Articles tagged with Colon Cancer
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A new study has found a significant increase in rare de novo genetic mutations in individuals with testicular cancer, suggesting these mutations may be indicative of conditions that result in reduced fertility. The researchers propose that the paradigm of a de novo germline disease etiology may be less applicable to late-onset cancers.
Researchers discover antibodies to malaria surface protein PfEMP1 mediate human immunity; CCL25 pathway suppresses colon cancer metastasis; and a retargeted botulinum toxin inhibits hormone production in acromegaly.
The study found that colon and rectal cancers have nearly indistinguishable genomic alterations, leading researchers to group them as one type of cancer. Several recurrent genetic errors contribute to colorectal cancer, with potential targets for treatment identified including genes ERBB2 and IGF2.
A new study supports CT colonography as a screening tool for colon cancer in Medicare-aged patients, detecting 9.3% of abnormal growths of cells. The procedure also identified extracolonic findings in 2.9% of patients and may increase screening compliance rates by 15% if covered.
A large population-based randomized trial found that flexible sigmoidoscopy screening reduced overall colorectal cancer mortality by 26% and incidence by 21% compared to usual care. The test detected 24% of diagnosed cancers with fewer side effects than colonoscopy.
A web-based video instructional program significantly improves patient compliance with colonoscopy screenings, cutting no-show rates by up to 40%. The study found that patients who watched the video were more likely to arrive prepared and cancel appointments less frequently, leading to better outcomes for cancer detection and treatment.
A new laxative-free CT colonography technique has been shown to be effective in detecting high-risk polyps, with an accuracy comparable to traditional colonoscopy. The procedure uses computer-aided systems to virtually cleanse and analyze images, reducing discomfort and preparation requirements.
Researchers found that a comprehensive care management program for chronic obstructive pulmonary disease (COPD) may not be safe or suitable for patients, as it led to excess mortality. In contrast, laxative-free colonography proved accurate in detecting most significant lesions and eliminated a major barrier to colon cancer screening. ...
A study of 7,424 privately insured colon cancer patients found that managed care presence and hospital competition increased the likelihood of laparoscopic surgery, which lowered costs. The researchers also discovered a 10% increase in HMO penetration was associated with a 10.3% increase in laparoscopy utilization.
A recent study published in the Journal of the National Cancer Institute found that physical activity is associated with reduced mortality in breast and colon cancer patients. The research suggests that exercise may provide benefits such as improved insulin levels, reduced inflammation, and enhanced immunity for cancer survivors.
A study by Fred Hutchinson Cancer Center found that women with low levels of fetal cells have a 70% lower risk of breast cancer, while those with high levels have a four-fold increased risk for colon cancer. The biological reasons behind this contradictory effect are unknown and require further investigation.
Researchers at Michigan State University found that prebiotic galacto-oligosaccharide can significantly reduce the severity of colitis in mice. The prebiotic stimulates beneficial bacteria growth, leading to a 50% reduction in inflammation and abnormal cells, precursors to colon cancer.
Dr. Scott Waldman has received a CURE grant to develop a molecular diagnostic test that identifies patients who will benefit from adjuvant chemotherapy, reducing racial disparities in colon cancer mortality. The test uses guanylyl cyclase C as a biomarker and could help stratify patients into more targeted treatment groups.
Researchers found that gamma and delta-tocopherols in vegetable oils prevent cancer formation and growth in animal models. Alpha-tocopherol supplements, however, showed no such benefit in preventing these types of cancer.
Researchers at Case Western Reserve University identified a set of master switches, called Variant Enhancer Loci (VELs), that regulate key genes in colon cancer. VELs are epigenetic changes that can potentially be reversed and may play a role in determining individual susceptibility to colon cancer.
Researchers have identified a key gene, TAK1, in KRAS mutant colon cancers that promotes disease progression. Pharmacological inhibition of TAK1 shows strong killing of tumor cells with minimal effects on normal cells.
A new non-invasive technology, stool DNA (sDNA) testing, is being studied in a five-year clinical trial to detect colon cancer in its earliest stages. The test aims to improve colon cancer screening rates and decrease mortality from the deadly disease by complementing colonoscopy.
A study by University of Kentucky researchers found that colorectal cancer screening rates were higher in the Appalachian population with multiple morbidities compared to those with no morbidities. The study revealed a dose-response relationship between the number of morbidities and the prevalence of colon cancer screening.
A study found that hospitals in Ontario with higher spending on intensive care and specialists had lower death rates, hospital readmissions, and better quality of care for severely ill patients. Higher-spending hospitals also saw longer lengths of stay and more medical specialist visits.
