutic interventions for treating cancer and other diseases.
SourceCold Spring Harbor Laboratory·JournalThe Journal of Pathology·DateApr 10, 2023
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateApr 7, 2023
A UNIGE team created customizable treatments by testing drugs on artificial tumors derived from patients' cancer tissue. The approach opens the way for optimized and tailored therapies against various cancers and diseases.
SourceUniversité de Genève·JournalJournal of Experimental & Clinical Cancer Research·TypeNews article·DateApr 4, 2023
A new study of over 200 people with premature aging syndromes caused by abnormally short telomeres suggests that chromosomal instability may not be the reason for increased cancer risk. Instead, immune system cells that age and die prematurely may play a role in cancer predisposition.
SourceJohns Hopkins Medicine·JournalCancer Cell·DateMar 30, 2023
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalJournal of Medicinal Chemistry·DateMar 30, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers found that cells in the colon undergo a type of molecular time travel, reverting back to an embryonic state and creating immature, non-functional cells that can form benign growths called adenomas. Blocking Sox9 in mouse models prevented adenoma formation and resulted in mature cell maturation.
SourceDana-Farber Cancer Institute·JournalScience Advances·DateMar 29, 2023
Scientists have engineered a unique strain of probiotic bacteria to over-express a metal transporter that binds and concentrates copper, facilitating the delivery of radionuclide therapy to cancer cells. This approach targets tumors without relying on specific receptors, making it potentially effective against treatment-resistant cancers.
SourceUniversity of Cincinnati·JournalAdvanced Healthcare Materials·TypeExperimental study·DateMar 28, 2023
Researchers found that physical activity can prevent cancer recurrence in stage III colon cancer patients by lowering the recurrence rate within the first year of treatment. This association persisted for approximately three years after surgery, suggesting a long-term survival benefit.
SourcePennington Biomedical Research Center·JournalBritish Journal of Sports Medicine·TypeRandomized controlled/clinical trial·DateMar 21, 2023
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeData/statistical analysis·DateFeb 20, 2023
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
SourceGoethe University Frankfurt·JournalGut·TypeExperimental study·DateFeb 17, 2023
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers at Ruhr University Bochum developed a new digital imaging method using artificial intelligence and infrared imaging to determine microsatellite status in colon cancer. This approach enables fast, label-free, and automated detection of the biomarker, which is crucial for personalized medicine.
SourceRuhr-University Bochum·JournalEuropean Journal of Cancer·TypeExperimental study·DateFeb 14, 2023
A Cancer Research UK-funded clinical trial found that chemotherapy before surgery reduces the chance of colon cancer returning within 2 years by 28%. The study involved 1,053 patients and showed significant benefits in terms of preventing cancer recurrence.
SourceCancer Research UK·JournalJournal of Clinical Oncology·TypeRandomized controlled/clinical trial·DateJan 19, 2023
A new study finds that exposure to salmonella bacteria increases colon cancer risk, with tumors developing earlier and growing larger in infected mice. The research highlights the potential for salmonella as an environmental risk factor for chronic diseases like colon cancer.
SourceUniversity of Illinois Chicago·JournalCell Reports Medicine·TypeExperimental study·DateJan 17, 2023
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
This study found that advanced colorectal neoplasia prevalence is low 10 or more years after a negative screening colonoscopy. Extended screening intervals may be recommended for female and younger participants without gastrointestinal symptoms.
SourceJAMA Network·JournalJAMA Internal Medicine·DateJan 17, 2023
A new study found that multiple negative faecal immunochemical tests can significantly reduce the risk of advanced neoplasia in a colonoscopy surveillance program. This could lead to longer intervals between screenings for people at above-average risk, reducing the burden on healthcare systems.
SourceFlinders University·JournalClinical Gastroenterology and Hepatology·TypeData/statistical analysis·DateJan 15, 2023
Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateJan 11, 2023
Research from Michigan Medicine reveals that high levels of ammonia in colon tumors can lead to reduced T cell growth and immunotherapy resistance. A study published in Cell Metabolism found that using an FDA-approved drug to lower ammonia levels made tumors more sensitive to treatment.
SourceMichigan Medicine - University of Michigan·JournalCell Metabolism·TypeExperimental study·DateDec 23, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A massive international data analysis uncovered hundreds of signals for new treatment and prevention targets in colorectal cancer. The study identified 250 independent risk associations, including 50 newly discovered ones, through analyzing genomic, transcriptomic, and methylomic data.
SourceCleveland Clinic·JournalNature Genetics·DateDec 20, 2022
Researchers discovered PDGF cross-signaling through alternative receptors in colorectal cancer cells, enabling bypassed signaling. This finding supports anti-PDGF therapy as a combination strategy alongside VEGF and EGF targeting.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateDec 15, 2022