Articles tagged with Colon Cancer
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A recent study found that nearly two-thirds of colon cancer patients who stopped chemotherapy died sooner than those who completed treatment, with survivors receiving longer-term benefits. The research highlights the importance of adherence to chemotherapy regimens for colon cancer patients.
Researchers found that mice with APC mutations are more resistant to radiation when receiving staggered doses, potentially impacting radiation treatment protocols for colon cancer patients. The study's findings could lead to adjustments in treatment timing to minimize damage and optimize repair processes.
Researchers at Thomas Jefferson University discovered a genetic signature that predicts colon cancer, distinguishing between stem cell and non-stem cell activity in colon crypts. This finding could lead to the development of new drugs by replacing lost molecules involved in cancer development.
The APC tumor suppressor has a novel function in regulating Wnt signaling in the nucleus. In this new study, researchers demonstrate that APC opposes beta-catenin activity directly at Wnt target genes. The findings suggest that full-length APC protein is necessary to repress c-Myc gene expression and prevent colon cancer progression.
A large cohort of post-menopausal women was studied to examine the relationship between physical activity and colon cancer risk. The results show no association between physical activity levels and a lower incidence of colon cancer.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a new compound, CDDO-Im, which shows strong protective effects against liver cancer. The compound works by activating Nrf2, a master switch that stimulates the cell's defense mechanisms and removes harmful chemicals.
A recent study found that reducing total dietary fat had no impact on the risk of breast cancer, colon cancer, heart disease, or stroke. Researchers believe that focusing on the types of fats consumed, rather than just reducing total fat, is crucial for disease prevention.
Women with Lynch syndrome have an equal risk of developing endometrial and colon cancers, and are at high risk for additional cancers. Prophylactic surgeries, such as hysterectomy and ovary removal, significantly reduce the risk of these two gynecological cancers.
Researchers found L1 in large quantities exclusively in aggressive colon cancer cells, enabling them to invade and metastasize more effectively. The discovery may have important implications for diagnosing colon cancer and designing new therapies.
The use of chemotherapy after surgery for stage III colon cancer has increased, leading to improved 5-year survival rates. Adjuvant chemotherapy benefits younger and elderly patients equally, while black patients with high-grade cancers see less significant improvements.
A study using virtual colonoscopy with computer-aided detection (CAD) found that CAD improved the performance of virtual colonoscopy by reducing perceptual error in interpreting large numbers of images. The technology detected polyps in 89.3% and 85.4% of patients with polyps 10mm and 8mm or larger, respectively.
A combination treatment of Xeloda and oxaliplatin (XELOX) has been shown to reduce hospital visits by over 60% in patients with early colon cancer. This results in more time for patients to spend with family and return to work, improving their quality of life.
Researchers found that people with diabetes are 1.4 times more likely to develop colon cancer compared to those without the condition. The study analyzed data from a nationally representative sample of patients and controlled for various factors, including age and obesity.
A study found that CT colonography can detect cancer lesions and polyps with nearly the same sensitivity as colonoscopy, avoiding fatal perforations but potentially leading to more cancer-related deaths. The method's higher cost is offset by its non-invasive nature and appeal to patients.
The blood test aims to identify individuals with improper control of the growth-promoting gene insulin-like growth factor 2 (IGF-2), which is associated with a higher risk of colon cancer. If successful, the test could help monitor those who need invasive colonoscopy or suggest dietary changes to reduce their risk.
Researchers found that combining interferon with irinotecan boosts IRF5 protein levels in colon cancer cells, leading to increased cell death. The combination therapy may limit side effects and make it harder for cancer cells to build resistance.
Researchers have identified a gene marker called vimentin that detects colon cancer with 46% accuracy using DNA stool tests. The marker has potential to be used in combination with other DNA markers to detect 100% of colon cancers.
Research has found a positive association between body mass index, fat-free mass, and waist circumference with an increased risk of myeloid leukemia. Additionally, modifications of the vimentin gene can be detected in fecal DNA of people with colon cancer, potentially serving as a biomarker for the disease.
A study found that 43% of women prefer female endoscopists, with 87% willing to wait for a female doctor and 14% willing to pay more. This preference may hinder colon cancer screening among women, emphasizing the need for targeted prevention programs.
A study found that 45 out of 500 virtual colonoscopy patients had clinically important extracolonic findings, including kidney cancers and abdominal aortic aneurysms. The study suggests that virtual colonoscopy may be more effective at detecting diseases outside the colon than in the colon.
