Articles tagged with Colon Cancer
A prospective study of 846 patients with stage III colon cancer found that regular aspirin use reduced the risk of recurrence by 55% and mortality by 48%. COX-2 inhibitors showed similar benefits, with no effect seen from acetaminophen use.
Researchers found statin chemoprevention to be a promising strategy for managing patients with chronic ulcerative colitis, preventing 90-96% of colon cancers. Compared to frequent colonoscopic surveillance, this approach may improve quality of life and reduce costs.
A clinical trial involving over 730 colorectal cancer patients suggests that keyhole surgery may be the new gold standard for colon cancer treatment, offering rapid recovery rates, less pain, and fewer complications. The study found similar cancer-related survival and quality of life outcomes between keyhole and open surgery groups.
A study published in the New England Journal of Medicine found that two to three percent of people with colon cancer may have Lynch syndrome mutations. Prescreening for the syndrome can help determine genetic counseling and testing needs, as well as estimate patient prognosis.
A portfolio of 173 genes is differentially expressed in patients with hereditary nonpolyposis colon cancer (HNPCC) treated with celecoxib, suggesting the drug may suppress colon polyp formation and early colon cancer.
A new study found that nearly two-thirds of men are up-to-date with prostate cancer screening, but only 47.6% have had a recent colon cancer screening. The researchers suggest using prostate cancer screenings as an opportunity to encourage men to get screened for colon cancer, which is projected to affect over 70,000 men this year.
Researchers found high quantities of the L1 protein, typically found in nerve cells, exclusively in aggressive and invasive front of colon cancer tumors. The discovery may lead to novel ways of diagnosing colon cancer and developing its therapy, as L1 plays a crucial role in tumor cell motility and invasion.
Researchers find that mice with a double dose of IGF2 develop more precursor cells in the colon, doubling cancer risk when combined with a colon-cancer-causing genetic mutation. This epigenetic problem may contribute to colon cancer development.
A cohort study in Japan found that daily coffee consumption was associated with a reduced risk of hepatocellular carcinoma (HCC). In contrast, no association was found between coffee consumption and colorectal cancer incidence. The authors suggest further studies to confirm these findings.
A study published in Genes and Development reveals a novel molecular player influencing colon cancer initiation. The research found that combining Foxl1 deficiency with an inactive APC gene accelerated tumor formation, highlighting the significance of mesenchymal-epithelial signaling in gastrointestinal tumorigenesis.
The American Gastroenterological Association recommends colonoscopy as the preferred screening method for colorectal cancer due to its ability to detect and remove precancerous polyps. In-office fecal occult blood tests are not recommended as a standalone screening test, but can be used in conjunction with flexible sigmoidoscopy.
A recent study published in JAMA found that long-term high consumption of red and processed meat is associated with an increased risk of colon cancer. The study, which included over 148,000 adults, also found that poultry and fish consumption was inversely linked to colon cancer risk.
A large European study found no association between vegetable and fruit intake and reduced breast cancer risk. The researchers analyzed data from 285,526 women and reported no significant associations for six specific vegetable subgroups.
A new stool DNA test has been found to detect a significant proportion of colorectal cancers, potentially overcoming barriers to screening among unwilling individuals. The test, which analyzes tumor-specific DNA, detected 52% of cancers in average-risk asymptomatic individuals.
A study comparing the relative sensitivity of colonoscopy, ACBE, and CTC found that colonoscopy detected 98% of large and 99% of small lesions, outperforming ACBE and CTC. The results have important implications for clinicians considering colon imaging tests and potentially for colon cancer screening programs.
Researchers have discovered a new gene, 15-PGDH, that acts as an antagonist to control the enzyme COX-2, a major early event in human colon tumors. The study found that 15-PGDH is directly controlled and activated by TGF-beta, and its presence can suppress COX-2 activity, potentially leading to tumor development without it.
A study by the Mayo Clinic found a direct correlation between high aortic calcium scores and heart attacks in patients who underwent virtual colonoscopy for colon cancer screening. The research suggests that CT colonography may identify cardiovascular disease risk, encouraging individuals to take advantage of diagnostic tools.
A recent study has revealed a genetic link to colon cancer, identifying the MutY human homologue (MYH) gene as a risk factor. The research found that children of MYH gene carriers have a higher risk of developing the disease, with a 1:2 ratio.
Researchers found that stronger, more flavorful onion varieties have higher antioxidant activity and can fight colon cancer cells more effectively. Shallots were also found to be strong cancer-fighters, outperforming milder-tasting onions.
