Articles tagged with Colon Cancer
New research adds to evidence that acetaminophen may prevent colon cancer in lab animals. The study found that pretreating animals with acetaminophen significantly protected them against cellular changes indicative of colon cancer. However, more animal research is needed before humans can be studied in clinical trials.
Researchers at Stanford University Medical Center have developed a novel approach to fighting cancer using a modified cold virus that targets cancer cells while leaving normal cells unharmed. In a phase I study, 28 patients who received the highest dose of the virus survived for nearly a year and saw significant tumor shrinkage.
Researchers found no statistical difference between sulindac and placebo groups in preventing polyp development or colon cancer, contradicting previous evidence. Sulindac may be ineffective at preventing polyps in newly diagnosed FAP patients, suggesting a need for alternative treatments.
Researchers have identified new markers for prostate and colon cancers, as well as a potential tumor suppressor gene. TIG1 was found to be expressed in normal prostate tissue but not malignant tumors, suggesting it may play a role in cancer progression.
Researchers identified a novel gene alteration that contributes to colon cancer growth, suggesting a new target for diagnosis and treatment. The discovery also hints at the possibility of reversing methylation-based tumor progression, potentially leading to a non-invasive diagnostic test.
A new study found that moderate to high calcium intake can lower the risk of distal colon cancer by 40-50% in women and men. However, excessive calcium consumption did not provide further benefits. Calcium may be the key component reducing colon cancer risk.
A new study published in Cancer Epidemiology, Biomarkers and Prevention suggests that dietary habits can significantly reduce colon cancer risk in individuals with a family history of the disease. Eating a diet high in folic acid, low in alcohol intake, and moderate in methionine may help lower this risk.
Researchers at the University of Maryland Greenebaum Cancer Center developed a new method using artificial neural networks to differentiate between two types of colon tumors. The study successfully diagnosed 12 out of 12 samples and reduced the number of genes necessary for diagnosis from 8,064 to 97.
The innovative procedure uses a 40-second CT scan to identify colon polyps, reducing the risk of puncturing and sedation. Virtual Colonoscopy has been shown to detect polyps as small as 3mm in diameter with high accuracy.
A new stool test developed by Johns Hopkins Medicine can detect the earliest, curable stages of colon cancer with high accuracy. The test uses a technology called Digital Protein Truncation to identify a key genetic marker of the disease, and has been shown to reliably detect cancers at an early stage, yielding no false positives.
A new test has detected colon cancer gene mutations in about 60% of early-stage colorectal cancer patients, with no false positive tests in healthy individuals. The test's high accuracy and low risk of false positives make it a promising tool for early detection and prevention.
A national clinical trial comparing minimally invasive and standard colon cancer surgeries found that laparoscopic-assisted colectomy patients experienced slightly shorter hospital stays and reduced pain medication needs, but no significant differences in post-operative pain or quality-of-life scores. The study suggests that while mini...
Researchers at Thomas Jefferson University identified a possible link between APC gene mutation and colon cancer, suggesting survivin's role in preventing programmed cell death. The study found that abnormal regulation of survivin may contribute to the development of colon cancer by allowing stem cells to overpopulate.
Researchers at Thomas Jefferson University developed a computer model showing that familial adenomatous polyposis (FAP) may begin when adult stem cells in the colon go out of control. The model suggests that an increase in stem cells triggers colon cancer, indicating that cancer may be a stem cell disorder.
Researchers at UNC will follow 1,000 newly diagnosed colon cancer patients for five years to study the impact of health literacy on patient outcomes. The study aims to improve survival rates and quality of life for patients with colon and lung cancers.
Research found that black raspberries can prevent esophageal cancer onset and inhibit precancerous cell growth in rats. Feeding rats with 5-10% black raspberries before and after NMBA treatment reduced tumors by 39-49% and 62-66.5%, respectively.
Prostate cancer screening is a contentious issue due to its potential impact on quality of life and the need for well-informed decision-making. The article highlights the limitations of current research, including the lack of data on risk-benefit analysis and the importance of avoiding unnecessary anxiety and treatment.
A new study published in New England Journal of Medicine found that age alone should not determine whether an older patient is offered chemotherapy after surgery for treatment of stage II and III colon cancer. The study showed a significant reduction in death risk and improved survival rates among patients over 70 with the disease.
A study by Ohio State University researchers reveals minute genetic changes in normal colonic tissue that may signal later development of certain types of colon cancer. The changes, which occur through hypermethylation, appear to be age-related and associated with microsatellite instability.
Researchers found that a fish oil-rich diet protects against colon cancer, while a corn oil-diet appears to promote it. The scientists also discovered how cancer spreads among cells in the colon, with a new understanding of cell damage varying from bottom to top within crypts.
