Articles tagged with Colon Cancer
A prospective multicenter trial found that 3-D virtual colonoscopy is more sensitive than conventional colonoscopy, detecting over 90% of significant polyps with minimal discomfort and cost
A new study identifies a specific DNA stretch on chromosome 9 that houses a susceptibility gene linked to increased colon cancer risk. Researchers analyzed blood samples from 53 families affected by colon cancer or pre-cancerous polyps and found a common genetic link.
Researchers identified a specific anticancer compound, methylpyridinium, in coffee with strong antioxidant content, suggesting it may offer protection against colon cancer. Drinking coffee, especially strong espresso-type brews, could provide some level of protection.
A large-scale clinical study by Nordic collaboration has provided new insights into the effects of chemotherapy in colorectal cancer. The analysis demonstrated that among 2,223 patients, those given chemotherapy as part of routine care had a five-year survival rate of 56%, compared to 49% for those treated by surgery alone.
In Sweden, rectal cancer patients have seen a dramatic improvement in five-year survival rates, jumping from 50% to 60%, thanks to changes in hospital practice and quality assurance measures.
A Canadian-led study found that about 83% of colon cancer patients benefit from traditional chemotherapy, while nearly 17% do not. Further research is needed to provide alternative treatments for those who don't respond to standard therapy.
A new study reveals that Katie Couric's on-air colonoscopy led to a significant increase in colon cancer screenings nationwide. Colonoscopy rates jumped over 20% in the days and months following Couric's test, sustained for nearly a year. The 'Katie Couric Effect' also showed an increase in screenings among women and people under age 50.
Two studies suggest that regular use of ibuprofen and aspirin inhibits breast cancer formation, while a low-dose tamoxifen regimen may effectively treat breast cancer with fewer side effects. Another study found that a combination of low-dose COX-2 inhibitors and fish oil may reduce colon cancer risk.
Pre-diabetic adults with impaired glucose tolerance (IGT) are nearly twice as likely to die from any cancer and four times more likely to die from colon cancer compared to those with normal glucose tolerance. Researchers suggest that high insulin levels may promote the development of cancer cells, but prevention methods are unclear.
Scientists at Case Western Reserve University have identified a new colon cancer gene, SLC5A8, which is silenced through aberrant methylation. The discovery offers potential for a new diagnostic test for early colon cancer detection.
UCSD researchers define multiple steps initiated by COX-2 enzymes, including cyclic adenosine monophosphate and Inhibitors of Apoptosis, leading to suppressed cell killing and uncontrolled growth. The study also explains how aspirin and NSAIDs can reduce colon cancer incidence by inhibiting COX-2.
Research suggests that frequent consumption of miso soup and high intake of isoflavones may lower breast cancer risk. Vitamin D analog paricalcitol also demonstrates antitumor activity against myeloid leukemia, myeloma, and colon cancer cells.
A large Canadian study found no significant difference in postoperative mortality between high- and low-volume hospitals for complex surgical procedures. The authors suggest that volume-based regionalization may have good reasons, but the main benefit of reduced mortality rates may be overstated.
A Danish population study of over 29,000 individuals found that alcohol, particularly beer and spirits, increases rectal cancer risk. In contrast, moderate wine consumption appears to have a protective effect, with those drinking around a third of their intake as wine being less likely to develop the disease.
Researchers have identified 46 new mutations in colon cancer genes that can be targeted by drugs, affecting approximately 30% of colorectal cancers. The study used a forward-looking approach to screen the genes that produce tyrosine kinases, resulting in the discovery of novel mutations that spur colon cancer.
Researchers discovered mutations in 14 tyrosine kinase genes, which play key roles in controlling cell growth and differentiation. These findings open the door to individualized treatment approaches for colorectal cancer, allowing for personalized therapeutics tailored to each patient's tumor DNA.
Researchers have developed a new colon cancer screening method that eliminates the need for cathartic cleansing, reducing patient discomfort. The innovative approach uses barium to tag fecal matter left in the colon, making it easier to detect polyps with low residue diets and reduced-hydration regimens.
A new study suggests that colonoscopy is more cost-effective in preventing colon cancer than promising Cox-II drugs. The study found that screening plus drugs was most effective but also the most costly option.
A study published by the American College of Radiology found that PET scans had a sensitivity rate of 93% compared to 46% for CT scans. Additionally, PET scans offered advantages over CT scans in terms of cost savings due to lower radiation exposure. The researchers recommend using PET scans for staging patients with suspected cancer s...
A new study published in The Lancet found that a high-fibre diet was associated with a lower risk of colorectal adenoma and colon cancer. Participants who consumed the most fibre had a 25% lower risk of developing adenoma compared to those who consumed less fibre.