A new medication, nitric oxide-donating aspirin, has shown promise in preventing colon cancer by inhibiting the growth of colon cancer cells. The treatment is hundreds to thousands of times more potent than traditional aspirin and may reduce the risk of development by up to 95%.
Researchers found that a class of polyphenols in apples, called procyanidins, significantly reduced precancerous lesions in laboratory animals. The study suggests that consuming whole apples, including the skin, may offer anti-cancer benefits.
A study found that highly dense breasts are associated with a higher risk of second breast cancer in women who have had ductal carcinoma in situ. Women with dense breast tissue also face a greater risk of invasive and ipsilateral breast cancer.
Researchers found that PGE2 activates PPARd through a signaling pathway promoting cell survival and polyp formation. This effect was not observed in mice lacking PPARd, highlighting the role of PPARd as a critical downstream mediator in PGE2-stimulated colorectal tumor growth.
Researchers have discovered that a mutant gene's failure to convert vitamin A into retinoic acid leads to colon cancer. Introducing retinoids may prevent or control the growth of colon cells, offering new avenues for therapy development.
A recent study found that popular magazines rarely provide in-depth information on prostate and colon cancer screening. Key points such as risk factors, early screening benefits, and potential harms are often missing from magazine articles. This lack of information may contribute to the public's misperception about cancer risks.
The American Gastroenterological Association disputes the validity of a recent study suggesting that too many surveillance colonoscopies are being performed. The study, published in Annals of Internal Medicine, highlights the importance of determining the clinical significance of small polyps and notes the need for further research to ...
The guideline states that routine adjuvant chemotherapy is not recommended for medically fit, average-risk patients with Stage II colon cancer. Patients who receive adjuvant chemotherapy have a small but significant benefit in survival rates, around 4-5% more chance of survival five years after surgery.
A randomized clinical trial showed that adjuvant chemotherapy and immunotherapy for colon cancer patients offer no disease-free or overall survival benefits after 10 years. The improvements in 5-year survival rates observed in the past have disappeared over time, suggesting that newer chemotherapy regimens may be more effective.
Researchers propose adding calcium and vitamin D to existing FDA-mandated enrichment mix in products like bread and pasta to reduce osteoporosis and colon cancer incidences. The measure could save 11,000 lives and $3 billion annually with minimal financial cost.
A recent study found that calcium supplementation can slightly decrease the risk of all types of colorectal polyps, with a greater effect on advanced lesions. Additionally, a diet high in fiber and low in fat may enhance this preventive effect.
A novel mutant gene variant of MLH1 significantly increases the risk of colon cancer among Israeli patients, with a 40-percent lifetime risk. Researchers discovered the gene in Sephardic and Ashkenazi Jews, Muslim and Christian Arabs, and other ethnic groups, suggesting its widespread presence globally.
A study has identified a biomarker that can predict which colon cancer patients are most likely to respond to a specific chemotherapy regimen. The enzyme thymidine phosphorylase (TP) is found in some, but not all, cancers and is believed to activate the drug capecitabine.
A study found that African-Americans are 1.67 times more likely to die within five years and 1.52 times more likely to die within ten years after surgical treatment for CRC compared to Caucasians. Racial differences were most pronounced in patients with stage II disease.
Researchers identified six genes with mutations that affect cancer development in colon cancers, providing potential new targets for therapy. The study also found significant mutations in tyrosine kinase and phosphatase families across various types of cancer.
A randomized clinical trial found that regional and systemic adjuvant chemotherapy regimens had similar survival rates for colon cancer patients, with the combination regimen offering no added benefit. The study, published in the Journal of the National Cancer Institute, also showed lower adverse reaction rates for regional therapy.
Colonoscopy emerges as a superior method for colon evaluation, surpassing alternative imaging tests in terms of accuracy and cost. New technologies like the ColonoSight device address patient discomfort and increase diagnostic efficiency.
Researchers found that a strong preference for female physicians delays colonoscopy procedures and increases costs. Additionally, a study revealed a significant association between diabetes mellitus and an increased risk of developing colon cancer. These findings highlight the need for interventions to address these barriers to care.
Researchers at SLU have developed oncolytic adenoviruses that target specific types of cancer cells, such as colon and lung cancer. These engineered viruses attack and destroy cancerous cells through a mechanism different from chemotherapy or radiation.
A recent study found that even health-conscious women are more likely to have had a mammogram or Pap smear than undergone a colonoscopy. Doctors suggest using breast cancer screening appointments as an opportunity to educate women about colorectal cancer risk and increase awareness.
A recent study by Merrill and colleagues found that soy GlcCer, a type of sphingolipid, can reduce the number of tumors in mice with colon cancer. The study's results suggest that consuming soybeans may help prevent colon cancer by targeting beta-catenin, a protein involved in cell growth.
