Articles tagged with Myocardial Infarction
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Researchers evaluated cord blood-derived CD133+ cells for treating myocardial infarction. The cells showed promising results, improving left ventricular ejection fraction and forming tubule-like structures. Further pre-clinical testing is needed to determine their clinical advantages.
Patients with reduced kidney function and high proteinuria at increased risk of death, heart attacks, or progression to kidney failure. The study suggests that future guidelines for chronic kidney disease classification should incorporate information on proteinuria levels.
The PLATO trial shows that ticagrelor, a stronger anticlotting medication, reduces the risk of cardiovascular death and heart attacks without increasing bleeding in heart attack patients. This new analysis finds significant and clinically relevant reductions in cardiovascular and total deaths, myocardial infarction, and stent thrombosis.
A team of researchers from Indiana University and Stanford University has determined how a 'chemical chaperone' activates the ALDH2 enzyme, which plays a crucial role in metabolizing toxins after a heart attack. The discovery could lead to new treatments by restoring enzyme function, reducing muscle damage caused by heart attacks.
The COMPARE study found that everolimus-eluting stents significantly reduced serious adverse cardiac events compared to paclitaxel-eluting stents. The study concluded that the use of second-generation everolimus-eluting stents was associated with a significant reduction in major adverse cardiac events at 1 year.
A study found that Medicare beneficiaries who attended more cardiac rehabilitation sessions had better outcomes, including a reduced risk of heart attack and death. Researchers analyzed data from over 30,000 patients age 65 and older, finding that those who attended all 36 sessions had the lowest mortality rates.
Researchers found that strict glucose control reduces cardiovascular issues for diabetics with fewer health problems, but not those with long-term serious coexisting conditions. Firm glucose control may benefit patients with multiple health issues.
A new study suggests that combining celebrex with low-dose aspirin may reduce the effectiveness of aspirin in preventing heart attack and stroke. Researchers found that celebrex interferes with aspirin's ability to block blood clots, particularly when taken in low doses.
Researchers have discovered a blood clotting agent that can be targeted without affecting normal wound healing, offering potential improvements over existing anticoagulant drugs. The findings suggest polyphosphate or factor XII could be new targets for drug development to reduce thrombosis risk.
A team of researchers at Karolinska Institutet has discovered a gene module underlying atherosclerosis development by analyzing total gene activity in organs relevant to coronary artery disease. The findings suggest that targeting the migration of white blood cells may help reduce the risk of adverse clinical effects.
A new Saint Louis University research suggests that individuals with type 2 diabetes and coronary artery disease have a more favorable prognosis when properly managed with medical care. The BARI 2D trial found significant improvements in treatment outcomes for patients receiving intensive medical therapy or bypass surgery.
A new study suggests that adult stem cells can differentiate into heart cells to repair damage, offering a promising new treatment for heart attack patients. The Phase I trial showed significant improvements in heart function and reduced arrhythmias after administration of the stem cells.
Healthcare professionals using a team approach saw significant improvements in treating patients having a heart attack, reducing door-to-balloon times by more than half since 2005. The study, published in the Journal of the American College of Cardiology, found widespread adoption of strategies to improve care across the nation.
Researchers at Imperial College London have identified TLR-2 as the trigger that leads to inflammation and damage in atherosclerosis, a condition causing heart attacks and strokes. Blocking this molecule could potentially treat atherosclerosis and reduce the risk of these diseases.
A new study reveals that dentists can identify patients at risk of a fatal cardiovascular disease using software called HeartScore. Six men who thought they were healthy received preventive treatment in time thanks to the dental care team's efforts.
A study of 29,513 patients with STEMI found no significant difference in death rates among hospitals with high, medium, or low primary angioplasty volumes. Despite lower door-to-balloon times and higher adherence to guidelines at high-volume centers, mortality rates remained consistent across the groups.
A new MEMS sensor can detect changes in bulk resistance for plaque characteristics and identify spots where back currents may be promoting plaque formation. This technology has the potential to improve heart attack treatment by distinguishing between stable and unstable plaque.
A new study published in the Journal of the American College of Cardiology found that women are less likely to exhibit signs of structural heart disease, which is a precursor to fatal cardiac arrest. This means that fewer women may be eligible for current treatments that can prevent sudden cardiac arrest.
A large study found acute heart attack patients received an average of 14.5 millisieverts of ionizing radiation, equivalent to 725 chest X-rays, during their hospital stay. Physicians may be unaware of cumulative dose accumulation from tests and should consider radiation exposure when diagnosing and treating heart attacks.