Research highlights the benefits of physical activity in reducing heart disease risk in women with diabetes. Regular walking and faster walking paces were associated with even lower risks. Additionally, a study suggests that ursodiol may reduce colon cancer risk for some patients with ulcerative colitis.
Researchers found a 2% survival benefit among patients undergoing colon cancer surgeries at high-volume hospitals compared to lower volume facilities. The study examined over 28,000 Medicare beneficiaries and controlled for age, sex, and cancer stage.
A new study by University of North Carolina at Chapel Hill researchers shows that watching a videotape explaining colon cancer procedures can increase screening rates by at least 15%. This could lead to significant reductions in deaths from colorectal cancer, with over 47,000 Americans dying annually.
Healthcare personnel working in poorly ventilated general hospital rooms were at risk for sero-conversion of tuberculosis. Improving ventilation to at least two air exchanges per hour can help prevent this risk. Additionally, a program using an educational videotape and brochure increased colon cancer screening rates among patients.
Mayo Clinic researchers developed a new, non-invasive DNA test that detected 91% of colorectal cancers and 73% of polyps. The test shows promise for reducing unnecessary colonoscopies and costs associated with colorectal cancer screening.
Scientists have nearly eliminated pre-cancerous colon polyps in mice susceptible to colon tumors by combining an aspirin-like compound with a drug that inhibits epidermal growth factor activity. The combination therapy successfully blocked the development of pre-cancerous polyps and reduced cancerous tumor formation by over 95%.
A new trial will compare the effectiveness of three colon cancer detection methods: air contrast barium enema, traditional colonoscopy, and virtual colonoscopy. The study aims to determine which method is most accurate, tolerable and cost-effective for detecting polyps and lesions in the colon.
Two studies found sigmoidoscopy detects few cancerous growths and none in asymptomatic patients with polyps, supporting the use of colonoscopy for regular screening. The research suggests that colonoscopy should be done every 5-10 years for people over 50 to save lives.
A UCSD researcher has been awarded a grant to study the incidence and impact of microsatellite instability on colon cancer in African-Americans. The research aims to understand why African-Americans have a higher death rate from colorectal cancer despite lower incidence rates.
A recent study suggests that aspirin-like drugs could be useful in treating cancer by reducing tumor growth and angiogenesis. The researchers found that eliminating the gene for cyclooxygenase-2 (COX-2) or using COX-2 inhibitors significantly slowed down lung tumor growth in animal models.
The UK Markey Cancer Center will establish local coalitions and develop community outreach programs to address cancer barriers in Appalachian regions. The network aims to increase public awareness of clinical trials and promote participation among rural, medically underserved patients.
A major study on colon cancer prevention found no link between dietary changes and reduced polyp recurrence. Despite initial hopes, researchers now recommend regular screening and colonoscopies for those with existing polyps.
A survey of 95 individuals with a parent or sibling diagnosed with colon cancer found strong interest in genetic testing for susceptibility to the disease. However, many fail to follow recommended screening guidelines, highlighting the need for targeted educational efforts and interventions.
Researchers discovered that the PTTG1 gene is highly expressed in colorectal tumors, pre-cancerous polyps, and invasive cancer. The gene appears to play an early role in cancer development, acting as a marker for malignant activity.
A study published in the American Journal of Clinical Nutrition found that lutein and zeaxanthin, two types of carotenoids, have a protective effect against colon cancer. The antioxidants in these compounds help neutralize oxygen radical species and reduce the risk of colon cancer, particularly in younger individuals.
Researchers at Case Western Reserve University will use the grant to identify a genetic link in colon cancer development and screen more families with high risk. The study aims to uncover common genetic mutations that make individuals vulnerable to adenomatous polyps.
The Vanderbilt-Ingram Cancer Center has been selected to participate in the National Cancer Institute's new Mouse Models of Human Cancers Consortium. Researchers will develop and evaluate mouse models for eight major organ systems, focusing on breast, prostate, lung, ovary, skin, blood and lymph system, colon, and brain cancers.
Researchers at Vion Pharmaceuticals have developed a novel gene-based anti-cancer drug delivery system using Salmonella bacteria. The TAPET technology has shown complete tumor regression in mice and high safety profiles, with potential applications for treating various types of cancer.
Scientists at UNC Chapel Hill study found that a protein called adenomatous polyposis coli (APC) helps destroy another protein, beta catenin, which can lead to cell proliferation and tumor formation if disrupted. Understanding this pathway may help block tumor development in humans.