A recent study has found that minimally invasive laparoscopically assisted colectomy is an acceptable alternative for treating colon cancer when performed by experienced surgeons. The procedure's success depends on stringent surgical standards being followed.
A seven-year international study involving 872 patients with colon cancer has resolved concerns about laparoscopic surgery, finding it to be as safe and effective as standard surgery. The study found similar rates of complications, cancer recurrence, and overall survival between the two groups.
Researchers identified a 23-gene signature that can predict disease recurrence in Dukes' B colon cancer patients with high accuracy. The study's findings have significant implications for personalized therapy decisions and could lead to improved patient outcomes.
A new five-year, $5.6 million NCI grant is supporting a clinical trial to study a blood test for detecting colorectal cancer recurrence based on the protein guanylyl cyclase C (GCC). The trial aims to determine if GCC testing by RT-PCR analysis is more sensitive and specific than current methods in early detection of recurrence.
Researchers found that African Americans and whites with identical health care coverage experience no racial disparity in colon cancer survival. While subtle differences were seen in treatment options, the study suggests equal access to care can eliminate disparities
Periostin is a protein that promotes metastatic growth of colon cancer by augmenting cell survival, and may be involved in the progression of other cancers. The study identified periostin as a potent promoter of late-stage tumor progression, highlighting its potential as a therapeutic target for preventing deadly metastatic cancers.
A new calculator tool, developed by Mayo Clinic researchers, helps physicians estimate colon cancer patient prognosis and aid in treatment decisions. The calculator considers four factors: lymph node status, tumor depth, grade, and age to provide more accurate five-year survival estimates with or without adjuvant chemotherapy.
Researchers have found that Nembutal, a sedative, can suppress the growth of colon cancer cells by inhibiting gamma-aminobutyric acid receptors. The study suggests a novel approach to treating cancers with neurotransmitter receptors on their surfaces.
Jefferson researchers have discovered a unique genetic signature for colon stem cells, which could lead to a better understanding of colon cancer development. The study found that specific genes are selectively expressed in the bottom of crypts, where stem cells reside.
A study published in the New England Journal of Medicine found that women taking estrogen and progestin hormone replacement therapy had a lower risk of colorectal cancer, but those who developed cancer had more advanced cases. The researchers emphasize the importance of regular colonoscopy for women over 50.
Researchers found that switched-off SFRP genes allow the WNT pathway to stay active, leading to colon cell growth and tumor formation. The study suggests that reactivating SFRPs may prevent colon cancer by stopping this chain reaction.
Scientists have pinpointed a new cancer gene target, PIK3CA, which is mutated in 32% of colon cancers and may be involved in tumor growth. The study suggests that targeted therapies could be more effective with fewer side effects, leading to personalized cancer treatment.
Researchers found that retinoblastoma survivors are at higher risk of epithelial cancers such as esophagus, stomach, colon, lung, breast, cervix, or prostate, despite low radiation therapy. High folate intake is associated with a lower risk of ovarian cancer, especially among women who consume alcohol.
Researchers at Mayo Clinic discovered a crucial link between the cancer gene CBP and protein p27Kip1 in the development of lymphoma, breast and colon cancers. The study found that the absence of CBP and low levels of p27Kip1 accelerate cancer growth in laboratory mice.
A study found that high levels of CRP in blood are associated with an increased risk of colon cancer, particularly in individuals who do not smoke. Elevated CRP concentrations were also found in people with rectal cancer, but the association was weaker.
A study published in The Journal of the American Medical Association found that people with higher CRP levels were more likely to develop colorectal cancers over an 11-year period. Median CRP levels were higher among those who developed colon cancer, and inflammation was linked to increased risk without being mediated by diabetes.
A recent study found a significant link between increased levels of C-reactive protein and colon cancer risk. However, the study's findings do not suggest that C-reactive protein is a definitive marker for colon cancer risk.
A study found that sigmoidoscopies are often inadequate in older women, with a significant increase in failures to reach the colon's lower third. The study suggests that age-related factors, such as bowel preparation difficulties and anatomical variations, may contribute to these findings.
Researchers found that colon cancer cells can revert to non-metastatic behavior when surrounded by other cells, reversing the invasive process. By targeting a specific gene called Slug, scientists hope to develop a drug to block metastasis in patients.
The study found that men who consumed high amounts of vitamin D, cereal fiber, and took non-steroidal anti-inflammatory drugs were less likely to have serious colon polyps or tumors. Smoking was significantly associated with a higher risk of having a tumor or benign polyps.