Researchers developed microscopic polymer beads that can deliver an antioxidant enzyme into the heart, reducing dying cells and improving heart function after a simulated heart attack. The enzyme, superoxide dismutase (SOD), soaks up toxic free radicals produced during a heart attack.
After a heart attack, patients experience shortness of breath and chest pain due to elevated cardiac biomarkers TnT and NTBNP. These biomarkers signal ongoing problems or past issues, highlighting the need for targeted treatment.
A new study funded by NIH will investigate whether Transcendental Meditation can aid in the treatment of coronary heart disease. The 12-week trial at Columbia University Medical Center will examine 56 patients with CHD, measuring changes in coronary artery disease using advanced non-invasive methods.
A recent study found that hospital mortality after a heart attack has declined significantly for younger women, particularly those under 55 years old, over the past 12 years. The researchers attribute this improvement to changes in patient characteristics and treatments.
A new study has found no significant gender differences in rates of chest discomfort or 'typical' symptoms such as arm discomfort, shortness of breath, and sweating. Female patients were more likely to have both classic symptoms of a heart attack and throat, jaw, and neck discomfort.
A study of 2,240 people found that high CRP levels were associated with an increased risk of heart attack and death, while lower levels were linked to reduced risk. The protein was not linked to an increased risk of stroke in the study, suggesting it may be more useful for predicting heart health.
A Kaiser Permanente program bundled two generic, low-cost drugs and gave daily doses to 68,560 people with diabetes or heart disease for two years, preventing 1,271 heart attacks and strokes. The study found a 60% reduction in hospitalization rates for heart attack or stroke among those taking the bundled drugs.
A non-invasive test can effectively screen for silent heart disease and identify high-risk patients, potentially preventing heart attacks and sudden deaths. Coronary artery calcium scans detected plaque in coronary arteries, which were more effective than standard measurements.
A study of young women with antiphospholipid syndrome reveals a significantly increased risk of stroke and heart attack, particularly when combined with smoking and oral contraceptive use. The findings emphasize the need for screening and warning young women about these cardiovascular risks.
A new study published in the Journal of the American College of Cardiology found that public smoking bans can significantly reduce the risk of heart attacks, especially among younger individuals and nonsmokers. The study suggests that banning smoking in public places and workplaces can prevent up to 154,000 heart attacks each year.
A systematic review of evidence found that flu can trigger heart attacks and cause cardiovascular death, but the influenza vaccine may reduce this risk. The review suggests that vaccination should be encouraged in people with existing cardiovascular disease, particularly during seasonal flu outbreaks.
A meta-analysis of 13 studies found that heart attack rates started to drop immediately following smoking ban implementation, reaching 17% after one year, then continuing to decline over time. The study provides strong evidence for the benefits of smoke-free laws in reducing cardiovascular disease.
Researchers have discovered that applying capsaicin to specific skin locations can trigger signals in the nervous system, activating cellular pathways that protect the heart. This technique has shown promise in reducing cardiac cell death by up to 85%.
A harmless shard from a childhood virus's shell may halt the complement response, a primordial part of the immune system that kills oxygen-deprived victims. This discovery could help save soldiers' lives and reduce brain damage caused by reperfusion injury.
Biomarker levels strongly predict bypass surgery outcome and identify patients at risk of complications. Current diagnostic standards may need reconsideration due to low sensitivity.
A new study published in JAMA suggests that immediate intervention for patients with acute coronary syndromes (ACS) may not provide a significant advantage in terms of outcomes. However, the strategy can still reduce hospital stay duration. The study evaluated data from 352 patients with ACS and found that both immediate and delayed in...
A new study published in The Lancet found that proton pump inhibitors do not negate the clinical benefit of clopidogrel or prasugrel in patients after a heart attack. The TRITON-TIMI 38 trial showed that PPIs can be safely used with these antiplatelet drugs to reduce gastrointestinal bleeding.
A large international study reveals patients with vascular disease experience a surprisingly high rate of recurring events such as strokes, heart attacks, and hospitalizations. Patients in Eastern Europe had the highest rate, while those in Australia and Japan had the lowest.
A landmark international study found that high doses of clopidogrel significantly reduce stent thrombosis and heart attacks in patients undergoing angioplasty. The study showed a 30% reduction in stent thrombosis risk and a 22% lower risk of heart attack with the higher dose regimen.
A phase II trial shows otamixaban, an intravenous blood clot inhibitor, reduces major coronary complications in high-risk ACS patients with lower bleeding rates compared to heparin. The study found intermediate doses of otamixaban offer a significant reduction in death and ischemic complications.
A new study published in The Lancet found that otamixaban significantly reduces the risk of death and second heart attacks in patients with non-ST-elevation acute coronary syndromes. The drug, which inhibits factor Xa, shows promise as an alternative to current standard treatments.