Researchers have discovered that nonsteroidal anti-inflammatory drugs (NSAIDs) block the IL-6 activation of STAT1, a protein that triggers malignant growth in colorectal cancer cells. The findings could lead to new treatments for the disease.
A novel combination treatment of celecoxib, a COX-2 inhibitor, and DHA from fish oil causes cell death in human colon cancer cells at low doses. This synergistic approach shows promise in reducing colon cancer risk with tolerable doses.
A new study identifies a genetic marker in blood samples that may indicate an increased risk of colon cancer. The researchers found that individuals with a family history of colon cancer, polyps, or personal history of the disease were more likely to have this marker in their blood.
A study found that green and white tea can prevent colon tumors as effectively as the prescription drug sulindac. Moderate consumption of these teas may provide cancer protection without side effects associated with NSAIDs. The combination of tea and sulindac showed an 80% tumor reduction.
A randomized, double-blind study of over 1100 patients found that low-dose aspirin reduced the incidence of polyps by 19% and advanced lesions by more than 40%. Regular aspirin tablets also showed significant reductions in adenoma occurrence.
A major study shows that taking 325 milligrams of aspirin daily can reduce the risk of developing polyps in the colon by 35%, a significant step towards preventing colorectal cancer. The study involved over 100 medical centers and clinics across the US, with patients who had previously suffered from colorectal cancer.
A large randomized trial found that daily aspirin use reduced the incidence of adenomas and prolonged time to appearance in colon cancer patients, offering strong evidence for its protective properties.
A daily aspirin regimen was found to significantly reduce the occurrence of pre-cancerous polyps in patients with a history of colorectal cancer, lowering their risk by about one-third. Aspirin's protective effect also prevented the development of new adenomas and reduced the number of existing polyps.
Researchers at the University of Pittsburgh Cancer Institute are testing acupuncture's efficacy in alleviating symptom distress and promoting emotional well-being in terminally ill colorectal cancer patients. The four-year study will compare acupuncture, sham acupuncture, and usual care to determine its benefits.
The session addresses heart disease in postmenopausal women, including sub-clinical atherosclerosis predictors and prevention measures. It also explores sarcopenia and frailty in older women, discussing muscle mass loss and body composition changes that contribute to disability.
Researchers found that people with a family history of colon cancer were more likely to have high-risk diets, including cooked red meat and low folate levels. Modification of these factors could provide broad benefits for individuals with a family history, regardless of their genes.
A study found that colonoscopy perforation rates are twice as high as those of sigmoidoscopy. The risk of perforation from sigmoidoscopy was about half that of colonoscopy, with 5% of perforations resulting in death within 14 days.
Research found that people with a specific iron overload gene mutation are at higher risk of developing colon cancer, especially with increasing age and iron intake. The study analyzed DNA samples from over 1,300 adults and found a significant association between HFE gene mutations and an increased risk of colon cancer.
Breast cancer patients with HER-2/neu overexpression have lower hormone receptor levels, affecting treatment response. HFE gene mutations increase colon cancer risk in the US population.
Screening for colorectal cancer is vital for early detection, with a significant reduction in mortality rates associated with early detection. Current techniques like colonoscopy are effective but expensive, prompting the need for alternative methods.
Researchers found that smoking is an important risk factor for developing colorectal polyps, with smokers being more likely to have larger polyps and a greater potential for malignancy. The study suggests that physicians should consider performing screening colonoscopy in current smokers before age 50.
A new study found that genetic test results for HNPCC may motivate colonoscopy screening among those who test positive, increasing screening rates. The American Association for Cancer Research recommends more targeted training on screening recommendations for underserved communities.
Dr. Albert de la Chapelle, an Ohio State University scientist, has spent 40 years studying the complex relationship between genetic mutation and disease. He has made groundbreaking discoveries on inherited diseases, including leukemia and lymphoma, as well as rare disorders like diastrophic dysplasia and Usher syndrome.
The University of Pittsburgh Cancer Institute has discovered three proteins present in liver tissue from colon cancer patients that are not found in normal liver tissue. The findings hold promise for developing a more sensitive tumor marker for early detection and predicting potential recurrence.
A study published in Science reveals a new risk factor for colon cancer, associated with the Bloom syndrome gene mutation. Researchers found that individuals carrying the mutated gene had nearly three times the risk of developing colon cancer compared to those without the mutation.
Researchers discovered a possible novel pathway for colon cancer in humans, associated with a single BLM mutation. The study found that almost two percent of patients with colon cancer carried the BLMAsh mutation, compared to less than one percent of healthy individuals.
