Articles tagged with Colon Cancer
A mouse study published in Cancer Prevention Research found that removing visceral fat reduces the development of intestinal tumors. The study also showed gender differences in how adiposity affects cancer risk, highlighting the need for targeted strategies to reduce abdominal obesity and promote weight loss.
A new study confirms colonoscopy is safe, with only a few cases of severe complications per 10,000 procedures. Regular screening can prevent colon cancer and significantly reduce mortality rates.
Scientists at Max Planck Institute for Molecular Genetics discovered a recurring pattern of over 13,000 epigenetic alterations in young mouse tumours, which is partly conserved in human colon carcinoma. This finding may facilitate the identification of novel clinical colon cancer biomarkers for early detection.
Researchers have identified a complex of proteins that promotes the growth of some types of colon and gastric cancers, leading to the potential development of new treatments using mTorc1 inhibitors. The discovery is significant as it highlights the role of inflammation in cancer growth, particularly for colon and gastric cancers.
A retrospective analysis of over 36,000 patients with colon cancer found that those with early stage disease and diabetes or high blood pressure have a greater risk for cancer return and death compared to patients without these conditions. High lipid levels were also found to be protective against recurrence.
Scientists at Northwestern University have identified a subset of immune cells called T-regulatory (Treg) cells in human colon cancer that can either protect against or promote tumor growth. The presence of the protein RORγt is key to this differentiation.
A University of Colorado Cancer Center review suggests rice bran offers anti-cancer properties due to its synergistic bioactive compounds. The clinical trial tests rice bran's effectiveness in preventing colon cancer recurrence, with researchers exploring the optimal composition and daily intake for chemoprevention.
A study by the University of Geneva reveals that colon polyps exhibit a 'mutator' profile associated with increased SNS mutations, leading to accelerated progression to malignancy. Three genes (APC, CTNNB1, and BRAF) are identified as initial causes on the road to cancer.
Researchers at McGill University discovered vitamin D's molecular basis for potential cancer prevention effects. Vitamin D inhibits cMYC production and function, slowing cell proliferation and potentially slowing cancer progression.
A new computer program has been developed to improve genetic test results for Lynch syndrome, a hereditary predisposition to colon cancer. The program helps assess the risk of colon cancer development by evaluating missense substitutions in mismatch repair genes.
The Asian Oncology Summit guidelines emphasize the importance of providing supportive, palliative and end-of-life care to patients with cancer in Asia. The guidelines provide recommendations for pain assessment, medication, professional education, and specialized interventions tailored to different levels of resources in Asian countries.
A recent study from Stanford University School of Medicine found that increased use of colonoscopy screening may be responsible for the significant decrease in colorectal cancer incidence over the past decade. The study analyzed data from over 2 million patients and found a correlation between Medicare's extension of colonoscopy covera...
A new study found that lactoferricin4-14, a milk protein, reduces colon cancer cell growth and DNA damage by prolonging the cell cycle and increasing DNA repair. This suggests that milk's cancer-preventive effects may be linked to its ability to promote DNA repair in normal cells.
New studies report that robotic-assisted bladder procedures and minimally invasive colorectal operations can improve outcomes in older patients. Robotic-assisted bladder surgery, which was previously not offered to patients over 80, showed a seven-day hospital stay and only three complications within 90 days.
New research findings show that rural colon cancer patients are more likely to receive late-stage diagnosis and inferior treatment, leading to poorer outcomes. Rural residents also have higher odds of dying from colon cancer than urban patients.
Researchers have discovered a link between reactivated R-spondin proteins and colon cancer development, potentially leading to more personalized therapies. The discovery involves gene mutations that trigger cell proliferation in the colon.
Scientists have identified a link between E. coli bacteria and colon cancer, with approximately two-thirds of patients with colon cancer carrying specific strains of the bacteria. The bacteria carry pks genes that produce a toxin that damages DNA in the gut lining, promoting cancer development.
Two Johns Hopkins scientists, Cynthia Sears and Peter Searson, received $500k combined for their projects addressing neglected areas of cancer research. Sears aims to explore bacterial causes of colon cancer, while Searson develops a lab-on-a-chip platform to study metastasis.
A new study has found a significant increase in rare de novo genetic mutations in individuals with testicular cancer, suggesting these mutations may be indicative of conditions that result in reduced fertility. The researchers propose that the paradigm of a de novo germline disease etiology may be less applicable to late-onset cancers.
Researchers discover antibodies to malaria surface protein PfEMP1 mediate human immunity; CCL25 pathway suppresses colon cancer metastasis; and a retargeted botulinum toxin inhibits hormone production in acromegaly.