A recent study found that virtual colonoscopy can detect extracolonic abnormalities in 63% of patients, with clinically important findings detected in 9%. The procedure is potentially cost-effective and can be used to screen for other conditions as well.
A study of 9,802 NYC residents found that nearly half are not undergoing timely screening for colon cancer, with lower uptake among African-Americans, women, and those with limited access to healthcare. The researchers emphasize the need for targeted interventions to increase screening rates in poor and uninsured communities.
A large study of 39,876 healthy women found no effect of vitamin E on total cancer or cardiovascular disease. However, vitamin E supplementation was associated with a reduced risk of cardiovascular deaths among all women and a decrease in heart attacks and cardiovascular deaths among women aged 65 years and older.
A recent study published in The Lancet Oncology has found that keyhole surgery is a safe and effective option for treating colon cancer. Patients who underwent keyhole surgery had less blood loss, shorter hospital stays, and faster recovery times compared to those who received open surgery.
Increased expression of claudin-1 has been found in human primary colon carcinomas and metastases. Claudin-1's mislocalization is associated with higher levels of expression and increased metastatic behavior in colon cancer cells.
A new study found that statin use can decrease the risk of colon cancer in people taking cholesterol-lowering medications. Researchers analyzed data from over 1,900 participants and found a 47% reduced risk of colorectal cancer among those taking statins.
A large-scale study found that colonoscopy outperforms flexible sigmoidoscopy in detecting advanced pre-cancerous polyps in women, highlighting the need for unique screening approaches in women. The study suggests that women should get a colonoscopy after age 50 to prevent colon cancer.
The American Gastroenterological Association emphasizes the importance of standard colonoscopy as the most cost-effective option for an accurate diagnosis of colon cancer. Meanwhile, researchers have identified factors that increase the rate of missed diagnoses during colonoscopies, including patient age, gender, and location of tumor....
A recent study by Mayo researchers suggests that using results from clinical trials for one and two years can be as predictive of long-term outcomes in cancer patients as three-year data. The goal of this new approach is to make promising new therapies available more quickly to help patients.
A new study found that exercise can reduce the risk of colon cancer recurrence and death by 40-50% in early-stage patients. Patients with high activity levels, ranking in the top two-fifths of the group, experienced this benefit.
Researchers found statin chemoprevention to be a promising strategy for managing patients with chronic ulcerative colitis, preventing 90-96% of colon cancers. Compared to frequent colonoscopic surveillance, this approach may improve quality of life and reduce costs.
A prospective study of 846 patients with stage III colon cancer found that regular aspirin use reduced the risk of recurrence by 55% and mortality by 48%. COX-2 inhibitors showed similar benefits, with no effect seen from acetaminophen use.
A clinical trial involving over 730 colorectal cancer patients suggests that keyhole surgery may be the new gold standard for colon cancer treatment, offering rapid recovery rates, less pain, and fewer complications. The study found similar cancer-related survival and quality of life outcomes between keyhole and open surgery groups.
A study published in the New England Journal of Medicine found that two to three percent of people with colon cancer may have Lynch syndrome mutations. Prescreening for the syndrome can help determine genetic counseling and testing needs, as well as estimate patient prognosis.
A portfolio of 173 genes is differentially expressed in patients with hereditary nonpolyposis colon cancer (HNPCC) treated with celecoxib, suggesting the drug may suppress colon polyp formation and early colon cancer.
Researchers found high quantities of the L1 protein, typically found in nerve cells, exclusively in aggressive and invasive front of colon cancer tumors. The discovery may lead to novel ways of diagnosing colon cancer and developing its therapy, as L1 plays a crucial role in tumor cell motility and invasion.
A new study found that nearly two-thirds of men are up-to-date with prostate cancer screening, but only 47.6% have had a recent colon cancer screening. The researchers suggest using prostate cancer screenings as an opportunity to encourage men to get screened for colon cancer, which is projected to affect over 70,000 men this year.
Researchers find that mice with a double dose of IGF2 develop more precursor cells in the colon, doubling cancer risk when combined with a colon-cancer-causing genetic mutation. This epigenetic problem may contribute to colon cancer development.
A cohort study in Japan found that daily coffee consumption was associated with a reduced risk of hepatocellular carcinoma (HCC). In contrast, no association was found between coffee consumption and colorectal cancer incidence. The authors suggest further studies to confirm these findings.
A study published in Genes and Development reveals a novel molecular player influencing colon cancer initiation. The research found that combining Foxl1 deficiency with an inactive APC gene accelerated tumor formation, highlighting the significance of mesenchymal-epithelial signaling in gastrointestinal tumorigenesis.
