Articles tagged with Colon Cancer
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Scientists at UNC Chapel Hill study found that a protein called adenomatous polyposis coli (APC) helps destroy another protein, beta catenin, which can lead to cell proliferation and tumor formation if disrupted. Understanding this pathway may help block tumor development in humans.
Researchers will examine strategies for persuading people to adopt healthier lifestyles, including better diets, exercise, and regular screening. The project aims to reduce the risk of colon cancer and save lives.
Researchers identified a possible new tumor-suppressor gene that plays a role in colon cancer and may predict response to new cancer therapy. The gene produces a protein important for fat cell maturity and metabolism, and its mutations may make tumors more susceptible to the antidiabetes drug troglitazone.
Researchers at Vanderbilt University Medical Center are exploring the role of aspirin and similar drugs in preventing colon cancer. They will study the mechanism of COX2 inhibition and its potential as a therapeutic target for colon cancer prevention.
Researchers have found a link between beta-catenin and cyclin D1 in colon cancer cells, leading to uncontrolled cell growth and tumor formation. This discovery may lead to new therapies for colon cancer and potentially other types of cancer.
Beta catenin disrupts cell regulation by synthesizing cyclin D1, allowing cells to proliferate out of control. The finding offers a potential new target for drug therapy in colon and other cancers.
Researchers at Penn discovered that chemoembolization doubles the survival time of adult patients with colon cancer that has spread to the liver. The procedure, which delivers chemotherapy directly to tumor cells, outperforms systemic chemotherapy in managing metastasized disease.
Researchers at Memorial Sloan-Kettering Cancer Center found nearly 20% of young patients with colorectal cancer have the HNPCC syndrome, a dominantly inherited disorder that increases lifetime risk of developing multiple cancers. Individuals with HNPCC require special surveillance to protect against additional cancers.
A study by researchers at Ohio State University found that genes involved in detoxifying cancer-causing chemicals play a role in the development of colorectal tumors. People with certain genetic mutations tend to develop tumors at younger ages or in the distal area of the large intestine.
A multi-centered study led by Dartmouth Medical School found that supplementation with calcium can reduce the recurrence rate of large bowel adenomas in people with a history of these particular polyps. The findings suggest promising measures that are fairly simple and inexpensive to help prevent colorectal cancer.
A new study found that calcium supplements moderately reduced the risk of recurring polyp growth in the colon and appeared to lower the risk of colon cancer. The study involved 832 patients who received 1200 milligrams of calcium carbonate daily for four years, with a 24% decrease in polyp numbers and a 19% decrease in recurrence risk.
Hopkins researchers found a genetic change called loss of imprinting (LOI) in 44% of colon cancer patients and 13% of healthy individuals. LOI is linked to microsatellite instability, which can predict patient outcomes.
A new human tumor-suppressor gene, PPP2R1B, has been identified as a potential indicator of susceptibility to lung and colon cancers. The study suggests that the gene's mutations may be inherited, making some individuals more susceptible to cigarette smoke-related chemicals.
Researchers at UT Southwestern Medical Center have developed an animal model for human colorectal cancer, which will facilitate research into the molecular mechanisms of the disease. The model, based on a colon cancer mouse, allows for testing of chemoprevention agents and new drug treatments.
Researchers at Johns Hopkins Oncology Center identify connection between APC and c-MYC genes, which conspire to initiate almost all colon cancers. The study suggests potential new drug strategies to prevent colon cancer by blocking the signal that activates c-MYC.
Researchers have found the first connection between the loss of a tumor suppressor gene and activation of an oncogene, providing new insights into the genesis of most cases of colon cancer. The study reveals that mutated APC genes switch on MYC, a gene associated with various cancers in animals and humans.
A study published in Nature Medicine suggests that the diabetes drug troglitazone may increase the risk of colon cancer by activating the PPAR receptor, which promotes tumor formation in the colon. The study found that mice treated with troglitazone developed a significantly greater number of colon polyps than those not treated.
A large randomized phase III study confirmed the efficacy of paclitaxel plus carboplatin in treating non-small cell lung cancer. Patients who received paclitaxel/carboplatin experienced a greater response rate and improvement in quality of life compared to cisplatin/etoposide.
Researchers have identified a new molecular switch that triggers mismatch repair in cells, which can prevent colon cancer. The discovery provides a foundation to specifically target anticancer drugs to this gene.
Scientists have identified a key genetic pathway responsible for 90 percent of colon cancers, which could lead to the development of targeted therapies. The mutation of the APC gene disrupts normal cell regulation, causing uncontrolled growth and cancer.
A new study reveals that a key signaling mechanism can turn healthy cells into tumors and lead to colon cancer. The researchers identified the role of beta-catenin in this process and found that it is involved in essentially all cases of colon cancer.
Researchers at UNC-CH launch first major investigation of colon cancer in both black and white populations, exploring environmental factors and dietary influences. The four-year study aims to identify key risk factors and promote a better understanding of the disease among African Americans.
A new virtual screening test for colon cancer uses spiral CT scans to build a three-dimensional image of the entire colon. This non-invasive test is more comfortable, convenient, and less expensive than traditional colonoscopy, which can help prevent colon cancer by detecting polyps early.