The study found that colon and rectal cancers have nearly indistinguishable genomic alterations, leading researchers to group them as one type of cancer. Several recurrent genetic errors contribute to colorectal cancer, with potential targets for treatment identified including genes ERBB2 and IGF2.
A new study supports CT colonography as a screening tool for colon cancer in Medicare-aged patients, detecting 9.3% of abnormal growths of cells. The procedure also identified extracolonic findings in 2.9% of patients and may increase screening compliance rates by 15% if covered.
A large population-based randomized trial found that flexible sigmoidoscopy screening reduced overall colorectal cancer mortality by 26% and incidence by 21% compared to usual care. The test detected 24% of diagnosed cancers with fewer side effects than colonoscopy.
A web-based video instructional program significantly improves patient compliance with colonoscopy screenings, cutting no-show rates by up to 40%. The study found that patients who watched the video were more likely to arrive prepared and cancel appointments less frequently, leading to better outcomes for cancer detection and treatment.
A new laxative-free CT colonography technique has been shown to be effective in detecting high-risk polyps, with an accuracy comparable to traditional colonoscopy. The procedure uses computer-aided systems to virtually cleanse and analyze images, reducing discomfort and preparation requirements.
Researchers found that a comprehensive care management program for chronic obstructive pulmonary disease (COPD) may not be safe or suitable for patients, as it led to excess mortality. In contrast, laxative-free colonography proved accurate in detecting most significant lesions and eliminated a major barrier to colon cancer screening. ...
A study of 7,424 privately insured colon cancer patients found that managed care presence and hospital competition increased the likelihood of laparoscopic surgery, which lowered costs. The researchers also discovered a 10% increase in HMO penetration was associated with a 10.3% increase in laparoscopy utilization.
A recent study published in the Journal of the National Cancer Institute found that physical activity is associated with reduced mortality in breast and colon cancer patients. The research suggests that exercise may provide benefits such as improved insulin levels, reduced inflammation, and enhanced immunity for cancer survivors.
A study by Fred Hutchinson Cancer Center found that women with low levels of fetal cells have a 70% lower risk of breast cancer, while those with high levels have a four-fold increased risk for colon cancer. The biological reasons behind this contradictory effect are unknown and require further investigation.
Researchers at Michigan State University found that prebiotic galacto-oligosaccharide can significantly reduce the severity of colitis in mice. The prebiotic stimulates beneficial bacteria growth, leading to a 50% reduction in inflammation and abnormal cells, precursors to colon cancer.
Dr. Scott Waldman has received a CURE grant to develop a molecular diagnostic test that identifies patients who will benefit from adjuvant chemotherapy, reducing racial disparities in colon cancer mortality. The test uses guanylyl cyclase C as a biomarker and could help stratify patients into more targeted treatment groups.
Researchers found that gamma and delta-tocopherols in vegetable oils prevent cancer formation and growth in animal models. Alpha-tocopherol supplements, however, showed no such benefit in preventing these types of cancer.
Researchers at Case Western Reserve University identified a set of master switches, called Variant Enhancer Loci (VELs), that regulate key genes in colon cancer. VELs are epigenetic changes that can potentially be reversed and may play a role in determining individual susceptibility to colon cancer.
Researchers have identified a key gene, TAK1, in KRAS mutant colon cancers that promotes disease progression. Pharmacological inhibition of TAK1 shows strong killing of tumor cells with minimal effects on normal cells.
A new non-invasive technology, stool DNA (sDNA) testing, is being studied in a five-year clinical trial to detect colon cancer in its earliest stages. The test aims to improve colon cancer screening rates and decrease mortality from the deadly disease by complementing colonoscopy.
A study by University of Kentucky researchers found that colorectal cancer screening rates were higher in the Appalachian population with multiple morbidities compared to those with no morbidities. The study revealed a dose-response relationship between the number of morbidities and the prevalence of colon cancer screening.
A study found that hospitals in Ontario with higher spending on intensive care and specialists had lower death rates, hospital readmissions, and better quality of care for severely ill patients. Higher-spending hospitals also saw longer lengths of stay and more medical specialist visits.
A survey of over 1,000 gastroenterologists found that pressure to increase colonoscopy volume negatively affects procedure quality and safety. Gastroenterologists reported reducing time examining the colon wall or aborting difficult procedures due to production pressures.
Scientists have developed a new aspirin compound called NOSH-aspirin that curbs the growth of 11 different types of human cancer cells in culture and shrinks human colon cancer tumors by 85% in live animals without adverse effects. The hybrid is more potent and safer than classic aspirin, requiring lower doses to be effective.
Researchers at Temple University found that high-fat diets alter metabolic pathways in healthy colon tissue, leading to increased colon cancer risk. Epigenetic marks on genes involved in breaking down carbohydrates and lipids were retrained in normal tissue from patients with colon cancer.