The American Gastroenterological Association recommends colonoscopy as the preferred screening method for colorectal cancer due to its ability to detect and remove precancerous polyps. In-office fecal occult blood tests are not recommended as a standalone screening test, but can be used in conjunction with flexible sigmoidoscopy.
A recent study published in JAMA found that long-term high consumption of red and processed meat is associated with an increased risk of colon cancer. The study, which included over 148,000 adults, also found that poultry and fish consumption was inversely linked to colon cancer risk.
A large European study found no association between vegetable and fruit intake and reduced breast cancer risk. The researchers analyzed data from 285,526 women and reported no significant associations for six specific vegetable subgroups.
A new stool DNA test has been found to detect a significant proportion of colorectal cancers, potentially overcoming barriers to screening among unwilling individuals. The test, which analyzes tumor-specific DNA, detected 52% of cancers in average-risk asymptomatic individuals.
A study comparing the relative sensitivity of colonoscopy, ACBE, and CTC found that colonoscopy detected 98% of large and 99% of small lesions, outperforming ACBE and CTC. The results have important implications for clinicians considering colon imaging tests and potentially for colon cancer screening programs.
Researchers have discovered a new gene, 15-PGDH, that acts as an antagonist to control the enzyme COX-2, a major early event in human colon tumors. The study found that 15-PGDH is directly controlled and activated by TGF-beta, and its presence can suppress COX-2 activity, potentially leading to tumor development without it.
A study by the Mayo Clinic found a direct correlation between high aortic calcium scores and heart attacks in patients who underwent virtual colonoscopy for colon cancer screening. The research suggests that CT colonography may identify cardiovascular disease risk, encouraging individuals to take advantage of diagnostic tools.
A recent study has revealed a genetic link to colon cancer, identifying the MutY human homologue (MYH) gene as a risk factor. The research found that children of MYH gene carriers have a higher risk of developing the disease, with a 1:2 ratio.
Researchers found that stronger, more flavorful onion varieties have higher antioxidant activity and can fight colon cancer cells more effectively. Shallots were also found to be strong cancer-fighters, outperforming milder-tasting onions.
A new medication, nitric oxide-donating aspirin, has shown promise in preventing colon cancer by inhibiting the growth of colon cancer cells. The treatment is hundreds to thousands of times more potent than traditional aspirin and may reduce the risk of development by up to 95%.
Researchers found that a class of polyphenols in apples, called procyanidins, significantly reduced precancerous lesions in laboratory animals. The study suggests that consuming whole apples, including the skin, may offer anti-cancer benefits.
A study found that highly dense breasts are associated with a higher risk of second breast cancer in women who have had ductal carcinoma in situ. Women with dense breast tissue also face a greater risk of invasive and ipsilateral breast cancer.
Researchers found that PGE2 activates PPARd through a signaling pathway promoting cell survival and polyp formation. This effect was not observed in mice lacking PPARd, highlighting the role of PPARd as a critical downstream mediator in PGE2-stimulated colorectal tumor growth.
Researchers have discovered that a mutant gene's failure to convert vitamin A into retinoic acid leads to colon cancer. Introducing retinoids may prevent or control the growth of colon cells, offering new avenues for therapy development.
A recent study found that popular magazines rarely provide in-depth information on prostate and colon cancer screening. Key points such as risk factors, early screening benefits, and potential harms are often missing from magazine articles. This lack of information may contribute to the public's misperception about cancer risks.
The American Gastroenterological Association disputes the validity of a recent study suggesting that too many surveillance colonoscopies are being performed. The study, published in Annals of Internal Medicine, highlights the importance of determining the clinical significance of small polyps and notes the need for further research to ...
The guideline states that routine adjuvant chemotherapy is not recommended for medically fit, average-risk patients with Stage II colon cancer. Patients who receive adjuvant chemotherapy have a small but significant benefit in survival rates, around 4-5% more chance of survival five years after surgery.
A randomized clinical trial showed that adjuvant chemotherapy and immunotherapy for colon cancer patients offer no disease-free or overall survival benefits after 10 years. The improvements in 5-year survival rates observed in the past have disappeared over time, suggesting that newer chemotherapy regimens may be more effective.
Researchers propose adding calcium and vitamin D to existing FDA-mandated enrichment mix in products like bread and pasta to reduce osteoporosis and colon cancer incidences. The measure could save 11,000 lives and $3 billion annually with minimal financial cost.
A recent study found that calcium supplementation can slightly decrease the risk of all types of colorectal polyps, with a greater effect on advanced lesions. Additionally, a diet high in fiber and low in fat may enhance this preventive effect.