Researchers will examine strategies for persuading people to adopt healthier lifestyles, including better diets, exercise, and regular screening. The project aims to reduce the risk of colon cancer and save lives.
Researchers identified a possible new tumor-suppressor gene that plays a role in colon cancer and may predict response to new cancer therapy. The gene produces a protein important for fat cell maturity and metabolism, and its mutations may make tumors more susceptible to the antidiabetes drug troglitazone.
Researchers at Vanderbilt University Medical Center are exploring the role of aspirin and similar drugs in preventing colon cancer. They will study the mechanism of COX2 inhibition and its potential as a therapeutic target for colon cancer prevention.
Researchers have found a link between beta-catenin and cyclin D1 in colon cancer cells, leading to uncontrolled cell growth and tumor formation. This discovery may lead to new therapies for colon cancer and potentially other types of cancer.
Beta catenin disrupts cell regulation by synthesizing cyclin D1, allowing cells to proliferate out of control. The finding offers a potential new target for drug therapy in colon and other cancers.
Researchers at Penn discovered that chemoembolization doubles the survival time of adult patients with colon cancer that has spread to the liver. The procedure, which delivers chemotherapy directly to tumor cells, outperforms systemic chemotherapy in managing metastasized disease.
Researchers at Memorial Sloan-Kettering Cancer Center found nearly 20% of young patients with colorectal cancer have the HNPCC syndrome, a dominantly inherited disorder that increases lifetime risk of developing multiple cancers. Individuals with HNPCC require special surveillance to protect against additional cancers.
A study by researchers at Ohio State University found that genes involved in detoxifying cancer-causing chemicals play a role in the development of colorectal tumors. People with certain genetic mutations tend to develop tumors at younger ages or in the distal area of the large intestine.
A multi-centered study led by Dartmouth Medical School found that supplementation with calcium can reduce the recurrence rate of large bowel adenomas in people with a history of these particular polyps. The findings suggest promising measures that are fairly simple and inexpensive to help prevent colorectal cancer.
A new study found that calcium supplements moderately reduced the risk of recurring polyp growth in the colon and appeared to lower the risk of colon cancer. The study involved 832 patients who received 1200 milligrams of calcium carbonate daily for four years, with a 24% decrease in polyp numbers and a 19% decrease in recurrence risk.
Hopkins researchers found a genetic change called loss of imprinting (LOI) in 44% of colon cancer patients and 13% of healthy individuals. LOI is linked to microsatellite instability, which can predict patient outcomes.
A new human tumor-suppressor gene, PPP2R1B, has been identified as a potential indicator of susceptibility to lung and colon cancers. The study suggests that the gene's mutations may be inherited, making some individuals more susceptible to cigarette smoke-related chemicals.
Researchers at UT Southwestern Medical Center have developed an animal model for human colorectal cancer, which will facilitate research into the molecular mechanisms of the disease. The model, based on a colon cancer mouse, allows for testing of chemoprevention agents and new drug treatments.
Researchers at Johns Hopkins Oncology Center identify connection between APC and c-MYC genes, which conspire to initiate almost all colon cancers. The study suggests potential new drug strategies to prevent colon cancer by blocking the signal that activates c-MYC.
Researchers have found the first connection between the loss of a tumor suppressor gene and activation of an oncogene, providing new insights into the genesis of most cases of colon cancer. The study reveals that mutated APC genes switch on MYC, a gene associated with various cancers in animals and humans.
A study published in Nature Medicine suggests that the diabetes drug troglitazone may increase the risk of colon cancer by activating the PPAR receptor, which promotes tumor formation in the colon. The study found that mice treated with troglitazone developed a significantly greater number of colon polyps than those not treated.
A large randomized phase III study confirmed the efficacy of paclitaxel plus carboplatin in treating non-small cell lung cancer. Patients who received paclitaxel/carboplatin experienced a greater response rate and improvement in quality of life compared to cisplatin/etoposide.
Researchers have identified a new molecular switch that triggers mismatch repair in cells, which can prevent colon cancer. The discovery provides a foundation to specifically target anticancer drugs to this gene.
Scientists have identified a key genetic pathway responsible for 90 percent of colon cancers, which could lead to the development of targeted therapies. The mutation of the APC gene disrupts normal cell regulation, causing uncontrolled growth and cancer.
A new study reveals that a key signaling mechanism can turn healthy cells into tumors and lead to colon cancer. The researchers identified the role of beta-catenin in this process and found that it is involved in essentially all cases of colon cancer.
Researchers at UNC-CH launch first major investigation of colon cancer in both black and white populations, exploring environmental factors and dietary influences. The four-year study aims to identify key risk factors and promote a better understanding of the disease among African Americans.