Research studies found small but statistically significant increases in cancer risks among BRCA1 mutation carriers, including colon, liver, pancreatic, and cervical cancers. Additionally, male BRCA1 mutation carriers had a slightly elevated risk of prostate cancer.
Research suggests that African-Americans with colon cancer fare equally well when receiving the same treatment as white patients, dispelling long-held theories about innate biological differences. The study found no significant disparities in survival rates between the two groups five years after treatment.
Researchers at Michigan Medicine have discovered a new predictive marker, HIP1, associated with an increased risk of developing prostate and colon cancer. HIP1 levels were found to rise significantly in tumor cells, making it a potential target for therapy.
Research suggests that nonsteroidal anti-inflammatory drugs like aspirin may be effective in treating uterine cancer by inhibiting the COX-2 enzyme. The study also found increased levels of COX-2 and prostaglandins in endometriosis, a painful condition where tissue from the uterus attaches to other organs.
A study of 219 patients with non-metastatic colon cancer found that laparoscopy-assisted colectomy (LAC) reduced tumour relapse and death from all causes by 60% and 50%, respectively. LAC also resulted in shorter hospital stays and lower perioperative morbidity compared to open colectomy.
A study of 219 patients with non-metastatic colon cancer found that laparoscopy-assisted colectomy (LAC) reduced perioperative morbidity, shortened hospital stays, and prolonged cancer-related survival. LAC was associated with a 60% lower risk of tumour relapse compared to open colectomy.
Anal cancer is under-recognized, but rates of 350 cases per million in HIV-negative men and double in HIV-positive men indicate a need for prevention. Stanford researcher Mark Welton proposes an approach using yearly pap smears to detect precancerous cells before they develop into cancer.
Researchers found that elderly patients with lymph node involvement in colon cancer experienced a 30% reduction in mortality at five years after diagnosis with both chemotherapy and surgery. This contradicts the common assumption that age is a deterrent for these treatments, allowing doctors and patients to make more informed decisions.
New studies suggest that vitamin D may help prevent colon cancer by activating the detoxification of lithocholic acid, a known carcinogen. Researchers found that vitamin D acts as a sensor for the toxic chemical, triggering proteins to clear it from the body.
A study by Michigan Medicine researchers found that Katie Couric's 2000 colonoscopy on-air campaign significantly increased colon cancer screenings, with a 19% rise and sustained increases for 40 weeks. The 'Couric Effect' suggests celebrity influence can drive public behavior change.
A recent study found that rats fed a diet rich in black raspberries had 80 percent fewer malignant tumors compared to those without berries. The antioxidants in black raspberries, such as anthocyanins and phenols, were also shown to have a significant impact on reducing tumor size and oxidative damage.
New research adds to evidence that acetaminophen may prevent colon cancer in lab animals. The study found that pretreating animals with acetaminophen significantly protected them against cellular changes indicative of colon cancer. However, more animal research is needed before humans can be studied in clinical trials.
Researchers at Stanford University Medical Center have developed a novel approach to fighting cancer using a modified cold virus that targets cancer cells while leaving normal cells unharmed. In a phase I study, 28 patients who received the highest dose of the virus survived for nearly a year and saw significant tumor shrinkage.
Researchers found no statistical difference between sulindac and placebo groups in preventing polyp development or colon cancer, contradicting previous evidence. Sulindac may be ineffective at preventing polyps in newly diagnosed FAP patients, suggesting a need for alternative treatments.
Researchers have identified new markers for prostate and colon cancers, as well as a potential tumor suppressor gene. TIG1 was found to be expressed in normal prostate tissue but not malignant tumors, suggesting it may play a role in cancer progression.
Researchers identified a novel gene alteration that contributes to colon cancer growth, suggesting a new target for diagnosis and treatment. The discovery also hints at the possibility of reversing methylation-based tumor progression, potentially leading to a non-invasive diagnostic test.
A new study found that moderate to high calcium intake can lower the risk of distal colon cancer by 40-50% in women and men. However, excessive calcium consumption did not provide further benefits. Calcium may be the key component reducing colon cancer risk.
A new study published in Cancer Epidemiology, Biomarkers and Prevention suggests that dietary habits can significantly reduce colon cancer risk in individuals with a family history of the disease. Eating a diet high in folic acid, low in alcohol intake, and moderate in methionine may help lower this risk.
Researchers at the University of Maryland Greenebaum Cancer Center developed a new method using artificial neural networks to differentiate between two types of colon tumors. The study successfully diagnosed 12 out of 12 samples and reduced the number of genes necessary for diagnosis from 8,064 to 97.