A survey of over 1,000 gastroenterologists found that pressure to increase colonoscopy volume negatively affects procedure quality and safety. Gastroenterologists reported reducing time examining the colon wall or aborting difficult procedures due to production pressures.
Scientists have developed a new aspirin compound called NOSH-aspirin that curbs the growth of 11 different types of human cancer cells in culture and shrinks human colon cancer tumors by 85% in live animals without adverse effects. The hybrid is more potent and safer than classic aspirin, requiring lower doses to be effective.
Researchers at Wake Forest Baptist Medical Center have identified distinct genetic patterns between cancer of the appendix and colon cancer. The study found that gene expression profiles differ significantly between the two types of cancer, suggesting a need for fresh approaches to treatment.
Researchers at Temple University found that high-fat diets alter metabolic pathways in healthy colon tissue, leading to increased colon cancer risk. Epigenetic marks on genes involved in breaking down carbohydrates and lipids were retrained in normal tissue from patients with colon cancer.
Virtual colonoscopies are comparably effective to standard colonoscopy in detecting colorectal cancer and precancerous polyps. The Colon Cancer Alliance and ACR urge Medicare to cover seniors for screening CT colonography, which is endorsed by the American Cancer Society.
A study published in The New England Journal of Medicine found that removing polyps by colonoscopy prevents not only colorectal cancer development but also deaths from the disease. Patients who underwent the procedure had a 53% lower death rate from colorectal cancer compared to those without removed polyps.
Researchers at MGH Cancer Center have discovered a potential treatment target for KRAS-mutant colon cancer, which may lead to new strategies for treatment-resistant tumors. Targeting TAK1 and BMP pathways may induce tumor cell death, offering hope for patients with KRAS-dependent colon cancers.
Researchers have identified an imbalance in the HNF4A gene variant as a potential biomarker for colon cancer. The study suggests that certain genetic variations may make individuals more susceptible to the disease, and drugs targeting Src kinase activity could potentially prevent or treat it.
Researchers found that rats given daily multivitamin and mineral supplements showed an 84% reduction in pre-cancerous lesions and did not develop tumors when exposed to carcinogens. The study suggests that regular supplement use could help protect against colon cancer, giving cancer patients valuable guidance.
A 1993 Chevrolet Corvette 40th Anniversary coupe was sold at the Barrett-Jackson Scottsdale Auction, raising $120,000 for cancer research at TGen. The funds support research into colon and prostate cancer in memory of Russ and Brian Jackson.
Scientists found that caffeoylquinic acid derivatives from mate tea induce apoptosis in human colon cancer cells, reducing markers of inflammation. The study suggests mate tea has potential as an anti-cancer agent and may be beneficial for other diseases associated with inflammation.
Researchers have discovered that luteolin, a flavonoid found in fruit and vegetables, can inhibit the activity of cell signaling pathways important for colon cancer cell growth. This inhibition leads to reduced IGF-II secretion, decreased receptor expression, and ultimately, cell death.
A recent study found that adding oxaliplatin to adjuvant chemotherapy for stage III colon cancer patients in the general population improved overall survival rates. The research also showed that this combination therapy was effective across various practice settings, including older and minority patients with comorbid conditions.
Researchers discovered a gene that protects against colorectal cancer by causing cell death, but this mechanism is often blocked in human cancers. The gene, DCC, codes for a 'dependence receptor' that induces apoptosis when it's depleted of ligands.
A study published in JAMA Network found that patients with myotonic muscular dystrophy are at an increased risk of developing certain types of cancer, including endometrial, brain, ovarian, and colon cancer. The study analyzed data from over 1,600 patients and found a significant excess of these cancers compared to the general population.
Research found that people with myotonic muscular dystrophy are at higher risk for developing four specific types of cancer. Additionally, there may be an increased risk for other cancers such as eye, thyroid, pancreas, and female reproductive organs. Patients should prioritize cancer screening, particularly colon cancer screening.
Almac's innovative test identifies patients who may benefit from chemotherapy, offering a breakthrough in managing stage 2 colon cancer. The technology uses genetic signatures to predict cancer recurrence, providing doctors with a valuable tool to improve patient outcomes.
Research at Johns Hopkins Medicine reveals that Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO), leading to DNA damage and tumor formation. A compound blocking SMO enzyme activity prevented DNA damage in cells.
Research suggests that adding ascorbate to hot dogs reduces N-nitroso compounds, potentially linked to colon cancer. However, colon cancer incidence rates have not changed since 1978.
Two independent research teams identify Fusobacterium in colon cancer tissue, a finding that could lead to new avenues for diagnosis and treatment of the disease. The bacteria were found more often in colon cancer tissues than normal tissue, sparking potential links between infection and colorectal tumors.