The HORIZONS-AMI study found that bivalirudin reduced clinical events and major bleeding in heart attack patients undergoing angioplasty. This is a significant finding with important clinical implications for the selection of treatment strategies for high-risk patients.
The PLATO study demonstrated that ticagrelor reduced cardiovascular events by 16% compared to clopidogrel, with no increase in major bleeding. The efficacy of ticagrelor was observed across all major acute coronary syndromes patient types, with a consistent benefit seen in secondary endpoints.
Recent discoveries of genetic variants affecting coronary artery disease and heart attack risk are promising for preventing the condition. The variants increase risk by 10-30% and are common, making them useful in prevention algorithms.
Recent observational studies show no overall safety issue with drug eluting stents compared to bare metal stents, with lower risks of death or myocardial infarction. However, late stent thrombosis remains higher and uniquely associated with drug eluting stents, necessitating improved patient selection and treatment strategies.
Women are slightly more likely to die from heart attacks due to a higher risk after severe presentations, while less severe cases show lower mortality rates. The study highlights the importance of considering sex in ACS research and delivery of care.
Women may have a slightly higher risk of death than men in the 30 days following an acute coronary syndrome, but this difference appears to be due to factors such as severity and type of ACS. After adjusting for clinical characteristics and angiographic data, no significant difference in 30-day mortality was found.
A recent study published in PLoS ONE suggests that heart attacks and strokes were rare in human history. The Tsimane Amazonian tribe, with a traditional lifestyle, shows low levels of atherosclerosis, contradicting the expected high risk of cardiovascular disease.
Researchers found that high levels of calcium in coronary arteries can predict severe cardiac events, including fatal heart attacks. The study suggests combining calcium scoring with other imaging tests can help identify patients at highest risk.
A novel drug Dz13 has been shown to reduce heart muscle damage after a heart attack and protect the heart's pumping action. The drug targets the c-Jun gene, which is responsible for inflammation and muscle death in the aftermath of a heart attack.
A team of researchers has found that transplanting sheets of clonally expanded heart cells improves heart function after a heart attack in mice. The cells secreted a molecule that induced the migration of endothelial cells and prevented oxidative stress, leading to improved heart function.
Researchers found that inhibiting Nox4 substantially inhibits hemangioma growth in a mouse model, while transplantation of cardiac progenitor cells improves heart function after myocardial infarction. Additionally, IL-17 and IL-22 play a crucial role in protecting individuals from developing kala azar, a lethal parasite disease.
A study published in the Clinical Journal of the American Society Nephrology found that dialysis does not affect the heart health of kidney disease patients who have had a heart attack. Researchers identified predictors of high risk, such as potassium levels and patient condition severity.
A study published by UCSF researchers found that bone marrow extract is as effective as bone marrow stem cells in improving cardiac function, decreasing scar tissue, and pumping capacity after a heart attack. Both therapies resulted in increased blood vessels and reduced cardiac cell death, showing promise for new treatments.
A new study by Dr. Thao Huynh analyzes the best way to treat patients with heart attacks, suggesting that reducing delays in providing primary PCI can maximize its effectiveness. The study also highlights the importance of optimal medical therapy after discharge to prevent repeat heart attacks.
A large study found that stroke survivors experience a decline in functional ability over five years, with those having Medicaid or no private insurance showing the greatest decline. Factors such as age, diabetes, and severe stroke severity also contribute to this decline.
A new study suggests that transferring heart attack patients to specialized hospitals for angioplasty within six hours after clot-busting drugs significantly improves outcomes, reducing repeat heart attacks and serious cardiac complications by 36%. Patients who received earlier angioplasty also had lower rates of chest pain and second ...
A recent study published in PLOS Medicine reveals that inflammatory markers are more strongly associated with fatal than nonfatal cardiovascular events in elderly individuals. The study found that elevated levels of IL-6 and other inflammatory markers were linked to a higher risk of fatal heart attacks and strokes.
The study found that oral rivaroxaban reduced the risk of death, heart attack, or stroke by 21% compared to placebo, with a lower risk of clinically significant bleeding. The medication inhibits factor Xa and has been shown effective in preventing venous thromboembolism.
Alan Davison, Alun G. Jones, and Michael J. Abrams discovered a new class of technetium complexes that showed localization in cardiac tissue after intravenous administration, leading to the development of myocardial perfusion imaging agents. Their work has enabled millions of people to receive better diagnosis and treatment for heart c...
A genetic analysis found that high levels of lipoprotein(a) are associated with an increased risk of heart attack, even after adjusting for other factors. The study suggests that reducing lipoprotein(a) levels may help lower the risk of heart attack.