Articles tagged with Creutzfeldt Jakob Disease
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Researchers investigated the relationship between protein aggregation and liquid-liquid phase separation, finding that droplet formation may actually protect against aggregation. The study, led by Paul Scherrer Institute, used over 500 conditions to test the behavior of alpha-synuclein proteins.
Madhu Kannan, a University of Minnesota Medical School assistant professor, has been selected for the Chan Zuckerberg Initiative's Collaborative Pairs Pilot Project Awards to explore innovative approaches to understanding human prion diseases. The project will utilize cutting-edge approaches combining gene editing and neural activity i...
Researchers discovered a new prion structure using electron microscopy, revealing key similarities and differences between distinct strains. This finding could lead to better understanding of how shape variations affect disease outcomes.
Researchers have developed a monoclonal antibody called PRN100, which showed safe and encouraging results in treating Creutzfeldt-Jakob disease (CJD) in six patients. While the findings are preliminary and require further studies, they offer new prospects for this rare and fatal disease.
Researchers discover misfolded prion proteins in skin samples from Creutzfeldt-Jakob disease patients, but find lower amounts in the skin compared to brain tissue. The study raises concerns about possible transmission of prion diseases through surgical procedures involving the skin.
Researchers at UTHealth have developed a blood test that can detect Creutzfeldt-Jakob disease with 100% sensitivity and specificity. The test uses a protein misfolding cyclic amplification assay to identify prions, which are infectious proteins responsible for the disease.
A new study has developed an algorithm for accurate CJD diagnosis, achieving 100% sensitivity and specificity. The method uses cerebrospinal fluid samples or nasal swabs, showing promise for early detection.
A recent study found Aβ plaques in brains of recipients with Creutzfeldt-Jakob disease, sparking concerns over transmissible Alzheimer's disease. The discovery highlights the potential risks of transplantation medicine and calls for heightened attention to this issue.
Scientists at SISSA create synthetic prion series for the first time, allowing precise control over their pathogenic behavior. The study verifies that these synthetic prions cause illness comparable to natural ones, paving the way for potential treatments for neurodegenerative diseases.
Researchers at UTHealth Medical School have found misfolded prion proteins in the urine of 13 out of 14 patients with variant Creutzfeldt-Jakob disease, providing a new potential diagnostic tool. This breakthrough could lead to the development of non-invasive tests for diagnosis and monitoring.
Researchers have developed a new nasal test that can quickly and accurately diagnose Creutzfeldt-Jakob disease, an incurable neurodegenerative disorder. The test was successfully tested in 97% of patients with the disease and showed 100% specificity for non-patients.
Researchers found a case of rapid hearing loss in a patient with Creutzfeldt-Jakob Disease, highlighting the need for clinicians to consider CJD when diagnosing patients with fast-progressing hearing impairment.
The American Academy of Neurology has released a new guideline to help doctors diagnose Creutzfeldt-Jakob disease, a rare and always fatal brain disorder. The guideline suggests that the 14-3-3 protein test can be useful in reducing uncertainty when the probability of the disease is between 20% and 90%.
A study by UTHealth suggests that Alzheimer's disease may arise from an infectious process similar to other neurological diseases. Researchers injected brain tissue from a confirmed Alzheimer's patient into mice, which developed plaques and brain alterations typical of the disease.
Researchers found that inhalation of prion-tainted aerosols induced disease with frightening efficiency in mice, infecting all within a single minute. This discovery challenges the widely held view that prions are not airborne and suggests precautionary measures for scientific labs, slaughterhouses, and animal feed plants.
Normally functioning prions prevent neurons from self-destruction by inducing overactive brain cells that respond longer and more vigorously to stimulation. This hyperactivity eventually leads to neuron death, potentially explaining why misfolded prions cause dementia.
A new study has identified four distinct biochemical subgroups in Creutzfeldt-Jakob disease, potentially representing different prion strains. These subgroups were found in both sporadic and iatrogenic cases of the disease, with no correlation to the prion protein gene.
A study reveals that variant Creutzfeldt-Jakob disease can be transmitted to humans with specific genetic variations, including methionine/valine (MV) and valine (VV), suggesting a significant public health issue. The transmission rate varies among these genotypes, with VV mice showing the highest susceptibility.
A new case of vCJD in Japan highlights the potential for misdiagnosis, as the patient's EEG showed a rare brainwave pattern characteristic. This discovery suggests revising the WHO definition to prevent missing cases.
Researchers found that small prions are significantly more infectious than large ones, yet there is a lower size limit beyond which infectivity is lost. The study's findings suggest that treatments targeting large prion deposits may do more harm than good by releasing the most infectious particles.
A study estimates that a person would need to eat at least 1.5kg of neural tissue from an infected animal to be at risk of developing vCJD. The investigation found the efficiency of infection from cow to primate could be 7-20 times lower than intraspecies infection for cattle.
Researchers found that immunization can stimulate the immune system to combat prion disease, which affects humans and animals. The study suggests that vaccination could be an effective therapy for prion diseases like Creutzfeldt-Jakob disease and Alzheimer's disease.
The number of UK deaths from vCJD has been declining, with a stabilization in the rate of mortality. The disease's mortality rate is no longer increasing exponentially, but further confirmation is needed to determine if the epidemic is in permanent decline.
A European epidemiological study found a weak but significant association between certain factors and sporadic CJD, including consumption of raw meat or brain tissue. The researchers noted that the study is only a first step and many questions remain to be answered.