Researchers have discovered strikingly high levels of Fusobacterium in colorectal tumors, suggesting a potential role in the disease. The findings offer an enticing lead for further research into diagnosing, preventing, and treating colon cancer.
A study published in the Journal of the National Cancer Institute found that African-American patients with resected stage II and III colon cancer experienced poorer overall and recurrence-free survival compared to whites. The five-year relative survival rates for black and white colorectal cancer patients were 57% and 68%, respectively.
Researchers at Medical College of Wisconsin show that CXCL12 protein inhibits metastasis in colon and melanoma cancers. The protein, naturally expressed in bone marrow and other organs prone to cancer metastasis, effectively blocks tumor growth and improves survival time.
Researchers at Duke University have developed a technology that uses angle-resolved low coherence interferometry to detect pre-cancerous cells in the colon. The device shines short bursts of light into tissue samples and analyzes scattered light for signs of dysplasia, with an accuracy rate of 85%.
The UT Southwestern-Parkland PROSPR Center aims to optimize colon cancer screening among Dallas residents, particularly those lacking insurance or underinsured. The partnership seeks to develop a model for screening that can be used by public hospitals nationwide.
Researchers discovered that PTK6 protein, which regulates cell growth in normal tissue, activates proliferation of damaged cells in cancerous breast tissue. Mice lacking PTK6 gene were highly resistant to carcinogen-induced colon tumors.
A new study published in the Journal of the American Dietetic Association found that consuming brassica vegetables and apples may lower the risk of proximal colon cancer. In contrast, increasing fruit juice consumption was associated with an increased risk of rectal cancer.
Researchers found that soy peptide lunasin binds to receptors in highly metastatic colon cancer cells, preventing them from attaching to the liver. Combining lunasin with chemotherapy drug oxaliplatin resulted in a sixfold reduction in new tumor sites.
Case Western Reserve University School of Medicine has been awarded a $11.3 million grant from the National Cancer Institute to establish a center for research on gastrointestinal cancers. The center will focus on translational research to develop new tests, treatments, and prevention methods for colon and esophageal cancers.
A significant increase in lymph node evaluation during colon cancer operations occurred over two decades, but this was not associated with a corresponding rise in node-positive cancers. Patients with high lymph node evaluation experienced lower relative hazard of death.
Researchers at Winship Cancer Institute of Emory University have identified a way to keep the cancer-preventive properties of celecoxib while avoiding its risks. The study shows that celecoxib inhibits an enzyme called GSK3 in lung cancer cells, causing apoptosis and disappearance of a protein called c-FLIP.
Researchers have identified a protein that plays a critical role in heart development and may also be a therapeutic target for halting colon cancer metastasis. BVES expression was found to be low in all stages of colon cancer and decreased levels were observed in many other types of epithelial cancers.
University of Florida researchers have developed a compound that targets and reduces growth factors and tyrosine kinases in colon cancer cells, leading to effective tumor suppression without toxicity. The modified apratoxin S4 shows promise as a novel anticancer therapy.
Researchers at the University of Houston discovered the potential for estrogen hormone compounds to prevent colon cancer by activating estrogen receptors. They also identified a key gene involved in breast cancer tumor cell growth, opening new opportunities for targeted therapeutics.
A new study developed a cost-effective way to identify patients at risk for Lynch syndrome, which could lead to earlier screenings and improved outcomes for colon and other cancers. The process uses two relatively inexpensive tests to eliminate possible carriers before full genome sequencing is required.
A new process has been developed to identify patients at risk of Lynch syndrome, a genetic mutation that increases cancer risk. The process uses two inexpensive tests to eliminate possible carriers before full genome sequencing, significantly reducing costs and improving accuracy.
Researchers confirm vitamin D's role in slowing down colon cancer cell growth and proliferation. The study found that a lack of vitamin D increases the aggressiveness of colon cancer, highlighting its potential as an anti-tumor agent.
A recent study published in Nutrition and Cancer found that high consumption of these foods was associated with a reduced risk of colon polyps by 33-40%, confirming the results of past studies. The protective effects may be due to their cancer-fighting agents, including fiber and detoxifying compounds.
Researchers found that testing every new colon cancer patient for Lynch syndrome can reduce cancer deaths at a reasonable cost. Testing multiple family members after the initial diagnosis is crucial to spreading the benefit across more relatives, according to the study.
Researchers at UT Southwestern Medical Center found at least 70 genetic mutations involved in the formation of colon cancer, surpassing previous estimates. This new understanding could lead to more effective treatments targeting multiple genes and pathways simultaneously.
A USC team identified a genetic marker that predicts patient response to cetuximab-based therapy for locally advanced rectal cancer. The study found that 45% of patients with a specific EGF61 variant emerged disease-free after treatment.