Researchers at Wake Forest Baptist Medical Center have identified distinct genetic patterns between cancer of the appendix and colon cancer. The study found that gene expression profiles differ significantly between the two types of cancer, suggesting a need for fresh approaches to treatment.
Virtual colonoscopies are comparably effective to standard colonoscopy in detecting colorectal cancer and precancerous polyps. The Colon Cancer Alliance and ACR urge Medicare to cover seniors for screening CT colonography, which is endorsed by the American Cancer Society.
A study published in The New England Journal of Medicine found that removing polyps by colonoscopy prevents not only colorectal cancer development but also deaths from the disease. Patients who underwent the procedure had a 53% lower death rate from colorectal cancer compared to those without removed polyps.
Researchers at MGH Cancer Center have discovered a potential treatment target for KRAS-mutant colon cancer, which may lead to new strategies for treatment-resistant tumors. Targeting TAK1 and BMP pathways may induce tumor cell death, offering hope for patients with KRAS-dependent colon cancers.
Researchers have identified an imbalance in the HNF4A gene variant as a potential biomarker for colon cancer. The study suggests that certain genetic variations may make individuals more susceptible to the disease, and drugs targeting Src kinase activity could potentially prevent or treat it.
Researchers found that rats given daily multivitamin and mineral supplements showed an 84% reduction in pre-cancerous lesions and did not develop tumors when exposed to carcinogens. The study suggests that regular supplement use could help protect against colon cancer, giving cancer patients valuable guidance.
A 1993 Chevrolet Corvette 40th Anniversary coupe was sold at the Barrett-Jackson Scottsdale Auction, raising $120,000 for cancer research at TGen. The funds support research into colon and prostate cancer in memory of Russ and Brian Jackson.
Scientists found that caffeoylquinic acid derivatives from mate tea induce apoptosis in human colon cancer cells, reducing markers of inflammation. The study suggests mate tea has potential as an anti-cancer agent and may be beneficial for other diseases associated with inflammation.
Researchers have discovered that luteolin, a flavonoid found in fruit and vegetables, can inhibit the activity of cell signaling pathways important for colon cancer cell growth. This inhibition leads to reduced IGF-II secretion, decreased receptor expression, and ultimately, cell death.
A recent study found that adding oxaliplatin to adjuvant chemotherapy for stage III colon cancer patients in the general population improved overall survival rates. The research also showed that this combination therapy was effective across various practice settings, including older and minority patients with comorbid conditions.
Researchers discovered a gene that protects against colorectal cancer by causing cell death, but this mechanism is often blocked in human cancers. The gene, DCC, codes for a 'dependence receptor' that induces apoptosis when it's depleted of ligands.
Research found that people with myotonic muscular dystrophy are at higher risk for developing four specific types of cancer. Additionally, there may be an increased risk for other cancers such as eye, thyroid, pancreas, and female reproductive organs. Patients should prioritize cancer screening, particularly colon cancer screening.
A study published in JAMA Network found that patients with myotonic muscular dystrophy are at an increased risk of developing certain types of cancer, including endometrial, brain, ovarian, and colon cancer. The study analyzed data from over 1,600 patients and found a significant excess of these cancers compared to the general population.
Almac's innovative test identifies patients who may benefit from chemotherapy, offering a breakthrough in managing stage 2 colon cancer. The technology uses genetic signatures to predict cancer recurrence, providing doctors with a valuable tool to improve patient outcomes.
Research at Johns Hopkins Medicine reveals that Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO), leading to DNA damage and tumor formation. A compound blocking SMO enzyme activity prevented DNA damage in cells.
Research suggests that adding ascorbate to hot dogs reduces N-nitroso compounds, potentially linked to colon cancer. However, colon cancer incidence rates have not changed since 1978.
Two independent research teams identify Fusobacterium in colon cancer tissue, a finding that could lead to new avenues for diagnosis and treatment of the disease. The bacteria were found more often in colon cancer tissues than normal tissue, sparking potential links between infection and colorectal tumors.
Researchers have discovered strikingly high levels of Fusobacterium in colorectal tumors, suggesting a potential role in the disease. The findings offer an enticing lead for further research into diagnosing, preventing, and treating colon cancer.
A study published in the Journal of the National Cancer Institute found that African-American patients with resected stage II and III colon cancer experienced poorer overall and recurrence-free survival compared to whites. The five-year relative survival rates for black and white colorectal cancer patients were 57% and 68%, respectively.
Researchers at Duke University have developed a technology that uses angle-resolved low coherence interferometry to detect pre-cancerous cells in the colon. The device shines short bursts of light into tissue samples and analyzes scattered light for signs of dysplasia, with an accuracy rate of 85%.